library(ggplot2)
library(tidyverse)
library(tidyr)
library(qqman)
library(cgwtools)
library(BiSeq)
library(reshape2)
library(gridExtra)
library(kableExtra)
## J20
# Load the unique dataset
load("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/Normalised_Data_Sesame.rdat")
source("/gpfs/ts0/projects/Research_Project-191406/Aisha/script/rrbs-ad-mice/PlotFunctions.R")
source("/gpfs/ts0/projects/Research_Project-191406/Aisha/script/rrbs-ad-mice/Array/BetaRegressionArray.R")
# Filter for J20 samples
pheno <- QCmetrics[which(QCmetrics$Tissue == "CortexEntorhinalis" & QCmetrics$AD_model == "J20"),]
betas <- Normalised_Sesame_Betas[,colnames(Normalised_Sesame_Betas) %in% pheno$Basename ]
pheno$Genotype <- as.factor(pheno$Genotype)

# Load pathology data to set ages
pathology_pheno <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_ECX_Pathology.csv", header = T, stringsAsFactors = F)
colnames(pathology_pheno)[colnames(pathology_pheno) == 'X...Sample_ID_ECX'] <- 'Sample_ID_ECX'
pheno$Sample_ID_ECX <- gsub(".*_", "", pheno$ExternalSampleID)

phenowPath <- merge(pheno,pathology_pheno, by = "Sample_ID_ECX")
colnames(phenowPath)[colnames(phenowPath) == 'Genotype.x'] <- 'Genotype'
pheno <- phenowPath

betas <- betas[,order(colnames(betas))]
pheno <- pheno[order(pheno$Basename),]
identical(colnames(betas), pheno$Basename)
## [1] TRUE
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT","TG"))
pheno$Chip_ID <- pheno$Slide

#Load coordinates matrix
probe_mapping_file <- read_csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/HorvathMammalChip_SpeciesGenomeCoordsUnique_v1.0.csv", col_types = cols(.default = "c"))
species_probes <- probe_mapping_file[, c('probeID','MusMusculus')]
species_probes <- as.data.frame(species_probes[!is.na(species_probes$MusMusculus),]) #24048 probes 
species_probes$Chr <- gsub(":.*","",species_probes$MusMusculus)
species_probes$Bp <- species_probes$MusMusculus
species_probes$Bp <- gsub("*.:","", species_probes$Bp)
species_probes <- species_probes[,-2]
species_probes$Position <- paste("chr", paste(species_probes$Chr, species_probes$Bp, sep = ":"), sep ="")
Coordinates <- species_probes

All samples are from Cortex Entorhinalis region. There are 40 samples, 20 in each genotype where each 5 samples are taken from ages 6 months, 9 months,10 months and 12 months.

Beta regression is used as to find sites with genotype differences. Chip is used as a covariate as some samples on the same chip clustered together on heatmaps. The p values are FDR adjusted to test for significant sites across the genome. Therefore the threshold on manhattan plots are drawn at -log10 0.05. A table of results is given for sites that pass this significant threshold.

Single models

Genotype

\[{Methylation } = {Genotype + Age + Genotype*Age + Chip}\]

# betaResultsChip <- BetaRegressionArray(betas = betas,
#                            pheno = pheno,
#                            formula = ~Genotype + Age_months+ Genotype*Age_months + Chip_ID,
#                            formulaNull = ~Genotype + Age_months+  Chip_ID,
#                            link = "probit")
# 
# save(betaResultsChip, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResults_J20.RData")
load("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResults_J20.RData")
betaResults <- betaResultsChip
# Add chr and bp before deleting rows
Chr <- species_probes$Chr[match(species_probes$probeID, betaResults[,"cpg"])]
Bp <- species_probes$Bp[match(species_probes$probeID, betaResults[,"cpg"])]

betaResults <- cbind(Bp, betaResults)
betaResults <- cbind(Chr, betaResults)

# Remove NA rows
# na_df <- as.data.frame(betaResults[rowSums(is.na(betaResults)) > 0,]) #54 probes has no data in columns
# betaResults <- betaResults[-which(betaResults[,"cpg"] %in% na_df$cpg),] #remove these NAs rows
betaResults <- betaResults[,c(17,1:16)]

# Add FDR pvalues

FDR_adj_genotype <- p.adjust(betaResults[,"p.val.Genotype"], method = "fdr")
FDR_adj_age <- p.adjust(betaResults[,"p.val.Age"], method = "fdr")
FDR_adj_Interaction <- p.adjust(betaResults[,"p.val.Interaction"], method = "fdr")

betaResults <- cbind(betaResults, FDR_adj_genotype, FDR_adj_age, FDR_adj_Interaction)
betaResults <- betaResults[,c(1:10,18,11:13,19,14:17,20)]

# Convert to data frame w/out factors
betaResults2 <- as.data.frame(betaResults)
betaResults2[] <- lapply(betaResults2, as.character)

for(i in 4:20){
  betaResults2[,i] <- as.numeric(as.character(betaResults2[,i]))
}
betaResults2[,"Bp"] <- as.numeric(as.character(betaResults2[,"Bp"]))

betaResults <- betaResults2
# Convert x and y to numbers and remove non autosomal

betaResults<- betaResults[-which(betaResults$Chr %in% c("CHR_MG51_PATCH",
                                                      "CHR_MG4200_PATCH","CHR_MG3699_PATCH")),]
betaResults$Chr <- gsub("X", 20, betaResults$Chr)
betaResults$Chr <- gsub("Y", 21, betaResults$Chr)

betaResults$Chr <- as.numeric(betaResults$Chr)
betaResults$Bp <- as.numeric(betaResults$Bp)

### Add gene names in
mm10_Manifest <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/mm10_Manifest.csv", stringsAsFactors = F, header = T, row.names = 1)

betaResults$Gene_Symbol <- mm10_Manifest$Gene_Symbol[match(betaResults$cpg, mm10_Manifest$cpg)]
# Save to outputs

# write.csv(betaResults, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_stats_table_J20.csv")
# 
# 
# sig_genotype <- betaResults[which(betaResults[,"FDR_adj_genotype"] < 0.05),]
# write.csv(sig_genotype, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_genotype.csv")
# 
# sig_age <- betaResults[which(betaResults[,"FDR_adj_age"] < 0.05),]
# write.csv(sig_age, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_age.csv")
# 
# sig_interaction <- betaResults[which(betaResults[,"FDR_adj_Interaction"] < 0.05),]
# write.csv(sig_interaction, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_interaction.csv")
threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"
rownames(betaResults) <- betaResults$cpg

# Genotype
manhattan(betaResults, p = "FDR_adj_genotype", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Genotype",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold, 
          cex.axis = 1.5, cex.lab = 1.2)

# chromosome problem?
# take chr 10 - 19
# 
# betaResults2 <- betaResults[which(betaResults$Chr == c(10:19)),]
# betaResults2 <- betaResults2[,c(2,3,11)]
# colnames(betaResults2) <- c("CHR", "BP", "P")
# betaResults2$BP = as.integer(format(betaResults2$BP, scientific=F))
# betaResults2$BP <- as.numeric(betaResults2$BP)
# 
# manhattan(betaResults, 
#           genomewide = -log10(threshold), suggestiveline = FALSE, 
#           logp=T)
# 
# manhattan(betaResults2, p = "FDR_adj_genotype", bp = "Bp", chr = "Chr", 
#           genomewide = -log10(threshold), suggestiveline = FALSE, 
#           logp=T, col = c("black", color_J20_TG), main = "Genotype",
#           las = 2, annotatePval = threshold, 
#           cex.axis = 1.5, cex.lab = 1.2)
# 
# for(i in 1:21) {
#   x = sum(is.na(betaResults[which(betaResults$Chr == i),]))
#   print(paste(i, x , sep = " - na:"))
# }
# 
# 
# library(gap)
# ops <- mht.control(colors=rep(c("lightgray","lightblue"),21),srt=0,yline=2.5,xline=2)
# mhtplot(betaResults[,c(2,3,4)])
# mhtplot(betaResults[,c(2,3,11)],ops,xlab="",ylab="",srt=0)
# axis(1,at=1:21)
# axis(2,at=1:16)
lamda <- qchisq(1-median(betaResults$p.val.Genotype),1)/qchisq(0.5,1)
qq(betaResults$p.val.Genotype, main = "Genotype (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_genotype),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_genotype, main = "Genotype (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_genotype),]
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT", "TG"))

## Genotypes = with covariates
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6) {
  # model<-lm(as.numeric(betas[rownames(betaResults)[i],]*100) ~ pheno$AgeMonths + pheno$Chip_ID) ## This needs to include all the confouders from your analysis model but not the vaiable you are interested in.
  # adjValues<-residuals(model)+coefficients(model)[1]
  # boxplot(adjValues ~ pheno$Genotype, xlab = "Genotype", ylab = "DNA methylation (%)", 
  #         main = paste(rownames(beta)[i], betaResults[i,"Gene_Symbol"], sep = " ")) ## we multiple by 100 to plot of a % scale rather than proportion
  # mtext(paste("P = ", signif(betaResults[i, "FDR_adj_genotype"],3)), side = 3, adj = 1, cex = 0.7) ## add P value to plot rounded to 3 sf
    plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
  
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_Genotype.pdf", onefile = T)
for(i in 1:6){
  plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()
## png 
##   2
if(length(which(betaResults$FDR_adj_genotype <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_genotype <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_genotype),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_genotype", "p.val.Genotype","meth.group1.WT",
                             "meth.group2.TG","meth.diff.Genotype" ,"estimate.Genotype","std.error.Genotype")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj.p.val", "raw p.val","meth WT",
                             "meth TG","meth diff" ,"estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}
cpg Gene Symbol Chr Bp FDR adj.p.val raw p.val meth WT meth TG meth diff estimate std error
cg22786134 Zbtb20 16 143557635 1.388063e-08 5.873412e-13 0.5298406 0.3021011 0.2277396 -0.5932364 0.0823552
cg06658605 Sox6 7 115747711 1.693876e-03 1.433483e-07 0.0688789 0.0533252 0.0155537 -0.1292403 0.0245662
cg16692177 Arx 20 93302229 2.009374e-03 2.550723e-07 0.7420701 0.5636319 0.1784382 -0.4895568 0.0949869
cg12137126 Bnc2 4 84284440 4.998737e-03 1.057576e-06 0.5393577 0.3916911 0.1476666 -0.3737298 0.0765744
cg22663524 Dynlrb2 8 116568832 4.998737e-03 9.198022e-07 0.9604932 0.9721683 -0.0116751 0.1572237 0.0320338
cg24737665 1810030O07Rik 20 12677624 9.170728e-03 2.328285e-06 0.3229701 0.2205363 0.1024338 -0.3109739 0.0658478
cg18877697 Sorcs1 19 150190045 1.768825e-02 5.239189e-06 0.9475681 0.9636657 -0.0160976 0.1731886 0.0380219
cg04989171 Klhl10 11 1100447124 3.061243e-02 1.165793e-05 0.9044784 0.9542121 -0.0497337 0.3796439 0.0865998
cg06179749 A3galt2 4 128743543 3.061243e-02 1.152140e-05 0.8774797 0.9444428 -0.0669631 0.4307245 0.0981943
cg22661567 Pbx3 2 34288768 3.067860e-02 1.298126e-05 0.8422430 0.7372830 0.1049600 -0.3687277 0.0845624
cg00519284 Trim2 3 84193329 4.142527e-02 1.928143e-05 0.9123697 0.9497284 -0.0373587 0.2867330 0.0671026
cg20256450 Ebf1 11 144904276 4.467111e-02 2.268241e-05 0.8654846 0.7844571 0.0810275 -0.3179623 0.0750494

Age

#Age 
manhattan(betaResults, p = "FDR_adj_age", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Age",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold, 
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Age),1)/qchisq(0.5,1)
qq(betaResults$p.val.Age, main = "Age (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_age),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_age, main = "Age (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

Interaction

The individual plots fot sites are the raw methylation values of the samples across ages. The dotted lines are the mean values for across the ages within genotypes.

#Interaction
manhattan(betaResults, p = "FDR_adj_Interaction", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Genotype*Age Interaction",
          chrlabs = c(1:19, "X", "Y"),las = 2, 
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Interaction),1)/qchisq(0.5,1)
qq(betaResults$p.val.Interaction, main = "Genotype*Age Interaction (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_Interaction),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_Interaction, main = "Interaction (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_Interaction),]
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT", "TG"))
pheno$col <-  ifelse(pheno$Genotype == "WT","#000000", color_J20_TG)

SamplesMean <- function(Genotype = Genotype, Age = Age, betas = betas, pheno = pheno, cpg = cpg){
    samples <- rownames(pheno[which(pheno$Genotype == Genotype & pheno$AgeMonths == Age),])
    betas_samples <-  betas[cpg,samples]
    mean_samples <- apply(betas_samples,1, mean)

    return(mean_samples)
  }

geno_age_mean <- matrix(NA, nrow = 4, ncol = 2)
colnames(geno_age_mean) <- c("WT", "TG")
rownames(geno_age_mean) <- c(6,8,10,12)
ages <- c(6,8,10,12)

par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6){
  # for( s in 1:4){
  #   j = ages[s]
  #   geno_age_mean[s,1] <- SamplesMean("WT", j, betas, pheno, cpg = rownames(betaResults)[i])
  #   geno_age_mean[s,2] <- SamplesMean("TG", j, betas, pheno, cpg = rownames(betaResults)[i])
  # }
  # geno_age_mean <- as.data.frame(geno_age_mean)
  # 
  # plot(pheno$AgeMonths, as.numeric(betas[rownames(betaResults)[i],]*100),
  #      xlab = "Age (months)", ylab = "DNA methylation (%)", pch = 16,
  #      main = paste(rownames(betas)[i], betaResults[i,"Gene_Symbol"], sep = " "),
  #      col = pheno$col)
  # lines(as.numeric(rownames(geno_age_mean)), geno_age_mean$WT*100, col = "#000000", lty = 2)
  # lines(as.numeric(rownames(geno_age_mean)), geno_age_mean$TG*100, col = color_J20_TG, lty = 2)
  # 
  # par(xpd  = TRUE)
  # legend(x ="topright",legend = levels(factor(pheno$Genotype)),
  #        col = c("#000000", color_J20_TG), pch = 19, cex = .7,
  #        inset=c(-0.02,-0.25))
  # 
  # par(xpd  = FALSE)
  # mtext(paste("P = ", signif(betaResults[i, "FDR_adj_Interaction"],3)), side = 3, adj = 1, cex = 0.7) ## add P value to plot rounded to 3 sf
  
    plotDMPInteraction(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
  
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_Interaction.pdf", onefile = T)
for(i in 1:6){
  plotDMPInteraction(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()
## png 
##   2

Pathology

\[{Methylation } = {Pathology + Chip}\]

# betaResultsPathology <- BetaRegressionArrayPathology(betas = betas,
#                                                      pheno = pheno,
#                                                      formula = ~Pathology_ECX + Chip_ID,
#                                                      link = "probit")
# resave(betaResultsPathology, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResults_J20.RData")
betaResults <- betaResultsPathology
# Add chr and bp before deleting rows
Chr <- species_probes$Chr[match(species_probes$probeID, betaResults[,"cpg"])]
Bp <- species_probes$Bp[match(species_probes$probeID, betaResults[,"cpg"])]

betaResults <- cbind(Bp, betaResults)
betaResults <- cbind(Chr, betaResults)

# Remove NA rows
# na_df <- as.data.frame(betaResults[rowSums(is.na(betaResults)) > 0,]) #54 probes has no data in columns
# betaResults <- betaResults[-which(betaResults[,"cpg"] %in% na_df$cpg),] #remove these NAs rows
betaResults <- betaResults[,c(10,1:9)]

# Add FDR pvalues

FDR_adj_pathology <- p.adjust(betaResults[,"p.val.Pathology"], method = "fdr")

betaResults <- cbind(betaResults, FDR_adj_pathology)
betaResults <- betaResults[,c(1:4,11,5:10)]

# Convert to data frame w/out factors
betaResults2 <- as.data.frame(betaResults)
betaResults2[] <- lapply(betaResults2, as.character)

for(i in 4:11){
  betaResults2[,i] <- as.numeric(as.character(betaResults2[,i]))
}
betaResults2[,"Bp"] <- as.numeric(as.character(betaResults2[,"Bp"]))
betaResults2[,"cpg"] <- as.character(betaResults2[,"cpg"]) 
betaResults <- betaResults2

# Convert x and y to numbers and remove non autosomal

betaResults<- betaResults[-which(betaResults$Chr %in% c("CHR_MG51_PATCH",
                                                      "CHR_MG4200_PATCH","CHR_MG3699_PATCH")),]
betaResults$Chr <- gsub("X", 20, betaResults$Chr)
betaResults$Chr <- gsub("Y", 21, betaResults$Chr)

betaResults$Chr <- as.numeric(betaResults$Chr)
betaResults$Bp <- as.numeric(betaResults$Bp)

### Add gene names in
mm10_Manifest <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/mm10_Manifest.csv", stringsAsFactors = F, header = T, row.names = 1)

betaResults$Gene_Symbol <- mm10_Manifest$Gene_Symbol[match(betaResults$cpg, mm10_Manifest$cpg)]
threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"


# Pathology
manhattan(betaResults, p = "FDR_adj_pathology", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Pathology",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold,
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Pathology),1)/qchisq(0.5,1)
qq(betaResults$p.val.Pathology, main = "Pathology (Raw pvalue")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_pathology),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_pathology, main = "Pathology (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_pathology),]
rownames(betaResults) <- betaResults$cpg

pheno$col <-  ifelse(pheno$Genotype == "WT","#000000", color_J20_TG )

## Pathologys
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6){
  plot(pheno$Pathology_ECX, as.numeric(betas[rownames(betaResults)[i],]*100),
       xlab = "Pathology", ylab = "DNA methylation (%)", pch = 16,
       main = paste(rownames(betas)[i], betaResults[i,"Gene_Symbol"], sep = " "),
       col = pheno$col) ## we multiple by 100 to plot of a % scale rather than proportion
  ## to add line of best fit
  mtext(paste("P = ", signif(betaResults[i, "FDR_adj_pathology"],3)), side = 3, adj = 0, cex = .7) ## add P value to plot rounded to 3 sf
   par(xpd  = TRUE)
  legend(x ="topright",legend = levels(factor(pheno$Genotype)),
         col = c("#000000",color_J20_TG), pch = 19, cex = .7,
         inset=c(-0.02,-0.25))
}

for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_Pathology.pdf", onefile = T)
for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()
## png 
##   2
if(length(which(betaResults$FDR_adj_pathology <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_pathology <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_pathology),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_pathology", "p.val.Pathology",
                                  "estimate.Pathology","std.error.Pathology")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj p.val", "raw p.val",
                                  "estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}
cpg Gene Symbol Chr Bp FDR adj p.val raw p.val estimate std error
cg02545439 Galnt16 12 180519195 3.412469e-04 1.443942e-08 0.3943410 0.0695721
cg16925284 Gm49450 15 198953551 4.290696e-03 7.193895e-07 0.3146902 0.0634961
cg24084896 D930028M14Rik 7 25163644 4.290696e-03 3.674663e-07 -0.2369138 0.0465900
cg25506728 Angpt1 15 142676311 4.290696e-03 7.262211e-07 0.2310496 0.0466369
cg06132693 Cnnm2 19 146762741 6.054642e-03 1.537166e-06 0.3328378 0.0692497
cg12387067 Anp32a 9 62341431 6.054642e-03 1.515291e-06 0.7978006 0.1658902
cg06602723 Hoxb8 11 196281684 1.595818e-02 4.726749e-06 0.4885969 0.1067606
cg03302758 Bcl6 16 123988550 1.664106e-02 8.065077e-06 0.2471026 0.0553613
cg03678139 Foxo6 4 120282578 1.664106e-02 8.449743e-06 0.2861854 0.0642614
cg12321152 Cnot9 1 74528774 1.664106e-02 5.848681e-06 -0.6334014 0.1397686
cg13985448 Tal1 4 115056666 1.664106e-02 6.404150e-06 0.1164221 0.0257994
cg14449811 Zfp692 11 158307741 1.664106e-02 7.487148e-06 0.2112247 0.0471552
cg11059410 Grik4 9 42897147 1.793359e-02 9.864878e-06 0.3144388 0.0711382
cg12712534 Cdh18 15 123460471 1.874060e-02 1.110178e-05 -0.3159684 0.0719005
cg09127786 Pou3f2 4 22487042 1.917475e-02 1.217032e-05 0.6658760 0.1522171
cg00010926 Pak3 20 143712313 1.961941e-02 1.494306e-05 -0.2345508 0.0541747
cg03934905 Tbr1 2 61806057 1.961941e-02 1.423275e-05 0.3825715 0.0881453
cg03957108 Otx1 11 122003031 1.961941e-02 1.457962e-05 0.4974932 0.1147634
cg20465666 Hoxc8 15 1102983967 2.075204e-02 1.755542e-05 0.5330550 0.1241421
cg22747196 Cux1 5 136605656 2.075204e-02 1.756191e-05 -0.2840638 0.0661563
cg00418090 Otx1 11 122053469 2.103896e-02 1.955754e-05 -0.4009728 0.0939072
cg03873904 Hoxc8 15 1102991177 2.103896e-02 1.958520e-05 0.5701313 0.1335337
cg26219540 Nr2f1 13 178181730 2.728389e-02 2.655310e-05 0.3995987 0.0951159
cg01537787 Onecut2 18 164340362 2.861036e-02 2.905465e-05 0.2866889 0.0685735
cg13944639 Fgf5 5 98254696 4.313427e-02 4.562928e-05 0.2991734 0.0733816
cg23442353 Csmd3 15 148791971 4.838120e-02 5.322689e-05 0.6049330 0.1496993
#save outputs

# write.csv(betaResults, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_stats_table_J20_Pathology.csv")
# 
# 
# sig_pathology <- betaResults[which(betaResults[,"FDR_adj_pathology"] < 0.05),]
# write.csv(sig_pathology, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_pathology.csv")

Full model

\[{Methylation } = {Genotype + Age + Pathology + Chip}\]

# betaResultsChip <- BetaRegressionFullModel(betas = betas,
#                            pheno = pheno,
#                            formula = ~Genotype + Age_months+ Pathology_ECX + Chip_ID,
#                            link = "probit")
# 
# save(betaResultsChip, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResultsFull_J20.RData")
load("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResultsFull_J20.RData")
betaResults <- betaResultsChip
# Add chr and bp before deleting rows
Chr <- species_probes$Chr[match(species_probes$probeID, betaResults[,"cpg"])]
Bp <- species_probes$Bp[match(species_probes$probeID, betaResults[,"cpg"])]

betaResults <- cbind(Bp, betaResults)
betaResults <- cbind(Chr, betaResults)



# Add FDR pvalues

FDR_adj_genotype <- p.adjust(betaResults[,"p.val.Genotype"], method = "fdr")
FDR_adj_age <- p.adjust(betaResults[,"p.val.Age"], method = "fdr")
FDR_adj_pathology <- p.adjust(betaResults[,"p.val.Pathology"], method = "fdr")

betaResults <- cbind(betaResults, FDR_adj_genotype, FDR_adj_age, FDR_adj_pathology)
betaResults <- betaResults[,c(16,1:15,17:19)]
# Convert to data frame w/out factors
betaResults2 <- as.data.frame(betaResults)
betaResults2[] <- lapply(betaResults2, as.character)

for(i in 3:ncol(betaResults2)){
  betaResults2[,i] <- as.numeric(as.character(betaResults2[,i]))
}
betaResults2[,"Bp"] <- as.numeric(as.character(betaResults2[,"Bp"]))

betaResults <- betaResults2
# Convert x and y to numbers and remove non autosomal

betaResults<- betaResults[-which(betaResults$Chr %in% c("CHR_MG51_PATCH",
                                                      "CHR_MG4200_PATCH","CHR_MG3699_PATCH")),]
betaResults$Chr <- gsub("X", 20, betaResults$Chr)
betaResults$Chr <- gsub("Y", 21, betaResults$Chr)

betaResults$Chr <- as.numeric(betaResults$Chr)
betaResults$Bp <- as.numeric(betaResults$Bp)

### Add gene names in
mm10_Manifest <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/mm10_Manifest.csv", stringsAsFactors = F, header = T, row.names = 1)

betaResults$Gene_Symbol <- mm10_Manifest$Gene_Symbol[match(betaResults$cpg, mm10_Manifest$cpg)]

Genotype

threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"
rownames(betaResults) <- betaResults$cpg

# Genotype
manhattan(betaResults, p = "FDR_adj_genotype", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Genotype",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold, 
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Genotype),1)/qchisq(0.5,1)
qq(betaResults$p.val.Genotype, main = "Genotype (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_genotype),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_genotype, main = "Genotype (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_genotype),]
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT", "TG"))

## Genotypes = with covariates
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6) {
  # model<-lm(as.numeric(betas[rownames(betaResults)[i],]*100) ~ pheno$AgeMonths + pheno$Chip_ID) ## This needs to include all the confouders from your analysis model but not the vaiable you are interested in.
  # adjValues<-residuals(model)+coefficients(model)[1]
  # boxplot(adjValues ~ pheno$Genotype, xlab = "Genotype", ylab = "DNA methylation (%)", 
  #         main = paste(rownames(beta)[i], betaResults[i,"Gene_Symbol"], sep = " ")) ## we multiple by 100 to plot of a % scale rather than proportion
  # mtext(paste("P = ", signif(betaResults[i, "FDR_adj_genotype"],3)), side = 3, adj = 1, cex = 0.7) ## add P value to plot rounded to 3 sf
    plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
  
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/FullJ20_Genotype.pdf", onefile = T)
for(i in 1:6){
  plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()
## png 
##   2
if(length(which(betaResults$FDR_adj_genotype <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_genotype <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_genotype),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_genotype", "p.val.Genotype","meth.group1.WT",
                             "meth.group2.TG","meth.diff.Genotype" ,"estimate.Genotype","std.error.Genotype")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj.p.val", "raw p.val","meth WT",
                             "meth TG","meth diff" ,"estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}
cpg Gene Symbol Chr Bp FDR adj.p.val raw p.val meth WT meth TG meth diff estimate std error
cg22786134 Zbtb20 16 143557635 2.839786e-102 1.201619e-106 0.5238258 0.3078391 0.2159867 -0.5617427 0.0256093
cg20595744 Gm15713 16 143410500 3.619690e-06 3.063251e-10 0.7887624 0.6996672 0.0890952 -0.2786907 0.0442679
cg27454350 Zbtb20 16 143098352 5.977849e-06 7.588349e-10 0.6418101 0.5647587 0.0770513 -0.2002557 0.0325444
cg11125461 Gm15713 16 143410464 3.288648e-05 5.566197e-09 0.5780648 0.4196300 0.1584349 -0.3997856 0.0685821
cg16113843 Iars 13 149706731 1.829845e-04 4.113484e-08 0.6270249 0.6654158 -0.0383909 0.1033057 0.0188311
cg27403476 Syt7 19 110397989 1.829845e-04 4.645653e-08 0.4367795 0.4664223 -0.0296428 0.0748731 0.0137021
cg13484596 Zbtb20 16 143122445 4.702376e-04 1.392825e-07 0.6954886 0.6097983 0.0856903 -0.2326756 0.0441829
cg21479658 Stag1 9 100757692 5.745184e-04 1.944800e-07 0.9407243 0.9298658 0.0108584 -0.0860901 0.0165414
cg08416404 Zbtb20 16 143122487 6.987306e-04 2.660930e-07 0.7217685 0.6363823 0.0853862 -0.2392978 0.0465017
cg02175825 Mms22l 4 23753322 1.722940e-03 7.290400e-07 0.9455830 0.9306330 0.0149501 -0.1229345 0.0248179
cg10581670 Faxc 4 22134234 2.348222e-03 1.092982e-06 0.8845655 0.8494533 0.0351122 -0.1640319 0.0336537
cg12137126 Bnc2 4 84284440 2.689792e-03 1.365781e-06 0.4967224 0.4434707 0.0532518 -0.1339598 0.0277353
cg12958309 Prcp 7 93023579 2.840230e-03 1.562349e-06 0.9307203 0.9101488 0.0205715 -0.1395051 0.0290449
cg16211444 Kdr 5 75974765 3.145668e-03 1.996573e-06 0.8311615 0.8045222 0.0266393 -0.1008796 0.0212210
cg25400358 Gpr137 19 16940676 3.145668e-03 1.888711e-06 0.3725133 0.4051138 -0.0326006 0.0850718 0.0178535
cg26056424 Lsamp 16 142134394 3.655871e-03 2.475096e-06 0.8605650 0.8238443 0.0367207 -0.1527461 0.0324290
cg10259984 Hif1an 19 144631546 5.134827e-03 3.693651e-06 0.7518206 0.8044994 -0.0526789 0.1775733 0.0383700
cg06182411 Rnf220 4 117492727 5.952079e-03 4.533382e-06 0.7872017 0.8156654 -0.0284637 0.1022195 0.0222929
cg05932603 Mier1 4 103115647 6.491168e-03 5.218643e-06 0.5009216 0.5510423 -0.0501206 0.1259849 0.0276537
cg03471163 4922502N22Rik 6 139293940 7.062166e-03 5.976529e-06 0.7588559 0.7982282 -0.0393723 0.1326821 0.0293076
cg08656426 Gm15713 16 143410634 7.603103e-03 7.077742e-06 0.5427007 0.4490743 0.0936265 -0.2352406 0.0523765
cg24882108 Vrk2 11 126815320 7.603103e-03 6.793335e-06 0.5285117 0.5747108 -0.0461991 0.1168514 0.0259666
cg17803853 Tshz2 2 169832358 8.429566e-03 8.203783e-06 0.9497590 0.9581028 -0.0083438 0.0865607 0.0194091
cg09374953 Ntm 9 29963230 9.057998e-03 9.490044e-06 0.2349023 0.2606353 -0.0257330 0.0814091 0.0183831
cg18938096 D030025E07Rik 3 128512077 9.057998e-03 9.581939e-06 0.7014092 0.6369681 0.0644411 -0.1780917 0.0402340
cg19751323 Cnnm2 19 146848643 1.066884e-02 1.173739e-05 0.6889091 0.6115550 0.0773540 -0.2093862 0.0477788
cg08906488 Emx2 19 159466097 1.144460e-02 1.307512e-05 0.4898986 0.4209032 0.0689955 -0.1742604 0.0399786
cg01079397.2 Nipbl 15 18444274 1.156653e-02 1.406436e-05 0.6249705 0.6813205 -0.0563500 0.1528329 0.0351918
cg05564167 Foxo6 4 120259922 1.156653e-02 1.490276e-05 0.2343866 0.2791339 -0.0447473 0.1390602 0.0321146
cg14778330 Sox12 2 152396680 1.156653e-02 1.517210e-05 0.1109299 0.0943091 0.0166208 -0.0930802 0.0215156
cg18271715 A830082K12Rik 13 178451535 1.156653e-02 1.432658e-05 0.7910646 0.8151571 -0.0240925 0.0869414 0.0200381
cg23692214 Zranb1 7 132949952 1.217960e-02 1.649165e-05 0.9233697 0.9330386 -0.0096689 0.0707022 0.0164128
cg01122656 Tsc2 17 124601401 1.242508e-02 2.192944e-05 0.5403463 0.5787357 -0.0383894 0.0973539 0.0229377
cg04272551 Hes1 16 130070353 1.242508e-02 2.212113e-05 0.0422949 0.0346338 0.0076611 -0.0920167 0.0216901
cg04609342 Ankrd11 8 122900647 1.242508e-02 2.033288e-05 0.7954745 0.8292595 -0.0337850 0.1256782 0.0294936
cg05176833 Dock3 9 106908482 1.242508e-02 2.260731e-05 0.9399689 0.9261055 0.0138634 -0.1071268 0.0252810
cg05200513 4933407E24Rik 4 124595060 1.242508e-02 2.152649e-05 0.1571185 0.1971223 -0.0400038 0.1544261 0.0363489
cg06490500 Clk4 11 151273070 1.242508e-02 2.234277e-05 0.6185218 0.6652710 -0.0467491 0.1252910 0.0295491
cg18663956 Casz1 4 148748300 1.242508e-02 1.794431e-05 0.9543674 0.9390646 0.0153027 -0.1417918 0.0330591
cg21160194 Vrk2 11 126815350 1.242508e-02 2.066124e-05 0.5863435 0.6558063 -0.0694629 0.1828956 0.0429572
cg25517295 Hnrnpk 13 158397883 1.242508e-02 2.230483e-05 0.3209971 0.3642007 -0.0432036 0.1176596 0.0277468
cg25709794 Zfhx3 8 107960787 1.242508e-02 2.003724e-05 0.8980618 0.8725941 0.0254677 -0.1318453 0.0309171
cg26912563 Pax6 2 105665147 1.242508e-02 1.877546e-05 0.7870539 0.7390946 0.0479593 -0.1556840 0.0363835
cg02861868 Ccar1 10 162764365 1.295826e-02 2.467405e-05 0.8187115 0.8362630 -0.0175515 0.0687488 0.0162998
cg02864518 Luc7l2 6 38568909 1.295826e-02 2.415197e-05 0.5420489 0.6028733 -0.0608244 0.1551945 0.0367535
cg06658605 Sox6 7 115747711 1.350222e-02 2.723727e-05 0.0646320 0.0599648 0.0046672 -0.0380583 0.0090714
cg19298873 Tbca 13 194707080 1.350222e-02 2.742381e-05 0.1176021 0.1507560 -0.0331539 0.1538629 0.0366876
cg26395444 Arih1 9 59392677 1.350222e-02 2.638541e-05 0.9610444 0.9688741 -0.0078297 0.1015614 0.0241663
cg06186797 Arx 20 93253878 1.418797e-02 2.941694e-05 0.9311491 0.9398556 -0.0087064 0.0691580 0.0165532
cg03937152 Meis2 2 115866234 1.615323e-02 3.423360e-05 0.9002087 0.8793000 0.0209087 -0.1112470 0.0268498
cg15889033 Tbc1d2b 9 90226116 1.615323e-02 3.485865e-05 0.6809404 0.7155795 -0.0346392 0.0994293 0.0240216
cg05758851 4930441J16Rik 2 74272815 1.618170e-02 3.560480e-05 0.8238279 0.8469768 -0.0231489 0.0935013 0.0226160
cg02166926 Fign 2 63981627 1.733083e-02 3.886658e-05 0.6949686 0.7182670 -0.0232984 0.0677172 0.0164597
cg07475226 Fbxo33 12 159202451 1.780577e-02 4.068512e-05 0.9276624 0.9383882 -0.0107258 0.0827826 0.0201734
cg00249321 Ush2a 1 188885043 1.957584e-02 4.599195e-05 0.5188421 0.5797482 -0.0609061 0.1540017 0.0377908
cg09176584 Lncbate1 8 108301392 1.957584e-02 4.638628e-05 0.2928150 0.3245937 -0.0317787 0.0902882 0.0221668
cg07948593 Zfp536 7 37689733 2.029648e-02 4.895270e-05 0.4515545 0.4888026 -0.0372481 0.0936633 0.0230665
cg17662507 Samd4 14 147052885 2.096172e-02 5.144416e-05 0.9364994 0.9197802 0.0167192 -0.1224398 0.0302398
cg18409580 Ccar1 10 162764505 2.118563e-02 5.289012e-05 0.9089436 0.9202493 -0.0113057 0.0724726 0.0179278
cg10983579 Gm14015 2 106577167 2.134357e-02 5.418755e-05 0.8126562 0.7789934 0.0336628 -0.1189289 0.0294613
cg01740606 Snora43 2 26636165 2.139708e-02 5.635272e-05 0.6103841 0.6503436 -0.0399595 0.1059281 0.0263007
cg19850445 Bcl9l 9 44500948 2.139708e-02 5.597529e-05 0.7251664 0.7657001 -0.0405337 0.1265003 0.0313962
cg25326950 Ptch1 13 163554990 2.139708e-02 5.703957e-05 0.9122030 0.8926159 0.0195871 -0.1138860 0.0282965
cg11719502 Sox2ot 3 34443847 2.160679e-02 5.851285e-05 0.5635815 0.6076905 -0.0441090 0.1132487 0.0281802
cg03100301 1700057H15Rik 4 124375613 2.176580e-02 7.179714e-05 0.8198052 0.7841941 0.0356111 -0.1281865 0.0322867
cg05174060 Kmt2b 7 30583455 2.176580e-02 6.770234e-05 0.7065365 0.7502072 -0.0436707 0.1318474 0.0330924
cg07237683 Arf6 12 169373008 2.176580e-02 6.588010e-05 0.1788442 0.2028218 -0.0239776 0.0881944 0.0221000
cg09496347 Bcor 20 12137509 2.176580e-02 6.990949e-05 0.3439306 0.3710155 -0.0270849 0.0725942 0.0182554
cg09497746 Cdx2 5 147307334 2.176580e-02 6.606506e-05 0.0341120 0.0435342 -0.0094223 0.1124565 0.0281844
cg10874497 Dmrt3 19 125608157 2.176580e-02 7.132287e-05 0.1994068 0.1569961 0.0424107 -0.1631386 0.0410739
cg13044883 Calcoco1 15 1102694513 2.176580e-02 6.710924e-05 0.3280490 0.2715931 0.0564559 -0.1626950 0.0408135
cg13721745 Slc6a5 7 49914687 2.176580e-02 7.183736e-05 0.2485232 0.2772656 -0.0287424 0.0881605 0.0222060
cg15026078 Maf 8 115705930 2.176580e-02 7.094103e-05 0.0502403 0.0434514 0.0067889 -0.0694384 0.0174771
cg16573364 Mef2c 13 183662407 2.176580e-02 6.229927e-05 0.5358787 0.5741173 -0.0382386 0.0968102 0.0241788
cg18149408 Mef2c 13 183663715 2.176580e-02 6.392031e-05 0.5825582 0.6439007 -0.0613426 0.1604628 0.0401373
cg19090691 Nkx2-3 19 143616760 2.176580e-02 6.083111e-05 0.0644402 0.0845719 -0.0201317 0.1435714 0.0358073
cg26438184 Dennd5b 6 149032497 2.176580e-02 7.172680e-05 0.7663515 0.7922453 -0.0258938 0.0873525 0.0220005
cg27356290 Kdm2a 19 14317872 2.176580e-02 6.585563e-05 0.9051056 0.9181879 -0.0130823 0.0817813 0.0204926
cg12814030 Zfp219 14 152008734 2.189488e-02 7.318984e-05 0.6477406 0.6948260 -0.0470853 0.1303490 0.0328693
cg08926137 Jarid2 13 144840826 2.237373e-02 7.573724e-05 0.0635857 0.0779772 -0.0143915 0.1065413 0.0269213
cg22253511 Cenpv 11 162536327 2.338707e-02 8.015709e-05 0.7127996 0.7586615 -0.0458619 0.1404213 0.0356044
cg26966072 Tmem114 16 18048535 2.355714e-02 8.173679e-05 0.9010807 0.8851530 0.0159276 -0.0865860 0.0219803
cg19977128 Ptch1 13 163554974 2.504278e-02 8.901086e-05 0.9101235 0.8875757 0.0225478 -0.1277800 0.0326074
cg26555185 D130009I18Rik 14 1104864151 2.504278e-02 8.886645e-05 0.4032751 0.3371070 0.0661681 -0.1754928 0.0447784
cg17365200 Wnk4 11 1101276836 2.522384e-02 9.072171e-05 0.3774116 0.4177815 -0.0403699 0.1047138 0.0267526
cg05555567 Lrmda 14 122155795 2.523831e-02 9.717099e-05 0.8008114 0.7557122 0.0450992 -0.1519469 0.0389852
cg07565103 Satb1 17 151803602 2.523831e-02 9.700563e-05 0.9176495 0.9272437 -0.0095942 0.0661324 0.0169659
cg17790227 Klhl32 4 24631504 2.523831e-02 9.718132e-05 0.4214954 0.4782027 -0.0567073 0.1434043 0.0367937
cg19222351 Nt5e 9 88069132 2.523831e-02 9.643342e-05 0.5400263 0.5728201 -0.0327938 0.0830584 0.0213003
cg21353753 Rps6ka3 20 159303254 2.523831e-02 9.642779e-05 0.9115570 0.8923590 0.0191980 -0.1112338 0.0285258
cg23720877 Taok3 5 117251049 2.523831e-02 9.628105e-05 0.4116886 0.4432738 -0.0315852 0.0805295 0.0206498
cg00349375 Zbtb20 16 143504369 2.550116e-02 1.019393e-04 0.1446153 0.1207299 0.0238853 -0.1115345 0.0287022
cg03523528 Cxxc5 18 135855704 2.550116e-02 1.000601e-04 0.4034178 0.4333087 -0.0298910 0.0765539 0.0196774
cg20202533 Kdm5c 20 152223244 2.550116e-02 1.008059e-04 0.6871317 0.7150229 -0.0278912 0.0803825 0.0206711
cg27052685 Pantr1 1 41919060 2.550116e-02 1.025096e-04 0.7949991 0.8248385 -0.0298395 0.1100727 0.0283359
cg01186017 Gm30731 4 22971304 2.635932e-02 1.070746e-04 0.7713003 0.7359004 0.0353999 -0.1123786 0.0290086
cg19257233 Zfp423 8 87873326 2.660363e-02 1.091927e-04 0.9670174 0.9580527 0.0089647 -0.1101377 0.0284652
cg03516596 5730522E02Rik 11 125855571 2.662561e-02 1.104096e-04 0.2834664 0.2216045 0.0618619 -0.1942110 0.0502292
cg09478405 Meis2 2 116001144 2.682395e-02 1.123671e-04 0.8981025 0.8780070 0.0200955 -0.1057319 0.0273760
cg01578720 Tbca 13 194707109 2.689447e-02 1.138005e-04 0.0811704 0.1202448 -0.0390743 0.2234778 0.0579091
cg10654251 Arx 20 93310099 2.733899e-02 1.203087e-04 0.9176925 0.8999695 0.0177231 -0.1083390 0.0281730
cg16915042 Kctd16 18 140260993 2.733899e-02 1.198614e-04 0.6834906 0.7300617 -0.0465711 0.1355174 0.0352322
cg20425337 Gm15713 16 143410472 2.733899e-02 1.186556e-04 0.5687901 0.4963969 0.0723932 -0.1823265 0.0473712
cg20945212 Ppp2r2b 18 142741144 2.733899e-02 1.196994e-04 0.7315876 0.6864934 0.0450943 -0.1316867 0.0342333
cg14678919 Gpr151 18 142738000 2.776436e-02 1.280546e-04 0.9446965 0.9318489 0.0128476 -0.1057670 0.0276142
cg21226616 Epc2 2 49548658 2.776436e-02 1.250549e-04 0.8531166 0.8811528 -0.0280362 0.1308752 0.0341176
cg22044758 Dlx6os1 6 6869472 2.776436e-02 1.274422e-04 0.4234609 0.3729798 0.0504811 -0.1309240 0.0341718
cg22490018 Hoxc9 15 1102975432 2.776436e-02 1.234778e-04 0.4576009 0.4314558 0.0261452 -0.0661895 0.0172408
cg26276608 Pds5a 5 65628105 2.776436e-02 1.271719e-04 0.8824376 0.8676455 0.0147922 -0.0719310 0.0187718
cg01955745 Ntm 9 29963226 2.784449e-02 1.307806e-04 0.1575273 0.1820087 -0.0244814 0.0969359 0.0253428
cg27559875 Slc25a37 14 169247600 2.784449e-02 1.306117e-04 0.4238895 0.3713467 0.0525428 -0.1363356 0.0356405
cg12195518 Fign 2 63979068 2.849021e-02 1.350190e-04 0.9395192 0.9473817 -0.0078625 0.0692297 0.0181366
cg04501234 Nhsl2 20 102076198 2.890092e-02 1.411625e-04 0.9315697 0.9408489 -0.0092791 0.0743551 0.0195357
cg19478904 Ankrd52 10 1128378126 2.890092e-02 1.390115e-04 0.2607236 0.2962307 -0.0355070 0.1058434 0.0277810
cg21677205 Dazap2 15 1100620645 2.890092e-02 1.405099e-04 0.5029567 0.5225381 -0.0195814 0.0491133 0.0128999
cg22454306 Skap2 6 51847017 2.890092e-02 1.418570e-04 0.7968241 0.8209473 -0.0241232 0.0886505 0.0232990
cg02070745 Iars 13 149706790 2.954071e-02 1.494349e-04 0.7348873 0.7787281 -0.0438408 0.1402427 0.0369838
cg03342744 Mir10a 11 196317269 2.954071e-02 1.509820e-04 0.6402314 0.5752446 0.0649868 -0.1693348 0.0446859
cg08911427 Mir6976 17 146553677 2.954071e-02 1.497714e-04 0.4049478 0.4369894 -0.0320416 0.0819540 0.0216155
cg10784922 Hdac8 20 102402632 2.954071e-02 1.512472e-04 0.8989316 0.9161579 -0.0172263 0.1041961 0.0274995
cg22584556 Qk 17 110209484 2.954071e-02 1.506240e-04 0.5014664 0.5518522 -0.0503859 0.1266667 0.0334210
cg21056089 Gapdh 6 125160566 2.980110e-02 1.538414e-04 0.4668060 0.4956379 -0.0288319 0.0723669 0.0191205
cg05092810 Nkx2-2os 2 147184058 2.999061e-02 1.598958e-04 0.0750036 0.0601339 0.0148696 -0.1141440 0.0302354
cg07254551 Epn2 11 161544247 2.999061e-02 1.598048e-04 0.7882907 0.8209626 -0.0326719 0.1185353 0.0313975
cg19635296 Lmo4 3 144195343 2.999061e-02 1.580771e-04 0.7632717 0.7131869 0.0500848 -0.1541472 0.0408010
cg20198417 Ebf3 7 137306981 2.999061e-02 1.568489e-04 0.6539657 0.7044785 -0.0505128 0.1412758 0.0373749
cg22204849 Fgfr2 7 130198480 3.012320e-02 1.618773e-04 0.9330218 0.9472945 -0.0142726 0.1204870 0.0319416
cg02737031 Dmd 20 84225999 3.115889e-02 1.687614e-04 0.6789543 0.6392433 0.0397110 -0.1083398 0.0288007
cg25375926 Mef2c 13 183662574 3.119913e-02 1.702995e-04 0.3347329 0.3738545 -0.0391216 0.1052197 0.0279882
cg08935648 4933407E24Rik 4 124595004 3.142541e-02 1.728643e-04 0.1611944 0.1927209 -0.0315266 0.1216478 0.0323903
cg20314902 Odf2 2 29893486 3.165151e-02 1.754473e-04 0.8471650 0.8628216 -0.0156567 0.0687346 0.0183196
cg09978510 Ythdf2 4 132204160 3.170773e-02 1.778101e-04 0.3467916 0.3860939 -0.0393023 0.1044827 0.0278723
cg25793931 Emx2 19 159466367 3.170773e-02 1.784424e-04 0.4630094 0.4200100 0.0429994 -0.1090129 0.0290877
cg00243488 4933407E24Rik 4 124595073 3.297200e-02 1.869525e-04 0.1699549 0.2217786 -0.0518236 0.1881430 0.0503592
cg19945696 Dnajc24 2 106074573 3.303201e-02 1.886904e-04 0.7161543 0.7577750 -0.0416207 0.1277085 0.0342043
cg07997719 Zbtb20 16 143503766 3.308144e-02 1.903726e-04 0.4770282 0.4129075 0.0641208 -0.1624587 0.0435376
cg07000689 Csnk1a1 18 161571809 3.341910e-02 1.937298e-04 0.8589499 0.8760496 -0.0170997 0.0798499 0.0214244
cg06075167 Igf1r 7 68193593 3.468159e-02 2.054510e-04 0.8096784 0.8426114 -0.0329331 0.1285370 0.0346254
cg17311369 Gm3279 6 55704259 3.468159e-02 2.052094e-04 0.6886093 0.7436791 -0.0550698 0.1628176 0.0438564
cg19115817 Papolg 11 123870836 3.468159e-02 2.039965e-04 0.9288363 0.9359899 -0.0071536 0.0547768 0.0147487
cg01136078 Foxo6 4 120267142 3.584735e-02 2.138737e-04 0.4011381 0.4515193 -0.0503812 0.1285785 0.0347318
cg20521676 Parva 7 112572874 3.601923e-02 2.164233e-04 0.8923733 0.8533159 0.0390574 -0.1884873 0.0509558
cg00773909 Mir196a-2 15 1102972145 3.657684e-02 2.291140e-04 0.3657644 0.3053226 0.0604418 -0.1660602 0.0450694
cg01901100 Apob 12 18108745 3.657684e-02 2.280691e-04 0.8404335 0.7945103 0.0459232 -0.1740698 0.0472283
cg22316499 C1d 11 117450891 3.657684e-02 2.240076e-04 0.6871698 0.7287535 -0.0415838 0.1212038 0.0328441
cg22532263 Zfp536 7 37180448 3.657684e-02 2.306076e-04 0.6683045 0.7173684 -0.0490640 0.1398056 0.0379609
cg25642165 Atxn2l 7 126492770 3.657684e-02 2.254222e-04 0.5436068 0.5764616 -0.0328548 0.0833249 0.0225894
cg26521186 Zbtb18 1 177447208 3.657684e-02 2.299312e-04 0.2916732 0.3367541 -0.0450809 0.1271652 0.0345217
cg27224831 Mamld1 20 71054025 3.657684e-02 2.223221e-04 0.6980457 0.7283510 -0.0303052 0.0890452 0.0241171
cg11011976 Ctnna2 6 76902439 3.686345e-02 2.344560e-04 0.9342175 0.9187439 0.0154736 -0.1112869 0.0302520
cg13545911 Mir9-3hg 7 79549161 3.686345e-02 2.386539e-04 0.6133210 0.5876083 0.0257127 -0.0665884 0.0181235
cg18506907 Msr1 8 39746398 3.686345e-02 2.384908e-04 0.5471902 0.5847455 -0.0375553 0.0954834 0.0259867
cg19489133 Gm19466 18 153693469 3.686345e-02 2.376792e-04 0.5084408 0.5361520 -0.0277113 0.0695846 0.0189336
cg03917189 Tcf4 18 169516558 3.780166e-02 2.487985e-04 0.4154034 0.4720571 -0.0566536 0.1435670 0.0391885
cg09122966 NA 9 51279844 3.780166e-02 2.480977e-04 0.9321844 0.9210505 0.0111339 -0.0800859 0.0218562
cg18717421 NA 17 132360251 3.780166e-02 2.495265e-04 0.0403221 0.0475263 -0.0072042 0.0776335 0.0211954
cg17416197 Mir148a 6 51088987 3.783821e-02 2.529699e-04 0.3860008 0.3394331 0.0465677 -0.1242530 0.0339560
cg21220963 Hsfy2 1 56800931 3.783821e-02 2.521937e-04 0.6480233 0.6971284 -0.0491051 0.1361699 0.0372047
cg01085196 5730522E02Rik 11 125855605 3.809073e-02 2.562698e-04 0.5683207 0.6052612 -0.0369405 0.0948887 0.0259549
cg03603703 Mpped2 2 106699448 3.846202e-02 2.603953e-04 0.5447236 0.5897026 -0.0449791 0.1144389 0.0313375
cg11586890 Zbtb9 17 126971176 3.930881e-02 2.677916e-04 0.5253514 0.5476972 -0.0223458 0.0562560 0.0154354
cg21247898 Sp8 12 1118720311 3.968732e-02 2.720495e-04 0.9081787 0.8887757 0.0194030 -0.1095797 0.0300997
cg03421587 Ebf3 7 137320038 4.126590e-02 2.869154e-04 0.4198978 0.3583557 0.0615422 -0.1607027 0.0443093
cg04747504 Gpr84 15 1103300439 4.126590e-02 2.881087e-04 0.3606207 0.4144448 -0.0538241 0.1406744 0.0387985
cg23046555 Pax2 19 144671400 4.126590e-02 2.872527e-04 0.0521240 0.0608798 -0.0087559 0.0771699 0.0212792
cg18132535 Psd2 18 135933577 4.126622e-02 2.898571e-04 0.1443521 0.1641741 -0.0198220 0.0835219 0.0230456
cg00134706 C230079O03Rik 7 136475745 4.153658e-02 3.111305e-04 0.9267537 0.9374448 -0.0106912 0.0816399 0.0226410
cg01657263 Gm43517 12 149386724 4.153658e-02 3.074337e-04 0.4226136 0.3551341 0.0674795 -0.1762842 0.0488463
cg08014701 Gm16136 15 137233288 4.153658e-02 3.034594e-04 0.0994397 0.1222207 -0.0227810 0.1207938 0.0334393
cg13209256 Dynlrb2 8 116385090 4.153658e-02 3.163621e-04 0.6216962 0.6725774 -0.0508812 0.1371026 0.0380680
cg15012766 Foxo6 4 120282597 4.153658e-02 3.137876e-04 0.0109115 0.0157909 -0.0048794 0.1437710 0.0398960
cg15698781 Depdc5 5 32903896 4.153658e-02 3.160314e-04 0.9511511 0.9561527 -0.0050016 0.0515673 0.0143171
cg16701356 Sp9 2 73278469 4.153658e-02 2.999567e-04 0.4884898 0.4718197 0.0166701 -0.0418406 0.0115731
cg17469239 Ptch1 13 163554662 4.153658e-02 3.149332e-04 0.8580497 0.8360233 0.0220263 -0.0933533 0.0259121
cg19806313 Ptprt 2 161580069 4.153658e-02 3.072386e-04 0.7725169 0.8045278 -0.0320109 0.1107447 0.0306847
cg21125558 Snrpa1 7 66070155 4.153658e-02 3.109605e-04 0.9266554 0.9036418 0.0230136 -0.1487403 0.0412481
cg21344777 Esrrb 12 186383978 4.153658e-02 2.988358e-04 0.3848982 0.3387481 0.0461501 -0.1232409 0.0340792
cg24830181 Ttc29 8 78271982 4.153658e-02 3.145639e-04 0.8482541 0.8699416 -0.0216876 0.0971413 0.0269612
cg25558559 Kcnma1 14 123373797 4.153658e-02 3.130326e-04 0.6655464 0.7224254 -0.0568789 0.1624134 0.0450614
cg27402320 Rnf220 4 117409830 4.153658e-02 3.021665e-04 0.4826728 0.5096145 -0.0269417 0.0675487 0.0186938
cg00060304 Pax6 2 105671196 4.222155e-02 3.233657e-04 0.3826731 0.3345366 0.0481365 -0.1289526 0.0358618
cg22580162 Fhl1 20 56790511 4.248262e-02 3.271628e-04 0.8131377 0.8385361 -0.0253984 0.0989409 0.0275388
cg04865264 Ovol2 2 144332183 4.389843e-02 3.400215e-04 0.0951971 0.1209749 -0.0257778 0.1392868 0.0388773
cg13815285 Esrp1 4 11344207 4.389843e-02 3.417810e-04 0.0590016 0.0531643 0.0058373 -0.0517069 0.0144377
cg14551953 Tbca 13 194707126 4.399314e-02 3.446044e-04 0.0607924 0.0794949 -0.0187025 0.1396788 0.0390248
cg24140160 Zbtb16 9 48737634 4.399314e-02 3.462414e-04 0.1022414 0.1300899 -0.0278485 0.1429166 0.0399432
cg13517739 Gm30731 4 23173922 4.435664e-02 3.509792e-04 0.7646933 0.7975657 -0.0328724 0.1114763 0.0311871
cg04198597 Bclaf1 10 120334502 4.469835e-02 3.555744e-04 0.9283971 0.9374097 -0.0090126 0.0694300 0.0194426
cg22208523 A3galt2 4 128743385 4.576407e-02 3.659886e-04 0.5179954 0.5489863 -0.0309909 0.0779776 0.0218825
cg03630442 Gm10532 18 175447239 4.604524e-02 3.701855e-04 0.6002846 0.5544150 0.0458696 -0.1172600 0.0329338
cg12469892 Rplp1 9 61756957 4.617327e-02 3.731687e-04 0.4240533 0.4520768 -0.0280235 0.0711187 0.0199863
cg02231349 Fez1 9 36922296 4.657666e-02 3.866412e-04 0.3797595 0.4369864 -0.0572270 0.1474984 0.0415601
cg02315120 Dab1 4 104452806 4.657666e-02 3.877587e-04 0.2138199 0.2391739 -0.0253540 0.0842746 0.0237508
cg10455041 Tfap2d 1 19106472 4.657666e-02 3.866117e-04 0.3546242 0.2938785 0.0607457 -0.1692236 0.0476813
cg14354194 Ahdc1 4 133043047 4.657666e-02 3.882538e-04 0.2174611 0.2499998 -0.0325387 0.1063062 0.0299628
cg15519745 Glis3 19 128540318 4.657666e-02 3.825099e-04 0.9557311 0.9440069 0.0117242 -0.1138335 0.0320489
cg27531402 Paupar 2 105660539 4.657666e-02 3.802229e-04 0.1171573 0.0965707 0.0205865 -0.1120239 0.0315254
cg08189414 Rnf220 4 117317956 4.670243e-02 3.912783e-04 0.3227740 0.3427774 -0.0200034 0.0550609 0.0155281
cg11559504 Tm4sf19 16 132381789 4.699374e-02 3.968711e-04 0.9047946 0.9207092 -0.0159146 0.1004935 0.0283707
cg23362864 Dph6 2 114438524 4.699374e-02 3.976959e-04 0.9194403 0.9274560 -0.0080157 0.0557860 0.0157516
cg21872209 Nr1d1 11 198767645 4.714393e-02 4.009618e-04 0.0827303 0.1163816 -0.0336513 0.1936669 0.0547167
cg23484089 Cntln 4 84987365 4.771133e-02 4.078064e-04 0.5140242 0.5377251 -0.0237009 0.0595434 0.0168440
cg06992077 Smim4 14 131110453 4.801882e-02 4.144984e-04 0.9198613 0.8995323 0.0203289 -0.1252476 0.0354741
cg19044429 Diaph3 14 186772639 4.801882e-02 4.140937e-04 0.7806095 0.8188683 -0.0382588 0.1368073 0.0387453
cg19608474 Brinp1 4 69346448 4.813964e-02 4.175782e-04 0.7244429 0.7744199 -0.0499769 0.1573907 0.0446028
cg02409454 Vrk1 12 1106143168 4.824172e-02 4.223527e-04 0.9021710 0.8727116 0.0294594 -0.1547185 0.0438830
cg21530396 Dlx1as 2 71538009 4.824172e-02 4.225463e-04 0.3893943 0.3230684 0.0663259 -0.1782376 0.0505554
cg11194264 Clk3 9 57758645 4.833220e-02 4.303912e-04 0.5220975 0.5751171 -0.0530196 0.1339986 0.0380601
cg12583945 Hnrnpk 13 158397873 4.833220e-02 4.316852e-04 0.3840981 0.4228012 -0.0387031 0.1000028 0.0284106
cg13425955 Ntm 9 29963228 4.833220e-02 4.335644e-04 0.1888620 0.2133553 -0.0244933 0.0872647 0.0247998
cg15337108 Gm7134 20 110318800 4.833220e-02 4.266986e-04 0.5615461 0.5989832 -0.0374370 0.0958257 0.0272001
cg24525396 Samd4b 7 28423482 4.833220e-02 4.333459e-04 0.8511492 0.8811865 -0.0300373 0.1395640 0.0396613
cg21849844 Gm5089 14 1122453423 4.870886e-02 4.390042e-04 0.1237836 0.1552080 -0.0314244 0.1419292 0.0403729
cg14569995 Nrxn1 17 190704057 4.997387e-02 4.525201e-04 0.7416452 0.7775578 -0.0359126 0.1155453 0.0329434

Pathology

threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"


# Pathology
manhattan(betaResults, p = "FDR_adj_pathology", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Pathology",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotateTop = threshold,
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Pathology),1)/qchisq(0.5,1)
qq(betaResults$p.val.Pathology, main = "Pathology (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_pathology),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_pathology, main = "Pathology (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_pathology),]
rownames(betaResults) <- betaResults$cpg

pheno$col <-  ifelse(pheno$Genotype == "WT","#000000", color_J20_TG )

## Pathologys
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6){
  plot(pheno$Pathology_HIP, as.numeric(betas[rownames(betaResults)[i],]*100),
       xlab = "Pathology", ylab = "DNA methylation (%)", pch = 16,
       main = paste(rownames(betas)[i], betaResults[i,"Gene_Symbol"], sep = " "),
       col = pheno$col) ## we multiple by 100 to plot of a % scale rather than proportion
  ## to add line of best fit
  mtext(paste("P = ", signif(betaResults[i, "FDR_adj_pathology"],3)), side = 3, adj = 0, cex = .7) ## add P value to plot rounded to 3 sf
   par(xpd  = TRUE)
  legend(x ="topright",legend = levels(factor(pheno$Genotype)),
         col = c("#000000",color_J20_TG), pch = 19, cex = .7,
         inset=c(-0.02,-0.25))
}

for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/FullJ20_Pathology.pdf", onefile = T)
for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()
## png 
##   2
if(length(which(betaResults$FDR_adj_pathology <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_pathology <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_pathology),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_pathology", "p.val.Pathology",
                                  "estimate.Pathology","std.error.Pathology")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj p.val", "raw p.val",
                                  "estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}
cpg Gene Symbol Chr Bp FDR adj p.val raw p.val estimate std error
cg10661056 Dynlrb2 8 116315711 6.899033e-10 2.919237e-14 -0.1605892 0.0211250
cg24330922 Mir1894 17 135917725 3.276473e-09 2.772795e-13 -0.2914966 0.0399037
cg12545634 Otp 13 194875724 7.063344e-09 8.966290e-13 -0.5193545 0.0726826
cg04088732 Lrmda 14 122591403 1.009655e-08 1.708891e-12 -0.4110130 0.0582470
cg15842149 Phtf1 3 103964049 2.140265e-08 4.528127e-12 0.4924910 0.0711730
cg13684553 Wdr20 12 1110738033 2.250388e-08 5.713337e-12 0.1945076 0.0282443
cg13399673 Ebf1 11 144745875 2.032541e-07 7.740391e-11 0.3423312 0.0526213
cg24771515 Spred1 2 117123179 2.032541e-07 6.296393e-11 -0.4139837 0.0633339
cg24185526 Wwox 8 114514776 2.032541e-07 7.586053e-11 0.2668579 0.0410009
cg24420776 Naaladl2 3 25432943 3.662527e-07 1.549751e-10 0.2969853 0.0464011
cg26748720 Dlx6os1 6 6834950 3.986766e-07 1.855644e-10 0.2606933 0.0409070
cg09313308 Cacna1c 6 118637833 5.491486e-07 2.788382e-10 -0.3239474 0.0513378
cg10742992 Slc10a7 8 78725651 6.545012e-07 3.600269e-10 -0.2471056 0.0394080
cg22521808 Gria3 20 41654900 7.358495e-07 4.926434e-10 -0.1827576 0.0293755
cg20288327 Runx1t1 4 13461023 7.358495e-07 5.175076e-10 0.3794277 0.0610631
cg09603678 Trim33 3 103353862 7.358495e-07 4.456227e-10 0.3226921 0.0517371
cg07591994 Prkg1 19 130569077 7.358495e-07 5.604575e-10 0.3018094 0.0486698
cg07484191 D030045P18Rik 10 146072064 7.358495e-07 5.408537e-10 -0.2917517 0.0470054
cg12137126 Bnc2 4 84284440 7.386746e-07 6.563774e-10 -0.2624328 0.0424906
cg25033328 Mbnl1 3 60614521 7.386746e-07 6.285882e-10 0.2079727 0.0336357
cg00143530 4933416E03Rik 2 159515463 7.386746e-07 6.002616e-10 0.2801231 0.0452515
cg06084735 Eny2 15 144428203 7.578411e-07 7.054756e-10 -0.1346557 0.0218425
cg27663652 5730522E02Rik 11 125595431 1.576615e-06 1.534386e-09 -0.3992854 0.0660991
cg15476397 Cdc23 18 134641516 1.838398e-06 1.948410e-09 0.3152640 0.0525260
cg10239446 2900052N01Rik 9 46899983 1.838398e-06 2.022526e-09 0.3664936 0.0611231
cg27189050 Tshz1 18 184003087 1.838398e-06 1.985004e-09 0.3962427 0.0660511
cg19386324 Ss18l1 2 180052472 1.843932e-06 2.106638e-09 -0.1019932 0.0170291
cg00983568 Tle1 4 72382768 1.913197e-06 2.266726e-09 -0.3970708 0.0664283
cg10082575 Egln3 12 153891064 2.120267e-06 2.601774e-09 0.3673070 0.0616811
cg02503970.2 St3gal1 15 167176741 2.766565e-06 3.511909e-09 -0.3477763 0.0588884
cg12838692 Arrdc3 13 180883841 3.399962e-06 4.459816e-09 -0.3954803 0.0674171
cg06842649 Klhl34 20 157834060 3.761707e-06 5.093497e-09 0.3327749 0.0569421
cg12553481 Foxp2 6 15203244 4.074341e-06 5.689216e-09 0.3864957 0.0663438
cg24012074 A830019L24Rik 3 143465770 4.466804e-06 6.426240e-09 0.3590448 0.0618481
cg14974683 Luc7l 17 126257971 4.809177e-06 7.122295e-09 -0.2055614 0.0355150
cg26258387 Lrp4 2 91501037 4.967953e-06 7.567652e-09 0.3313314 0.0573454
cg24837228 Ahdc1 4 133077439 5.184380e-06 8.116703e-09 0.4512552 0.0782612
cg10078989 Eny2 15 144428206 6.086851e-06 9.787176e-09 -0.0940628 0.0164033
cg27046016 Olig3 10 119414816 6.496340e-06 1.072049e-08 0.3121884 0.0545887
cg07066261 Ube2w 1 16581971 6.775646e-06 1.153580e-08 -0.1764189 0.0309157
cg00373808 Diaph3 14 187124705 6.775646e-06 1.175481e-08 0.4345989 0.0762021
cg14667871 Fbxl7 15 126895001 6.957814e-06 1.236526e-08 -0.2108471 0.0370257
cg19806313 Ptprt 2 161580069 7.219526e-06 1.344134e-08 0.2593279 0.0456534
cg01556456 Klf12 14 199614019 7.219526e-06 1.324965e-08 0.2850380 0.0501579
cg25246309 Arl15 13 1113880152 8.307987e-06 1.581938e-08 -0.3914740 0.0692576
cg19562013 Casz1 4 148831759 8.499091e-06 1.654289e-08 -0.1376601 0.0243873
cg09647169 Dach1 14 197891539 9.075427e-06 1.804871e-08 0.2663163 0.0473053
cg20433084 Gm10578 7 137199097 9.655721e-06 1.961133e-08 0.3340936 0.0594960
cg16030195 Gtdc1 2 44570610 1.017442e-05 2.109536e-08 0.2675743 0.0477575
cg00523349 Gm6249 7 136798196 1.060430e-05 2.331497e-08 0.2666880 0.0477473
cg06761799 Tef 15 181795511 1.060430e-05 2.378119e-08 0.2530206 0.0453282
cg26059055 Fgfr1 8 25563492 1.060430e-05 2.378150e-08 0.2421805 0.0433862
cg17996417 Prpf3 3 95835441 1.060430e-05 2.341036e-08 -0.3810151 0.0682248
cg09098248 Gsk3b 16 138243560 1.132368e-05 2.600592e-08 0.4249599 0.0763438
cg21444333 Nxph1 6 9332250 1.132368e-05 2.635307e-08 0.3708470 0.0666501
cg24226732 Hat1 2 71420679 1.157372e-05 2.791445e-08 0.1710989 0.0308062
cg27000043 Rsf1 7 97581072 1.157372e-05 2.783680e-08 -0.2194196 0.0395029
cg15227204 Chchd3 6 32887534 1.228441e-05 3.014834e-08 -0.3648546 0.0658514
cg27076613 Meis2 2 115866382 1.237443e-05 3.089289e-08 0.1671180 0.0301859
cg03048497 Cstf3 2 104653007 1.245795e-05 3.264380e-08 0.3091232 0.0559334
cg06223742 Ofcc1 13 140032275 1.245795e-05 3.268282e-08 0.3590797 0.0649751
cg12882820 NA 12 153071200 1.245795e-05 3.206151e-08 0.3452476 0.0624341
cg09093559 Sorbs1 19 140327476 1.249271e-05 3.330261e-08 0.1772575 0.0320937
cg22572197 Tshz2 2 169913005 1.273072e-05 3.447579e-08 0.3047632 0.0552403
cg20464713 B230303A05Rik 13 116642715 1.345387e-05 3.700341e-08 -0.1020491 0.0185389
cg16057023 Crebzf 7 90444115 1.425154e-05 3.980034e-08 -0.2419871 0.0440639
cg08035723 Gm13205 4 148981632 1.436458e-05 4.094915e-08 0.3097175 0.0564487
cg24489237 Pbx1 1 168431393 1.436458e-05 4.133167e-08 -0.1354239 0.0246896
cg27213004 Vil1 1 74428201 1.554657e-05 4.539049e-08 -0.1458362 0.0266685
cg12910744 Tsc22d2 3 58461501 1.568705e-05 4.646441e-08 0.2234341 0.0408895
cg26555185 D130009I18Rik 14 1104864151 1.816576e-05 5.511505e-08 -0.3658195 0.0673209
cg05387438 Zfp407 18 184351123 1.816576e-05 5.534358e-08 0.3107243 0.0571896
cg12598907 Rrp15 1 186835890 1.874629e-05 5.790544e-08 0.2907640 0.0535956
cg19323953 Slc35b3 13 139297245 1.961773e-05 6.142731e-08 0.3429815 0.0633439
cg23295280 Zfat 15 168178901 1.966311e-05 6.240143e-08 0.2138030 0.0395070
cg00686910 Casz1 4 148930461 2.134757e-05 6.865043e-08 0.3912663 0.0725283
cg27434492 Mex3c 18 173590837 2.144005e-05 6.985503e-08 -0.4316034 0.0800519
cg03496300 Pax6 2 105675604 2.178188e-05 7.189042e-08 -0.2890016 0.0536541
cg22328770 Klf12 14 199987480 2.259278e-05 7.552276e-08 0.1562148 0.0290497
cg10783532 Arf6 12 169372988 2.536958e-05 8.587850e-08 0.1781578 0.0332736
cg06490500 Clk4 11 151273070 3.557676e-05 1.232313e-07 0.2384857 0.0450940
cg11147619 Grb14 2 64523477 3.557676e-05 1.234415e-07 0.2721125 0.0514553
cg01734369 Kcnh7 2 63554431 3.876964e-05 1.361605e-07 0.3135516 0.0594935
cg02811998 Rplp1 9 61881494 3.882916e-05 1.380125e-07 0.4508355 0.0855820
cg22450874 Foxp1 6 99233038 4.157296e-05 1.495241e-07 0.2719141 0.0517622
cg21692907 Dnajc24 2 106133504 4.286108e-05 1.559706e-07 0.2734118 0.0521244
cg24937992 Foxp1 6 99004845 4.878782e-05 1.796023e-07 0.2018811 0.0386797
cg18533392 4930524B15Rik 11 131934515 5.010749e-05 1.865806e-07 0.4629331 0.0888166
cg18489876 Gtdc1 2 44570615 5.492268e-05 2.068345e-07 -0.2543935 0.0489869
cg17538314 Tbc1d5 17 150898066 5.555686e-05 2.115735e-07 0.3872906 0.0746387
cg17879021 Cnot6 11 149683236 5.613002e-05 2.161313e-07 0.4326891 0.0834518
cg16767916 Pou3f3 1 42698296 5.779797e-05 2.249995e-07 0.1187749 0.0229410
cg03876095 Uhmk1 1 170208692 5.995996e-05 2.384901e-07 0.3930175 0.0760700
cg03799825 Rbm15 3 107325242 5.995996e-05 2.373285e-07 0.3860326 0.0747049
cg01204422 Tshz2 2 169811809 6.331202e-05 2.545019e-07 0.1829867 0.0355014
cg18838779 Msi2 11 188508796 6.447168e-05 2.618915e-07 0.3799613 0.0737934
cg14729575 Atp5g3 2 74070945 6.474216e-05 2.657297e-07 0.3128802 0.0607976
cg20778358 Gm15511 9 69378887 6.845054e-05 2.838469e-07 0.2290235 0.0446103
cg15905834 4930441H08Rik 7 71349248 7.287946e-05 3.052963e-07 0.2354127 0.0459777
cg11477279 Dmd 20 83924933 7.596758e-05 3.214470e-07 0.3003091 0.0587641
cg13353999 Klhl14 18 121654505 8.137567e-05 3.483207e-07 -0.1277876 0.0250799
cg20592694 6030471H07Rik 4 84153903 8.137567e-05 3.512173e-07 0.2626419 0.0515625
cg05312831 Gm6260 3 143588221 8.518469e-05 3.712615e-07 0.3374790 0.0663919
cg21430924 Cyp7b1 3 18190066 8.531643e-05 3.754457e-07 0.4223128 0.0831160
cg17421638 1700081H04Rik 5 119143619 8.577739e-05 3.811038e-07 0.3357927 0.0661249
cg00249321 Ush2a 1 188885043 8.714789e-05 3.945679e-07 0.2931270 0.0577982
cg16451152 Gm33948 18 127497778 8.714789e-05 3.931262e-07 0.3466958 0.0683514
cg20807047 Nr2f1 13 178189051 8.864687e-05 4.051057e-07 0.2950477 0.0582345
cg14161476 Adamts16 13 170770254 9.123255e-05 4.207823e-07 0.3102650 0.0613256
cg19393451 Epha7 4 28821092 9.413109e-05 4.381340e-07 0.1977743 0.0391509
cg04146048 Herc1 9 66388775 9.447879e-05 4.437501e-07 0.2119941 0.0419860
cg07278571 Usp34 11 123464618 9.497209e-05 4.503256e-07 0.3837331 0.0760417
cg21167371 Zxdc 6 90370480 9.497209e-05 4.541043e-07 0.1179451 0.0233797
cg03480718 Barhl2 5 106464970 9.713083e-05 4.685361e-07 -0.4368288 0.0866936
cg25011187 Foxp2 6 15441102 1.070258e-04 5.277634e-07 0.1542876 0.0307595
cg25201652 Mir5127 18 181897933 1.070258e-04 5.281037e-07 0.2401773 0.0478840
cg25210850 Lrrtm4 6 80018906 1.070258e-04 5.298530e-07 -0.5277958 0.1052398
cg04521925 Marcks 10 137138511 1.070472e-04 5.344888e-07 -0.1465556 0.0292322
cg01160956 Lrrc40 3 158148694 1.096060e-04 5.519027e-07 0.3219117 0.0642881
cg07687957 2310008N11Rik 8 26626581 1.257033e-04 6.382771e-07 0.1655012 0.0332381
cg16121098 Tnrc6a 7 123174200 1.264037e-04 6.471816e-07 0.3923901 0.0788474
cg10652918 Srbd1 17 186041000 1.288625e-04 6.652236e-07 -0.1478487 0.0297408
cg19917700 Mir5127 18 181510247 1.321547e-04 6.878104e-07 0.3777060 0.0760772
cg24884825 Rora 9 69114348 1.328354e-04 6.969742e-07 -0.2786066 0.0561457
cg18344896 Lsamp 16 140850285 1.364350e-04 7.216342e-07 0.4003108 0.0807819
cg21947307 Fan1 7 64337943 1.401609e-04 7.472719e-07 0.1752068 0.0354049
cg07504399 Mir592 6 27936694 1.407872e-04 7.565682e-07 0.2957266 0.0597880
cg25069285 Top1 2 160721901 1.491290e-04 8.238854e-07 -0.2897519 0.0587777
cg13610315 Kmt2d 15 198844394 1.491290e-04 8.247844e-07 0.1663523 0.0337469
cg15488194 Mbnl1 3 60528353 1.491290e-04 8.078566e-07 -0.3513763 0.0712231
cg16561874 Unc79 12 1102949403 1.491290e-04 8.266365e-07 0.2634895 0.0534573
cg03571234 Dmd 20 85149157 1.523286e-04 8.508178e-07 0.2896336 0.0588287
cg15950887 Nfat5 8 107324738 1.586485e-04 8.928301e-07 0.3238979 0.0659147
cg21302471 Sos1 17 180449379 1.646545e-04 9.335971e-07 0.3377944 0.0688654
cg11328905 Nt5el 13 1105131370 1.807481e-04 1.033409e-06 0.3609138 0.0738795
cg25944824 Sall4 2 168767130 1.807481e-04 1.040145e-06 -0.2751357 0.0563354
cg06443336 Mir5127 18 181898194 2.030967e-04 1.177348e-06 0.1200648 0.0247077
cg18164741 Phf12 11 178028934 2.119967e-04 1.237911e-06 0.3332011 0.0687088
cg18681528 Tle1 4 72382259 2.176749e-04 1.287028e-06 0.2264544 0.0467712
cg11961894 Lmo3 6 138402670 2.176749e-04 1.289489e-06 0.3427150 0.0707889
cg06803118 Zc2hc1a 3 7535949 2.179756e-04 1.300494e-06 0.3175975 0.0656237
cg23078557 Vrk1 12 1106129498 2.372031e-04 1.425246e-06 0.2472003 0.0512710
cg02653214 Btaf1 19 137023698 2.410562e-04 1.458598e-06 0.3796408 0.0788156
cg02268145 Hoxd9 2 74697942 2.451955e-04 1.494019e-06 -0.0691910 0.0143787
cg05070816 Zfp131 13 1119775925 2.475901e-04 1.519086e-06 0.4339010 0.0902323
cg10604788 Cnot1 8 95775311 2.584925e-04 1.596916e-06 -0.3376531 0.0703633
cg05758851 4930441J16Rik 2 74272815 2.637867e-04 1.651946e-06 0.1640058 0.0342255
cg14494932 Casz1 4 148930449 2.637867e-04 1.643463e-06 0.1753643 0.0365880
cg21573997 Foxp2 6 15256450 2.889570e-04 1.834027e-06 0.3008649 0.0630625
cg22723228 C130074G19Rik 1 184898591 2.889570e-04 1.830898e-06 0.1541099 0.0322997
cg19056238 A730082K24Rik 7 115193624 2.958428e-04 1.902767e-06 -0.2571335 0.0539801
cg17909166 Mannr 3 29826111 2.958428e-04 1.891351e-06 0.2492448 0.0523107
cg09016032 Mapkap1 2 34462677 2.989384e-04 1.935327e-06 0.2682126 0.0563464
cg12225504 Tcf4 18 169408610 3.017520e-04 1.966310e-06 0.1989203 0.0418176
cg22952564 1700006H21Rik 13 1107618395 3.078876e-04 2.019319e-06 -0.3102014 0.0652852
cg00597118 Azin1 15 138514606 3.167663e-04 2.090955e-06 0.2603802 0.0548813
cg22369908 Sox12 2 152396791 3.192628e-04 2.134452e-06 -0.0995320 0.0209972
cg12071536 Hoxc9 15 1102981651 3.192628e-04 2.122017e-06 -0.3055236 0.0644368
cg22026774 Creb1 1 64574175 3.249227e-04 2.186041e-06 0.2566406 0.0541960
cg11399644 Srsf6 2 162933039 3.288414e-04 2.226320e-06 0.2836816 0.0599532
cg16715342 Setd1b 5 123141137 3.341687e-04 2.276527e-06 -0.0921764 0.0194992
cg19629739 Trps1 15 150659118 3.446389e-04 2.377021e-06 0.3379627 0.0716265
cg03073543 Prdm16 4 154421031 3.446389e-04 2.373405e-06 0.2405092 0.0509692
cg21162812 Asxl3 18 122344317 3.544173e-04 2.459461e-06 -0.2958824 0.0628006
cg13962734 4933430M04Rik 11 124448309 3.721795e-04 2.598469e-06 0.3458838 0.0735884
cg01202361 4930405A10Rik 14 122457591 3.757539e-04 2.655224e-06 0.3623230 0.0771584
cg03286705 Uncx 5 139549021 3.757539e-04 2.639766e-06 -0.2626151 0.0559109
cg02448802 Six3 17 185393753 3.921853e-04 2.787929e-06 0.2262492 0.0482834
cg27646139 Satb1 17 151739337 4.062222e-04 2.904902e-06 0.2368988 0.0506472
cg13662954 Bmper 9 22954674 4.307110e-04 3.104773e-06 0.2015879 0.0432243
cg03617050 Cacna1d 14 130089325 4.307110e-04 3.116472e-06 0.1638029 0.0351283
cg17406224 Cdk5rap2 4 69618413 4.555972e-04 3.315818e-06 0.1817324 0.0390804
cg01311296 Dyrk1a 16 194694783 4.643028e-04 3.418470e-06 0.2448126 0.0527167
cg12566943 Vwc2l 1 70750958 4.643028e-04 3.403320e-06 0.1703192 0.0366684
cg08304325 Gm28036 2 156098355 4.726279e-04 3.499762e-06 0.2988614 0.0644227
cg20630917 Tanc1 2 59799651 4.955506e-04 3.690471e-06 0.3487187 0.0753482
cg21160194 Vrk2 11 126815350 4.982973e-04 3.742833e-06 0.3020646 0.0653088
cg26741512 Mbnl1 3 60614538 4.982973e-04 3.774181e-06 0.1489497 0.0322162
cg12366733 Hoxb6 11 196299102 4.982973e-04 3.771484e-06 -0.1902757 0.0411532
cg27224831 Mamld1 20 71054025 5.219465e-04 3.975389e-06 0.1691671 0.0366745
cg21226777 Gm20172 1 25504481 5.332155e-04 4.083781e-06 -0.2091648 0.0454008
cg01823948 Nrxn3 12 189112244 5.442240e-04 4.191121e-06 0.2454939 0.0533488
cg08823201 Otx2 14 148750623 5.561269e-04 4.306319e-06 0.1683356 0.0366264
cg11454083 Slc25a5 20 36798422 5.937236e-04 4.622568e-06 0.1747651 0.0381481
cg27046391 Pebp4 14 169885697 5.940453e-04 4.675345e-06 0.2707155 0.0591230
cg18170214 Cacna2d2 9 107459085 5.940453e-04 4.658276e-06 -0.3546924 0.0774502
cg17762161 Zfp507 7 35980788 6.008190e-04 4.754079e-06 0.2780121 0.0607629
cg11232667 Cemip 7 84110734 6.064847e-04 4.824572e-06 0.1865095 0.0407914
cg06643163 Tnr 1 159816317 6.103148e-04 4.880866e-06 0.1934990 0.0423426
cg18185838 Tenm3 8 48434449 6.329967e-04 5.089044e-06 0.2906196 0.0637172
cg14194584 Rassf10 7 112906565 6.375545e-04 5.178231e-06 0.2545069 0.0558443
cg21193679 Satb1 17 151828363 6.375545e-04 5.179641e-06 0.2071164 0.0454464
cg26376143 Epc1 18 16436069 6.421820e-04 5.244409e-06 0.2368408 0.0519985
cg11929511 Kdm7a 6 39205484 6.478591e-04 5.318185e-06 -0.1406428 0.0308981
cg10277318 Pbx3 2 34275832 6.495529e-04 5.359574e-06 0.2649771 0.0582342
cg25382102 Dmbx1 4 115944224 6.675431e-04 5.536261e-06 -0.2011877 0.0442816
cg03471163 4922502N22Rik 6 139293940 6.764490e-04 5.638744e-06 0.2013998 0.0443661
cg11724972 Zfp507 7 36075168 6.821117e-04 5.714811e-06 0.2280815 0.0502750
cg20494382 Ankrd28 14 131711989 6.996539e-04 5.950596e-06 0.2965308 0.0654863
cg22533833 Foxp2 6 15396674 6.996539e-04 5.945908e-06 0.2333916 0.0515406
cg11545945 Poll 19 145541583 6.996539e-04 5.931938e-06 -0.0695990 0.0153681
cg23043982 4930441H08Rik 7 71349212 7.003841e-04 5.986442e-06 0.2346633 0.0518379
cg24243964 Ofcc1 13 140504405 7.230927e-04 6.211138e-06 0.2564557 0.0567497
cg01580681 Hand2os1 8 57322330 7.246708e-04 6.255357e-06 0.1895409 0.0419564
cg26621766 Bbx 16 150197628 7.343132e-04 6.369661e-06 0.2943258 0.0652067
cg23484089 Cntln 4 84987365 7.506591e-04 6.548719e-06 0.1177418 0.0261193
cg27609789 Acaca 11 184349543 7.506591e-04 6.584695e-06 -0.2415046 0.0535880
cg17593187 Rps6kc1 1 190807769 7.506591e-04 6.606740e-06 0.2344153 0.0520232
cg12134769 Syn2 6 115274241 7.579693e-04 6.703152e-06 0.2021623 0.0448960
cg00217702 Trpm7 2 126822534 7.676894e-04 6.821596e-06 0.2397525 0.0532880
cg18828923 Mir6417 5 51931612 7.695733e-04 6.870900e-06 0.2892714 0.0643161
cg02148584 Ppargc1a 5 51587374 7.755573e-04 6.957142e-06 0.2082512 0.0463296
cg09079792 Sox12 2 152396787 7.947167e-04 7.162639e-06 -0.0985552 0.0219558
cg11534391 Pdzrn4 15 192597108 8.125177e-04 7.391838e-06 -0.3134468 0.0699333
cg21118939 Hnrnpa3 2 75314992 8.125177e-04 7.367841e-06 0.1438316 0.0320854
cg10128645 Tbc1d8b 20 139732363 8.149337e-04 7.448300e-06 0.2625093 0.0585898
cg05642781 Armh1 4 117240036 8.197149e-04 7.526684e-06 -0.1218604 0.0272118
cg27447131 Megf11 9 64700117 8.240250e-04 7.601127e-06 0.1663820 0.0371710
cg20586522 A830082K12Rik 13 178602077 8.350546e-04 7.738203e-06 -0.2045171 0.0457297
cg27078219 4933406G16Rik 11 119174759 8.589959e-04 7.996408e-06 0.2472379 0.0553689
cg12906630 Taok1 11 177553737 8.914665e-04 8.336398e-06 0.2785179 0.0624990
cg25046890 4933406K04Rik 12 1107105036 8.961274e-04 8.417902e-06 0.2325839 0.0522159
cg10405348 Gm12128 11 137679586 8.965864e-04 8.460152e-06 0.3284802 0.0737628
cg23593195 Csde1 3 103040589 9.106251e-04 8.631153e-06 0.2045444 0.0459764
cg27528346 Faf1 4 109763279 9.221012e-04 8.778943e-06 0.3730922 0.0839305
cg05475402 Pbx3 2 34229562 9.473014e-04 9.058948e-06 0.2337063 0.0526544
cg17806656 D030025E07Rik 3 128674698 9.617074e-04 9.237405e-06 0.2224224 0.0501596
cg05812699 Tenm2 11 136636152 9.831126e-04 9.484605e-06 0.1546591 0.0349228
cg09537487 Fign 2 63752740 1.014614e-03 9.831445e-06 0.3501856 0.0792123
cg08351436 Uncx 5 139550131 1.018436e-03 9.911577e-06 -0.2105715 0.0476504
cg27192328 Sat1 20 155215212 1.030396e-03 1.007158e-05 0.1567144 0.0354908
cg11924467 Idh2 7 80086014 1.042337e-03 1.023239e-05 0.1219856 0.0276473
cg14215583 Lbx1 19 145244415 1.108370e-03 1.092752e-05 -0.2165739 0.0492442
cg20614809 2810405F15Rik 2 116201460 1.113016e-03 1.102043e-05 0.3347728 0.0761519
cg04197976 1700008P02Rik 3 6104803 1.116960e-03 1.110674e-05 0.2498904 0.0568654
cg24282768 Itgb7 15 1102215554 1.120851e-03 1.129420e-05 0.2705908 0.0616270
cg19298067 Mir6378 3 35262810 1.120851e-03 1.121552e-05 0.1925585 0.0438400
cg02958663 Rragc 4 124087234 1.120851e-03 1.133120e-05 0.1279082 0.0291358
cg14812516 Abcd4 12 184590133 1.120851e-03 1.133515e-05 -0.0871185 0.0198448
cg27175110 Mbd5 2 49258247 1.121474e-03 1.146263e-05 0.2188190 0.0498725
cg14530830 Nog 11 189301114 1.121474e-03 1.148380e-05 -0.2466125 0.0562123
cg14592546 Zfp521 18 113589851 1.121474e-03 1.147917e-05 0.2099557 0.0478558
cg25200003 Atxn2 5 121781111 1.131223e-03 1.167299e-05 0.0949923 0.0216699
cg14070544 Uri1 7 37887160 1.131223e-03 1.167937e-05 0.1629578 0.0371754
cg11473209 Dlx1 2 71530661 1.136056e-03 1.177734e-05 -0.3593310 0.0820078
cg16299574 Rragc 4 124087355 1.137706e-03 1.184258e-05 0.0992362 0.0226543
cg23188031 Cuedc2 19 146330747 1.141134e-03 1.192655e-05 0.1730897 0.0395279
cg03443886 Arx 20 93377747 1.142963e-03 1.199403e-05 0.1874530 0.0428200
cg03345607 Foxp2 6 15123751 1.153020e-03 1.217901e-05 0.1671222 0.0382050
cg18539981 Cacna1e 1 154561732 1.153020e-03 1.219714e-05 0.1478820 0.0338091
cg06658605 Sox6 7 115747711 1.168071e-03 1.240578e-05 -0.0605285 0.0138499
cg20092403 Tmem260 14 148393336 1.169771e-03 1.247334e-05 0.2897882 0.0663260
cg22103694 Rbfox1 16 17555264 1.184709e-03 1.280841e-05 0.1844174 0.0422651
cg26603143 Sox4 13 128949874 1.184709e-03 1.283313e-05 -0.0992672 0.0227524
cg14247424 Epha3 16 163958324 1.184709e-03 1.276344e-05 -0.3002004 0.0687883
cg18058532 Pax6 2 105675601 1.184709e-03 1.277033e-05 -0.2253022 0.0516274
cg13142119 Prrx1 1 163248395 1.190630e-03 1.294766e-05 0.3067564 0.0703410
cg10972783 Mllt10 2 18048432 1.194763e-03 1.304315e-05 -0.2114147 0.0484965
cg26851215 Npas3 12 153647596 1.195753e-03 1.314887e-05 0.1852173 0.0425043
cg07367585 Ola1 2 73128115 1.195753e-03 1.315516e-05 0.1999130 0.0458778
cg18506907 Msr1 8 39746398 1.216427e-03 1.343408e-05 0.1737723 0.0399209
cg25430192 Dlx6os1 6 6871767 1.217867e-03 1.350151e-05 -0.2862769 0.0657833
cg24901288 Msantd4 9 4427125 1.246054e-03 1.386672e-05 0.0812673 0.0186995
cg23503238 Zbtb7c 18 175835728 1.262303e-03 1.415060e-05 0.1480253 0.0340953
cg17199893 Hoxb5os 11 196310702 1.262303e-03 1.415437e-05 -0.2589021 0.0596349
cg22618711 A930004D18Rik 2 18035793 1.286851e-03 1.453854e-05 0.3001709 0.0692345
cg07467137 Dynll2 11 187981285 1.286851e-03 1.452276e-05 0.2217331 0.0511400
cg16673182 Lcorl 5 45732367 1.362285e-03 1.544841e-05 -0.3493055 0.0808167
cg10586028 Cdk8 5 146283668 1.374838e-03 1.566230e-05 0.2481824 0.0574608
cg24268851 Atp9b 18 180812934 1.374838e-03 1.570711e-05 0.2689437 0.0622767
cg11846721 Sdk1 5 141245156 1.386393e-03 1.589779e-05 0.2101188 0.0486852
cg18033417 Ptma 1 86545796 1.419084e-03 1.633271e-05 0.2116096 0.0490985
cg13615735 Fign 2 64366825 1.424696e-03 1.645758e-05 0.2683627 0.0622909
cg22773167 Rhob 12 18499563 1.425153e-03 1.652317e-05 -0.0530141 0.0123079
cg00423854 Sall1 8 89560560 1.455771e-03 1.693975e-05 0.1835163 0.0426601
cg02132378 Satb1 17 151702531 1.457935e-03 1.707554e-05 0.1391392 0.0323575
cg25362942 Rac2 15 178564932 1.457935e-03 1.708831e-05 -0.1306724 0.0303897
cg23805666 1700123L14Rik 6 96180617 1.463076e-03 1.721047e-05 0.3021725 0.0703003
cg16278300 Reln 5 22080769 1.475076e-03 1.741405e-05 0.1421629 0.0330942
cg12830810 Psme4 11 130807816 1.493242e-03 1.769169e-05 0.2598219 0.0605336
cg02321338 Gm10248 14 122930623 1.503205e-03 1.787334e-05 0.1800246 0.0419645
cg11099953 Tshz3 7 36873887 1.523994e-03 1.839670e-05 -0.0961924 0.0224564
cg17260978 Zbtb20 16 143371444 1.523994e-03 1.829679e-05 0.2684641 0.0626561
cg13634725 Ndufb9 15 158941539 1.523994e-03 1.831221e-05 0.2280349 0.0532228
cg17777454 Kalrn 16 134175763 1.523994e-03 1.844295e-05 0.2005224 0.0468187
cg00013247 Cdh5 8 103896817 1.523994e-03 1.837896e-05 0.2726008 0.0636364
cg08629862 Phf12 11 178030104 1.530976e-03 1.865701e-05 0.2356602 0.0550558
cg16007321 Nr5a2 1 136854380 1.530976e-03 1.860599e-05 0.1818532 0.0424792
cg15243041 Cacng4 11 1107735172 1.532085e-03 1.873535e-05 0.1709688 0.0399511
cg02429111 Stx17 4 48092407 1.545290e-03 1.896222e-05 0.2377898 0.0556003
cg14877474 Itpr1 6 108391888 1.550381e-03 1.909029e-05 0.1625608 0.0380235
cg26547442 I730028E13Rik 9 61145110 1.565976e-03 1.934858e-05 0.3549150 0.0830739
cg17011396 Hmx3 7 131497027 1.573707e-03 1.951069e-05 -0.1505081 0.0352443
cg25149527 Cacna2d3 14 128827255 1.584483e-03 1.971133e-05 0.2809625 0.0658279
cg04281230 Mir195b 2 56336072 1.604849e-03 2.003260e-05 0.2257936 0.0529469
cg10316830 Zbtb44 9 31066713 1.654419e-03 2.072136e-05 -0.2160615 0.0507547
cg10471264 Bcl11a 11 124078433 1.661592e-03 2.095182e-05 -0.2899815 0.0681588
cg12324159 Slc14a2 18 178753832 1.661592e-03 2.088518e-05 0.2884126 0.0677787
cg19489133 Gm19466 18 153693469 1.690095e-03 2.138274e-05 0.1244755 0.0292888
cg24676367 Tnik 3 28668013 1.700278e-03 2.158353e-05 0.2931967 0.0690224
cg03990624 Irx3 8 91827376 1.717432e-03 2.194663e-05 0.0954674 0.0224941
cg25133549 Tnrc6a 7 123170393 1.717432e-03 2.191470e-05 0.2407627 0.0567244
cg01168718 Gabrg2 11 141389625 1.717769e-03 2.202361e-05 0.1336173 0.0314889
cg04787747 Donson 16 191678171 1.719481e-03 2.223251e-05 0.1339533 0.0315838
cg13505793 Otp 13 194880332 1.719481e-03 2.226383e-05 -0.3657658 0.0862475
cg24743148 Esrrb 12 186580800 1.719481e-03 2.216894e-05 -0.1585646 0.0373810
cg03450698 Zic4 9 91399020 1.741695e-03 2.262515e-05 0.2047908 0.0483308
cg00194417 Tshz3 7 36458294 1.771159e-03 2.308285e-05 0.3028978 0.0715601
cg07023974 Rbfox2 15 177095035 1.794370e-03 2.346128e-05 0.3216605 0.0760586
cg20200185 Satb1 17 151803730 1.815670e-03 2.381659e-05 0.1836604 0.0434624
cg19000923 Il1rap 16 126662986 1.822984e-03 2.398968e-05 0.2139166 0.0506419
cg04290072 Prkd1 12 150295408 1.834543e-03 2.421941e-05 0.3567635 0.0845020
cg19381434 Lrmda 14 122363208 1.849376e-03 2.465000e-05 0.2721084 0.0645115
cg20194570 Kcnn2 18 145685661 1.849376e-03 2.455100e-05 0.2673507 0.0633699
cg21119395 Rps6ka3 20 159363542 1.849376e-03 2.458373e-05 0.2445062 0.0579592
cg26178630 Gm6249 7 136738628 1.904847e-03 2.555056e-05 0.1276718 0.0303267
cg10070910 4930405A10Rik 14 122534894 1.904847e-03 2.552643e-05 0.3180250 0.0755387
cg06333512 Bend4 5 67434890 1.909462e-03 2.587351e-05 0.1990507 0.0473137
cg13094532 Lrmda 14 122192352 1.909462e-03 2.593565e-05 0.2296320 0.0545898
cg04900296 Ppp2r1b 9 50913478 1.909462e-03 2.591128e-05 0.1303768 0.0309926
cg00718342 Fmn1 2 113619072 1.909462e-03 2.576411e-05 0.1514966 0.0360020
cg02762813 Cnot6 11 149683231 1.958811e-03 2.668884e-05 0.3067778 0.0730420
cg20468818 Xylt1 7 117579259 1.962123e-03 2.681698e-05 0.1988816 0.0473647
cg08982699 Celf6 9 59589242 1.969652e-03 2.724363e-05 0.2051619 0.0489021
cg22070870 Foxp1 6 98945391 1.969652e-03 2.725326e-05 0.2366584 0.0564106
cg08150966 AU016765 17 164547121 1.969652e-03 2.719005e-05 0.1802259 0.0429538
cg13844820 Elavl4 4 110287961 1.969652e-03 2.712380e-05 0.1651384 0.0393528
cg10040836 Nr2f2 7 70359974 1.977049e-03 2.743927e-05 -0.1001196 0.0238736
cg27484500 A330048O09Rik 13 148284927 1.995427e-03 2.784991e-05 0.1076701 0.0256946
cg17475635 Rbfox1 16 17520747 1.995427e-03 2.786319e-05 0.1749473 0.0417509
cg06750335 Mir195b 2 56119710 2.005193e-03 2.833895e-05 0.0619607 0.0148004
cg06674865 Wnt2 6 18024340 2.005193e-03 2.811562e-05 0.2529083 0.0603857
cg07479793 1700109G15Rik 11 184766109 2.005193e-03 2.831861e-05 0.2765542 0.0660573
cg08005019 C130071C03Rik 13 183729752 2.005193e-03 2.822703e-05 -0.1482860 0.0354131
cg14576454 Irx3 8 91990999 2.038306e-03 2.889318e-05 0.2966645 0.0709381
cg24414269 Cdk12 11 198224594 2.040783e-03 2.901464e-05 0.3339927 0.0798822
cg19753302 Atad2b 12 15119192 2.057053e-03 2.933301e-05 0.1076853 0.0257708
cg09117361 Fap 2 62503122 2.058087e-03 2.943483e-05 0.1586078 0.0379645
cg23053149 Ric8b 10 185004830 2.080442e-03 2.984258e-05 0.1673805 0.0400944
cg02522446 Mir196a-2 15 1102970938 2.085935e-03 3.000964e-05 -0.0475370 0.0113905
cg15060270 Spred2 11 119924391 2.114803e-03 3.051445e-05 -0.1225231 0.0293849
cg15035143 Mir142 11 187756842 2.122365e-03 3.071336e-05 0.0692433 0.0166126
cg17663591 Csmd1 8 15892880 2.122627e-03 3.086859e-05 0.2347536 0.0563369
cg11567215 4930524B15Rik 11 131931452 2.122627e-03 3.089679e-05 0.2432975 0.0583902
cg06562958 Ola1 2 73143899 2.125166e-03 3.106837e-05 0.1741530 0.0418085
cg15439774 Gm38409 14 167555169 2.125166e-03 3.111360e-05 -0.0626607 0.0150440
cg15677669 Fgf13 20 59125894 2.185863e-03 3.209472e-05 0.2909908 0.0699822
cg10378662 Sox5os3 6 144503671 2.196149e-03 3.251955e-05 0.2314982 0.0557147
cg13263798 Strbp 2 37580741 2.196149e-03 3.246763e-05 0.2087136 0.0502267
cg21191048 Celf4 18 126197240 2.196149e-03 3.252453e-05 0.3182001 0.0765819
cg14172937 Slc12a5 2 164968267 2.201301e-03 3.269398e-05 -0.0856883 0.0206287
cg23179251 Foxp2 6 15416584 2.204407e-03 3.292666e-05 0.2321290 0.0559048
cg03451546 Hoxb7 11 196285274 2.204407e-03 3.284368e-05 -0.3347077 0.0805982
cg02508227 Ascc3 10 150763653 2.221881e-03 3.328168e-05 0.2706899 0.0652302
cg10932472 Pbx3 2 34254181 2.270944e-03 3.411268e-05 0.2434754 0.0587521
cg14415460 Slc6a6 6 91748402 2.275921e-03 3.428374e-05 0.3883723 0.0937425
cg20426917 Tas1r2 4 139737094 2.333414e-03 3.524855e-05 0.3829075 0.0925657
cg20733736 Gm10578 7 137248673 2.363306e-03 3.600009e-05 0.1244203 0.0301132
cg02253804 4933427E13Rik 11 125287618 2.363306e-03 3.591199e-05 -0.2025494 0.0490159
cg26135564 Gzf1 2 148707212 2.363306e-03 3.589647e-05 -0.1034284 0.0250285
cg27531402 Paupar 2 105660539 2.405418e-03 3.683121e-05 -0.1934066 0.0468693
cg06798772 Lrmda 14 122037387 2.405418e-03 3.684515e-05 0.2034333 0.0493002
cg12813238 Cacna2d4 6 119359495 2.407099e-03 3.697275e-05 0.1363899 0.0330592
cg15428926 Bnc2 4 84307165 2.420718e-03 3.728437e-05 0.2480226 0.0601457
cg10353262 Zfp148 16 133434686 2.435657e-03 3.761752e-05 -0.1301191 0.0315697
cg04297588 A730082K24Rik 7 115089065 2.454953e-03 3.801942e-05 -0.2628076 0.0638007
cg16666801 NA 19 155931560 2.491097e-03 3.868457e-05 0.1650557 0.0401088
cg25993405 Tcf4 18 169529964 2.561058e-03 3.998775e-05 0.2467848 0.0600808
cg13602621 Sp5 2 70425883 2.561058e-03 3.991770e-05 0.1816421 0.0442172
cg20888789 Hat1 2 71421302 2.563506e-03 4.029918e-05 0.1982649 0.0482895
cg01579422 Atg4c 4 99266846 2.563506e-03 4.035139e-05 0.2647110 0.0644778
cg20187980 Celf2 2 8029261 2.563506e-03 4.034417e-05 0.0833327 0.0202978
cg15772697 Gm12128 11 137650267 2.570110e-03 4.056409e-05 0.2322405 0.0565855
cg05371975 Srek1 13 1103764400 2.570885e-03 4.068511e-05 0.1086714 0.0264823
cg04246600 4930433B08Rik 3 18714425 2.574773e-03 4.085559e-05 0.2675026 0.0652034
cg08152313 Foxp2 6 15407361 2.579125e-03 4.114290e-05 0.2835148 0.0691337
cg26299486 4930555K19Rik 15 140961245 2.579125e-03 4.112141e-05 0.2001349 0.0488005
cg08772487 Nedd4 9 72619984 2.589577e-03 4.141921e-05 0.3098546 0.0755850
cg09141136 Usp34 11 123414775 2.606139e-03 4.179439e-05 0.2082193 0.0508183
cg24654889 Gm32123 14 124837753 2.618504e-03 4.210348e-05 0.1434721 0.0350306
cg12015981 Cyld 8 88758504 2.630354e-03 4.240532e-05 0.2228548 0.0544349
cg19261448 Rora 9 69210492 2.645510e-03 4.276160e-05 0.1126722 0.0275346
cg21176649 1700057H15Rik 4 124219373 2.649867e-03 4.294416e-05 0.1626176 0.0397497
cg00719335 Gpat3 5 101033928 2.684734e-03 4.362281e-05 0.2239388 0.0547875
cg19044429 Diaph3 14 186772639 2.708792e-03 4.435757e-05 0.2368759 0.0580077
cg19642684 Baz2b 2 59983809 2.708792e-03 4.432617e-05 0.1202818 0.0294542
cg23254416 Pcsk1 13 175099328 2.708792e-03 4.427244e-05 0.2520337 0.0617129
cg22758731 Adk 14 121369281 2.777236e-03 4.559589e-05 -0.2553109 0.0626203
cg20420324 Slc12a8 16 133466940 2.857240e-03 4.703027e-05 0.2788986 0.0685269
cg10784922 Hdac8 20 102402632 2.963421e-03 4.890340e-05 0.1689060 0.0415942
cg17971729 Cdc42bpa 1 180093965 2.966881e-03 4.911890e-05 0.1812680 0.0446497
cg02259423 Gm6639 3 35464455 2.966881e-03 4.921159e-05 0.2796705 0.0688956
cg19336073 Pigv 4 133679041 3.062220e-03 5.104175e-05 0.2023500 0.0499530
cg15383869 Skor1 9 63217522 3.062220e-03 5.105212e-05 0.2784830 0.0687484
cg06413694 Rps6kc1 1 190713945 3.075729e-03 5.140747e-05 0.1555413 0.0384135
cg01548368 Aatf 11 184376647 3.161833e-03 5.298040e-05 0.1759561 0.0435311
cg03574837 Rassf10 7 112876092 3.291131e-03 5.528621e-05 0.2028146 0.0503003
cg25802459 Zdhhc1 8 105476640 3.336099e-03 5.618277e-05 0.1239778 0.0307767
cg14023941 Lncbate1 8 108281792 3.338548e-03 5.636529e-05 0.1383862 0.0343601
cg12441103 A730082K24Rik 7 115223729 3.356875e-03 5.681674e-05 0.2494755 0.0619714
cg10234511 Casz1 4 148867362 3.417902e-03 5.828352e-05 -0.1383812 0.0344261
cg07848252 Ago1 4 126443081 3.417902e-03 5.803573e-05 0.2021158 0.0502693
cg16698248 Tcf4 18 169593590 3.417902e-03 5.825273e-05 -0.2823008 0.0702279
cg13273888 Rbm15 3 107326119 3.439431e-03 5.893501e-05 0.1703263 0.0424010
cg09529245 Gm33948 18 127629535 3.439431e-03 5.894171e-05 0.2523279 0.0628149
cg25069660 Qk 17 110209154 3.441946e-03 5.913045e-05 0.1261244 0.0314035
cg19090034 5730522E02Rik 11 125536284 3.445659e-03 5.934005e-05 0.1307972 0.0325737
cg09286791 Bahcc1 11 1120232977 3.451055e-03 5.957899e-05 -0.1525192 0.0379923
cg23711940 Fancb 20 165129188 3.494063e-03 6.046934e-05 0.2771118 0.0690884
cg27313161 Med13 11 186270438 3.525259e-03 6.115839e-05 0.0580567 0.0144841
cg11531782 Etv1 12 138773113 3.599363e-03 6.259630e-05 0.2146873 0.0536342
cg06492659 Mtrex 13 1112901501 3.623299e-03 6.316587e-05 0.2712879 0.0678108
cg18496572 E330013P04Rik 19 160148961 3.674361e-03 6.421153e-05 0.1765154 0.0441645
cg19605887 Gm33301 15 140314514 3.743646e-03 6.558073e-05 0.3189755 0.0799082
cg23885267 Nnt 13 1119151081 3.802615e-03 6.677465e-05 -0.0612261 0.0153545
cg24727294 Dach1 14 198536637 3.816046e-03 6.777420e-05 0.2496775 0.0626706
cg12249796 Gm13205 4 148984460 3.816046e-03 6.734344e-05 0.1457693 0.0365751
cg26430247 Gsk3b 16 138243494 3.816046e-03 6.781786e-05 0.1510710 0.0379212
cg09751476 Pax6 2 105720279 3.816046e-03 6.752744e-05 0.1778809 0.0446395
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cg06931862 Hoxa9 6 52226298 3.847702e-03 6.854324e-05 -0.1574632 0.0395508
cg24995571 Zfp507 7 35892595 3.919572e-03 6.998940e-05 0.3133223 0.0787970
cg09513654 Tcf7l2 19 155888060 3.942725e-03 7.056965e-05 -0.1999342 0.0503061
cg15802836 Unc79 12 1102949676 3.982604e-03 7.145195e-05 -0.1613791 0.0406353
cg18980984 A830082K12Rik 13 179346083 4.008428e-03 7.219673e-05 0.2796960 0.0704714
cg20125647 Sost 11 1101963996 4.008428e-03 7.225449e-05 0.0665384 0.0167656
cg23505379 Gm4791 9 47055111 4.013629e-03 7.251808e-05 0.3457404 0.0871350
cg07922932 Gpcpd1 2 132530686 4.080502e-03 7.389899e-05 0.2204036 0.0556101
cg16774573 Cables1 18 111905983 4.083094e-03 7.429148e-05 0.2162475 0.0545789
cg03619501 Lrmda 14 122046656 4.083094e-03 7.417969e-05 0.1928801 0.0486768
cg26472407 Scyl3 1 163934647 4.118483e-03 7.510964e-05 0.1158012 0.0292465
cg24823249 Car11 7 45700451 4.123409e-03 7.537395e-05 -0.2590200 0.0654314
cg05513775 Cacybp 1 160219348 4.135860e-03 7.595156e-05 0.2444498 0.0617792
cg25180674 Cnot2 10 1116507099 4.135860e-03 7.585841e-05 0.2726348 0.0688973
cg00687049 Camsap1 2 25952744 4.138040e-03 7.616670e-05 -0.2241159 0.0566500
cg19298746 Ipo5 14 1120911270 4.163070e-03 7.697972e-05 0.1149576 0.0290766
cg24079029 5730522E02Rik 11 126043567 4.163070e-03 7.689504e-05 0.2200273 0.0556485
cg11022831 Pbx3 2 34288925 4.167827e-03 7.741968e-05 -0.3152107 0.0797547
cg06794599 Fbxo33 12 159202482 4.167827e-03 7.742039e-05 -0.1605198 0.0406148
cg03165986 Bcl11a 11 124168136 4.199926e-03 7.819436e-05 0.2373516 0.0600910
cg13044883 Calcoco1 15 1102694513 4.236496e-03 7.905449e-05 -0.2456492 0.0622330
cg23237751 Atp11c 20 60236388 4.295246e-03 8.033254e-05 0.2471525 0.0626749
cg15693636 Celf2 2 6553935 4.296860e-03 8.054454e-05 0.1785174 0.0452771
cg27569107 Smarce1 11 199225045 4.306947e-03 8.128034e-05 0.1765520 0.0448034
cg15812839 Mef2c 13 183491076 4.306947e-03 8.120995e-05 0.2746759 0.0697005
cg12499300 Vps41 13 118613622 4.306947e-03 8.107148e-05 0.2996949 0.0760413
cg15659936 Celf4 18 125753508 4.367124e-03 8.260079e-05 0.1265304 0.0321410
cg10986437 Zfhx4 3 5222996 4.384169e-03 8.310870e-05 0.2444478 0.0621174
cg06860536 4930402F11Rik 7 69226496 4.402084e-03 8.389540e-05 0.1871181 0.0475765
cg11895464 4933406G16Rik 11 119265492 4.402084e-03 8.400710e-05 0.1716598 0.0436497
cg23170538 4933427E13Rik 11 125287626 4.402084e-03 8.367800e-05 -0.2333922 0.0593328
cg18014986 Gm20696 6 99467586 4.451093e-03 8.513070e-05 0.2713896 0.0690651
cg14699463 Chrd 16 120736085 4.469535e-03 8.567256e-05 -0.2064734 0.0525652
cg16820308 A830082K12Rik 13 178678608 4.473638e-03 8.594049e-05 -0.2214296 0.0563836
cg20546446 Slitrk1 14 1108913232 4.484631e-03 8.634144e-05 -0.2769437 0.0705395
cg20405104 Wwc1 11 136152724 4.548751e-03 8.800026e-05 -0.1435112 0.0365960
cg21007937 Tra2a 6 49252508 4.548751e-03 8.812608e-05 0.2612980 0.0666380
cg18059870 Slitrk1 14 1108913223 4.548751e-03 8.815334e-05 -0.1623146 0.0413954
cg26278617 Mir205 1 193610520 4.589667e-03 8.914049e-05 0.2398747 0.0612176
cg25326950 Ptch1 13 163554990 4.621606e-03 9.034749e-05 -0.1784293 0.0455741
cg21870895 Fto 8 91622456 4.621606e-03 9.029688e-05 0.1431266 0.0365559
cg25019647 Cdca2 14 167633016 4.621606e-03 9.029543e-05 -0.1083423 0.0276716
cg22454306 Skap2 6 51847017 4.689223e-03 9.226688e-05 0.1377189 0.0352215
cg00859590 B230323A14Rik 9 69670263 4.689223e-03 9.246300e-05 -0.1971957 0.0504393
cg14155184 Tmem63b 17 145662872 4.689223e-03 9.188092e-05 -0.2289085 0.0585281
cg23977950 Uncx 5 139549064 4.689223e-03 9.230996e-05 -0.2010928 0.0514309
cg14219120 Rragc 4 124087353 4.704533e-03 9.296395e-05 -0.0450695 0.0115319
cg13385016 Pitx2 3 129219349 4.730925e-03 9.368565e-05 -0.2440330 0.0624702
cg11873500 Ppfia2 10 1106835255 4.818733e-03 9.562838e-05 0.2172277 0.0556791
cg07847256 3100003L05Rik 7 124502578 4.845940e-03 9.637338e-05 0.2380797 0.0610532
cg20246785 Tnrc6b 15 180929729 4.892231e-03 9.750099e-05 0.2801050 0.0718821
cg11079986 Dlx1 2 71530104 4.919617e-03 9.825495e-05 -0.1010330 0.0259401
cg08307607 2900052N01Rik 9 46899689 5.062415e-03 1.016480e-04 0.2267430 0.0583393
cg11718387 Mir466f-4 13 171301635 5.062415e-03 1.015339e-04 0.2405001 0.0618746
cg02925560 Mab21l2 3 86560624 5.062415e-03 1.017496e-04 0.3404405 0.0875983
cg02973003 Gdf11 10 1128889342 5.097851e-03 1.026775e-04 0.2036192 0.0524228
cg18026227 Zfhx4 3 5218543 5.098004e-03 1.028963e-04 -0.2646488 0.0681442
cg00923443 Ccn3 15 154768444 5.105273e-03 1.032590e-04 -0.2082434 0.0536322
cg02594577 Stag1 9 100643642 5.172556e-03 1.048642e-04 0.1356426 0.0349680
cg03296938 Srbd1 17 185889818 5.172556e-03 1.050576e-04 0.1234671 0.0318329
cg02536733 Slc5a8 10 188902482 5.218887e-03 1.062195e-04 0.2236925 0.0577133
cg06998890 Ralgapb 2 158443304 5.229373e-03 1.068249e-04 0.1615901 0.0417056
cg25231515 Npas3 12 153647611 5.229373e-03 1.068754e-04 0.1793534 0.0462916
cg19695329 Fignl1 11 111758242 5.238103e-03 1.075274e-04 0.1627169 0.0420137
cg23733711 Tenm2 11 136714644 5.238103e-03 1.077188e-04 0.3075047 0.0794070
cg02146878 Wapl 14 134692111 5.238103e-03 1.072913e-04 0.2318345 0.0598517
cg02864518 Luc7l2 6 38568909 5.248798e-03 1.086050e-04 0.2186465 0.0564903
cg15663090 Agap1 1 89798683 5.248798e-03 1.083915e-04 0.1800862 0.0465219
cg11230269 Trrap 5 144816379 5.248798e-03 1.085827e-04 0.1651584 0.0426703
cg01491819 Nova1 12 147400865 5.298291e-03 1.098533e-04 0.0869439 0.0224793
cg22719807 Kif2a 13 1106993939 5.332912e-03 1.108863e-04 0.1842976 0.0476782
cg14700070 Mbnl1 3 60614690 5.332912e-03 1.110224e-04 -0.1498090 0.0387590
cg05575546 Nxph1 6 8956282 5.423333e-03 1.131343e-04 -0.1894829 0.0490819
cg22671032 Smad2 18 176286898 5.522746e-03 1.154418e-04 0.1722848 0.0446842
cg10436985 Pou3f4 20 110817802 5.538355e-03 1.162368e-04 0.1703508 0.0442018
cg18261844 Pou2f1 1 166002575 5.538355e-03 1.160300e-04 -0.1533949 0.0397977
cg14141896 Stra6 9 58061322 5.622555e-03 1.182419e-04 0.2170975 0.0563927
cg15736995 Gm10440 5 54279237 5.697468e-03 1.200583e-04 0.2612687 0.0679325
cg11777734 Ankfn1 11 189718503 5.705795e-03 1.204752e-04 0.1980544 0.0515075
cg26182201 2310008N11Rik 8 26530005 5.707345e-03 1.207495e-04 0.0626360 0.0162920
cg18640545 Mtx2 2 75073959 5.709961e-03 1.210464e-04 0.1078010 0.0280440
cg19715364 Nfib 4 82292742 5.815391e-03 1.240197e-04 0.1854289 0.0483134
cg17864122 1700061F12Rik 2 9388546 5.815391e-03 1.235573e-04 0.1813719 0.0472451
cg14388852 Ndufb2 6 39615743 5.815391e-03 1.238775e-04 -0.1780621 0.0463906
cg06647284 Calu 6 29361379 5.835140e-03 1.246878e-04 0.1466730 0.0382287
cg03957964 4930519K11Rik 14 124003796 5.925207e-03 1.268631e-04 -0.1335964 0.0348591
cg11985489 Gm14664 20 61026826 5.951016e-03 1.276675e-04 -0.3324798 0.0867886
cg20281703 Zbtb20 16 143221998 6.016626e-03 1.293296e-04 0.2043192 0.0533787
cg22956901 Gm36669 6 16769056 6.034555e-03 1.299703e-04 0.1746550 0.0456434
cg27505352 Prpf38b 3 108910375 6.051777e-03 1.305973e-04 -0.1464237 0.0382774
cg14587979 Gpd2 2 57567463 6.065451e-03 1.311491e-04 0.2668861 0.0697871
cg03626038 1810013L24Rik 16 18855906 6.075567e-03 1.316248e-04 0.1016877 0.0265962
cg13785336 Chmp4b 2 154694714 6.162659e-03 1.337724e-04 -0.2543298 0.0665888
cg18998268 Cntfr 4 41686224 6.184911e-03 1.345172e-04 0.0502547 0.0131624
cg08733030 Ptprm 17 166842810 6.220591e-03 1.355564e-04 0.1663040 0.0435791
cg21170489 Ahcyl2 6 29906720 6.234814e-03 1.361301e-04 0.2977082 0.0780343
cg22068328 Mbd5 2 49258068 6.254200e-03 1.368181e-04 0.2947007 0.0772712
cg09299803 Gm10578 7 137238669 6.315062e-03 1.384167e-04 0.1368567 0.0359111
cg06151126 Bnc2 4 84367260 6.342691e-03 1.392907e-04 0.2552900 0.0670154
cg07434650 B230303A05Rik 13 116745834 6.426105e-03 1.413944e-04 -0.2595000 0.0681869
cg25050264 Arhgef6 20 57243436 6.477335e-03 1.429669e-04 0.2346665 0.0617060
cg09715291 1700017J07Rik 2 169078340 6.477335e-03 1.430698e-04 0.2071978 0.0544856
cg00847015 Skap2 6 51863306 6.692799e-03 1.481121e-04 0.1094308 0.0288415
cg10605443 Mef2c 13 183461653 7.113564e-03 1.580257e-04 0.2240341 0.0592980
cg24868356 Lhx1os 11 184564293 7.113564e-03 1.580023e-04 0.1487024 0.0393586
cg27381861 Zfp536 7 37450470 7.167513e-03 1.595524e-04 0.2228674 0.0590266
cg05308779 Fignl1 11 111761323 7.167513e-03 1.598307e-04 0.1303547 0.0345285
cg00452125 1700109G15Rik 11 184726113 7.172333e-03 1.603113e-04 0.1545624 0.0409488
cg01301067 Appl1 14 126949582 7.172333e-03 1.608487e-04 0.2656056 0.0703835
cg05399218 Pax6 2 105684792 7.172333e-03 1.606098e-04 0.1185401 0.0314091
cg19945696 Dnajc24 2 106074573 7.204078e-03 1.618654e-04 0.1941596 0.0514723
cg20129790 Celf4 18 125486897 7.216442e-03 1.624486e-04 -0.0645182 0.0171080
cg20051624 Gapvd1 2 34717294 7.227614e-03 1.630059e-04 0.2664262 0.0706632
cg06059859 Arntl 7 113207518 7.227668e-03 1.634470e-04 -0.0671711 0.0178187
cg07408640 Sfta3-ps 12 156473156 7.227668e-03 1.636188e-04 0.1997952 0.0530040
cg09228164 Pcdhgc4 18 137815784 7.284901e-03 1.652227e-04 -0.1589995 0.0422086
cg07150211 H2al1j 20 11672294 7.291253e-03 1.656752e-04 0.1916844 0.0508944
cg15048337 B230323A14Rik 9 69735124 7.296258e-03 1.664064e-04 0.1541132 0.0409308
cg07951445 Dpyd 3 118756377 7.296258e-03 1.662825e-04 0.2324927 0.0617445
cg08845156 Tmem218 9 37197254 7.324548e-03 1.673616e-04 0.2089323 0.0555112
cg25403836 Ola1 2 73157339 7.350405e-03 1.682634e-04 0.0936246 0.0248840
cg25828009 Zbtb10 3 9280356 7.403426e-03 1.697904e-04 0.2174662 0.0578340
cg24882108 Vrk2 11 126815320 7.471710e-03 1.716726e-04 0.1507677 0.0401253
cg09911517 Acaca 11 184362082 7.493050e-03 1.724800e-04 0.1879101 0.0500260
cg04501234 Nhsl2 20 102076198 7.508655e-03 1.731569e-04 0.1097369 0.0292221
cg16663507 Nova1 12 146696409 7.575027e-03 1.750080e-04 0.2494024 0.0664612
cg16713026 Pex14 4 149061890 7.590678e-03 1.756908e-04 0.2441724 0.0650844
cg05714931 Hgf 5 16778822 7.599436e-03 1.765366e-04 -0.2140147 0.0570642
cg01998099 Ccnt1 15 198546772 7.599436e-03 1.763850e-04 0.1674154 0.0446365
cg26530885 Ptprg 14 112156087 7.614422e-03 1.772070e-04 0.1773694 0.0473052
cg14419060 Cd101 3 101007499 7.670302e-03 1.788320e-04 -0.2185272 0.0583177
cg00469450 Ctcf 8 105671326 7.670569e-03 1.794874e-04 0.2794480 0.0745938
cg01451179 Pex14 4 149061892 7.670569e-03 1.793799e-04 0.1831041 0.0488745
cg04404249 C030029H02Rik 7 136196703 7.832525e-03 1.836085e-04 0.2071585 0.0553816
cg03215611 Slc25a36 9 97089531 7.843086e-03 1.841879e-04 0.1014787 0.0271350
cg14539976 Otx1 11 122017592 7.998405e-03 1.881739e-04 0.2477481 0.0663424
cg05457273 Kcnn2 18 145559339 8.016335e-03 1.892741e-04 -0.0669142 0.0179254
cg25429952 9230020A06Rik 11 171409556 8.016335e-03 1.890131e-04 0.2819244 0.0755168
cg10033233 Psmd7 8 107603547 8.018117e-03 1.896555e-04 -0.2167819 0.0580809
cg17860780 Mir3064 11 1106782730 8.028845e-03 1.902489e-04 0.2125717 0.0569649
cg01784456 A930004D18Rik 2 18030916 8.056306e-03 1.913475e-04 0.1975800 0.0529680
cg06530207 1700121N20Rik 12 1106479602 8.056306e-03 1.915814e-04 -0.2159093 0.0578866
cg05773824 Mllt3 4 88030453 8.065546e-03 1.921424e-04 0.2259084 0.0605794
cg03565531 Gm21054 6 103966835 8.183756e-03 1.953048e-04 0.1407697 0.0377904
cg26476875 Rnf11 4 109454311 8.278277e-03 1.979108e-04 0.1400204 0.0376230
cg07241696 Sdc3 4 130780937 8.311574e-03 1.990586e-04 -0.2179262 0.0585790
cg02409454 Vrk1 12 1106143168 8.320547e-03 1.996255e-04 -0.2601964 0.0699549
cg01434924 1700057H15Rik 4 124465387 8.368336e-03 2.011262e-04 0.1565978 0.0421234
cg25430306 Ush2a 1 188199813 8.416040e-03 2.026288e-04 0.2405263 0.0647322
cg17416197 Mir148a 6 51088987 8.520845e-03 2.055127e-04 -0.1928817 0.0519597
cg21410921 Tsx 20 103389499 8.530259e-03 2.061007e-04 0.1976226 0.0532472
cg03847760 Wdr7 18 163852649 8.596798e-03 2.080721e-04 -0.2178567 0.0587372
cg16089221 Msantd2 9 37513620 8.616406e-03 2.089113e-04 -0.1616487 0.0435947
cg00857016 Gm13205 4 148988880 8.617383e-03 2.092996e-04 0.1014449 0.0273619
cg20638433 5730522E02Rik 11 125601998 8.617823e-03 2.096750e-04 0.1331542 0.0359190
cg25848520 Eif3m 2 105003814 8.771017e-03 2.137734e-04 0.2652736 0.0716538
cg13517739 Gm30731 4 23173922 8.796519e-03 2.155115e-04 0.1739476 0.0470116
cg03649609 Pou5f2 13 177890165 8.796519e-03 2.153392e-04 -0.2217857 0.0599371
cg03160987 Mir3108 8 108942881 8.796519e-03 2.154105e-04 0.3262141 0.0881607
cg16299341 Osbpl9 4 109202173 8.826965e-03 2.166310e-04 -0.1909002 0.0516115
cg14090030 Tenm4 7 95639922 8.871873e-03 2.181085e-04 0.2021692 0.0546837
cg11921792 Trps1 15 150776685 8.907462e-03 2.194130e-04 0.2693366 0.0728814
cg19384540 Zfp536 7 37569908 8.907462e-03 2.197373e-04 -0.1569830 0.0424832
cg10283598 Csnk1g3 18 154058160 8.909564e-03 2.201661e-04 0.0993276 0.0268840
cg18663956 Casz1 4 148748300 9.001467e-03 2.228180e-04 -0.1997270 0.0541026
cg14471976 5730522E02Rik 11 125693548 9.011128e-03 2.234384e-04 0.1710558 0.0463449
cg02347319 Stag2 20 42151270 9.018805e-03 2.240104e-04 0.3171504 0.0859422
cg24517026 C430042M11Rik 17 183861967 9.047933e-03 2.251168e-04 0.1363440 0.0369594
cg24839708 Brpf1 6 113319793 9.075607e-03 2.261893e-04 0.2854755 0.0774105
cg21097107 Wdr72 9 74148365 9.193226e-03 2.295097e-04 0.2494622 0.0677131
cg18366518 1700061F12Rik 2 9435461 9.240166e-03 2.312279e-04 0.1658370 0.0450375
cg04415268 Ptprg 14 112220661 9.240166e-03 2.314636e-04 -0.1475957 0.0400864
cg03346667 Npm1 11 133155218 9.258334e-03 2.323104e-04 0.1491532 0.0405196
cg06455702 Hoxd9 2 74699205 9.276272e-03 2.331530e-04 -0.1280056 0.0347833
cg21801898 Mosmo 7 120730535 9.276460e-03 2.335503e-04 0.1552084 0.0421802
cg18491911 Celf2 2 6607954 9.344806e-03 2.356664e-04 -0.2093411 0.0569271
cg14290519 Ranbp17 11 133300099 9.480972e-03 2.395016e-04 0.2483180 0.0676020
cg16573177 Sfta3-ps 12 156459074 9.486647e-03 2.400463e-04 -0.0666471 0.0181469
cg21584134 Grb14 2 64863657 9.583814e-03 2.429105e-04 0.2067926 0.0563526
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cg03371633 Got2 8 96780622 1.057127e-02 2.800158e-04 0.1169089 0.0321787
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cg11211699 B130024G19Rik 7 70424012 1.061911e-02 2.835297e-04 0.1626111 0.0447977
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cg07039010 Irx3 8 91665636 1.085495e-02 2.968094e-04 0.1642819 0.0454060
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cg07960607 Mir5120 4 44561054 1.098462e-02 3.030497e-04 -0.2543057 0.0703925
cg23531839 Rasa1 13 185227004 1.099422e-02 3.040476e-04 0.2152389 0.0595928
cg01819137 Pou4f3 18 142395941 1.099422e-02 3.042450e-04 0.0684754 0.0189596
cg25112368 Ebf1 11 144904134 1.100743e-02 3.050763e-04 0.1994370 0.0552312
cg03957712 Atf7ip 6 136603295 1.105335e-02 3.068167e-04 0.1249920 0.0346289
cg18440438 Nfib 4 82295056 1.112240e-02 3.092038e-04 0.2666720 0.0739223
cg12149303 Sp3 2 72936705 1.117448e-02 3.111245e-04 0.1698619 0.0471072
cg23712344 Rarb 14 116575148 1.117859e-02 3.117120e-04 -0.1047586 0.0290563
cg13155053 Arrdc3 13 180515064 1.118190e-02 3.122776e-04 0.1883247 0.0522414
cg13160087 Gm30731 4 23050906 1.119019e-02 3.129824e-04 0.1839661 0.0510406
cg03415532 B3galt2 1 143640696 1.120809e-02 3.139575e-04 -0.0885959 0.0245860
cg16846234 4930448I06Rik 1 41121063 1.129384e-02 3.168374e-04 0.1450921 0.0402907
cg02576158 Mink1 11 170607772 1.130500e-02 3.176287e-04 0.0950058 0.0263870
cg20668249 Wdr1 5 38526859 1.131878e-02 3.189738e-04 0.1771684 0.0492219
cg24667552 1700109G15Rik 11 184723068 1.131878e-02 3.189539e-04 0.1028063 0.0285621
cg26709901 Nrxn1 17 190704070 1.133444e-02 3.198946e-04 0.1881529 0.0522845
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cg16477041 Foxd3 4 99444890 1.135869e-02 3.215404e-04 0.1590894 0.0442247
cg21461483 Dnm2 9 21478929 1.146596e-02 3.260325e-04 0.1834451 0.0510465
cg16920926 Otx1 11 122078917 1.146596e-02 3.252945e-04 0.1728462 0.0480893
cg02001174 Igbp1b 6 138709002 1.146596e-02 3.260166e-04 -0.2519682 0.0701139
cg23147149 Mnt 11 174831009 1.146829e-02 3.265841e-04 0.0714369 0.0198809
cg11577476 Galnt3 2 66093670 1.146870e-02 3.270809e-04 0.2499099 0.0695576
cg23864825 Pbx3 2 34245162 1.148707e-02 3.280910e-04 -0.1063023 0.0295938
cg12311671 Pou6f2 13 118336540 1.151844e-02 3.294741e-04 0.1347886 0.0375356
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cg23938194 Kpnb1 11 197171664 1.163285e-02 3.345736e-04 0.1247117 0.0347682
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cg02384111 Pld2 11 170551229 1.164872e-02 3.361638e-04 0.2153779 0.0600657
cg00847238 Sec63 10 142783450 1.164872e-02 3.358039e-04 0.1212035 0.0337992
cg02877097 Ythdf2 4 132204574 1.164872e-02 3.366510e-04 0.1279446 0.0356856
cg23179691 Pax1 2 147340143 1.170999e-02 3.390440e-04 0.1606750 0.0448377
cg12435096 Mosmo 7 120731161 1.170999e-02 3.404038e-04 0.2854921 0.0796922
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cg08034440 Evx2 2 74651128 1.170999e-02 3.398784e-04 0.2511562 0.0700997
cg07239853 Gm6260 3 143790463 1.189241e-02 3.472163e-04 0.2376769 0.0664411
cg12847291 Nfia 4 98116888 1.189241e-02 3.466063e-04 0.1686472 0.0471382
cg18535797 A730082K24Rik 7 115092883 1.189241e-02 3.467792e-04 0.2352361 0.0657527
cg23469509 Atp1a2 1 172280627 1.189484e-02 3.477905e-04 0.1617764 0.0452290
cg04345269 Zfp521 18 114091264 1.192351e-02 3.491333e-04 0.1678941 0.0469526
cg24700341 Exoc2 13 130877357 1.199345e-02 3.516886e-04 0.1481527 0.0414539
cg19526275 Stard10 7 101343963 1.200049e-02 3.524031e-04 0.0972544 0.0272164
cg08882563 Bcl9 3 97265823 1.200770e-02 3.531229e-04 0.2196249 0.0614706
cg23589509 Egfl6 20 166576332 1.205426e-02 3.550021e-04 0.1863996 0.0521915
cg10032440 Dscaml1 9 45753597 1.205519e-02 3.555395e-04 0.1998210 0.0559556
cg23698708 Ebf1 11 144753656 1.212663e-02 3.592824e-04 0.1214311 0.0340304
cg21328218 Fignl1 11 111761313 1.212663e-02 3.602123e-04 -0.1258538 0.0352765
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cg05655186 Cryba1 11 177712091 1.212663e-02 3.590486e-04 0.3100936 0.0868978
cg24056059 Rragc 4 124087199 1.212663e-02 3.601812e-04 0.0991459 0.0277902
cg07445298 Lhx9 1 138831029 1.214185e-02 3.619598e-04 0.1408369 0.0394903
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cg01487930 Sap130 18 131648226 1.214185e-02 3.622057e-04 -0.0760410 0.0213228
cg04222851 Dennd1a 2 38126568 1.216543e-02 3.634237e-04 0.1311370 0.0367813
cg09079366 Habp2 19 156234679 1.220148e-02 3.650169e-04 0.1084458 0.0304267
cg25343690 Gm7134 20 110076539 1.221836e-02 3.660391e-04 0.1571413 0.0440983
cg19002093 Fign 2 63980880 1.238096e-02 3.714339e-04 0.2382095 0.0669205
cg22025436 Crem 18 13268118 1.242414e-02 3.739314e-04 0.0908500 0.0255352
cg13843674 Gm12353 4 19611805 1.242414e-02 3.738277e-04 0.1707094 0.0479803
cg27245728 Prickle2 6 92545149 1.242414e-02 3.743065e-04 0.1563469 0.0439477
cg15946322 Ythdc1 5 86829448 1.247829e-02 3.764661e-04 0.2240086 0.0629936
cg08560335 Lmo4 3 144327472 1.249764e-02 3.775787e-04 0.1723543 0.0484784
cg05079374 Sox6 7 115406148 1.262979e-02 3.821057e-04 0.2453045 0.0690582
cg02551260 Psmd7 8 107603376 1.271796e-02 3.853111e-04 -0.2243734 0.0632048
cg20911152 Gm29443 7 16564897 1.275593e-02 3.870012e-04 0.2113981 0.0595690
cg23798080 Vti1a 19 155384487 1.277191e-02 3.880265e-04 0.2055583 0.0579348
cg25639785 Slc25a21 12 157076737 1.277509e-02 3.886636e-04 0.1415510 0.0398998
cg21677205 Dazap2 15 1100620645 1.277741e-02 3.897446e-04 0.0709924 0.0200151
cg16889221 Pepd 7 34908796 1.277741e-02 3.898157e-04 0.1728818 0.0487419
cg17527816 Pea15a 1 172199224 1.289769e-02 3.957689e-04 0.1018072 0.0287356
cg20273694 Mir6994 19 111920859 1.289769e-02 3.956184e-04 0.1491090 0.0420856
cg27435315 Spred2 11 119763506 1.289769e-02 3.957366e-04 -0.2493509 0.0703802
cg01962309 Hps1 19 142931604 1.289769e-02 3.962139e-04 0.1923929 0.0543085
cg24125696 Etnk1 6 143192891 1.289769e-02 3.956007e-04 0.1792778 0.0506005
cg12616024 Epha4 1 77310546 1.291694e-02 3.973517e-04 0.1951722 0.0551048
cg12583849 Ccdc171 4 83865659 1.295760e-02 3.995762e-04 0.2250766 0.0635744
cg00712594 Zfp423 8 87749998 1.295760e-02 3.996992e-04 0.1662462 0.0469584
cg14464354 Btrc 19 145446927 1.302768e-02 4.024121e-04 -0.1238888 0.0350117
cg07211246 Lmo4 3 143972273 1.305974e-02 4.039552e-04 0.2510986 0.0709822
cg06109074 Mir721 5 136434679 1.316558e-02 4.077861e-04 -0.0875727 0.0247731
cg04121186 Gm16551 9 74855098 1.317330e-02 4.088680e-04 -0.2174697 0.0615313
cg21221291 Zfhx3 8 108790378 1.317330e-02 4.096973e-04 0.1029245 0.0291261
cg26538921 Cadm1 9 47386643 1.317330e-02 4.094529e-04 0.2094424 0.0592664
cg23738105 Ascl1 10 187389201 1.319408e-02 4.114600e-04 0.2085982 0.0590491
cg13235828 Fgfr2 7 130198471 1.319408e-02 4.109610e-04 0.0825858 0.0233759
cg18315873 Mir1951 2 115658903 1.320293e-02 4.134121e-04 0.1834931 0.0519609
cg07473509 Nrxn3 12 188900430 1.320293e-02 4.131286e-04 0.1666960 0.0472019
cg24824483 1700095J12Rik 4 138103318 1.320293e-02 4.130297e-04 0.1598387 0.0452594
cg06611078 1700019E08Rik 2 45605993 1.321210e-02 4.142582e-04 -0.2677816 0.0758410
cg19024429 Npvf 6 50667827 1.322587e-02 4.152498e-04 -0.2404545 0.0681136
cg27251994 Asxl1 2 153397902 1.325366e-02 4.166831e-04 0.1222865 0.0346491
cg00557468 Mir6944 13 155473000 1.362695e-02 4.289954e-04 0.1909718 0.0542291
cg20350922 Foxp1 6 98945174 1.365873e-02 4.311519e-04 0.2422378 0.0688128
cg04814124 Zfhx2 14 155072830 1.365873e-02 4.306031e-04 0.2162817 0.0614335
cg02260294 Zadh2 18 184232712 1.378774e-02 4.358076e-04 0.2576108 0.0732391
cg17398634 Spag9 11 194044414 1.385279e-02 4.384500e-04 -0.2515516 0.0715491
cg19192708 Cadps2 6 23464398 1.387537e-02 4.409260e-04 0.2181816 0.0620841
cg05297127 Ing4 6 125047229 1.387537e-02 4.405924e-04 0.2082887 0.0592656
cg21203153 Msx2 13 153463666 1.387537e-02 4.406742e-04 -0.1926405 0.0548139
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cg02960107 Zeb2 2 45113126 1.394121e-02 4.467655e-04 -0.0764823 0.0217849
cg02523045 Phip 9 82916003 1.394121e-02 4.452987e-04 0.1662651 0.0473464
cg03915996 Tshz3 7 36731998 1.394121e-02 4.454031e-04 0.1768442 0.0503599
cg02227217 1700034P13Rik 1 9724383 1.394121e-02 4.471474e-04 0.1491901 0.0424974
cg03833577 Zfpm2 15 140825525 1.394121e-02 4.468654e-04 -0.2084714 0.0593811
cg14620112 Mllt10 2 18050739 1.399714e-02 4.495336e-04 -0.2628966 0.0749174
cg15715091 Hectd1 12 151754997 1.413643e-02 4.546053e-04 0.1222511 0.0348674
cg19962725 Skor1 9 63136182 1.418734e-02 4.568430e-04 -0.2486924 0.0709564
cg12296383 Map3k7 4 31328928 1.429041e-02 4.607664e-04 0.1590173 0.0454000
cg17633606 Lef1 3 131137275 1.435085e-02 4.647993e-04 0.1528526 0.0436689
cg00038376 Tbca 13 194685382 1.435085e-02 4.651441e-04 0.2030564 0.0580150
cg00312241 Camp 9 109842511 1.435085e-02 4.643116e-04 0.2470783 0.0705829
cg01943432 Cacna1c 6 118741872 1.435085e-02 4.640007e-04 0.1133263 0.0323723
cg19834279 Jag1 2 137090872 1.437540e-02 4.665481e-04 0.1279230 0.0365571
cg09922578 Ppp3cb 14 120523702 1.447250e-02 4.703119e-04 0.2650688 0.0757963
cg11547453 Zdhhc16 19 141939710 1.447385e-02 4.709681e-04 0.1032819 0.0295366
cg18828625 Fign 2 64097221 1.449644e-02 4.723165e-04 -0.1971958 0.0564064
cg12543498 C230079O03Rik 7 136360574 1.450903e-02 4.734738e-04 0.1388605 0.0397274
cg07173733 Smc5 19 123257597 1.450903e-02 4.739547e-04 -0.1419349 0.0406101
cg24176069 Hoxc4 15 1103032736 1.451083e-02 4.746276e-04 -0.1760521 0.0503772
cg21757210 Gm13205 4 148988739 1.451314e-02 4.753170e-04 0.1403836 0.0401751
cg00599230 Phf12 11 178024926 1.452049e-02 4.761722e-04 -0.0786384 0.0225079
cg11741181 Rbm39 2 156178850 1.452757e-02 4.770192e-04 -0.2480278 0.0710002
cg04724018 Stag2 20 42276562 1.457869e-02 4.793147e-04 0.1840801 0.0527139
cg23552337 Bcl11a 11 124087341 1.458239e-02 4.800532e-04 -0.2037183 0.0583445
cg17764331 4930441J16Rik 2 74151997 1.468151e-02 4.839376e-04 0.1861652 0.0533502
cg07502526 4933427E13Rik 11 125311276 1.475609e-02 4.875100e-04 0.1064786 0.0305313
cg05376468 Jakmip2 18 143562614 1.475609e-02 4.876448e-04 0.1138168 0.0326361
cg11232780 Gm30731 4 22987129 1.488816e-02 4.926393e-04 0.2000238 0.0574001
cg00658751 Srrm4 5 116516215 1.494844e-02 4.952663e-04 0.2101961 0.0603439
cg06678289 Mir760 3 122293026 1.499564e-02 4.974648e-04 0.0882426 0.0253417
cg01369969 Cyp7b1 3 18206157 1.504655e-02 4.997900e-04 -0.2138920 0.0614479
cg01088086 Slit2 5 48249843 1.505031e-02 5.005519e-04 0.1946635 0.0559304
cg03779905 Tmem28 20 99821662 1.507222e-02 5.019185e-04 0.0623170 0.0179086
cg26456205 Hoxb5 11 196303344 1.526948e-02 5.091336e-04 -0.2160413 0.0621540
cg12237348 Kcnma1 14 123363933 1.535867e-02 5.127573e-04 0.1091907 0.0314308
cg27633182 Prdm16 4 154456684 1.538714e-02 5.144132e-04 0.1616168 0.0465334
cg24364591 Zfp507 7 36208018 1.538714e-02 5.150097e-04 -0.2529509 0.0728372
cg19910880 Gm16294 15 140517435 1.539012e-02 5.164122e-04 0.1485139 0.0427736
cg09401976 Pcf11 7 92669488 1.539012e-02 5.157629e-04 0.1470613 0.0423511
cg04733387 Ptprd 4 75942064 1.542189e-02 5.181305e-04 0.2141627 0.0616970
cg23087335 Hmx3 7 131497689 1.544921e-02 5.203559e-04 0.1339154 0.0385918
cg09494436 Zfp608 18 154889026 1.544921e-02 5.197943e-04 0.1624638 0.0468149
cg18117590 1700108J01Rik 14 1122233303 1.546010e-02 5.213770e-04 -0.2349075 0.0677059
cg25581768 Egln3 12 153837501 1.547147e-02 5.224150e-04 0.1404929 0.0404996
cg10180387 Bnc2 4 84285345 1.547663e-02 5.232442e-04 -0.1330857 0.0383691
cg17853439 Acvr2a 2 48250479 1.562136e-02 5.287981e-04 0.1210414 0.0349252
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cg19792425 Arx 20 93367360 2.279064e-02 9.479624e-04 0.0598652 0.0181106
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cg02740381 Lin52 12 184483220 2.290542e-02 9.575828e-04 0.1594720 0.0482853
cg19891121 Zfp407 18 184556584 2.290975e-02 9.587334e-04 0.1212287 0.0367097
cg24913251 Ddx20 3 105667001 2.301809e-02 9.642412e-04 0.2235682 0.0677324
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cg22245041 Ss18 18 114637456 2.321282e-02 9.768685e-04 0.1920516 0.0582486
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cg09531545 Atg4c 4 99375004 2.321282e-02 9.817081e-04 0.1109509 0.0336652
cg12395671 Cpeb2 5 43289357 2.342681e-02 9.972228e-04 0.1526695 0.0463857
cg03265769 Egln3 12 153926698 2.342681e-02 9.948608e-04 0.1032302 0.0313581
cg05839622 Kmt2a 9 44846885 2.342681e-02 9.956360e-04 0.1573364 0.0477971
cg13530363 Vps11 9 44356271 2.342681e-02 9.926873e-04 0.0749191 0.0227538
cg04901692 5730522E02Rik 11 125732749 2.342681e-02 9.933962e-04 0.1293458 0.0392863
cg01967702 Lrmda 14 122152590 2.342681e-02 9.963592e-04 0.2467321 0.0749592
cg19977128 Ptch1 13 163554974 2.348904e-02 1.001083e-03 -0.1731525 0.0526264
cg10446885 Tfap2b 1 19700110 2.348904e-02 1.001860e-03 -0.1552334 0.0471833
cg12315723 Fubp1 3 152232778 2.350250e-02 1.003428e-03 0.2211255 0.0672203
cg13690286 Stard10 7 101321745 2.350927e-02 1.004712e-03 0.1151066 0.0349953
cg16825463 Luc7l3 11 194292456 2.361482e-02 1.010222e-03 0.0968236 0.0294506
cg07597118 Nrxn3 12 189191170 2.379806e-02 1.019068e-03 0.1088876 0.0331448
cg03603703 Mpped2 2 106699448 2.387488e-02 1.024378e-03 0.1586687 0.0483195
cg02334175 Gm7977 3 48408625 2.387488e-02 1.023752e-03 0.1623721 0.0494447
cg10870239 Abraxas2 7 132859278 2.392794e-02 1.027667e-03 0.1603533 0.0488459
cg09374907 Map4k4 1 40011704 2.394484e-02 1.029406e-03 -0.1404444 0.0427876
cg04949439 Kirrel3 9 34540639 2.402220e-02 1.033748e-03 0.1124375 0.0342674
cg14455689 Ptprg 14 112102727 2.444657e-02 1.053045e-03 0.1628443 0.0497089
cg12358638 D130009I18Rik 14 1104567917 2.446421e-02 1.054840e-03 0.1995080 0.0609096
cg09816614 4930405A10Rik 14 122505740 2.449056e-02 1.057012e-03 0.2174292 0.0663927
cg22713419 Pptc7 5 122323483 2.455720e-02 1.060928e-03 0.1177913 0.0359794
cg20224547 Psmb7 2 38602739 2.459086e-02 1.064107e-03 0.1615809 0.0493678
cg10790706 Immp1l 2 105913713 2.459086e-02 1.064463e-03 0.1981171 0.0605324
cg27272373 Wdr26 1 181177698 2.461920e-02 1.066731e-03 0.1564421 0.0478079
cg23728998 Tenm3 8 48311607 2.466550e-02 1.069781e-03 0.1530751 0.0467905
cg07087497 Ctdspl2 2 121988813 2.486038e-02 1.079928e-03 0.2270081 0.0694463
cg09487905 Scn1a 2 66289062 2.486038e-02 1.081389e-03 0.1763065 0.0539419
cg15357236 Zfhx3 8 107940370 2.486038e-02 1.080450e-03 0.1087443 0.0332684
cg08167680 Sgip1 4 102933612 2.488954e-02 1.083711e-03 0.2283635 0.0698821
cg07869104 Pcdh9 14 193013748 2.493352e-02 1.086681e-03 0.2436374 0.0745738
cg04397347 Riok3 18 112148951 2.509891e-02 1.096924e-03 0.1042934 0.0319486
cg03491724 Nme2 11 193945469 2.509891e-02 1.097075e-03 -0.1824647 0.0558958
cg25843357 Ttll11 2 36011563 2.509891e-02 1.096704e-03 -0.0572366 0.0175332
cg25997426 Hsf5 11 187616232 2.512184e-02 1.099694e-03 0.1639057 0.0502209
cg11979881 Ivns1abp 1 151354712 2.512184e-02 1.100203e-03 0.1482408 0.0454230
cg24551749 Atp5g2 15 1102672488 2.528207e-02 1.108290e-03 0.0951161 0.0291634
cg07658653 Otx1 11 122078880 2.547469e-02 1.117812e-03 0.1986190 0.0609436
cg07719417 4933406G16Rik 11 119265522 2.547864e-02 1.119614e-03 -0.0962306 0.0295312
cg22244593 Nrip1 16 176358445 2.547864e-02 1.122298e-03 0.1257666 0.0386033
cg08942224 9330117O12Rik 18 154580906 2.547864e-02 1.122120e-03 0.1446532 0.0443998
cg15661483 Mir26a-1 9 119026968 2.547864e-02 1.120357e-03 0.1331332 0.0408582
cg21398335 Mir7669 3 90009203 2.548861e-02 1.124819e-03 0.1325155 0.0406827
cg05215308 Skap2 6 51993405 2.548861e-02 1.124894e-03 0.1146816 0.0352079
cg01743293 Lmo1 7 109161740 2.550771e-02 1.127578e-03 0.2312594 0.0710127
cg19390002 Sox6 7 115476530 2.550771e-02 1.127896e-03 0.1844699 0.0566465
cg00419202 6530403H02Rik 3 120429522 2.551389e-02 1.129249e-03 0.1880937 0.0577653
cg14589467 Ccar2 14 170131344 2.556215e-02 1.133548e-03 0.1140144 0.0350264
cg18276556 Lama2 10 127146028 2.556215e-02 1.133299e-03 0.1997662 0.0613692
cg19065912 Zfp503 14 121994537 2.572956e-02 1.142060e-03 -0.2623076 0.0806364
cg03516596 5730522E02Rik 11 125855571 2.576639e-02 1.144785e-03 -0.2428897 0.0746826
cg15763339 Pik3c2a 7 116356348 2.579703e-02 1.147238e-03 0.1321031 0.0406261
cg09984378 Son 16 191665726 2.590421e-02 1.154064e-03 0.2218962 0.0682758
cg25973323 Kat6b 14 121622056 2.590421e-02 1.154197e-03 0.1611269 0.0495780
cg09170211 Casz1 4 148908991 2.601857e-02 1.161494e-03 0.2113997 0.0650827
cg12966966 Gm10578 7 137172887 2.601857e-02 1.160911e-03 0.1090134 0.0335600
cg07000752 Tbc1d8b 20 139732366 2.608536e-02 1.165580e-03 0.2342145 0.0721288
cg24156613 Bcor 20 12073854 2.609511e-02 1.167119e-03 0.1350060 0.0415813
cg22557786 A330032B11Rik 19 137105799 2.610413e-02 1.168838e-03 0.1532569 0.0472086
cg13103551 Mrps9 1 42873506 2.610413e-02 1.169732e-03 0.1159097 0.0357067
cg17525319 Ebf3 7 137269475 2.611857e-02 1.171484e-03 0.1004045 0.0309343
cg18822954 Otx1 11 122079002 2.613028e-02 1.173115e-03 -0.0663967 0.0204591
cg05871467 Cul3 1 80322986 2.617089e-02 1.176046e-03 0.1534391 0.0472902
cg18384829 Mef2a 7 67268326 2.618342e-02 1.178825e-03 0.0847658 0.0261304
cg24480649 Tox3 8 90349787 2.618342e-02 1.178039e-03 -0.0482565 0.0148749
cg03722442 Gm12830 4 114821978 2.633509e-02 1.186767e-03 -0.0448074 0.0138207
cg06113157 Pou3f2 4 22487053 2.641208e-02 1.191355e-03 -0.2501988 0.0771994
cg01988652 Huwe1 20 151934846 2.664572e-02 1.204033e-03 -0.1735428 0.0535970
cg20481374 Mir107 19 134840942 2.664572e-02 1.204148e-03 0.2206335 0.0681410
cg23439597 Mir5127 18 181897999 2.665431e-02 1.205664e-03 0.0753114 0.0232619
cg07630183 Adgrl3 5 81787520 2.669110e-02 1.208457e-03 0.0891771 0.0275503
cg02349847 Btbd10 7 113325939 2.670053e-02 1.211144e-03 0.2716752 0.0839477
cg13627994 Ankrd28 14 131706789 2.670053e-02 1.210930e-03 0.2056300 0.0635388
cg18683425 Rnf165 18 177458560 2.675352e-02 1.215812e-03 0.2344997 0.0724851
cg15711932 Cdca7l 12 1117806197 2.675352e-02 1.215067e-03 -0.1498202 0.0463077
cg00317287 Grb14 2 64653430 2.677217e-02 1.217792e-03 0.2002884 0.0619191
cg04102296 Gm11149 9 49507625 2.683137e-02 1.221620e-03 0.2543019 0.0786391
cg13742657 Ncoa1 12 14297555 2.686598e-02 1.224333e-03 0.1614200 0.0499266
cg24151104 Sp5 2 70444422 2.692919e-02 1.228353e-03 -0.2071515 0.0640897
cg27501557 Nktr 9 121728640 2.699955e-02 1.234079e-03 0.1684016 0.0521224
cg23352003 Kctd1 18 115151237 2.699955e-02 1.234990e-03 -0.1847898 0.0571985
cg26375896 Maf 8 115703346 2.699955e-02 1.234110e-03 0.2498994 0.0773472
cg20464004 1700019E08Rik 2 45998159 2.704101e-02 1.238031e-03 0.1792954 0.0555099
cg12639822 Memo1 17 174217091 2.706184e-02 1.240129e-03 0.1066719 0.0330306
cg22537620 Calcoco1 15 1102777386 2.708465e-02 1.242596e-03 -0.1494585 0.0462875
cg24657928 Galntl6 8 57958356 2.708465e-02 1.243467e-03 0.1257622 0.0389511
cg03909395 Cadps2 6 23328921 2.712614e-02 1.246519e-03 -0.1906011 0.0590459
cg27527751 Efna5 17 162568906 2.722009e-02 1.251988e-03 0.1125852 0.0348910
cg15762979 Nckap1l 15 1103472825 2.731331e-02 1.257432e-03 0.1508637 0.0467719
cg23346326 Megf9 4 70811057 2.740987e-02 1.263037e-03 -0.1104905 0.0342686
cg12790916 Ythdf3 3 16189491 2.753508e-02 1.269972e-03 -0.2647178 0.0821421
cg02394031 Mecom 3 30349545 2.770420e-02 1.279655e-03 -0.1689514 0.0524612
cg18824846 Hspa2 12 176405157 2.770420e-02 1.280116e-03 0.1247608 0.0387408
cg11164166 Bcor 20 12058729 2.773381e-02 1.287932e-03 0.1354769 0.0420911
cg10815883 Map2k5 9 63230130 2.773381e-02 1.286158e-03 0.2146723 0.0666881
cg23623785 Zmym2 14 156959842 2.773381e-02 1.282847e-03 0.1505895 0.0467700
cg08640766 Gm28036 2 156098175 2.773381e-02 1.289699e-03 0.1367978 0.0425067
cg21739934 4931429L15Rik 9 46510498 2.773381e-02 1.289363e-03 -0.0934824 0.0290468
cg22376496 Fgf18 11 133117167 2.773381e-02 1.287375e-03 0.1610721 0.0500414
cg10152878 Mtx2 2 74884757 2.773381e-02 1.287312e-03 0.2337538 0.0726215
cg22656609 Kdm7a 6 39149334 2.773444e-02 1.290902e-03 0.1481577 0.0460404
cg08752411 Zfp521 18 113739154 2.775033e-02 1.292816e-03 0.1646654 0.0511769
cg18775232 Cul3 1 80267265 2.775160e-02 1.296947e-03 0.2335891 0.0726186
cg12938952 Sall3 18 180984755 2.775160e-02 1.297445e-03 -0.2449645 0.0761577
cg00738572 Hmx3 7 131497749 2.775160e-02 1.294530e-03 0.1152771 0.0358316
cg15885769 Skap1 11 196582700 2.775160e-02 1.297572e-03 0.1245193 0.0387125
cg01408643 Kcnj2 11 1111215267 2.777291e-02 1.300919e-03 -0.1437821 0.0447115
cg14428370 Pou4f1 14 1104280663 2.777291e-02 1.300435e-03 0.2126074 0.0661117
cg15116103 Pola1 20 93442543 2.782955e-02 1.308999e-03 0.1570999 0.0488799
cg03897040 Mir6356 18 168737474 2.782955e-02 1.309380e-03 0.2558877 0.0796187
cg08018810 Klhl13 20 23284637 2.782955e-02 1.306457e-03 0.1204165 0.0374597
cg05013596 Col4a3 1 82716095 2.782955e-02 1.309460e-03 0.1508955 0.0469509
cg09276076 Ropn1l 15 131458854 2.782955e-02 1.306654e-03 0.1187665 0.0369469
cg19888236 NA 19 155999537 2.807077e-02 1.321997e-03 0.2718001 0.0846423
cg15454070 Shoc2 19 153988209 2.812738e-02 1.325854e-03 0.0981566 0.0305753
cg08715757 Arhgap15 2 43781405 2.814520e-02 1.329076e-03 0.1812436 0.0564687
cg18932952 Irf5 6 29531247 2.814520e-02 1.328896e-03 0.1273375 0.0396731
cg11730804 Tenm2 11 136476047 2.843800e-02 1.344105e-03 0.1965505 0.0612996
cg14811158 Fign 2 63670294 2.848097e-02 1.347342e-03 0.1692028 0.0527818
cg08594840 Phtf1 3 104046855 2.850361e-02 1.349619e-03 0.0920132 0.0287073
cg07784624 Msantd4 9 4427068 2.876508e-02 1.363216e-03 0.1007093 0.0314488
cg07992909 Zswim8 14 120723211 2.877910e-02 1.365098e-03 0.1670280 0.0521648
cg15061730 Mex3c 18 173590634 2.883112e-02 1.370844e-03 0.0917577 0.0286678
cg08945781 Lcor 19 141552465 2.883112e-02 1.369848e-03 0.1534199 0.0479298
cg03237342 Tcf12 9 71976205 2.883112e-02 1.371226e-03 -0.2003403 0.0625938
cg16273547 Gtdc1 2 44465677 2.884088e-02 1.373667e-03 0.2005863 0.0626807
cg08912313 Cntln 4 85130193 2.884088e-02 1.374131e-03 0.1671461 0.0522327
cg02076583 Wwox 8 114597725 2.895316e-02 1.380705e-03 0.2202801 0.0688665
cg02361987 Srsf7 17 180204686 2.905650e-02 1.386863e-03 -0.1403343 0.0438905
cg00843792 Lrrc41 4 116075485 2.910920e-02 1.390610e-03 -0.0790424 0.0247271
cg24613973 Kctd1 18 115063559 2.922898e-02 1.397569e-03 0.0442984 0.0138643
cg22036685 Il20rb 9 100252389 2.927287e-02 1.400906e-03 0.1133736 0.0354906
cg16800482 Ezh2 6 47544597 2.933523e-02 1.405132e-03 0.0984889 0.0308395
cg15708887 Gm36669 6 16548312 2.959479e-02 1.418817e-03 0.1081474 0.0338935
cg08729928 Zfhx3 8 108086809 2.971450e-02 1.427071e-03 -0.2432763 0.0762832
cg25565513 Hoxd13 2 74670026 2.971450e-02 1.427018e-03 -0.0750183 0.0235231
cg01118512 Mdfic 6 15806147 2.980084e-02 1.432478e-03 0.1622595 0.0508966
cg14702549 Nt5e 9 88073699 2.994548e-02 1.440698e-03 0.1592696 0.0499846
cg14302062 Tmem33 5 67231771 2.996802e-02 1.443050e-03 -0.1095928 0.0343993
cg05176833 Dock3 9 106908482 2.998430e-02 1.445283e-03 -0.1292674 0.0405806
cg14233818 Sox14 9 99869140 2.998430e-02 1.446372e-03 -0.1137358 0.0357072
cg00634704 Osr2 15 135302847 3.002360e-02 1.449538e-03 0.1947341 0.0611487
cg10974737 Rbm39 2 156178858 3.016670e-02 1.458999e-03 -0.2141657 0.0672902
cg03956142 Mlf1 3 67340821 3.016670e-02 1.457790e-03 0.2086239 0.0655440
cg07394963 Cbll1 12 131494695 3.029769e-02 1.466617e-03 0.1749032 0.0549801
cg14182445 Foxp2 6 15123062 3.032314e-02 1.469776e-03 0.1492117 0.0469133
cg12780461 Gm33948 18 127411031 3.032314e-02 1.471871e-03 0.2049646 0.0644508
cg07600198 Mir6340 2 173688226 3.032314e-02 1.472659e-03 0.0959801 0.0301822
cg18536396 Zfp36l1 12 180109166 3.032314e-02 1.472981e-03 0.0744887 0.0234244
cg19329327 Gm6260 3 143822617 3.049825e-02 1.482778e-03 0.1505784 0.0473810
cg16102730 Mapkap1 2 34455816 3.055244e-02 1.486705e-03 0.1618228 0.0509314
cg17977572 Eri3 4 117640819 3.056711e-02 1.488713e-03 0.2184261 0.0687550
cg21129179 5730522E02Rik 11 125659855 3.063289e-02 1.494294e-03 0.1047095 0.0329712
cg11417765 B230323A14Rik 9 69769881 3.063289e-02 1.494509e-03 -0.1856669 0.0584640
cg03586368 4922502N22Rik 6 139278907 3.065818e-02 1.497040e-03 0.1614061 0.0508325
cg12016197 Smad2 18 176423687 3.067554e-02 1.499185e-03 -0.1467783 0.0462317
cg07777480 Ddx10 9 53233936 3.069084e-02 1.501232e-03 0.2302769 0.0725408
cg21611883 Myo1d 11 180779074 3.082363e-02 1.509326e-03 -0.1503514 0.0473864
cg08999225 Ikzf2 1 69745593 3.082363e-02 1.510336e-03 0.1613109 0.0508436
cg16004878 C1d 11 117370785 3.082380e-02 1.511648e-03 0.0911477 0.0287311
cg22390917 Son 16 191657370 3.086513e-02 1.514981e-03 0.0807324 0.0254532
cg11479269 Pcdh10 3 45385298 3.088970e-02 1.518801e-03 0.1747353 0.0551030
cg20138719 1700039M10Rik 14 157602629 3.088970e-02 1.518149e-03 0.1755722 0.0553647
cg21429502 Hoxc8 15 1102994015 3.097603e-02 1.524356e-03 -0.0843487 0.0266084
cg09496347 Bcor 20 12137509 3.100008e-02 1.526852e-03 0.0902999 0.0284900
cg25269791 Dnm1l 16 116314006 3.105314e-02 1.530779e-03 0.2223069 0.0701553
cg14915305 Mir3961 13 182297283 3.134011e-02 1.550288e-03 0.1577959 0.0498549
cg10880576 1700113H08Rik 10 187154172 3.134011e-02 1.548073e-03 0.1350027 0.0426479
cg16388915 Chchd3 6 32853555 3.134011e-02 1.546872e-03 0.1730294 0.0546568
cg09715604 Plxna4os1 6 32505020 3.134011e-02 1.551556e-03 0.1513011 0.0478065
cg08007141 Tmem33 5 67205742 3.134011e-02 1.549905e-03 0.0883545 0.0279146
cg11419859 Grin1os 2 25292431 3.150640e-02 1.561122e-03 0.1768475 0.0559100
cg23254987 4930441H08Rik 7 71353777 3.151562e-02 1.562912e-03 0.1608947 0.0508719
cg24604865 Isl2 9 55582032 3.171713e-02 1.574248e-03 0.1957087 0.0619207
cg16733575 Barhl2 5 106463695 3.182174e-02 1.580786e-03 -0.1058092 0.0334900
cg00110825 Khdrbs1 4 129714003 3.183137e-02 1.583959e-03 0.1964630 0.0621946
cg10986567 Hnrnpa0 13 158127177 3.183137e-02 1.583356e-03 -0.1317883 0.0417189
cg02810085 Fubp3 2 31547821 3.203300e-02 1.595347e-03 0.1903360 0.0602948
cg06285055 Kdm5c 20 152248797 3.209971e-02 1.600028e-03 0.1636761 0.0518635
cg22498951 Bclaf1 10 120327474 3.219257e-02 1.606018e-03 0.2443984 0.0774685
cg15139258 Mir32 4 56895262 3.219615e-02 1.607560e-03 0.1621703 0.0514087
cg20650821 Hmx3 7 131497414 3.222716e-02 1.610472e-03 0.0926768 0.0293838
cg00095474 4930432J09Rik 14 1104208467 3.229053e-02 1.617386e-03 0.1642458 0.0520960
cg12712534 Cdh18 15 123460471 3.229053e-02 1.617737e-03 0.1281301 0.0406415
cg17073188 Rnf165 18 177462340 3.229053e-02 1.616551e-03 0.1528362 0.0484747
cg11406035 Mir568 16 143610525 3.233759e-02 1.621463e-03 0.0896447 0.0284404
cg08690021 Pou5f2 13 177894038 3.236871e-02 1.625672e-03 0.2070227 0.0656952
cg15673180 Nxpe4 9 48140964 3.236871e-02 1.625763e-03 -0.1463195 0.0464323
cg19732321 Tnik 3 28666123 3.275391e-02 1.646496e-03 0.1525227 0.0484577
cg15180682 Zfhx4 3 5243807 3.279200e-02 1.651164e-03 0.1066791 0.0339017
cg14991111 Slc23a4 6 35051175 3.279200e-02 1.651186e-03 0.1080769 0.0343460
cg26828604 Ppp4r3b 11 129211174 3.297059e-02 1.662969e-03 0.1717392 0.0546135
cg25172570 Nup98 7 102180437 3.297059e-02 1.661879e-03 0.1778280 0.0565463
cg25709820 1700019E08Rik 2 45922451 3.305636e-02 1.668694e-03 0.1457448 0.0463620
cg27559875 Slc25a37 14 169247600 3.310036e-02 1.672315e-03 -0.1709379 0.0543870
cg00211423 Map2k5 9 63230124 3.310915e-02 1.674161e-03 0.2429492 0.0773067
cg08359777 Mettl21a 1 64597484 3.312653e-02 1.676441e-03 0.2484740 0.0790747
cg25658543 Eif4g2 7 111077241 3.314395e-02 1.678725e-03 0.1417123 0.0451044
cg11355954 Sp3os 2 73100005 3.315634e-02 1.680755e-03 0.1044932 0.0332620
cg04546455 Sdccag8 1 176994933 3.319822e-02 1.684283e-03 0.1029786 0.0327863
cg02230564 Bub3 7 131585765 3.335843e-02 1.693823e-03 0.1856665 0.0591436
cg27207181 Cldn18 9 99744719 3.338680e-02 1.703025e-03 0.1939794 0.0618230
cg06989803 Psmd6 14 114116174 3.338680e-02 1.700907e-03 0.1236411 0.0394009
cg02480322 Ranbp17 11 133300082 3.338680e-02 1.703740e-03 0.2004131 0.0638759
cg24163300 Actrt1 20 47061038 3.338680e-02 1.697408e-03 0.1803966 0.0574763
cg06784608 Vwc2l 1 70726076 3.338680e-02 1.700221e-03 0.0562682 0.0179304
cg10287351 Gm33301 15 140314643 3.338680e-02 1.703505e-03 0.1556369 0.0496042
cg19992880 Bnip3l 14 167016510 3.343907e-02 1.707822e-03 -0.1913385 0.0609973
cg14778330 Sox12 2 152396680 3.369745e-02 1.722444e-03 -0.1037899 0.0331138
cg14156441 Trib1 15 159653092 3.380146e-02 1.730621e-03 -0.0834943 0.0266504
cg04094567 Adgrl3 5 81787557 3.380146e-02 1.730350e-03 -0.1347195 0.0430003
cg27650171 Vars2 17 135668010 3.381369e-02 1.732678e-03 0.1557557 0.0497210
cg09420504 Mzt1 14 198708241 3.392366e-02 1.742619e-03 0.1575556 0.0503225
cg24665462 Arx 20 93377896 3.392366e-02 1.740333e-03 0.1216456 0.0388483
cg13027777 Hivep2 10 113967546 3.392366e-02 1.741773e-03 -0.1241229 0.0396425
cg22827537 Tnrc6a 7 123187460 3.403553e-02 1.749806e-03 0.1205255 0.0385102
cg04354551 Myo9a 9 59907416 3.407459e-02 1.753256e-03 0.1917550 0.0612806
cg11236345 Elavl4 4 110205350 3.409755e-02 1.755880e-03 0.1983765 0.0634056
cg02047891 Gm765 6 98510788 3.411192e-02 1.758064e-03 0.1196791 0.0382566
cg15362498 Egln3 12 153872523 3.421313e-02 1.764728e-03 0.1075846 0.0344027
cg19561086 Vrk2 11 126802756 3.425339e-02 1.768254e-03 0.1536551 0.0491441
cg05313144 Asxl1 2 153397926 3.445875e-02 1.780313e-03 0.1217655 0.0389696
cg04941359 Elavl2 4 91252641 3.452745e-02 1.785323e-03 0.2479971 0.0793896
cg03597059 Prkd1 12 150295286 3.464797e-02 1.794487e-03 0.1257377 0.0402710
cg07158988 Bcl9l 9 44499562 3.464797e-02 1.794256e-03 -0.0896277 0.0287054
cg06994774 Lamc1 1 153220108 3.469821e-02 1.798557e-03 0.0968738 0.0310331
cg12131127 Bzw2 12 136124023 3.472142e-02 1.801230e-03 0.0850141 0.0272377
cg26000775 Satb2 1 56845683 3.475988e-02 1.804695e-03 0.1313200 0.0420814
cg03768031 Zfp507 7 36134486 3.496448e-02 1.822341e-03 0.1282802 0.0411450
cg15476781 Esrrg 1 188000524 3.496448e-02 1.825089e-03 0.1320704 0.0423668
cg07257404 Gm38100 1 175994037 3.496448e-02 1.817638e-03 0.1467276 0.0470505
cg21706719 Mettl15 2 108649465 3.496448e-02 1.822872e-03 0.0776183 0.0248963
cg22860697 Otx1 11 122081234 3.496448e-02 1.825675e-03 -0.1387556 0.0445127
cg24975558 Prune2 19 117039707 3.496448e-02 1.822605e-03 0.0668718 0.0214490
cg16256434 Egln3 12 153926651 3.496448e-02 1.821466e-03 0.1325168 0.0425020
cg17064345 A3galt2 4 128743400 3.509703e-02 1.834081e-03 0.1170249 0.0375578
cg11614260 Serbp1 6 67272179 3.510196e-02 1.840280e-03 0.1499820 0.0481504
cg14572170 Alcam 16 152268799 3.510196e-02 1.840154e-03 0.2221765 0.0713273
cg09260635 Maf 8 115303446 3.510196e-02 1.836152e-03 -0.1610069 0.0516788
cg05664157 Prpf38b 3 108910475 3.510196e-02 1.839463e-03 -0.1366741 0.0438762
cg19872161 Rsbn1 3 103928487 3.513120e-02 1.843299e-03 0.1710565 0.0549247
cg15482183 Arhgap15os 2 44208107 3.521753e-02 1.849319e-03 0.2205057 0.0708242
cg12814030 Zfp219 14 152008734 3.530128e-02 1.855211e-03 0.1575921 0.0506323
cg24470121 Mfsd4a 1 132067688 3.533297e-02 1.858371e-03 -0.1441150 0.0463097
cg00741609 Tlx1 19 145153509 3.533786e-02 1.860123e-03 0.1949444 0.0626488
cg05350610 Ofcc1 13 140067890 3.541911e-02 1.865899e-03 0.1320003 0.0424331
cg14107769 Med1 11 198158408 3.543900e-02 1.869946e-03 -0.1518169 0.0488134
cg22075146 Cacna2d2 9 107521814 3.543900e-02 1.868579e-03 -0.0903003 0.0290321
cg10436531 Klf7 1 64156601 3.550661e-02 1.875016e-03 0.0904268 0.0290823
cg13922970 Tlk1 2 70825269 3.558399e-02 1.880608e-03 -0.0900054 0.0289549
cg03219288 Otx1 11 122034351 3.582743e-02 1.894990e-03 0.0873986 0.0281367
cg23292290 Skor1 9 63217746 3.590539e-02 1.900632e-03 0.1457130 0.0469234
cg07639660 Hottip 6 52270993 3.590791e-02 1.902285e-03 -0.1562512 0.0503212
cg05272031 Tspan2 3 102748870 3.610245e-02 1.914864e-03 0.2911557 0.0938265
cg27473842 Dnajc24 2 106040743 3.610245e-02 1.915646e-03 0.1131648 0.0364694
cg24411365 Hif1an 19 144641627 3.621687e-02 1.923250e-03 0.2252297 0.0726117
cg08827873 Lsamp 16 141923938 3.624405e-02 1.926227e-03 0.1934498 0.0623755
cg25762464 Pola1 20 93429282 3.627582e-02 1.929450e-03 0.1763582 0.0568736
cg11832449 Npas3 12 153566876 3.636491e-02 1.937195e-03 0.1320829 0.0426116
cg06933499 En1 1 120600428 3.636491e-02 1.937267e-03 -0.1712231 0.0552389
cg15033935 4930405A10Rik 14 122442862 3.640764e-02 1.941084e-03 0.1498552 0.0483544
cg02106733 Dlg1 16 131847647 3.654430e-02 1.949916e-03 0.1530825 0.0494172
cg07011087 Nkain2 10 132402289 3.656239e-02 1.953976e-03 0.1899268 0.0613233
cg10221825 Gbx2 1 89941764 3.656239e-02 1.953941e-03 -0.1862622 0.0601400
cg02422559 Wsb1 11 179243528 3.656528e-02 1.955677e-03 0.2176579 0.0702829
cg13086047 Pax2 19 144783640 3.658693e-02 1.958494e-03 0.1571512 0.0507520
cg17872415 St8sia5 18 177145050 3.658693e-02 1.959931e-03 -0.1964891 0.0634606
cg04339551 Dyrk1a 16 194663790 3.659241e-02 1.966066e-03 0.2404257 0.0776742
cg18649537 Gm33948 18 127497681 3.659241e-02 1.965980e-03 0.0859710 0.0277745
cg00222071 Evx2 2 74659901 3.659241e-02 1.962584e-03 -0.0812785 0.0262541
cg00128439 Dhx40 11 186773846 3.659241e-02 1.967966e-03 0.2109168 0.0681470
cg03434240 Prdm11 2 92973815 3.659241e-02 1.966780e-03 0.1889920 0.0610596
cg26984621 Tnks 8 34889680 3.662929e-02 1.974600e-03 0.1637921 0.0529382
cg00191058 Zbtb20 16 143537693 3.662929e-02 1.973282e-03 0.1998110 0.0645755
cg16452780 Bcor 20 11800828 3.662929e-02 1.973661e-03 0.0892050 0.0288300
cg16328301 Tmem183a 1 134355555 3.673125e-02 1.981650e-03 0.1530086 0.0494698
cg27603363 Tab3 20 85502422 3.674328e-02 1.985441e-03 0.1780754 0.0575848
cg04080945 Dach1 14 198536605 3.674328e-02 1.990073e-03 0.1905206 0.0616231
cg13406103 Zcchc3 2 152413751 3.674328e-02 1.987535e-03 0.0782168 0.0252958
cg20217707 Gtdc1 2 44575843 3.674328e-02 1.986308e-03 0.1565142 0.0506146
cg06684308 Lmo4 3 144227877 3.674328e-02 1.988886e-03 0.1187643 0.0384116
cg12734405 Mbnl2 14 1120404663 3.676733e-02 2.002266e-03 0.2018420 0.0653232
cg26891414 Rrp15 1 186782828 3.676733e-02 2.002040e-03 0.1649489 0.0533827
cg18138089 Abi1 2 22971228 3.676733e-02 1.993117e-03 0.0994724 0.0321786
cg08708887 Zc3h3 15 175834947 3.676733e-02 2.000121e-03 0.0997659 0.0322845
cg25567445 Mecom 3 30349622 3.676733e-02 1.997254e-03 0.1653192 0.0534903
cg08441764 Cux2 5 121895458 3.676733e-02 1.994660e-03 -0.1207805 0.0390745
cg16018243 Tbr1 2 61804111 3.676733e-02 1.999404e-03 -0.1177917 0.0381163
cg09451873 1700019E08Rik 2 45837015 3.704313e-02 2.018853e-03 0.2088403 0.0676418
cg14785049 Otx1 11 122045641 3.709523e-02 2.023262e-03 -0.0854304 0.0276761
cg01977579 Pabpc1 15 136608780 3.712114e-02 2.026246e-03 0.0844229 0.0273536
cg04861468 Prpf3 3 95849776 3.715308e-02 2.029858e-03 0.1563125 0.0506550
cg26256970 Ophn1 20 98891023 3.715308e-02 2.031134e-03 0.2397256 0.0776907
cg22142552 Foxp1 6 98944641 3.722640e-02 2.036717e-03 0.1165160 0.0377707
cg07724254 Otx1 11 122079063 3.732162e-02 2.043506e-03 0.1394618 0.0452235
cg04182655 Relt 7 100835411 3.759507e-02 2.060069e-03 0.0877501 0.0284771
cg12961607 Srsf7 17 180204844 3.760545e-02 2.062229e-03 0.1130415 0.0366884
cg26934556 Fnbp1l 3 122552145 3.766434e-02 2.069488e-03 0.2312320 0.0750735
cg09394345 B130024G19Rik 7 71145669 3.766434e-02 2.071070e-03 0.1809903 0.0587660
cg13832595 Ythdc1 5 86830558 3.766434e-02 2.071833e-03 0.2339901 0.0759773
cg07598624 Mab21l2 3 86600486 3.766434e-02 2.070458e-03 0.1617321 0.0525115
cg24557648 Zfp407 18 184415164 3.767770e-02 2.074163e-03 0.1982073 0.0643655
cg08568054 Celf4 18 125810565 3.774938e-02 2.079706e-03 0.1974444 0.0641343
cg16751878 Cdk17 10 193239073 3.783287e-02 2.086390e-03 0.1737205 0.0564458
cg25658983 Siah3 14 175455793 3.783287e-02 2.087507e-03 -0.1368200 0.0444583
cg05039938 Sspn 6 146001860 3.791436e-02 2.095213e-03 0.0833939 0.0271077
cg06659440 Bcl11a 11 124061974 3.791436e-02 2.095175e-03 -0.1026952 0.0333816
cg03561281 Nsd2 5 33882862 3.792923e-02 2.097639e-03 0.1262678 0.0410487
cg14896592 Gm32123 14 125039202 3.813525e-02 2.112260e-03 0.1479144 0.0481183
cg23043074 Ebf1 11 144963757 3.813525e-02 2.111748e-03 0.1452557 0.0472522
cg26425349 Usp14 18 110016574 3.816729e-02 2.115650e-03 0.2267689 0.0737820
cg17126395 Mtdh 15 134123727 3.822048e-02 2.121597e-03 0.2349330 0.0764591
cg01872427 Map3k20 2 72378730 3.822048e-02 2.121832e-03 0.1896446 0.0617207
cg12131548 Mindy2 9 70616830 3.823789e-02 2.124417e-03 0.1604515 0.0522258
cg14826942 Macroh2a1 13 156088286 3.831680e-02 2.130423e-03 -0.4449525 0.1448686
cg20156837 Cyhr1 15 176649121 3.840312e-02 2.136847e-03 0.1165697 0.0379641
cg21513836 Fgf14 14 1124677591 3.841514e-02 2.139141e-03 -0.1395653 0.0454580
cg08206382 Dock11 20 36052505 3.861649e-02 2.152543e-03 0.0952263 0.0310352
cg20515845 Rhpn1 15 175726102 3.861649e-02 2.154915e-03 0.1744386 0.0568573
cg07895812 Epb41l4b 4 57077026 3.861649e-02 2.156889e-03 -0.1045422 0.0340780
cg04275146 Ccdc73 2 104894033 3.861649e-02 2.155509e-03 0.1192926 0.0388838
cg13455298 Tbc1d2b 9 90420292 3.861979e-02 2.158708e-03 -0.2399858 0.0782354
cg25558559 Kcnma1 14 123373797 3.870828e-02 2.171843e-03 0.2085109 0.0680148
cg14547563 Nf1 11 179565959 3.870828e-02 2.169787e-03 0.2217916 0.0723402
cg15720698 Zeb2 2 45021122 3.870828e-02 2.166584e-03 0.1805486 0.0588798
cg10998986 Pbx1 1 168183013 3.870828e-02 2.171331e-03 -0.2005330 0.0654110
cg18174545 Dcun1d4 5 73560623 3.870828e-02 2.169172e-03 0.1099058 0.0358462
cg24455002 Nova1 12 146698919 3.882422e-02 2.179992e-03 0.1470960 0.0479993
cg08220031 Zc3h15 2 83658119 3.921592e-02 2.203645e-03 0.1387565 0.0453257
cg24325388 Cct2 10 1117081035 3.927908e-02 2.208856e-03 0.1308791 0.0427624
cg02883001 Prpf38b 3 108905875 3.931755e-02 2.212683e-03 0.0854030 0.0279086
cg22512644 Usp34 11 123454666 3.937007e-02 2.219568e-03 0.1594646 0.0521269
cg06685968 Gm28308 6 52213380 3.937007e-02 2.220010e-03 -0.0744286 0.0243302
cg17630503 Trip12 1 84763867 3.937007e-02 2.220636e-03 0.2559061 0.0836563
cg03137308 Zfhx4 3 5330211 3.950662e-02 2.230010e-03 0.1737366 0.0568183
cg11766397 1700109G15Rik 11 184641449 3.950904e-02 2.233477e-03 0.2282541 0.0746590
cg27359471 Mir6348 1 168479781 3.950904e-02 2.233491e-03 -0.1084169 0.0354618
cg22183370 NA 19 155931449 3.954707e-02 2.237314e-03 0.1474590 0.0482400
cg05316560 Uri1 7 37896740 3.972859e-02 2.249264e-03 0.1511595 0.0494765
cg25092086 1700066C05Rik 16 180507696 3.972916e-02 2.250977e-03 0.2128506 0.0696740
cg04590080 Tent4b 8 88199980 3.974858e-02 2.254779e-03 -0.0671791 0.0219939
cg21104978 Slc12a2 18 157900084 3.974858e-02 2.262169e-03 0.2014767 0.0659830
cg07720842 Dock3 9 106952382 3.974858e-02 2.257668e-03 0.1676120 0.0548817
cg17711602 Gata3 2 9892450 3.974858e-02 2.259569e-03 -0.1959150 0.0641543
cg24370741 4933430M04Rik 11 124371323 3.974858e-02 2.258728e-03 0.1990567 0.0651807
cg02211939 Bnc2 4 84536772 3.974858e-02 2.261429e-03 0.1156628 0.0378780
cg05942016 Snord90 2 37398289 3.983789e-02 2.271199e-03 0.0904028 0.0296182
cg10380094 Rasal2 1 157299192 3.983789e-02 2.272309e-03 -0.1499054 0.0491152
cg22346366 Ntrk3 7 78698952 3.983789e-02 2.269150e-03 0.1950678 0.0639035
cg17144424 Rrp15 1 186850638 3.985578e-02 2.275016e-03 0.1934115 0.0633770
cg11195606 Nr4a3 4 48084740 3.988005e-02 2.279776e-03 0.1467284 0.0480898
cg27273275 Rnf165 18 177461822 3.988005e-02 2.278937e-03 0.0978668 0.0320744
cg05223397 Ush2a 1 188199902 3.988162e-02 2.286423e-03 0.1657687 0.0543457
cg12843514 Pola1 20 93409227 3.988162e-02 2.286392e-03 0.1829630 0.0599826
cg27029166 Prpf3 3 95849739 3.988162e-02 2.286616e-03 -0.2123275 0.0696102
cg26016635 Grid2 6 64665919 3.988162e-02 2.282572e-03 0.0684864 0.0224489
cg02675830 Chic2 5 75006723 3.989604e-02 2.290200e-03 0.1834750 0.0601604
cg06721025 Arhgap15os 2 44081178 3.989604e-02 2.290819e-03 0.1346812 0.0441624
cg12942440 Tmem218 9 37197230 3.996132e-02 2.296849e-03 0.1477133 0.0484481
cg10397346 Dyrk1a 16 194692018 3.996132e-02 2.297949e-03 0.0975563 0.0319988
cg01925203 Arhgap15os 2 44241449 4.009142e-02 2.308823e-03 0.1499657 0.0492121
cg20433492 Glra2 20 165289411 4.009142e-02 2.307480e-03 0.1261562 0.0413965
cg13186343 Eri3 4 117651865 4.014618e-02 2.316266e-03 0.0883092 0.0289884
cg18433069 U2surp 9 95488000 4.014618e-02 2.317073e-03 0.1509444 0.0495507
cg16972264 Ubp1 9 113959475 4.014618e-02 2.315982e-03 0.0942143 0.0309264
cg09901424 Bcor 20 12073910 4.039266e-02 2.333008e-03 0.1583999 0.0520334
cg23247277 Mtfr2 10 120399661 4.039967e-02 2.336455e-03 0.1772561 0.0582360
cg06380810 Tac4 11 195210847 4.039967e-02 2.336832e-03 -0.1182293 0.0388439
cg15667815 Mir3961 13 183055290 4.042339e-02 2.339914e-03 -0.1579234 0.0518920
cg02156108 9130227L01Rik 1 55937082 4.045800e-02 2.343630e-03 0.1822559 0.0598968
cg27144659 Hmgxb4 8 75000023 4.056409e-02 2.351492e-03 0.1564358 0.0514283
cg15845854 Mir378d 10 1126615911 4.063455e-02 2.359015e-03 0.1779943 0.0585341
cg05749574 Birc6 17 174702420 4.063455e-02 2.358416e-03 0.1015071 0.0333802
cg04191285 Tox 4 6795755 4.065268e-02 2.363508e-03 -0.1128208 0.0371086
cg14142471 Gm19585 17 152330431 4.065268e-02 2.361868e-03 0.1297353 0.0426691
cg05850866 Sorl1 9 41940096 4.071529e-02 2.368871e-03 0.1684104 0.0554053
cg09844922 Lmo1 7 109208266 4.075586e-02 2.372956e-03 0.2060702 0.0678066
cg10688581 Meis2 2 115905164 4.080732e-02 2.383474e-03 0.2151011 0.0708092
cg16275162 Lmo3 6 138380280 4.080732e-02 2.386766e-03 0.1696340 0.0558496
cg08491617 Foxp2 6 15282431 4.080732e-02 2.385625e-03 0.0640173 0.0210758
cg19789891 Zfp536 7 37640105 4.080732e-02 2.381251e-03 0.1662903 0.0547361
cg03559209 Lhx2 2 38369048 4.080732e-02 2.388039e-03 -0.1049515 0.0345556
cg09099665 Klhl29 12 15239931 4.080732e-02 2.386118e-03 -0.1335509 0.0439685
cg21695479 Gpat3 5 101090620 4.080732e-02 2.383682e-03 0.1694516 0.0557823
cg27052685 Pantr1 1 41919060 4.087952e-02 2.393994e-03 0.1316370 0.0433526
cg14058051 BC006965 11 1112542761 4.097838e-02 2.403251e-03 0.1377582 0.0453859
cg21536160 Wwox 8 114604747 4.097838e-02 2.402925e-03 0.2485806 0.0818964
cg09674317 Cadps2 6 23451541 4.123940e-02 2.420304e-03 0.1264306 0.0416832
cg27311928 Vsx2 12 184520904 4.134081e-02 2.437107e-03 0.1594775 0.0526147
cg01313856 Btrc 19 145312174 4.134081e-02 2.435423e-03 0.1731398 0.0571183
cg00257950 Rere 4 150526330 4.134081e-02 2.430886e-03 -0.1075817 0.0354843
cg25810458 Zfp407 18 184353434 4.134081e-02 2.429653e-03 0.1548215 0.0510630
cg03463065 Fam172a 13 177470318 4.134081e-02 2.443749e-03 -0.2634122 0.0869284
cg27113320 Btrc 19 145324768 4.134081e-02 2.435548e-03 0.1919255 0.0633159
cg09521804 Cnbp 6 87844086 4.134081e-02 2.438253e-03 0.2001973 0.0660521
cg27603860 Evx2 2 74651651 4.134081e-02 2.442741e-03 -0.2074923 0.0684715
cg11861802 Sall1 8 89675078 4.134081e-02 2.441583e-03 0.1693841 0.0558933
cg03214411 Gria2 3 80689229 4.134081e-02 2.439987e-03 0.0508578 0.0167810
cg09189709 Rc3h2 2 37374406 4.136603e-02 2.446990e-03 0.1711527 0.0564894
cg02839202 Relt 7 100836113 4.143929e-02 2.453077e-03 -0.1183889 0.0390842
cg25587386 Elavl2 4 91311575 4.149436e-02 2.458092e-03 0.1601845 0.0528932
cg23283355 Luc7l2 6 38554998 4.155334e-02 2.463345e-03 0.1912228 0.0631555
cg15318407 Zfhx4 3 5242669 4.156394e-02 2.466650e-03 0.2376986 0.0785157
cg12366082 Dach1 14 197786926 4.156394e-02 2.467491e-03 0.2324872 0.0767969
cg15430884 Bnc2 4 84406340 4.157369e-02 2.469828e-03 0.1847965 0.0610491
cg16915042 Kctd16 18 140260993 4.164722e-02 2.475959e-03 0.1634085 0.0539968
cg23234941 Dach1 14 198019552 4.171475e-02 2.481739e-03 0.1924542 0.0636095
cg11956374 Gm6260 3 143914577 4.172996e-02 2.484410e-03 -0.1567586 0.0518170
cg14411125 Cadm1 9 47829386 4.173971e-02 2.487470e-03 -0.1711074 0.0565670
cg20913926 Dennd1a 2 38159825 4.173971e-02 2.488523e-03 -0.2342771 0.0774538
cg20916701 Pex14 4 149044311 4.182291e-02 2.495253e-03 0.2476550 0.0818988
cg05182469 R3hcc1l 19 142539790 4.189732e-02 2.501465e-03 0.1928515 0.0637913
cg19014505 Elavl4 4 110205455 4.193433e-02 2.505449e-03 0.1520600 0.0503063
cg17416451 Kctd15 7 34650549 4.201431e-02 2.512005e-03 0.1100096 0.0364042
cg16747818 Tex13a 20 138220467 4.201485e-02 2.513815e-03 0.1996146 0.0660609
cg05951790 Oga 19 145761597 4.207975e-02 2.523929e-03 0.1317373 0.0436150
cg15024159 Cadm1 9 47275051 4.207975e-02 2.524820e-03 0.0951739 0.0315109
cg17840695 Pcgf1 6 83078431 4.207975e-02 2.524547e-03 0.0347868 0.0115173
cg22870684 Shank2 7 144285038 4.207975e-02 2.520270e-03 -0.1987750 0.0658000
cg21947443 Llph 10 1120245913 4.208080e-02 2.528445e-03 0.1516253 0.0502084
cg17577212 Gpr26 7 131778664 4.208080e-02 2.527773e-03 0.0879147 0.0291109
cg23141081 Rps13 7 116350858 4.217641e-02 2.535974e-03 0.1446170 0.0479020
cg03134455 Prdm16 4 154456678 4.225700e-02 2.542608e-03 0.1165979 0.0386313
cg20971724 4930513N10Rik 8 95788655 4.260901e-02 2.567394e-03 0.0925691 0.0307000
cg12896068 Skor1 9 63217539 4.260901e-02 2.566209e-03 0.1647870 0.0546481
cg23839018 Dhx35 2 158882721 4.272360e-02 2.576107e-03 -0.1089306 0.0361385
cg24217623 Pbx3 2 34359904 4.281644e-02 2.583517e-03 0.1889813 0.0627140
cg02273345 Csmd3 15 147755439 4.284801e-02 2.587235e-03 0.1815058 0.0602419
cg24296072 Cntnap2 6 47107964 4.290840e-02 2.592697e-03 -0.1040484 0.0345411
cg13613983 Pura 18 136286952 4.299125e-02 2.599522e-03 -0.0583412 0.0193727
cg15115387 Klhl28 12 164957641 4.299126e-02 2.601341e-03 0.1459190 0.0484572
cg19537999 Prune2 19 117060278 4.304966e-02 2.606697e-03 0.1158676 0.0384856
cg21005654 Ptf1aos 2 19455293 4.306226e-02 2.610069e-03 -0.1913822 0.0635762
cg14678442 Nog 11 189301072 4.306226e-02 2.612926e-03 -0.1258943 0.0418261
cg13484249 Agap1 1 89824306 4.306226e-02 2.611202e-03 0.2598132 0.0863124
cg03775588 Pax6 2 105682292 4.314319e-02 2.619662e-03 -0.3605501 0.1198173
cg26939636 Lmo1 7 109261998 4.333558e-02 2.633178e-03 0.1308647 0.0435113
cg26809863 Ift20 11 178541365 4.338899e-02 2.638667e-03 0.1536096 0.0510845
cg25664402 Akt3 1 177258708 4.338899e-02 2.640095e-03 0.1069828 0.0355802
cg07520422 Pou4f3 18 142421771 4.347607e-02 2.648961e-03 0.1002074 0.0333382
cg02523575 Pparg 6 115463248 4.347607e-02 2.649073e-03 0.1482884 0.0493345
cg20274287 Riok3 18 112148939 4.379349e-02 2.670272e-03 0.1468383 0.0488915
cg16769396 Fmr1 20 68710760 4.379349e-02 2.672120e-03 0.1567254 0.0521872
cg11570499 Celf2 2 6606834 4.392422e-02 2.684836e-03 0.1696247 0.0565097
cg14792778 Cdh18 15 123460342 4.392422e-02 2.682906e-03 0.1333962 0.0444371
cg14363797 Kif5a 10 1127262785 4.392422e-02 2.687531e-03 -0.1535929 0.0511740
cg23075119 Ltbp3 19 15741195 4.392422e-02 2.686498e-03 0.1311293 0.0436879
cg27325093 St18 1 6757890 4.394732e-02 2.692664e-03 -0.1490713 0.0496771
cg19235908 Arhgap15os 2 44303060 4.394732e-02 2.691438e-03 -0.2487534 0.0828917
cg16149925 Mipol1 12 157331895 4.399178e-02 2.697249e-03 0.0812840 0.0270921
cg26905937 Arx 20 93368053 4.402738e-02 2.701295e-03 0.1877414 0.0625840
cg23476265 Pnisr 4 21874644 4.402992e-02 2.705177e-03 0.1606578 0.0535634
cg03756336 Sox2ot 3 34443842 4.402992e-02 2.703747e-03 0.1101116 0.0367093
cg19821567 Camta1 4 151549205 4.412937e-02 2.713154e-03 0.1365293 0.0455326
cg04296683 Lrch2 20 147480505 4.415281e-02 2.716464e-03 0.1478765 0.0493230
cg24033437 Sox6 7 115919833 4.419158e-02 2.721283e-03 0.1926000 0.0642517
cg10583229 D030024E09Rik 15 161692982 4.419158e-02 2.722589e-03 0.1886522 0.0629378
cg22776920 Eya4 10 123109996 4.424961e-02 2.728036e-03 0.2396856 0.0799797
cg02230860 Fam193b 13 155569789 4.429182e-02 2.733031e-03 -0.1183100 0.0394857
cg14318001 Srsf5 12 180948286 4.429182e-02 2.734387e-03 0.0859919 0.0287011
cg13276805 Fam118b 9 35227390 4.434879e-02 2.740953e-03 0.1707679 0.0570103
cg02736176 Otx1 11 122045575 4.434879e-02 2.741657e-03 0.0897242 0.0299549
cg07584109 Srek1 13 1103764328 4.448227e-02 2.751791e-03 0.1548395 0.0517134
cg01444413 Pogz 3 94862487 4.452884e-02 2.756626e-03 0.1149800 0.0384080
cg13634781 Adgrb3 1 25228464 4.452884e-02 2.758440e-03 -0.1519946 0.0507757
cg05633263 Srcin1 11 197558366 4.456092e-02 2.762313e-03 -0.1301745 0.0434927
cg05638983 I730028E13Rik 9 61145113 4.465336e-02 2.769933e-03 0.2170327 0.0725333
cg09133264 A830082K12Rik 13 179141544 4.477624e-02 2.781344e-03 0.1269617 0.0424490
cg09200783 Tmem260 14 148456488 4.477624e-02 2.780405e-03 0.1103639 0.0368983
cg04336027 4930519F24Rik 9 100210798 4.479074e-02 2.784141e-03 0.2163945 0.0723578
cg09235324 Ltbp1 17 175276435 4.484347e-02 2.789316e-03 0.2052911 0.0686581
cg17619764 Slc35b3 13 138814686 4.488694e-02 2.793919e-03 0.1612848 0.0539496
cg09391013 Meis1 11 118882620 4.488701e-02 2.795823e-03 0.1737709 0.0581302
cg14536337 Hoxa13 6 52257206 4.504705e-02 2.807697e-03 -0.1330770 0.0445365
cg15982050 Skap1 11 196644683 4.510135e-02 2.816807e-03 0.1302065 0.0435903
cg00264131 Cadm1 9 47529152 4.510135e-02 2.813478e-03 0.1617437 0.0541417
cg15813117 Otx1 11 122053455 4.510135e-02 2.816367e-03 0.0926461 0.0310154
cg26089982 Esx1 20 137162685 4.513898e-02 2.821067e-03 0.1109128 0.0371369
cg14748407 Lcor 19 141552490 4.521076e-02 2.827466e-03 0.2130779 0.0713614
cg09481972 Hoxc6 15 1102998229 4.530297e-02 2.835149e-03 0.1808733 0.0605927
cg23413592 Mapkap1 2 34455835 4.532616e-02 2.838519e-03 0.2228497 0.0746639
cg06750881 Gtdc1 2 44633244 4.534629e-02 2.841699e-03 -0.1558985 0.0522384
cg18409580 Ccar1 10 162764505 4.539695e-02 2.846794e-03 0.0819498 0.0274648
cg22036407 Ppp6r3 19 13478308 4.544681e-02 2.854308e-03 0.1456987 0.0488429
cg05513929 Nrxn1 17 190162430 4.544681e-02 2.855689e-03 0.1153487 0.0386705
cg12799227 Scn9a 2 66563587 4.544681e-02 2.852626e-03 0.0866778 0.0290554
cg11407867 Nlk 11 178572376 4.546199e-02 2.872376e-03 0.1884383 0.0632115
cg25323435 Mef2c 13 183524300 4.546199e-02 2.858738e-03 -0.1722198 0.0577428
cg04550865 Lrmda 14 122075063 4.546199e-02 2.875880e-03 0.2155522 0.0723159
cg19471843 Ccdc171 4 83865444 4.546199e-02 2.862730e-03 0.1391722 0.0466691
cg15146514 Ogt 20 101642982 4.546199e-02 2.873725e-03 -0.1072041 0.0359633
cg23390662 Hoxb5 11 196303511 4.546199e-02 2.866410e-03 -0.0465405 0.0156087
cg04976865 Dedd 1 171341015 4.546199e-02 2.874006e-03 0.1050267 0.0352332
cg21283418 Castor2 5 133663018 4.546199e-02 2.864503e-03 0.1222871 0.0410096
cg17563080 Pola1 20 93561931 4.546199e-02 2.871129e-03 0.1453989 0.0487718
cg07982366 Sertad4 1 192898853 4.546199e-02 2.870714e-03 0.0933666 0.0313179
cg09570546 Zfp507 7 35866145 4.554712e-02 2.887047e-03 0.0969923 0.0325531
cg01960173 Usf2 7 30956011 4.554712e-02 2.885523e-03 -0.1000359 0.0335727
cg07256954 Diaph3 14 186866446 4.554712e-02 2.886975e-03 0.2029872 0.0681274
cg09982766 Tra2a 6 49252486 4.555196e-02 2.897097e-03 0.1607856 0.0539830
cg26081366 Hnrnph1 11 150381469 4.555196e-02 2.898270e-03 -0.2496427 0.0838198
cg10146038 Zfhx3 8 108731923 4.555196e-02 2.894600e-03 -0.0488300 0.0163930
cg10606240 Dnajc24 2 106149981 4.555196e-02 2.898919e-03 -0.1465719 0.0492140
cg05950040 Ccdc66 14 127480699 4.555196e-02 2.891972e-03 0.1619581 0.0543667
cg12396418 Eif5a 11 169921304 4.555196e-02 2.892835e-03 -0.0852952 0.0286331
cg11559504 Tm4sf19 16 132381789 4.555604e-02 2.903354e-03 0.1253970 0.0421108
cg16208774 Cadps 14 112507197 4.555604e-02 2.902398e-03 -0.0688168 0.0231093
cg20406520 Zfp740 15 1102208834 4.555604e-02 2.904962e-03 0.1247714 0.0419031
cg27340951 Zcchc7 4 44799925 4.558526e-02 2.908754e-03 0.2210864 0.0742593
cg16909474 Ankrd17 5 90228955 4.560937e-02 2.912222e-03 0.1629129 0.0547265
cg21793027 Tusc3 8 39096970 4.567829e-02 2.920469e-03 0.1404213 0.0471848
cg07442023 Triqk 4 13248594 4.567829e-02 2.920488e-03 -0.1954504 0.0656759
cg17630580 Tle4 19 115058022 4.578437e-02 2.931145e-03 0.1635718 0.0549846
cg23647082 Zc3h3 15 175835247 4.578437e-02 2.929490e-03 0.1010286 0.0339587
cg17362055 2900052N01Rik 9 46660555 4.578618e-02 2.935136e-03 0.2154131 0.0724211
cg17092321 Gm29443 7 16564516 4.578618e-02 2.933967e-03 0.1292583 0.0434544
cg25821931 Pard3b 1 61782823 4.578822e-02 2.937204e-03 0.0815888 0.0274319
cg24677779 Nckap1 2 80545047 4.586050e-02 2.943781e-03 0.1507305 0.0506904
cg02369056 Zc3h3 15 175808394 4.590532e-02 2.949567e-03 0.1088010 0.0365970
cg03952681 Eif3j1 2 122011852 4.590532e-02 2.950543e-03 0.1850858 0.0622588
cg21942865 Calm2 17 187532300 4.591555e-02 2.953143e-03 -0.2213770 0.0744732
cg23012887 Scaf8 17 13159304 4.598452e-02 2.959525e-03 0.1172934 0.0394673
cg24918496 Lta4h 10 193482277 4.610228e-02 2.972956e-03 0.0878906 0.0295876
cg00611309 Dach1 14 197588276 4.610228e-02 2.969769e-03 -0.2532888 0.0852580
cg10712152 Zfhx3 8 108675009 4.610228e-02 2.972542e-03 -0.1175715 0.0395788
cg11551674 Slc35b3 13 138976848 4.611037e-02 2.975429e-03 0.2121858 0.0714366
cg19494369 5730522E02Rik 11 125531214 4.615979e-02 2.980571e-03 0.1204723 0.0405667
cg25713925 Tnpo3 6 29571035 4.616966e-02 2.983162e-03 0.2305824 0.0776511
cg06501452 AW554918 18 125241225 4.632023e-02 2.994851e-03 0.2171693 0.0731637
cg02021058 Kdm6a 20 18279682 4.646961e-02 3.007168e-03 -0.2104230 0.0709210
cg26872866 Slc35b3 13 139047589 4.646961e-02 3.010408e-03 0.1661752 0.0560140
cg08375848 Enox2 20 49038892 4.646961e-02 3.009394e-03 0.1097274 0.0369854
cg24472499 Mir691 16 174295737 4.667489e-02 3.027656e-03 0.0745970 0.0251599
cg26150823 Dph6 2 114460272 4.667489e-02 3.026929e-03 0.1620818 0.0546652
cg20211977 Mapkap1 2 34557013 4.678633e-02 3.038845e-03 0.1637019 0.0552341
cg25278451 Gm33948 18 127629619 4.678633e-02 3.038167e-03 0.1153868 0.0389314
cg04769815 Ndufa4 6 11535060 4.683042e-02 3.043690e-03 -0.1683263 0.0568038
cg09955719 Insm1 2 146223670 4.686627e-02 3.048003e-03 0.1054249 0.0355822
cg01240843 Mipol1 12 157317198 4.687917e-02 3.050825e-03 0.2038502 0.0688086
cg21540320 Zeb2 2 45058392 4.697018e-02 3.058736e-03 0.1288609 0.0435080
cg27640306 Bzw2 12 136134899 4.712628e-02 3.070896e-03 0.1632449 0.0551400
cg10359643 Foxp2 6 15286296 4.722819e-02 3.079535e-03 0.1068655 0.0361070
cg04759478 Tlx3 11 133192777 4.728140e-02 3.086414e-03 0.2422603 0.0818724
cg18674676 Filip1 9 79815872 4.728140e-02 3.087006e-03 0.2235290 0.0755436
cg16937191 Ebf1 11 144904213 4.742942e-02 3.098677e-03 0.1687282 0.0570456
cg12321772 Cnot2 10 1116498239 4.747335e-02 3.105564e-03 0.1104328 0.0373451
cg12378720 2810403D21Rik 20 108832856 4.747335e-02 3.104016e-03 0.1618158 0.0547184
cg11515877 Rwdd3 3 121059818 4.758218e-02 3.121685e-03 0.0966568 0.0327041
cg08600163 Arid5b 10 168279760 4.758218e-02 3.118903e-03 -0.1028832 0.0348076
cg06225551 Son 16 191664950 4.758218e-02 3.118851e-03 0.0988779 0.0334524
cg01194026 Sema3d 5 12585096 4.758218e-02 3.122751e-03 0.1620766 0.0548410
cg19179483 Opcml 9 28687441 4.758218e-02 3.120435e-03 -0.2037395 0.0689330
cg18261337 Dennd4a 9 64873065 4.770479e-02 3.132816e-03 0.1810468 0.0612805
cg04267424 Pbx1 1 168431932 4.773292e-02 3.136683e-03 -0.0668234 0.0226212
cg12143541 Vapa 17 165594964 4.773765e-02 3.139014e-03 0.1190539 0.0403055
cg15814754 Tpm1 9 67032452 4.782606e-02 3.146851e-03 -0.0633875 0.0214653
cg03617806 Zbtb7a 10 181144164 4.783286e-02 3.149322e-03 -0.1512422 0.0512204
cg01526265 4930555B11Rik 2 57182126 4.805792e-02 3.166174e-03 -0.1154671 0.0391264
cg00906973 Tfap2a 13 140738322 4.815024e-02 3.174293e-03 -0.1133632 0.0384239
cg20211859 Uchl3 14 1101667659 4.817143e-02 3.177729e-03 0.1787682 0.0605994
cg12221457 Snx10 6 51657154 4.817694e-02 3.180131e-03 -0.0800110 0.0271245
cg26879535 Gm12130 11 139042068 4.830063e-02 3.194426e-03 0.1280357 0.0434258
cg23145858 Nova1 12 146697884 4.830063e-02 3.191719e-03 0.1074004 0.0364237
cg21364331 Poll 19 145540169 4.830063e-02 3.192429e-03 0.2104013 0.0713569
cg04647787 Arx 20 93377867 4.832626e-02 3.200060e-03 0.1192567 0.0404557
cg13489443 Nkx6-1 5 101658915 4.832626e-02 3.200212e-03 -0.0898102 0.0304666
cg12001273 Tox 4 6687495 4.844176e-02 3.213360e-03 0.1514116 0.0513860
cg22978368 Gm13205 4 148973075 4.844176e-02 3.214009e-03 0.1043697 0.0354217
cg06029967 Smad7 18 175370701 4.844176e-02 3.211046e-03 -0.1456408 0.0494238
cg00678568 Srek1 13 1103764404 4.849050e-02 3.219295e-03 0.0665338 0.0225846
cg09474736 Celf4 18 126146657 4.849764e-02 3.221821e-03 0.0897475 0.0304669
cg05671448 Cpeb1 7 81355885 4.867185e-02 3.235454e-03 0.0912637 0.0309953
cg11781618 Nrxn1 17 190702065 4.871592e-02 3.240444e-03 0.1437706 0.0488358
cg27151981 Zfc3h1 10 1115431709 4.878122e-02 3.246852e-03 0.1329252 0.0451613
cg21846387 Rab3ip 10 1116910140 4.894142e-02 3.259586e-03 0.1051930 0.0357540
cg16197517 Pdha1 20 160086396 4.921529e-02 3.279909e-03 0.1032302 0.0351098
cg11212378 Mms22l 4 23732743 4.925398e-02 3.284571e-03 0.1553861 0.0528566
cg17470118 Ebf1 11 144657355 4.934124e-02 3.292478e-03 0.2130281 0.0724826
cg02294284 Slitrk1 14 1108913248 4.955144e-02 3.309337e-03 -0.1984918 0.0675731
cg00252404 Foxp1 6 99505418 4.955144e-02 3.319079e-03 0.0974455 0.0331839
cg25572043 Ankrd28 14 131781852 4.955144e-02 3.311737e-03 -0.2106741 0.0717258
cg01445252 Myof 19 137881931 4.955144e-02 3.319085e-03 0.1028529 0.0350254
cg26137465 Mknk1 4 115864274 4.955144e-02 3.315999e-03 -0.0830952 0.0282943
cg14030728 Npr2 4 43632736 4.955144e-02 3.316003e-03 -0.1137424 0.0387298
cg25611243 Sox5 6 144871553 4.956722e-02 3.323269e-03 0.2627006 0.0894715
cg11389621 Rnf165 18 177461770 4.956722e-02 3.325587e-03 0.1241812 0.0422972
cg18758604 Dbpht2 12 174295362 4.956722e-02 3.326434e-03 0.1233062 0.0420003
cg13916266 Chd3 11 169369837 4.967046e-02 3.338650e-03 -0.2009155 0.0684619
cg05598763 Strbp 2 37580758 4.967046e-02 3.341769e-03 0.1749277 0.0596125
cg18753452 Pcbp2 15 1102486092 4.967046e-02 3.341238e-03 0.0968893 0.0330177
cg25691921 Bcor 20 11821997 4.967046e-02 3.340307e-03 0.0898977 0.0306342
cg19575317 Cdkl5 20 160807536 4.967054e-02 3.343877e-03 0.1146202 0.0390633
cg11902343 Gtdc1 2 44394747 4.971629e-02 3.349060e-03 0.1924801 0.0656092
cg02494169 Lrmda 14 122075044 4.978865e-02 3.356041e-03 0.1610164 0.0548965
cg02785457 Tank 2 61656497 4.981575e-02 3.362083e-03 0.1620543 0.0552609
cg15863913 Mms22l 4 23628807 4.981575e-02 3.360956e-03 0.1979782 0.0675086
cg07210941 Zfpm2 15 140662229 4.998167e-02 3.375396e-03 0.2246353 0.0766332
# Save to outputs

write.csv(betaResults, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_stats_table_FullJ20.csv")


sig_genotype <- betaResults[which(betaResults[,"FDR_adj_genotype"] < 0.05),]
write.csv(sig_genotype, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_FullJ20_sig_genotype.csv")

sig_age <- betaResults[which(betaResults[,"FDR_adj_age"] < 0.05),]
write.csv(sig_age, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_FullJ20_sig_age.csv")

sig_pathology <- betaResults[which(betaResults[,"FDR_adj_pathology"] < 0.05),]
write.csv(sig_pathology, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_FullJ20_sig_interaction.csv")