J20 Array Beta Regression Results

library(ggplot2)
library(tidyverse)
library(tidyr)
library(qqman)
library(cgwtools)
library(BiSeq)
library(reshape2)
library(gridExtra)
library(kableExtra)
## J20
# Load the unique dataset
load("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/Normalised_Data_Sesame.rdat")
source("/gpfs/ts0/projects/Research_Project-191406/Aisha/script/rrbs-ad-mice/PlotFunctions.R")
source("/gpfs/ts0/projects/Research_Project-191406/Aisha/script/rrbs-ad-mice/Array/BetaRegressionArray.R")
# Filter for J20 samples
pheno <- QCmetrics[which(QCmetrics$Tissue == "CortexEntorhinalis" & QCmetrics$AD_model == "J20"),]
betas <- Normalised_Sesame_Betas[,colnames(Normalised_Sesame_Betas) %in% pheno$Basename ]
pheno$Genotype <- as.factor(pheno$Genotype)

# Load pathology data to set ages
pathology_pheno <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_ECX_Pathology.csv", header = T, stringsAsFactors = F)
colnames(pathology_pheno)[colnames(pathology_pheno) == 'X...Sample_ID_ECX'] <- 'Sample_ID_ECX'
pheno$Sample_ID_ECX <- gsub(".*_", "", pheno$ExternalSampleID)

phenowPath <- merge(pheno,pathology_pheno, by = "Sample_ID_ECX")
colnames(phenowPath)[colnames(phenowPath) == 'Genotype.x'] <- 'Genotype'
pheno <- phenowPath

betas <- betas[,order(colnames(betas))]
pheno <- pheno[order(pheno$Basename),]
identical(colnames(betas), pheno$Basename)

## [1] TRUE

pheno$Genotype <- factor(pheno$Genotype, levels = c("WT","TG"))
pheno$Chip_ID <- pheno$Slide

#Load coordinates matrix
probe_mapping_file <- read_csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/HorvathMammalChip_SpeciesGenomeCoordsUnique_v1.0.csv", col_types = cols(.default = "c"))
species_probes <- probe_mapping_file[, c('probeID','MusMusculus')]
species_probes <- as.data.frame(species_probes[!is.na(species_probes$MusMusculus),]) #24048 probes 
species_probes$Chr <- gsub(":.*","",species_probes$MusMusculus)
species_probes$Bp <- species_probes$MusMusculus
species_probes$Bp <- gsub("*.:","", species_probes$Bp)
species_probes <- species_probes[,-2]
species_probes$Position <- paste("chr", paste(species_probes$Chr, species_probes$Bp, sep = ":"), sep ="")
Coordinates <- species_probes

All samples are from Cortex Entorhinalis region. There are 40 samples, 20 in each genotype where each 5 samples are taken from ages 6 months, 9 months,10 months and 12 months.

Beta regression is used as to find sites with genotype differences. Chip is used as a covariate as some samples on the same chip clustered together on heatmaps. The p values are FDR adjusted to test for significant sites across the genome. Therefore the threshold on manhattan plots are drawn at -log10 0.05. A table of results is given for sites that pass this significant threshold.

Single models

Genotype

\[{Methylation } = {Genotype + Age + Genotype*Age + Chip}\]

# betaResultsChip <- BetaRegressionArray(betas = betas,
#                            pheno = pheno,
#                            formula = ~Genotype + Age_months+ Genotype*Age_months + Chip_ID,
#                            formulaNull = ~Genotype + Age_months+  Chip_ID,
#                            link = "probit")
# 
# save(betaResultsChip, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResults_J20.RData")

load("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResults_J20.RData")
betaResults <- betaResultsChip
# Add chr and bp before deleting rows
Chr <- species_probes$Chr[match(species_probes$probeID, betaResults[,"cpg"])]
Bp <- species_probes$Bp[match(species_probes$probeID, betaResults[,"cpg"])]

betaResults <- cbind(Bp, betaResults)
betaResults <- cbind(Chr, betaResults)

# Remove NA rows
# na_df <- as.data.frame(betaResults[rowSums(is.na(betaResults)) > 0,]) #54 probes has no data in columns
# betaResults <- betaResults[-which(betaResults[,"cpg"] %in% na_df$cpg),] #remove these NAs rows
betaResults <- betaResults[,c(17,1:16)]

# Add FDR pvalues

FDR_adj_genotype <- p.adjust(betaResults[,"p.val.Genotype"], method = "fdr")
FDR_adj_age <- p.adjust(betaResults[,"p.val.Age"], method = "fdr")
FDR_adj_Interaction <- p.adjust(betaResults[,"p.val.Interaction"], method = "fdr")

betaResults <- cbind(betaResults, FDR_adj_genotype, FDR_adj_age, FDR_adj_Interaction)
betaResults <- betaResults[,c(1:10,18,11:13,19,14:17,20)]

# Convert to data frame w/out factors
betaResults2 <- as.data.frame(betaResults)
betaResults2[] <- lapply(betaResults2, as.character)

for(i in 4:20){
  betaResults2[,i] <- as.numeric(as.character(betaResults2[,i]))
}
betaResults2[,"Bp"] <- as.numeric(as.character(betaResults2[,"Bp"]))

betaResults <- betaResults2
# Convert x and y to numbers and remove non autosomal

betaResults<- betaResults[-which(betaResults$Chr %in% c("CHR_MG51_PATCH",
                                                      "CHR_MG4200_PATCH","CHR_MG3699_PATCH")),]
betaResults$Chr <- gsub("X", 20, betaResults$Chr)
betaResults$Chr <- gsub("Y", 21, betaResults$Chr)

betaResults$Chr <- as.numeric(betaResults$Chr)
betaResults$Bp <- as.numeric(betaResults$Bp)

### Add gene names in
mm10_Manifest <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/mm10_Manifest.csv", stringsAsFactors = F, header = T, row.names = 1)

betaResults$Gene_Symbol <- mm10_Manifest$Gene_Symbol[match(betaResults$cpg, mm10_Manifest$cpg)]

# Save to outputs

# write.csv(betaResults, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_stats_table_J20.csv")
# 
# 
# sig_genotype <- betaResults[which(betaResults[,"FDR_adj_genotype"] < 0.05),]
# write.csv(sig_genotype, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_genotype.csv")
# 
# sig_age <- betaResults[which(betaResults[,"FDR_adj_age"] < 0.05),]
# write.csv(sig_age, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_age.csv")
# 
# sig_interaction <- betaResults[which(betaResults[,"FDR_adj_Interaction"] < 0.05),]
# write.csv(sig_interaction, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_interaction.csv")

threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"
rownames(betaResults) <- betaResults$cpg

# Genotype
manhattan(betaResults, p = "FDR_adj_genotype", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Genotype",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold, 
          cex.axis = 1.5, cex.lab = 1.2)

# chromosome problem?
# take chr 10 - 19
# 
# betaResults2 <- betaResults[which(betaResults$Chr == c(10:19)),]
# betaResults2 <- betaResults2[,c(2,3,11)]
# colnames(betaResults2) <- c("CHR", "BP", "P")
# betaResults2$BP = as.integer(format(betaResults2$BP, scientific=F))
# betaResults2$BP <- as.numeric(betaResults2$BP)
# 
# manhattan(betaResults, 
#           genomewide = -log10(threshold), suggestiveline = FALSE, 
#           logp=T)
# 
# manhattan(betaResults2, p = "FDR_adj_genotype", bp = "Bp", chr = "Chr", 
#           genomewide = -log10(threshold), suggestiveline = FALSE, 
#           logp=T, col = c("black", color_J20_TG), main = "Genotype",
#           las = 2, annotatePval = threshold, 
#           cex.axis = 1.5, cex.lab = 1.2)
# 
# for(i in 1:21) {
#   x = sum(is.na(betaResults[which(betaResults$Chr == i),]))
#   print(paste(i, x , sep = " - na:"))
# }
# 
# 
# library(gap)
# ops <- mht.control(colors=rep(c("lightgray","lightblue"),21),srt=0,yline=2.5,xline=2)
# mhtplot(betaResults[,c(2,3,4)])
# mhtplot(betaResults[,c(2,3,11)],ops,xlab="",ylab="",srt=0)
# axis(1,at=1:21)
# axis(2,at=1:16)

lamda <- qchisq(1-median(betaResults$p.val.Genotype),1)/qchisq(0.5,1)
qq(betaResults$p.val.Genotype, main = "Genotype (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_genotype),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_genotype, main = "Genotype (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_genotype),]
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT", "TG"))

## Genotypes = with covariates
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6) {
  # model<-lm(as.numeric(betas[rownames(betaResults)[i],]*100) ~ pheno$AgeMonths + pheno$Chip_ID) ## This needs to include all the confouders from your analysis model but not the vaiable you are interested in.
  # adjValues<-residuals(model)+coefficients(model)[1]
  # boxplot(adjValues ~ pheno$Genotype, xlab = "Genotype", ylab = "DNA methylation (%)", 
  #         main = paste(rownames(beta)[i], betaResults[i,"Gene_Symbol"], sep = " ")) ## we multiple by 100 to plot of a % scale rather than proportion
  # mtext(paste("P = ", signif(betaResults[i, "FDR_adj_genotype"],3)), side = 3, adj = 1, cex = 0.7) ## add P value to plot rounded to 3 sf
    plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
  
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_Genotype.pdf", onefile = T)
for(i in 1:6){
  plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()

## png 
##   2

if(length(which(betaResults$FDR_adj_genotype <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_genotype <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_genotype),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_genotype", "p.val.Genotype","meth.group1.WT",
                             "meth.group2.TG","meth.diff.Genotype" ,"estimate.Genotype","std.error.Genotype")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj.p.val", "raw p.val","meth WT",
                             "meth TG","meth diff" ,"estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}

cpg	Gene Symbol	Chr	Bp	FDR adj.p.val	raw p.val	meth WT	meth TG	meth diff	estimate	std error
cg22786134	Zbtb20	16	143557635	1.388063e-08	5.873412e-13	0.5298406	0.3021011	0.2277396	-0.5932364	0.0823552
cg06658605	Sox6	7	115747711	1.693876e-03	1.433483e-07	0.0688789	0.0533252	0.0155537	-0.1292403	0.0245662
cg16692177	Arx	20	93302229	2.009374e-03	2.550723e-07	0.7420701	0.5636319	0.1784382	-0.4895568	0.0949869
cg12137126	Bnc2	4	84284440	4.998737e-03	1.057576e-06	0.5393577	0.3916911	0.1476666	-0.3737298	0.0765744
cg22663524	Dynlrb2	8	116568832	4.998737e-03	9.198022e-07	0.9604932	0.9721683	-0.0116751	0.1572237	0.0320338
cg24737665	1810030O07Rik	20	12677624	9.170728e-03	2.328285e-06	0.3229701	0.2205363	0.1024338	-0.3109739	0.0658478
cg18877697	Sorcs1	19	150190045	1.768825e-02	5.239189e-06	0.9475681	0.9636657	-0.0160976	0.1731886	0.0380219
cg04989171	Klhl10	11	1100447124	3.061243e-02	1.165793e-05	0.9044784	0.9542121	-0.0497337	0.3796439	0.0865998
cg06179749	A3galt2	4	128743543	3.061243e-02	1.152140e-05	0.8774797	0.9444428	-0.0669631	0.4307245	0.0981943
cg22661567	Pbx3	2	34288768	3.067860e-02	1.298126e-05	0.8422430	0.7372830	0.1049600	-0.3687277	0.0845624
cg00519284	Trim2	3	84193329	4.142527e-02	1.928143e-05	0.9123697	0.9497284	-0.0373587	0.2867330	0.0671026
cg20256450	Ebf1	11	144904276	4.467111e-02	2.268241e-05	0.8654846	0.7844571	0.0810275	-0.3179623	0.0750494

Age

#Age 
manhattan(betaResults, p = "FDR_adj_age", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Age",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold, 
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Age),1)/qchisq(0.5,1)
qq(betaResults$p.val.Age, main = "Age (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_age),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_age, main = "Age (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

Interaction

The individual plots fot sites are the raw methylation values of the samples across ages. The dotted lines are the mean values for across the ages within genotypes.

#Interaction
manhattan(betaResults, p = "FDR_adj_Interaction", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Genotype*Age Interaction",
          chrlabs = c(1:19, "X", "Y"),las = 2, 
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Interaction),1)/qchisq(0.5,1)
qq(betaResults$p.val.Interaction, main = "Genotype*Age Interaction (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_Interaction),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_Interaction, main = "Interaction (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_Interaction),]
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT", "TG"))
pheno$col <-  ifelse(pheno$Genotype == "WT","#000000", color_J20_TG)

SamplesMean <- function(Genotype = Genotype, Age = Age, betas = betas, pheno = pheno, cpg = cpg){
    samples <- rownames(pheno[which(pheno$Genotype == Genotype & pheno$AgeMonths == Age),])
    betas_samples <-  betas[cpg,samples]
    mean_samples <- apply(betas_samples,1, mean)

    return(mean_samples)
  }

geno_age_mean <- matrix(NA, nrow = 4, ncol = 2)
colnames(geno_age_mean) <- c("WT", "TG")
rownames(geno_age_mean) <- c(6,8,10,12)
ages <- c(6,8,10,12)

par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6){
  # for( s in 1:4){
  #   j = ages[s]
  #   geno_age_mean[s,1] <- SamplesMean("WT", j, betas, pheno, cpg = rownames(betaResults)[i])
  #   geno_age_mean[s,2] <- SamplesMean("TG", j, betas, pheno, cpg = rownames(betaResults)[i])
  # }
  # geno_age_mean <- as.data.frame(geno_age_mean)
  # 
  # plot(pheno$AgeMonths, as.numeric(betas[rownames(betaResults)[i],]*100),
  #      xlab = "Age (months)", ylab = "DNA methylation (%)", pch = 16,
  #      main = paste(rownames(betas)[i], betaResults[i,"Gene_Symbol"], sep = " "),
  #      col = pheno$col)
  # lines(as.numeric(rownames(geno_age_mean)), geno_age_mean$WT*100, col = "#000000", lty = 2)
  # lines(as.numeric(rownames(geno_age_mean)), geno_age_mean$TG*100, col = color_J20_TG, lty = 2)
  # 
  # par(xpd  = TRUE)
  # legend(x ="topright",legend = levels(factor(pheno$Genotype)),
  #        col = c("#000000", color_J20_TG), pch = 19, cex = .7,
  #        inset=c(-0.02,-0.25))
  # 
  # par(xpd  = FALSE)
  # mtext(paste("P = ", signif(betaResults[i, "FDR_adj_Interaction"],3)), side = 3, adj = 1, cex = 0.7) ## add P value to plot rounded to 3 sf
  
    plotDMPInteraction(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
  
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_Interaction.pdf", onefile = T)
for(i in 1:6){
  plotDMPInteraction(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()

## png 
##   2

Pathology

\[{Methylation } = {Pathology + Chip}\]

# betaResultsPathology <- BetaRegressionArrayPathology(betas = betas,
#                                                      pheno = pheno,
#                                                      formula = ~Pathology_ECX + Chip_ID,
#                                                      link = "probit")
# resave(betaResultsPathology, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResults_J20.RData")

betaResults <- betaResultsPathology
# Add chr and bp before deleting rows
Chr <- species_probes$Chr[match(species_probes$probeID, betaResults[,"cpg"])]
Bp <- species_probes$Bp[match(species_probes$probeID, betaResults[,"cpg"])]

betaResults <- cbind(Bp, betaResults)
betaResults <- cbind(Chr, betaResults)

# Remove NA rows
# na_df <- as.data.frame(betaResults[rowSums(is.na(betaResults)) > 0,]) #54 probes has no data in columns
# betaResults <- betaResults[-which(betaResults[,"cpg"] %in% na_df$cpg),] #remove these NAs rows
betaResults <- betaResults[,c(10,1:9)]

# Add FDR pvalues

FDR_adj_pathology <- p.adjust(betaResults[,"p.val.Pathology"], method = "fdr")

betaResults <- cbind(betaResults, FDR_adj_pathology)
betaResults <- betaResults[,c(1:4,11,5:10)]

# Convert to data frame w/out factors
betaResults2 <- as.data.frame(betaResults)
betaResults2[] <- lapply(betaResults2, as.character)

for(i in 4:11){
  betaResults2[,i] <- as.numeric(as.character(betaResults2[,i]))
}
betaResults2[,"Bp"] <- as.numeric(as.character(betaResults2[,"Bp"]))
betaResults2[,"cpg"] <- as.character(betaResults2[,"cpg"]) 
betaResults <- betaResults2

# Convert x and y to numbers and remove non autosomal

betaResults<- betaResults[-which(betaResults$Chr %in% c("CHR_MG51_PATCH",
                                                      "CHR_MG4200_PATCH","CHR_MG3699_PATCH")),]
betaResults$Chr <- gsub("X", 20, betaResults$Chr)
betaResults$Chr <- gsub("Y", 21, betaResults$Chr)

betaResults$Chr <- as.numeric(betaResults$Chr)
betaResults$Bp <- as.numeric(betaResults$Bp)

### Add gene names in
mm10_Manifest <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/mm10_Manifest.csv", stringsAsFactors = F, header = T, row.names = 1)

betaResults$Gene_Symbol <- mm10_Manifest$Gene_Symbol[match(betaResults$cpg, mm10_Manifest$cpg)]

threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"


# Pathology
manhattan(betaResults, p = "FDR_adj_pathology", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Pathology",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold,
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Pathology),1)/qchisq(0.5,1)
qq(betaResults$p.val.Pathology, main = "Pathology (Raw pvalue")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_pathology),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_pathology, main = "Pathology (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_pathology),]
rownames(betaResults) <- betaResults$cpg

pheno$col <-  ifelse(pheno$Genotype == "WT","#000000", color_J20_TG )

## Pathologys
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6){
  plot(pheno$Pathology_ECX, as.numeric(betas[rownames(betaResults)[i],]*100),
       xlab = "Pathology", ylab = "DNA methylation (%)", pch = 16,
       main = paste(rownames(betas)[i], betaResults[i,"Gene_Symbol"], sep = " "),
       col = pheno$col) ## we multiple by 100 to plot of a % scale rather than proportion
  ## to add line of best fit
  mtext(paste("P = ", signif(betaResults[i, "FDR_adj_pathology"],3)), side = 3, adj = 0, cex = .7) ## add P value to plot rounded to 3 sf
   par(xpd  = TRUE)
  legend(x ="topright",legend = levels(factor(pheno$Genotype)),
         col = c("#000000",color_J20_TG), pch = 19, cex = .7,
         inset=c(-0.02,-0.25))
}

for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/J20_Pathology.pdf", onefile = T)
for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()

## png 
##   2

if(length(which(betaResults$FDR_adj_pathology <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_pathology <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_pathology),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_pathology", "p.val.Pathology",
                                  "estimate.Pathology","std.error.Pathology")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj p.val", "raw p.val",
                                  "estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}

cpg	Gene Symbol	Chr	Bp	FDR adj p.val	raw p.val	estimate	std error
cg02545439	Galnt16	12	180519195	3.412469e-04	1.443942e-08	0.3943410	0.0695721
cg16925284	Gm49450	15	198953551	4.290696e-03	7.193895e-07	0.3146902	0.0634961
cg24084896	D930028M14Rik	7	25163644	4.290696e-03	3.674663e-07	-0.2369138	0.0465900
cg25506728	Angpt1	15	142676311	4.290696e-03	7.262211e-07	0.2310496	0.0466369
cg06132693	Cnnm2	19	146762741	6.054642e-03	1.537166e-06	0.3328378	0.0692497
cg12387067	Anp32a	9	62341431	6.054642e-03	1.515291e-06	0.7978006	0.1658902
cg06602723	Hoxb8	11	196281684	1.595818e-02	4.726749e-06	0.4885969	0.1067606
cg03302758	Bcl6	16	123988550	1.664106e-02	8.065077e-06	0.2471026	0.0553613
cg03678139	Foxo6	4	120282578	1.664106e-02	8.449743e-06	0.2861854	0.0642614
cg12321152	Cnot9	1	74528774	1.664106e-02	5.848681e-06	-0.6334014	0.1397686
cg13985448	Tal1	4	115056666	1.664106e-02	6.404150e-06	0.1164221	0.0257994
cg14449811	Zfp692	11	158307741	1.664106e-02	7.487148e-06	0.2112247	0.0471552
cg11059410	Grik4	9	42897147	1.793359e-02	9.864878e-06	0.3144388	0.0711382
cg12712534	Cdh18	15	123460471	1.874060e-02	1.110178e-05	-0.3159684	0.0719005
cg09127786	Pou3f2	4	22487042	1.917475e-02	1.217032e-05	0.6658760	0.1522171
cg00010926	Pak3	20	143712313	1.961941e-02	1.494306e-05	-0.2345508	0.0541747
cg03934905	Tbr1	2	61806057	1.961941e-02	1.423275e-05	0.3825715	0.0881453
cg03957108	Otx1	11	122003031	1.961941e-02	1.457962e-05	0.4974932	0.1147634
cg20465666	Hoxc8	15	1102983967	2.075204e-02	1.755542e-05	0.5330550	0.1241421
cg22747196	Cux1	5	136605656	2.075204e-02	1.756191e-05	-0.2840638	0.0661563
cg00418090	Otx1	11	122053469	2.103896e-02	1.955754e-05	-0.4009728	0.0939072
cg03873904	Hoxc8	15	1102991177	2.103896e-02	1.958520e-05	0.5701313	0.1335337
cg26219540	Nr2f1	13	178181730	2.728389e-02	2.655310e-05	0.3995987	0.0951159
cg01537787	Onecut2	18	164340362	2.861036e-02	2.905465e-05	0.2866889	0.0685735
cg13944639	Fgf5	5	98254696	4.313427e-02	4.562928e-05	0.2991734	0.0733816
cg23442353	Csmd3	15	148791971	4.838120e-02	5.322689e-05	0.6049330	0.1496993

#save outputs

# write.csv(betaResults, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_stats_table_J20_Pathology.csv")
# 
# 
# sig_pathology <- betaResults[which(betaResults[,"FDR_adj_pathology"] < 0.05),]
# write.csv(sig_pathology, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_J20_sig_pathology.csv")

Full model

\[{Methylation } = {Genotype + Age + Pathology + Chip}\]

# betaResultsChip <- BetaRegressionFullModel(betas = betas,
#                            pheno = pheno,
#                            formula = ~Genotype + Age_months+ Pathology_ECX + Chip_ID,
#                            link = "probit")
# 
# save(betaResultsChip, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResultsFull_J20.RData")

load("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/ArrayBetaRegResultsFull_J20.RData")
betaResults <- betaResultsChip
# Add chr and bp before deleting rows
Chr <- species_probes$Chr[match(species_probes$probeID, betaResults[,"cpg"])]
Bp <- species_probes$Bp[match(species_probes$probeID, betaResults[,"cpg"])]

betaResults <- cbind(Bp, betaResults)
betaResults <- cbind(Chr, betaResults)



# Add FDR pvalues

FDR_adj_genotype <- p.adjust(betaResults[,"p.val.Genotype"], method = "fdr")
FDR_adj_age <- p.adjust(betaResults[,"p.val.Age"], method = "fdr")
FDR_adj_pathology <- p.adjust(betaResults[,"p.val.Pathology"], method = "fdr")

betaResults <- cbind(betaResults, FDR_adj_genotype, FDR_adj_age, FDR_adj_pathology)
betaResults <- betaResults[,c(16,1:15,17:19)]
# Convert to data frame w/out factors
betaResults2 <- as.data.frame(betaResults)
betaResults2[] <- lapply(betaResults2, as.character)

for(i in 3:ncol(betaResults2)){
  betaResults2[,i] <- as.numeric(as.character(betaResults2[,i]))
}
betaResults2[,"Bp"] <- as.numeric(as.character(betaResults2[,"Bp"]))

betaResults <- betaResults2
# Convert x and y to numbers and remove non autosomal

betaResults<- betaResults[-which(betaResults$Chr %in% c("CHR_MG51_PATCH",
                                                      "CHR_MG4200_PATCH","CHR_MG3699_PATCH")),]
betaResults$Chr <- gsub("X", 20, betaResults$Chr)
betaResults$Chr <- gsub("Y", 21, betaResults$Chr)

betaResults$Chr <- as.numeric(betaResults$Chr)
betaResults$Bp <- as.numeric(betaResults$Bp)

### Add gene names in
mm10_Manifest <- read.csv("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/mm10_Manifest.csv", stringsAsFactors = F, header = T, row.names = 1)

betaResults$Gene_Symbol <- mm10_Manifest$Gene_Symbol[match(betaResults$cpg, mm10_Manifest$cpg)]

Genotype

threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"
rownames(betaResults) <- betaResults$cpg

# Genotype
manhattan(betaResults, p = "FDR_adj_genotype", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Genotype",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotatePval = threshold, 
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Genotype),1)/qchisq(0.5,1)
qq(betaResults$p.val.Genotype, main = "Genotype (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_genotype),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_genotype, main = "Genotype (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_genotype),]
pheno$Genotype <- factor(pheno$Genotype, levels = c("WT", "TG"))

## Genotypes = with covariates
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6) {
  # model<-lm(as.numeric(betas[rownames(betaResults)[i],]*100) ~ pheno$AgeMonths + pheno$Chip_ID) ## This needs to include all the confouders from your analysis model but not the vaiable you are interested in.
  # adjValues<-residuals(model)+coefficients(model)[1]
  # boxplot(adjValues ~ pheno$Genotype, xlab = "Genotype", ylab = "DNA methylation (%)", 
  #         main = paste(rownames(beta)[i], betaResults[i,"Gene_Symbol"], sep = " ")) ## we multiple by 100 to plot of a % scale rather than proportion
  # mtext(paste("P = ", signif(betaResults[i, "FDR_adj_genotype"],3)), side = 3, adj = 1, cex = 0.7) ## add P value to plot rounded to 3 sf
    plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
  
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/FullJ20_Genotype.pdf", onefile = T)
for(i in 1:6){
  plotDMPGenotype(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()

## png 
##   2

if(length(which(betaResults$FDR_adj_genotype <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_genotype <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_genotype),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_genotype", "p.val.Genotype","meth.group1.WT",
                             "meth.group2.TG","meth.diff.Genotype" ,"estimate.Genotype","std.error.Genotype")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj.p.val", "raw p.val","meth WT",
                             "meth TG","meth diff" ,"estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}

cpg	Gene Symbol	Chr	Bp	FDR adj.p.val	raw p.val	meth WT	meth TG	meth diff	estimate	std error
cg22786134	Zbtb20	16	143557635	2.839786e-102	1.201619e-106	0.5238258	0.3078391	0.2159867	-0.5617427	0.0256093
cg20595744	Gm15713	16	143410500	3.619690e-06	3.063251e-10	0.7887624	0.6996672	0.0890952	-0.2786907	0.0442679
cg27454350	Zbtb20	16	143098352	5.977849e-06	7.588349e-10	0.6418101	0.5647587	0.0770513	-0.2002557	0.0325444
cg11125461	Gm15713	16	143410464	3.288648e-05	5.566197e-09	0.5780648	0.4196300	0.1584349	-0.3997856	0.0685821
cg16113843	Iars	13	149706731	1.829845e-04	4.113484e-08	0.6270249	0.6654158	-0.0383909	0.1033057	0.0188311
cg27403476	Syt7	19	110397989	1.829845e-04	4.645653e-08	0.4367795	0.4664223	-0.0296428	0.0748731	0.0137021
cg13484596	Zbtb20	16	143122445	4.702376e-04	1.392825e-07	0.6954886	0.6097983	0.0856903	-0.2326756	0.0441829
cg21479658	Stag1	9	100757692	5.745184e-04	1.944800e-07	0.9407243	0.9298658	0.0108584	-0.0860901	0.0165414
cg08416404	Zbtb20	16	143122487	6.987306e-04	2.660930e-07	0.7217685	0.6363823	0.0853862	-0.2392978	0.0465017
cg02175825	Mms22l	4	23753322	1.722940e-03	7.290400e-07	0.9455830	0.9306330	0.0149501	-0.1229345	0.0248179
cg10581670	Faxc	4	22134234	2.348222e-03	1.092982e-06	0.8845655	0.8494533	0.0351122	-0.1640319	0.0336537
cg12137126	Bnc2	4	84284440	2.689792e-03	1.365781e-06	0.4967224	0.4434707	0.0532518	-0.1339598	0.0277353
cg12958309	Prcp	7	93023579	2.840230e-03	1.562349e-06	0.9307203	0.9101488	0.0205715	-0.1395051	0.0290449
cg16211444	Kdr	5	75974765	3.145668e-03	1.996573e-06	0.8311615	0.8045222	0.0266393	-0.1008796	0.0212210
cg25400358	Gpr137	19	16940676	3.145668e-03	1.888711e-06	0.3725133	0.4051138	-0.0326006	0.0850718	0.0178535
cg26056424	Lsamp	16	142134394	3.655871e-03	2.475096e-06	0.8605650	0.8238443	0.0367207	-0.1527461	0.0324290
cg10259984	Hif1an	19	144631546	5.134827e-03	3.693651e-06	0.7518206	0.8044994	-0.0526789	0.1775733	0.0383700
cg06182411	Rnf220	4	117492727	5.952079e-03	4.533382e-06	0.7872017	0.8156654	-0.0284637	0.1022195	0.0222929
cg05932603	Mier1	4	103115647	6.491168e-03	5.218643e-06	0.5009216	0.5510423	-0.0501206	0.1259849	0.0276537
cg03471163	4922502N22Rik	6	139293940	7.062166e-03	5.976529e-06	0.7588559	0.7982282	-0.0393723	0.1326821	0.0293076
cg08656426	Gm15713	16	143410634	7.603103e-03	7.077742e-06	0.5427007	0.4490743	0.0936265	-0.2352406	0.0523765
cg24882108	Vrk2	11	126815320	7.603103e-03	6.793335e-06	0.5285117	0.5747108	-0.0461991	0.1168514	0.0259666
cg17803853	Tshz2	2	169832358	8.429566e-03	8.203783e-06	0.9497590	0.9581028	-0.0083438	0.0865607	0.0194091
cg09374953	Ntm	9	29963230	9.057998e-03	9.490044e-06	0.2349023	0.2606353	-0.0257330	0.0814091	0.0183831
cg18938096	D030025E07Rik	3	128512077	9.057998e-03	9.581939e-06	0.7014092	0.6369681	0.0644411	-0.1780917	0.0402340
cg19751323	Cnnm2	19	146848643	1.066884e-02	1.173739e-05	0.6889091	0.6115550	0.0773540	-0.2093862	0.0477788
cg08906488	Emx2	19	159466097	1.144460e-02	1.307512e-05	0.4898986	0.4209032	0.0689955	-0.1742604	0.0399786
cg01079397.2	Nipbl	15	18444274	1.156653e-02	1.406436e-05	0.6249705	0.6813205	-0.0563500	0.1528329	0.0351918
cg05564167	Foxo6	4	120259922	1.156653e-02	1.490276e-05	0.2343866	0.2791339	-0.0447473	0.1390602	0.0321146
cg14778330	Sox12	2	152396680	1.156653e-02	1.517210e-05	0.1109299	0.0943091	0.0166208	-0.0930802	0.0215156
cg18271715	A830082K12Rik	13	178451535	1.156653e-02	1.432658e-05	0.7910646	0.8151571	-0.0240925	0.0869414	0.0200381
cg23692214	Zranb1	7	132949952	1.217960e-02	1.649165e-05	0.9233697	0.9330386	-0.0096689	0.0707022	0.0164128
cg01122656	Tsc2	17	124601401	1.242508e-02	2.192944e-05	0.5403463	0.5787357	-0.0383894	0.0973539	0.0229377
cg04272551	Hes1	16	130070353	1.242508e-02	2.212113e-05	0.0422949	0.0346338	0.0076611	-0.0920167	0.0216901
cg04609342	Ankrd11	8	122900647	1.242508e-02	2.033288e-05	0.7954745	0.8292595	-0.0337850	0.1256782	0.0294936
cg05176833	Dock3	9	106908482	1.242508e-02	2.260731e-05	0.9399689	0.9261055	0.0138634	-0.1071268	0.0252810
cg05200513	4933407E24Rik	4	124595060	1.242508e-02	2.152649e-05	0.1571185	0.1971223	-0.0400038	0.1544261	0.0363489
cg06490500	Clk4	11	151273070	1.242508e-02	2.234277e-05	0.6185218	0.6652710	-0.0467491	0.1252910	0.0295491
cg18663956	Casz1	4	148748300	1.242508e-02	1.794431e-05	0.9543674	0.9390646	0.0153027	-0.1417918	0.0330591
cg21160194	Vrk2	11	126815350	1.242508e-02	2.066124e-05	0.5863435	0.6558063	-0.0694629	0.1828956	0.0429572
cg25517295	Hnrnpk	13	158397883	1.242508e-02	2.230483e-05	0.3209971	0.3642007	-0.0432036	0.1176596	0.0277468
cg25709794	Zfhx3	8	107960787	1.242508e-02	2.003724e-05	0.8980618	0.8725941	0.0254677	-0.1318453	0.0309171
cg26912563	Pax6	2	105665147	1.242508e-02	1.877546e-05	0.7870539	0.7390946	0.0479593	-0.1556840	0.0363835
cg02861868	Ccar1	10	162764365	1.295826e-02	2.467405e-05	0.8187115	0.8362630	-0.0175515	0.0687488	0.0162998
cg02864518	Luc7l2	6	38568909	1.295826e-02	2.415197e-05	0.5420489	0.6028733	-0.0608244	0.1551945	0.0367535
cg06658605	Sox6	7	115747711	1.350222e-02	2.723727e-05	0.0646320	0.0599648	0.0046672	-0.0380583	0.0090714
cg19298873	Tbca	13	194707080	1.350222e-02	2.742381e-05	0.1176021	0.1507560	-0.0331539	0.1538629	0.0366876
cg26395444	Arih1	9	59392677	1.350222e-02	2.638541e-05	0.9610444	0.9688741	-0.0078297	0.1015614	0.0241663
cg06186797	Arx	20	93253878	1.418797e-02	2.941694e-05	0.9311491	0.9398556	-0.0087064	0.0691580	0.0165532
cg03937152	Meis2	2	115866234	1.615323e-02	3.423360e-05	0.9002087	0.8793000	0.0209087	-0.1112470	0.0268498
cg15889033	Tbc1d2b	9	90226116	1.615323e-02	3.485865e-05	0.6809404	0.7155795	-0.0346392	0.0994293	0.0240216
cg05758851	4930441J16Rik	2	74272815	1.618170e-02	3.560480e-05	0.8238279	0.8469768	-0.0231489	0.0935013	0.0226160
cg02166926	Fign	2	63981627	1.733083e-02	3.886658e-05	0.6949686	0.7182670	-0.0232984	0.0677172	0.0164597
cg07475226	Fbxo33	12	159202451	1.780577e-02	4.068512e-05	0.9276624	0.9383882	-0.0107258	0.0827826	0.0201734
cg00249321	Ush2a	1	188885043	1.957584e-02	4.599195e-05	0.5188421	0.5797482	-0.0609061	0.1540017	0.0377908
cg09176584	Lncbate1	8	108301392	1.957584e-02	4.638628e-05	0.2928150	0.3245937	-0.0317787	0.0902882	0.0221668
cg07948593	Zfp536	7	37689733	2.029648e-02	4.895270e-05	0.4515545	0.4888026	-0.0372481	0.0936633	0.0230665
cg17662507	Samd4	14	147052885	2.096172e-02	5.144416e-05	0.9364994	0.9197802	0.0167192	-0.1224398	0.0302398
cg18409580	Ccar1	10	162764505	2.118563e-02	5.289012e-05	0.9089436	0.9202493	-0.0113057	0.0724726	0.0179278
cg10983579	Gm14015	2	106577167	2.134357e-02	5.418755e-05	0.8126562	0.7789934	0.0336628	-0.1189289	0.0294613
cg01740606	Snora43	2	26636165	2.139708e-02	5.635272e-05	0.6103841	0.6503436	-0.0399595	0.1059281	0.0263007
cg19850445	Bcl9l	9	44500948	2.139708e-02	5.597529e-05	0.7251664	0.7657001	-0.0405337	0.1265003	0.0313962
cg25326950	Ptch1	13	163554990	2.139708e-02	5.703957e-05	0.9122030	0.8926159	0.0195871	-0.1138860	0.0282965
cg11719502	Sox2ot	3	34443847	2.160679e-02	5.851285e-05	0.5635815	0.6076905	-0.0441090	0.1132487	0.0281802
cg03100301	1700057H15Rik	4	124375613	2.176580e-02	7.179714e-05	0.8198052	0.7841941	0.0356111	-0.1281865	0.0322867
cg05174060	Kmt2b	7	30583455	2.176580e-02	6.770234e-05	0.7065365	0.7502072	-0.0436707	0.1318474	0.0330924
cg07237683	Arf6	12	169373008	2.176580e-02	6.588010e-05	0.1788442	0.2028218	-0.0239776	0.0881944	0.0221000
cg09496347	Bcor	20	12137509	2.176580e-02	6.990949e-05	0.3439306	0.3710155	-0.0270849	0.0725942	0.0182554
cg09497746	Cdx2	5	147307334	2.176580e-02	6.606506e-05	0.0341120	0.0435342	-0.0094223	0.1124565	0.0281844
cg10874497	Dmrt3	19	125608157	2.176580e-02	7.132287e-05	0.1994068	0.1569961	0.0424107	-0.1631386	0.0410739
cg13044883	Calcoco1	15	1102694513	2.176580e-02	6.710924e-05	0.3280490	0.2715931	0.0564559	-0.1626950	0.0408135
cg13721745	Slc6a5	7	49914687	2.176580e-02	7.183736e-05	0.2485232	0.2772656	-0.0287424	0.0881605	0.0222060
cg15026078	Maf	8	115705930	2.176580e-02	7.094103e-05	0.0502403	0.0434514	0.0067889	-0.0694384	0.0174771
cg16573364	Mef2c	13	183662407	2.176580e-02	6.229927e-05	0.5358787	0.5741173	-0.0382386	0.0968102	0.0241788
cg18149408	Mef2c	13	183663715	2.176580e-02	6.392031e-05	0.5825582	0.6439007	-0.0613426	0.1604628	0.0401373
cg19090691	Nkx2-3	19	143616760	2.176580e-02	6.083111e-05	0.0644402	0.0845719	-0.0201317	0.1435714	0.0358073
cg26438184	Dennd5b	6	149032497	2.176580e-02	7.172680e-05	0.7663515	0.7922453	-0.0258938	0.0873525	0.0220005
cg27356290	Kdm2a	19	14317872	2.176580e-02	6.585563e-05	0.9051056	0.9181879	-0.0130823	0.0817813	0.0204926
cg12814030	Zfp219	14	152008734	2.189488e-02	7.318984e-05	0.6477406	0.6948260	-0.0470853	0.1303490	0.0328693
cg08926137	Jarid2	13	144840826	2.237373e-02	7.573724e-05	0.0635857	0.0779772	-0.0143915	0.1065413	0.0269213
cg22253511	Cenpv	11	162536327	2.338707e-02	8.015709e-05	0.7127996	0.7586615	-0.0458619	0.1404213	0.0356044
cg26966072	Tmem114	16	18048535	2.355714e-02	8.173679e-05	0.9010807	0.8851530	0.0159276	-0.0865860	0.0219803
cg19977128	Ptch1	13	163554974	2.504278e-02	8.901086e-05	0.9101235	0.8875757	0.0225478	-0.1277800	0.0326074
cg26555185	D130009I18Rik	14	1104864151	2.504278e-02	8.886645e-05	0.4032751	0.3371070	0.0661681	-0.1754928	0.0447784
cg17365200	Wnk4	11	1101276836	2.522384e-02	9.072171e-05	0.3774116	0.4177815	-0.0403699	0.1047138	0.0267526
cg05555567	Lrmda	14	122155795	2.523831e-02	9.717099e-05	0.8008114	0.7557122	0.0450992	-0.1519469	0.0389852
cg07565103	Satb1	17	151803602	2.523831e-02	9.700563e-05	0.9176495	0.9272437	-0.0095942	0.0661324	0.0169659
cg17790227	Klhl32	4	24631504	2.523831e-02	9.718132e-05	0.4214954	0.4782027	-0.0567073	0.1434043	0.0367937
cg19222351	Nt5e	9	88069132	2.523831e-02	9.643342e-05	0.5400263	0.5728201	-0.0327938	0.0830584	0.0213003
cg21353753	Rps6ka3	20	159303254	2.523831e-02	9.642779e-05	0.9115570	0.8923590	0.0191980	-0.1112338	0.0285258
cg23720877	Taok3	5	117251049	2.523831e-02	9.628105e-05	0.4116886	0.4432738	-0.0315852	0.0805295	0.0206498
cg00349375	Zbtb20	16	143504369	2.550116e-02	1.019393e-04	0.1446153	0.1207299	0.0238853	-0.1115345	0.0287022
cg03523528	Cxxc5	18	135855704	2.550116e-02	1.000601e-04	0.4034178	0.4333087	-0.0298910	0.0765539	0.0196774
cg20202533	Kdm5c	20	152223244	2.550116e-02	1.008059e-04	0.6871317	0.7150229	-0.0278912	0.0803825	0.0206711
cg27052685	Pantr1	1	41919060	2.550116e-02	1.025096e-04	0.7949991	0.8248385	-0.0298395	0.1100727	0.0283359
cg01186017	Gm30731	4	22971304	2.635932e-02	1.070746e-04	0.7713003	0.7359004	0.0353999	-0.1123786	0.0290086
cg19257233	Zfp423	8	87873326	2.660363e-02	1.091927e-04	0.9670174	0.9580527	0.0089647	-0.1101377	0.0284652
cg03516596	5730522E02Rik	11	125855571	2.662561e-02	1.104096e-04	0.2834664	0.2216045	0.0618619	-0.1942110	0.0502292
cg09478405	Meis2	2	116001144	2.682395e-02	1.123671e-04	0.8981025	0.8780070	0.0200955	-0.1057319	0.0273760
cg01578720	Tbca	13	194707109	2.689447e-02	1.138005e-04	0.0811704	0.1202448	-0.0390743	0.2234778	0.0579091
cg10654251	Arx	20	93310099	2.733899e-02	1.203087e-04	0.9176925	0.8999695	0.0177231	-0.1083390	0.0281730
cg16915042	Kctd16	18	140260993	2.733899e-02	1.198614e-04	0.6834906	0.7300617	-0.0465711	0.1355174	0.0352322
cg20425337	Gm15713	16	143410472	2.733899e-02	1.186556e-04	0.5687901	0.4963969	0.0723932	-0.1823265	0.0473712
cg20945212	Ppp2r2b	18	142741144	2.733899e-02	1.196994e-04	0.7315876	0.6864934	0.0450943	-0.1316867	0.0342333
cg14678919	Gpr151	18	142738000	2.776436e-02	1.280546e-04	0.9446965	0.9318489	0.0128476	-0.1057670	0.0276142
cg21226616	Epc2	2	49548658	2.776436e-02	1.250549e-04	0.8531166	0.8811528	-0.0280362	0.1308752	0.0341176
cg22044758	Dlx6os1	6	6869472	2.776436e-02	1.274422e-04	0.4234609	0.3729798	0.0504811	-0.1309240	0.0341718
cg22490018	Hoxc9	15	1102975432	2.776436e-02	1.234778e-04	0.4576009	0.4314558	0.0261452	-0.0661895	0.0172408
cg26276608	Pds5a	5	65628105	2.776436e-02	1.271719e-04	0.8824376	0.8676455	0.0147922	-0.0719310	0.0187718
cg01955745	Ntm	9	29963226	2.784449e-02	1.307806e-04	0.1575273	0.1820087	-0.0244814	0.0969359	0.0253428
cg27559875	Slc25a37	14	169247600	2.784449e-02	1.306117e-04	0.4238895	0.3713467	0.0525428	-0.1363356	0.0356405
cg12195518	Fign	2	63979068	2.849021e-02	1.350190e-04	0.9395192	0.9473817	-0.0078625	0.0692297	0.0181366
cg04501234	Nhsl2	20	102076198	2.890092e-02	1.411625e-04	0.9315697	0.9408489	-0.0092791	0.0743551	0.0195357
cg19478904	Ankrd52	10	1128378126	2.890092e-02	1.390115e-04	0.2607236	0.2962307	-0.0355070	0.1058434	0.0277810
cg21677205	Dazap2	15	1100620645	2.890092e-02	1.405099e-04	0.5029567	0.5225381	-0.0195814	0.0491133	0.0128999
cg22454306	Skap2	6	51847017	2.890092e-02	1.418570e-04	0.7968241	0.8209473	-0.0241232	0.0886505	0.0232990
cg02070745	Iars	13	149706790	2.954071e-02	1.494349e-04	0.7348873	0.7787281	-0.0438408	0.1402427	0.0369838
cg03342744	Mir10a	11	196317269	2.954071e-02	1.509820e-04	0.6402314	0.5752446	0.0649868	-0.1693348	0.0446859
cg08911427	Mir6976	17	146553677	2.954071e-02	1.497714e-04	0.4049478	0.4369894	-0.0320416	0.0819540	0.0216155
cg10784922	Hdac8	20	102402632	2.954071e-02	1.512472e-04	0.8989316	0.9161579	-0.0172263	0.1041961	0.0274995
cg22584556	Qk	17	110209484	2.954071e-02	1.506240e-04	0.5014664	0.5518522	-0.0503859	0.1266667	0.0334210
cg21056089	Gapdh	6	125160566	2.980110e-02	1.538414e-04	0.4668060	0.4956379	-0.0288319	0.0723669	0.0191205
cg05092810	Nkx2-2os	2	147184058	2.999061e-02	1.598958e-04	0.0750036	0.0601339	0.0148696	-0.1141440	0.0302354
cg07254551	Epn2	11	161544247	2.999061e-02	1.598048e-04	0.7882907	0.8209626	-0.0326719	0.1185353	0.0313975
cg19635296	Lmo4	3	144195343	2.999061e-02	1.580771e-04	0.7632717	0.7131869	0.0500848	-0.1541472	0.0408010
cg20198417	Ebf3	7	137306981	2.999061e-02	1.568489e-04	0.6539657	0.7044785	-0.0505128	0.1412758	0.0373749
cg22204849	Fgfr2	7	130198480	3.012320e-02	1.618773e-04	0.9330218	0.9472945	-0.0142726	0.1204870	0.0319416
cg02737031	Dmd	20	84225999	3.115889e-02	1.687614e-04	0.6789543	0.6392433	0.0397110	-0.1083398	0.0288007
cg25375926	Mef2c	13	183662574	3.119913e-02	1.702995e-04	0.3347329	0.3738545	-0.0391216	0.1052197	0.0279882
cg08935648	4933407E24Rik	4	124595004	3.142541e-02	1.728643e-04	0.1611944	0.1927209	-0.0315266	0.1216478	0.0323903
cg20314902	Odf2	2	29893486	3.165151e-02	1.754473e-04	0.8471650	0.8628216	-0.0156567	0.0687346	0.0183196
cg09978510	Ythdf2	4	132204160	3.170773e-02	1.778101e-04	0.3467916	0.3860939	-0.0393023	0.1044827	0.0278723
cg25793931	Emx2	19	159466367	3.170773e-02	1.784424e-04	0.4630094	0.4200100	0.0429994	-0.1090129	0.0290877
cg00243488	4933407E24Rik	4	124595073	3.297200e-02	1.869525e-04	0.1699549	0.2217786	-0.0518236	0.1881430	0.0503592
cg19945696	Dnajc24	2	106074573	3.303201e-02	1.886904e-04	0.7161543	0.7577750	-0.0416207	0.1277085	0.0342043
cg07997719	Zbtb20	16	143503766	3.308144e-02	1.903726e-04	0.4770282	0.4129075	0.0641208	-0.1624587	0.0435376
cg07000689	Csnk1a1	18	161571809	3.341910e-02	1.937298e-04	0.8589499	0.8760496	-0.0170997	0.0798499	0.0214244
cg06075167	Igf1r	7	68193593	3.468159e-02	2.054510e-04	0.8096784	0.8426114	-0.0329331	0.1285370	0.0346254
cg17311369	Gm3279	6	55704259	3.468159e-02	2.052094e-04	0.6886093	0.7436791	-0.0550698	0.1628176	0.0438564
cg19115817	Papolg	11	123870836	3.468159e-02	2.039965e-04	0.9288363	0.9359899	-0.0071536	0.0547768	0.0147487
cg01136078	Foxo6	4	120267142	3.584735e-02	2.138737e-04	0.4011381	0.4515193	-0.0503812	0.1285785	0.0347318
cg20521676	Parva	7	112572874	3.601923e-02	2.164233e-04	0.8923733	0.8533159	0.0390574	-0.1884873	0.0509558
cg00773909	Mir196a-2	15	1102972145	3.657684e-02	2.291140e-04	0.3657644	0.3053226	0.0604418	-0.1660602	0.0450694
cg01901100	Apob	12	18108745	3.657684e-02	2.280691e-04	0.8404335	0.7945103	0.0459232	-0.1740698	0.0472283
cg22316499	C1d	11	117450891	3.657684e-02	2.240076e-04	0.6871698	0.7287535	-0.0415838	0.1212038	0.0328441
cg22532263	Zfp536	7	37180448	3.657684e-02	2.306076e-04	0.6683045	0.7173684	-0.0490640	0.1398056	0.0379609
cg25642165	Atxn2l	7	126492770	3.657684e-02	2.254222e-04	0.5436068	0.5764616	-0.0328548	0.0833249	0.0225894
cg26521186	Zbtb18	1	177447208	3.657684e-02	2.299312e-04	0.2916732	0.3367541	-0.0450809	0.1271652	0.0345217
cg27224831	Mamld1	20	71054025	3.657684e-02	2.223221e-04	0.6980457	0.7283510	-0.0303052	0.0890452	0.0241171
cg11011976	Ctnna2	6	76902439	3.686345e-02	2.344560e-04	0.9342175	0.9187439	0.0154736	-0.1112869	0.0302520
cg13545911	Mir9-3hg	7	79549161	3.686345e-02	2.386539e-04	0.6133210	0.5876083	0.0257127	-0.0665884	0.0181235
cg18506907	Msr1	8	39746398	3.686345e-02	2.384908e-04	0.5471902	0.5847455	-0.0375553	0.0954834	0.0259867
cg19489133	Gm19466	18	153693469	3.686345e-02	2.376792e-04	0.5084408	0.5361520	-0.0277113	0.0695846	0.0189336
cg03917189	Tcf4	18	169516558	3.780166e-02	2.487985e-04	0.4154034	0.4720571	-0.0566536	0.1435670	0.0391885
cg09122966	NA	9	51279844	3.780166e-02	2.480977e-04	0.9321844	0.9210505	0.0111339	-0.0800859	0.0218562
cg18717421	NA	17	132360251	3.780166e-02	2.495265e-04	0.0403221	0.0475263	-0.0072042	0.0776335	0.0211954
cg17416197	Mir148a	6	51088987	3.783821e-02	2.529699e-04	0.3860008	0.3394331	0.0465677	-0.1242530	0.0339560
cg21220963	Hsfy2	1	56800931	3.783821e-02	2.521937e-04	0.6480233	0.6971284	-0.0491051	0.1361699	0.0372047
cg01085196	5730522E02Rik	11	125855605	3.809073e-02	2.562698e-04	0.5683207	0.6052612	-0.0369405	0.0948887	0.0259549
cg03603703	Mpped2	2	106699448	3.846202e-02	2.603953e-04	0.5447236	0.5897026	-0.0449791	0.1144389	0.0313375
cg11586890	Zbtb9	17	126971176	3.930881e-02	2.677916e-04	0.5253514	0.5476972	-0.0223458	0.0562560	0.0154354
cg21247898	Sp8	12	1118720311	3.968732e-02	2.720495e-04	0.9081787	0.8887757	0.0194030	-0.1095797	0.0300997
cg03421587	Ebf3	7	137320038	4.126590e-02	2.869154e-04	0.4198978	0.3583557	0.0615422	-0.1607027	0.0443093
cg04747504	Gpr84	15	1103300439	4.126590e-02	2.881087e-04	0.3606207	0.4144448	-0.0538241	0.1406744	0.0387985
cg23046555	Pax2	19	144671400	4.126590e-02	2.872527e-04	0.0521240	0.0608798	-0.0087559	0.0771699	0.0212792
cg18132535	Psd2	18	135933577	4.126622e-02	2.898571e-04	0.1443521	0.1641741	-0.0198220	0.0835219	0.0230456
cg00134706	C230079O03Rik	7	136475745	4.153658e-02	3.111305e-04	0.9267537	0.9374448	-0.0106912	0.0816399	0.0226410
cg01657263	Gm43517	12	149386724	4.153658e-02	3.074337e-04	0.4226136	0.3551341	0.0674795	-0.1762842	0.0488463
cg08014701	Gm16136	15	137233288	4.153658e-02	3.034594e-04	0.0994397	0.1222207	-0.0227810	0.1207938	0.0334393
cg13209256	Dynlrb2	8	116385090	4.153658e-02	3.163621e-04	0.6216962	0.6725774	-0.0508812	0.1371026	0.0380680
cg15012766	Foxo6	4	120282597	4.153658e-02	3.137876e-04	0.0109115	0.0157909	-0.0048794	0.1437710	0.0398960
cg15698781	Depdc5	5	32903896	4.153658e-02	3.160314e-04	0.9511511	0.9561527	-0.0050016	0.0515673	0.0143171
cg16701356	Sp9	2	73278469	4.153658e-02	2.999567e-04	0.4884898	0.4718197	0.0166701	-0.0418406	0.0115731
cg17469239	Ptch1	13	163554662	4.153658e-02	3.149332e-04	0.8580497	0.8360233	0.0220263	-0.0933533	0.0259121
cg19806313	Ptprt	2	161580069	4.153658e-02	3.072386e-04	0.7725169	0.8045278	-0.0320109	0.1107447	0.0306847
cg21125558	Snrpa1	7	66070155	4.153658e-02	3.109605e-04	0.9266554	0.9036418	0.0230136	-0.1487403	0.0412481
cg21344777	Esrrb	12	186383978	4.153658e-02	2.988358e-04	0.3848982	0.3387481	0.0461501	-0.1232409	0.0340792
cg24830181	Ttc29	8	78271982	4.153658e-02	3.145639e-04	0.8482541	0.8699416	-0.0216876	0.0971413	0.0269612
cg25558559	Kcnma1	14	123373797	4.153658e-02	3.130326e-04	0.6655464	0.7224254	-0.0568789	0.1624134	0.0450614
cg27402320	Rnf220	4	117409830	4.153658e-02	3.021665e-04	0.4826728	0.5096145	-0.0269417	0.0675487	0.0186938
cg00060304	Pax6	2	105671196	4.222155e-02	3.233657e-04	0.3826731	0.3345366	0.0481365	-0.1289526	0.0358618
cg22580162	Fhl1	20	56790511	4.248262e-02	3.271628e-04	0.8131377	0.8385361	-0.0253984	0.0989409	0.0275388
cg04865264	Ovol2	2	144332183	4.389843e-02	3.400215e-04	0.0951971	0.1209749	-0.0257778	0.1392868	0.0388773
cg13815285	Esrp1	4	11344207	4.389843e-02	3.417810e-04	0.0590016	0.0531643	0.0058373	-0.0517069	0.0144377
cg14551953	Tbca	13	194707126	4.399314e-02	3.446044e-04	0.0607924	0.0794949	-0.0187025	0.1396788	0.0390248
cg24140160	Zbtb16	9	48737634	4.399314e-02	3.462414e-04	0.1022414	0.1300899	-0.0278485	0.1429166	0.0399432
cg13517739	Gm30731	4	23173922	4.435664e-02	3.509792e-04	0.7646933	0.7975657	-0.0328724	0.1114763	0.0311871
cg04198597	Bclaf1	10	120334502	4.469835e-02	3.555744e-04	0.9283971	0.9374097	-0.0090126	0.0694300	0.0194426
cg22208523	A3galt2	4	128743385	4.576407e-02	3.659886e-04	0.5179954	0.5489863	-0.0309909	0.0779776	0.0218825
cg03630442	Gm10532	18	175447239	4.604524e-02	3.701855e-04	0.6002846	0.5544150	0.0458696	-0.1172600	0.0329338
cg12469892	Rplp1	9	61756957	4.617327e-02	3.731687e-04	0.4240533	0.4520768	-0.0280235	0.0711187	0.0199863
cg02231349	Fez1	9	36922296	4.657666e-02	3.866412e-04	0.3797595	0.4369864	-0.0572270	0.1474984	0.0415601
cg02315120	Dab1	4	104452806	4.657666e-02	3.877587e-04	0.2138199	0.2391739	-0.0253540	0.0842746	0.0237508
cg10455041	Tfap2d	1	19106472	4.657666e-02	3.866117e-04	0.3546242	0.2938785	0.0607457	-0.1692236	0.0476813
cg14354194	Ahdc1	4	133043047	4.657666e-02	3.882538e-04	0.2174611	0.2499998	-0.0325387	0.1063062	0.0299628
cg15519745	Glis3	19	128540318	4.657666e-02	3.825099e-04	0.9557311	0.9440069	0.0117242	-0.1138335	0.0320489
cg27531402	Paupar	2	105660539	4.657666e-02	3.802229e-04	0.1171573	0.0965707	0.0205865	-0.1120239	0.0315254
cg08189414	Rnf220	4	117317956	4.670243e-02	3.912783e-04	0.3227740	0.3427774	-0.0200034	0.0550609	0.0155281
cg11559504	Tm4sf19	16	132381789	4.699374e-02	3.968711e-04	0.9047946	0.9207092	-0.0159146	0.1004935	0.0283707
cg23362864	Dph6	2	114438524	4.699374e-02	3.976959e-04	0.9194403	0.9274560	-0.0080157	0.0557860	0.0157516
cg21872209	Nr1d1	11	198767645	4.714393e-02	4.009618e-04	0.0827303	0.1163816	-0.0336513	0.1936669	0.0547167
cg23484089	Cntln	4	84987365	4.771133e-02	4.078064e-04	0.5140242	0.5377251	-0.0237009	0.0595434	0.0168440
cg06992077	Smim4	14	131110453	4.801882e-02	4.144984e-04	0.9198613	0.8995323	0.0203289	-0.1252476	0.0354741
cg19044429	Diaph3	14	186772639	4.801882e-02	4.140937e-04	0.7806095	0.8188683	-0.0382588	0.1368073	0.0387453
cg19608474	Brinp1	4	69346448	4.813964e-02	4.175782e-04	0.7244429	0.7744199	-0.0499769	0.1573907	0.0446028
cg02409454	Vrk1	12	1106143168	4.824172e-02	4.223527e-04	0.9021710	0.8727116	0.0294594	-0.1547185	0.0438830
cg21530396	Dlx1as	2	71538009	4.824172e-02	4.225463e-04	0.3893943	0.3230684	0.0663259	-0.1782376	0.0505554
cg11194264	Clk3	9	57758645	4.833220e-02	4.303912e-04	0.5220975	0.5751171	-0.0530196	0.1339986	0.0380601
cg12583945	Hnrnpk	13	158397873	4.833220e-02	4.316852e-04	0.3840981	0.4228012	-0.0387031	0.1000028	0.0284106
cg13425955	Ntm	9	29963228	4.833220e-02	4.335644e-04	0.1888620	0.2133553	-0.0244933	0.0872647	0.0247998
cg15337108	Gm7134	20	110318800	4.833220e-02	4.266986e-04	0.5615461	0.5989832	-0.0374370	0.0958257	0.0272001
cg24525396	Samd4b	7	28423482	4.833220e-02	4.333459e-04	0.8511492	0.8811865	-0.0300373	0.1395640	0.0396613
cg21849844	Gm5089	14	1122453423	4.870886e-02	4.390042e-04	0.1237836	0.1552080	-0.0314244	0.1419292	0.0403729
cg14569995	Nrxn1	17	190704057	4.997387e-02	4.525201e-04	0.7416452	0.7775578	-0.0359126	0.1155453	0.0329434

Pathology

threshold <- 0.05
betaResults$SNP <- betaResults$Gene_Symbol
color_J20_TG <- "#FF5A62"


# Pathology
manhattan(betaResults, p = "FDR_adj_pathology", bp = "Bp", chr = "Chr", 
          genomewide = -log10(threshold), suggestiveline = FALSE, 
          logp=T, col = c("black", color_J20_TG), main = "Pathology",
          chrlabs = c(1:19, "X", "Y"),las = 2, annotateTop = threshold,
          cex.axis = 1.5, cex.lab = 1.2)

lamda <- qchisq(1-median(betaResults$p.val.Pathology),1)/qchisq(0.5,1)
qq(betaResults$p.val.Pathology, main = "Pathology (Raw pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

lamda <- qchisq(1-median(betaResults$FDR_adj_pathology),1)/qchisq(0.5,1)
qq(betaResults$FDR_adj_pathology, main = "Pathology (FDR corrected pvalue)")
mtext(paste("Lamda = ", signif(lamda,3)), side = 3, adj = 1)

betaResults <- betaResults[order(betaResults$FDR_adj_pathology),]
rownames(betaResults) <- betaResults$cpg

pheno$col <-  ifelse(pheno$Genotype == "WT","#000000", color_J20_TG )

## Pathologys
par(mfrow = c(2,3)) ## will plot 6 figures per page in 2 rows by 3 columns
for(i in 1:6){
  plot(pheno$Pathology_HIP, as.numeric(betas[rownames(betaResults)[i],]*100),
       xlab = "Pathology", ylab = "DNA methylation (%)", pch = 16,
       main = paste(rownames(betas)[i], betaResults[i,"Gene_Symbol"], sep = " "),
       col = pheno$col) ## we multiple by 100 to plot of a % scale rather than proportion
  ## to add line of best fit
  mtext(paste("P = ", signif(betaResults[i, "FDR_adj_pathology"],3)), side = 3, adj = 0, cex = .7) ## add P value to plot rounded to 3 sf
   par(xpd  = TRUE)
  legend(x ="topright",legend = levels(factor(pheno$Genotype)),
         col = c("#000000",color_J20_TG), pch = 19, cex = .7,
         inset=c(-0.02,-0.25))
}

for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}

pdf("/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/FullJ20_Pathology.pdf", onefile = T)
for(i in 1:6){
  plotDMPPathology(cpg = rownames(betaResults[i,]) , color = color_J20_TG, betaResults = betaResults,
                   betas = betas, pheno = pheno)
}
dev.off()

## png 
##   2

if(length(which(betaResults$FDR_adj_pathology <  threshold)) > 0){
  betaResults2 <- betaResults[(which(betaResults$FDR_adj_pathology <  threshold)),]
  betaResults2 <-  betaResults2[order(betaResults2$FDR_adj_pathology),]
  betaResults2 <- betaResults2[,c("cpg","Gene_Symbol", "Chr","Bp","FDR_adj_pathology", "p.val.Pathology",
                                  "estimate.Pathology","std.error.Pathology")]
  rownames(betaResults2) <- NULL
  colnames(betaResults2) <- c("cpg","Gene Symbol", "Chr","Bp","FDR adj p.val", "raw p.val",
                                  "estimate","std error")
  betaResults2[,c(5,6)] <- format(betaResults2[,c(5,6)], scientific=T)
  kable(betaResults2) %>%
    kable_styling() %>%
    scroll_box(width = "100%", height = "520px")
}

cpg	Gene Symbol	Chr	Bp	FDR adj p.val	raw p.val	estimate	std error
cg10661056	Dynlrb2	8	116315711	6.899033e-10	2.919237e-14	-0.1605892	0.0211250
cg24330922	Mir1894	17	135917725	3.276473e-09	2.772795e-13	-0.2914966	0.0399037
cg12545634	Otp	13	194875724	7.063344e-09	8.966290e-13	-0.5193545	0.0726826
cg04088732	Lrmda	14	122591403	1.009655e-08	1.708891e-12	-0.4110130	0.0582470
cg15842149	Phtf1	3	103964049	2.140265e-08	4.528127e-12	0.4924910	0.0711730
cg13684553	Wdr20	12	1110738033	2.250388e-08	5.713337e-12	0.1945076	0.0282443
cg13399673	Ebf1	11	144745875	2.032541e-07	7.740391e-11	0.3423312	0.0526213
cg24771515	Spred1	2	117123179	2.032541e-07	6.296393e-11	-0.4139837	0.0633339
cg24185526	Wwox	8	114514776	2.032541e-07	7.586053e-11	0.2668579	0.0410009
cg24420776	Naaladl2	3	25432943	3.662527e-07	1.549751e-10	0.2969853	0.0464011
cg26748720	Dlx6os1	6	6834950	3.986766e-07	1.855644e-10	0.2606933	0.0409070
cg09313308	Cacna1c	6	118637833	5.491486e-07	2.788382e-10	-0.3239474	0.0513378
cg10742992	Slc10a7	8	78725651	6.545012e-07	3.600269e-10	-0.2471056	0.0394080
cg22521808	Gria3	20	41654900	7.358495e-07	4.926434e-10	-0.1827576	0.0293755
cg20288327	Runx1t1	4	13461023	7.358495e-07	5.175076e-10	0.3794277	0.0610631
cg09603678	Trim33	3	103353862	7.358495e-07	4.456227e-10	0.3226921	0.0517371
cg07591994	Prkg1	19	130569077	7.358495e-07	5.604575e-10	0.3018094	0.0486698
cg07484191	D030045P18Rik	10	146072064	7.358495e-07	5.408537e-10	-0.2917517	0.0470054
cg12137126	Bnc2	4	84284440	7.386746e-07	6.563774e-10	-0.2624328	0.0424906
cg25033328	Mbnl1	3	60614521	7.386746e-07	6.285882e-10	0.2079727	0.0336357
cg00143530	4933416E03Rik	2	159515463	7.386746e-07	6.002616e-10	0.2801231	0.0452515
cg06084735	Eny2	15	144428203	7.578411e-07	7.054756e-10	-0.1346557	0.0218425
cg27663652	5730522E02Rik	11	125595431	1.576615e-06	1.534386e-09	-0.3992854	0.0660991
cg15476397	Cdc23	18	134641516	1.838398e-06	1.948410e-09	0.3152640	0.0525260
cg10239446	2900052N01Rik	9	46899983	1.838398e-06	2.022526e-09	0.3664936	0.0611231
cg27189050	Tshz1	18	184003087	1.838398e-06	1.985004e-09	0.3962427	0.0660511
cg19386324	Ss18l1	2	180052472	1.843932e-06	2.106638e-09	-0.1019932	0.0170291
cg00983568	Tle1	4	72382768	1.913197e-06	2.266726e-09	-0.3970708	0.0664283
cg10082575	Egln3	12	153891064	2.120267e-06	2.601774e-09	0.3673070	0.0616811
cg02503970.2	St3gal1	15	167176741	2.766565e-06	3.511909e-09	-0.3477763	0.0588884
cg12838692	Arrdc3	13	180883841	3.399962e-06	4.459816e-09	-0.3954803	0.0674171
cg06842649	Klhl34	20	157834060	3.761707e-06	5.093497e-09	0.3327749	0.0569421
cg12553481	Foxp2	6	15203244	4.074341e-06	5.689216e-09	0.3864957	0.0663438
cg24012074	A830019L24Rik	3	143465770	4.466804e-06	6.426240e-09	0.3590448	0.0618481
cg14974683	Luc7l	17	126257971	4.809177e-06	7.122295e-09	-0.2055614	0.0355150
cg26258387	Lrp4	2	91501037	4.967953e-06	7.567652e-09	0.3313314	0.0573454
cg24837228	Ahdc1	4	133077439	5.184380e-06	8.116703e-09	0.4512552	0.0782612
cg10078989	Eny2	15	144428206	6.086851e-06	9.787176e-09	-0.0940628	0.0164033
cg27046016	Olig3	10	119414816	6.496340e-06	1.072049e-08	0.3121884	0.0545887
cg07066261	Ube2w	1	16581971	6.775646e-06	1.153580e-08	-0.1764189	0.0309157
cg00373808	Diaph3	14	187124705	6.775646e-06	1.175481e-08	0.4345989	0.0762021
cg14667871	Fbxl7	15	126895001	6.957814e-06	1.236526e-08	-0.2108471	0.0370257
cg19806313	Ptprt	2	161580069	7.219526e-06	1.344134e-08	0.2593279	0.0456534
cg01556456	Klf12	14	199614019	7.219526e-06	1.324965e-08	0.2850380	0.0501579
cg25246309	Arl15	13	1113880152	8.307987e-06	1.581938e-08	-0.3914740	0.0692576
cg19562013	Casz1	4	148831759	8.499091e-06	1.654289e-08	-0.1376601	0.0243873
cg09647169	Dach1	14	197891539	9.075427e-06	1.804871e-08	0.2663163	0.0473053
cg20433084	Gm10578	7	137199097	9.655721e-06	1.961133e-08	0.3340936	0.0594960
cg16030195	Gtdc1	2	44570610	1.017442e-05	2.109536e-08	0.2675743	0.0477575
cg00523349	Gm6249	7	136798196	1.060430e-05	2.331497e-08	0.2666880	0.0477473
cg06761799	Tef	15	181795511	1.060430e-05	2.378119e-08	0.2530206	0.0453282
cg26059055	Fgfr1	8	25563492	1.060430e-05	2.378150e-08	0.2421805	0.0433862
cg17996417	Prpf3	3	95835441	1.060430e-05	2.341036e-08	-0.3810151	0.0682248
cg09098248	Gsk3b	16	138243560	1.132368e-05	2.600592e-08	0.4249599	0.0763438
cg21444333	Nxph1	6	9332250	1.132368e-05	2.635307e-08	0.3708470	0.0666501
cg24226732	Hat1	2	71420679	1.157372e-05	2.791445e-08	0.1710989	0.0308062
cg27000043	Rsf1	7	97581072	1.157372e-05	2.783680e-08	-0.2194196	0.0395029
cg15227204	Chchd3	6	32887534	1.228441e-05	3.014834e-08	-0.3648546	0.0658514
cg27076613	Meis2	2	115866382	1.237443e-05	3.089289e-08	0.1671180	0.0301859
cg03048497	Cstf3	2	104653007	1.245795e-05	3.264380e-08	0.3091232	0.0559334
cg06223742	Ofcc1	13	140032275	1.245795e-05	3.268282e-08	0.3590797	0.0649751
cg12882820	NA	12	153071200	1.245795e-05	3.206151e-08	0.3452476	0.0624341
cg09093559	Sorbs1	19	140327476	1.249271e-05	3.330261e-08	0.1772575	0.0320937
cg22572197	Tshz2	2	169913005	1.273072e-05	3.447579e-08	0.3047632	0.0552403
cg20464713	B230303A05Rik	13	116642715	1.345387e-05	3.700341e-08	-0.1020491	0.0185389
cg16057023	Crebzf	7	90444115	1.425154e-05	3.980034e-08	-0.2419871	0.0440639
cg08035723	Gm13205	4	148981632	1.436458e-05	4.094915e-08	0.3097175	0.0564487
cg24489237	Pbx1	1	168431393	1.436458e-05	4.133167e-08	-0.1354239	0.0246896
cg27213004	Vil1	1	74428201	1.554657e-05	4.539049e-08	-0.1458362	0.0266685
cg12910744	Tsc22d2	3	58461501	1.568705e-05	4.646441e-08	0.2234341	0.0408895
cg26555185	D130009I18Rik	14	1104864151	1.816576e-05	5.511505e-08	-0.3658195	0.0673209
cg05387438	Zfp407	18	184351123	1.816576e-05	5.534358e-08	0.3107243	0.0571896
cg12598907	Rrp15	1	186835890	1.874629e-05	5.790544e-08	0.2907640	0.0535956
cg19323953	Slc35b3	13	139297245	1.961773e-05	6.142731e-08	0.3429815	0.0633439
cg23295280	Zfat	15	168178901	1.966311e-05	6.240143e-08	0.2138030	0.0395070
cg00686910	Casz1	4	148930461	2.134757e-05	6.865043e-08	0.3912663	0.0725283
cg27434492	Mex3c	18	173590837	2.144005e-05	6.985503e-08	-0.4316034	0.0800519
cg03496300	Pax6	2	105675604	2.178188e-05	7.189042e-08	-0.2890016	0.0536541
cg22328770	Klf12	14	199987480	2.259278e-05	7.552276e-08	0.1562148	0.0290497
cg10783532	Arf6	12	169372988	2.536958e-05	8.587850e-08	0.1781578	0.0332736
cg06490500	Clk4	11	151273070	3.557676e-05	1.232313e-07	0.2384857	0.0450940
cg11147619	Grb14	2	64523477	3.557676e-05	1.234415e-07	0.2721125	0.0514553
cg01734369	Kcnh7	2	63554431	3.876964e-05	1.361605e-07	0.3135516	0.0594935
cg02811998	Rplp1	9	61881494	3.882916e-05	1.380125e-07	0.4508355	0.0855820
cg22450874	Foxp1	6	99233038	4.157296e-05	1.495241e-07	0.2719141	0.0517622
cg21692907	Dnajc24	2	106133504	4.286108e-05	1.559706e-07	0.2734118	0.0521244
cg24937992	Foxp1	6	99004845	4.878782e-05	1.796023e-07	0.2018811	0.0386797
cg18533392	4930524B15Rik	11	131934515	5.010749e-05	1.865806e-07	0.4629331	0.0888166
cg18489876	Gtdc1	2	44570615	5.492268e-05	2.068345e-07	-0.2543935	0.0489869
cg17538314	Tbc1d5	17	150898066	5.555686e-05	2.115735e-07	0.3872906	0.0746387
cg17879021	Cnot6	11	149683236	5.613002e-05	2.161313e-07	0.4326891	0.0834518
cg16767916	Pou3f3	1	42698296	5.779797e-05	2.249995e-07	0.1187749	0.0229410
cg03876095	Uhmk1	1	170208692	5.995996e-05	2.384901e-07	0.3930175	0.0760700
cg03799825	Rbm15	3	107325242	5.995996e-05	2.373285e-07	0.3860326	0.0747049
cg01204422	Tshz2	2	169811809	6.331202e-05	2.545019e-07	0.1829867	0.0355014
cg18838779	Msi2	11	188508796	6.447168e-05	2.618915e-07	0.3799613	0.0737934
cg14729575	Atp5g3	2	74070945	6.474216e-05	2.657297e-07	0.3128802	0.0607976
cg20778358	Gm15511	9	69378887	6.845054e-05	2.838469e-07	0.2290235	0.0446103
cg15905834	4930441H08Rik	7	71349248	7.287946e-05	3.052963e-07	0.2354127	0.0459777
cg11477279	Dmd	20	83924933	7.596758e-05	3.214470e-07	0.3003091	0.0587641
cg13353999	Klhl14	18	121654505	8.137567e-05	3.483207e-07	-0.1277876	0.0250799
cg20592694	6030471H07Rik	4	84153903	8.137567e-05	3.512173e-07	0.2626419	0.0515625
cg05312831	Gm6260	3	143588221	8.518469e-05	3.712615e-07	0.3374790	0.0663919
cg21430924	Cyp7b1	3	18190066	8.531643e-05	3.754457e-07	0.4223128	0.0831160
cg17421638	1700081H04Rik	5	119143619	8.577739e-05	3.811038e-07	0.3357927	0.0661249
cg00249321	Ush2a	1	188885043	8.714789e-05	3.945679e-07	0.2931270	0.0577982
cg16451152	Gm33948	18	127497778	8.714789e-05	3.931262e-07	0.3466958	0.0683514
cg20807047	Nr2f1	13	178189051	8.864687e-05	4.051057e-07	0.2950477	0.0582345
cg14161476	Adamts16	13	170770254	9.123255e-05	4.207823e-07	0.3102650	0.0613256
cg19393451	Epha7	4	28821092	9.413109e-05	4.381340e-07	0.1977743	0.0391509
cg04146048	Herc1	9	66388775	9.447879e-05	4.437501e-07	0.2119941	0.0419860
cg07278571	Usp34	11	123464618	9.497209e-05	4.503256e-07	0.3837331	0.0760417
cg21167371	Zxdc	6	90370480	9.497209e-05	4.541043e-07	0.1179451	0.0233797
cg03480718	Barhl2	5	106464970	9.713083e-05	4.685361e-07	-0.4368288	0.0866936
cg25011187	Foxp2	6	15441102	1.070258e-04	5.277634e-07	0.1542876	0.0307595
cg25201652	Mir5127	18	181897933	1.070258e-04	5.281037e-07	0.2401773	0.0478840
cg25210850	Lrrtm4	6	80018906	1.070258e-04	5.298530e-07	-0.5277958	0.1052398
cg04521925	Marcks	10	137138511	1.070472e-04	5.344888e-07	-0.1465556	0.0292322
cg01160956	Lrrc40	3	158148694	1.096060e-04	5.519027e-07	0.3219117	0.0642881
cg07687957	2310008N11Rik	8	26626581	1.257033e-04	6.382771e-07	0.1655012	0.0332381
cg16121098	Tnrc6a	7	123174200	1.264037e-04	6.471816e-07	0.3923901	0.0788474
cg10652918	Srbd1	17	186041000	1.288625e-04	6.652236e-07	-0.1478487	0.0297408
cg19917700	Mir5127	18	181510247	1.321547e-04	6.878104e-07	0.3777060	0.0760772
cg24884825	Rora	9	69114348	1.328354e-04	6.969742e-07	-0.2786066	0.0561457
cg18344896	Lsamp	16	140850285	1.364350e-04	7.216342e-07	0.4003108	0.0807819
cg21947307	Fan1	7	64337943	1.401609e-04	7.472719e-07	0.1752068	0.0354049
cg07504399	Mir592	6	27936694	1.407872e-04	7.565682e-07	0.2957266	0.0597880
cg25069285	Top1	2	160721901	1.491290e-04	8.238854e-07	-0.2897519	0.0587777
cg13610315	Kmt2d	15	198844394	1.491290e-04	8.247844e-07	0.1663523	0.0337469
cg15488194	Mbnl1	3	60528353	1.491290e-04	8.078566e-07	-0.3513763	0.0712231
cg16561874	Unc79	12	1102949403	1.491290e-04	8.266365e-07	0.2634895	0.0534573
cg03571234	Dmd	20	85149157	1.523286e-04	8.508178e-07	0.2896336	0.0588287
cg15950887	Nfat5	8	107324738	1.586485e-04	8.928301e-07	0.3238979	0.0659147
cg21302471	Sos1	17	180449379	1.646545e-04	9.335971e-07	0.3377944	0.0688654
cg11328905	Nt5el	13	1105131370	1.807481e-04	1.033409e-06	0.3609138	0.0738795
cg25944824	Sall4	2	168767130	1.807481e-04	1.040145e-06	-0.2751357	0.0563354
cg06443336	Mir5127	18	181898194	2.030967e-04	1.177348e-06	0.1200648	0.0247077
cg18164741	Phf12	11	178028934	2.119967e-04	1.237911e-06	0.3332011	0.0687088
cg18681528	Tle1	4	72382259	2.176749e-04	1.287028e-06	0.2264544	0.0467712
cg11961894	Lmo3	6	138402670	2.176749e-04	1.289489e-06	0.3427150	0.0707889
cg06803118	Zc2hc1a	3	7535949	2.179756e-04	1.300494e-06	0.3175975	0.0656237
cg23078557	Vrk1	12	1106129498	2.372031e-04	1.425246e-06	0.2472003	0.0512710
cg02653214	Btaf1	19	137023698	2.410562e-04	1.458598e-06	0.3796408	0.0788156
cg02268145	Hoxd9	2	74697942	2.451955e-04	1.494019e-06	-0.0691910	0.0143787
cg05070816	Zfp131	13	1119775925	2.475901e-04	1.519086e-06	0.4339010	0.0902323
cg10604788	Cnot1	8	95775311	2.584925e-04	1.596916e-06	-0.3376531	0.0703633
cg05758851	4930441J16Rik	2	74272815	2.637867e-04	1.651946e-06	0.1640058	0.0342255
cg14494932	Casz1	4	148930449	2.637867e-04	1.643463e-06	0.1753643	0.0365880
cg21573997	Foxp2	6	15256450	2.889570e-04	1.834027e-06	0.3008649	0.0630625
cg22723228	C130074G19Rik	1	184898591	2.889570e-04	1.830898e-06	0.1541099	0.0322997
cg19056238	A730082K24Rik	7	115193624	2.958428e-04	1.902767e-06	-0.2571335	0.0539801
cg17909166	Mannr	3	29826111	2.958428e-04	1.891351e-06	0.2492448	0.0523107
cg09016032	Mapkap1	2	34462677	2.989384e-04	1.935327e-06	0.2682126	0.0563464
cg12225504	Tcf4	18	169408610	3.017520e-04	1.966310e-06	0.1989203	0.0418176
cg22952564	1700006H21Rik	13	1107618395	3.078876e-04	2.019319e-06	-0.3102014	0.0652852
cg00597118	Azin1	15	138514606	3.167663e-04	2.090955e-06	0.2603802	0.0548813
cg22369908	Sox12	2	152396791	3.192628e-04	2.134452e-06	-0.0995320	0.0209972
cg12071536	Hoxc9	15	1102981651	3.192628e-04	2.122017e-06	-0.3055236	0.0644368
cg22026774	Creb1	1	64574175	3.249227e-04	2.186041e-06	0.2566406	0.0541960
cg11399644	Srsf6	2	162933039	3.288414e-04	2.226320e-06	0.2836816	0.0599532
cg16715342	Setd1b	5	123141137	3.341687e-04	2.276527e-06	-0.0921764	0.0194992
cg19629739	Trps1	15	150659118	3.446389e-04	2.377021e-06	0.3379627	0.0716265
cg03073543	Prdm16	4	154421031	3.446389e-04	2.373405e-06	0.2405092	0.0509692
cg21162812	Asxl3	18	122344317	3.544173e-04	2.459461e-06	-0.2958824	0.0628006
cg13962734	4933430M04Rik	11	124448309	3.721795e-04	2.598469e-06	0.3458838	0.0735884
cg01202361	4930405A10Rik	14	122457591	3.757539e-04	2.655224e-06	0.3623230	0.0771584
cg03286705	Uncx	5	139549021	3.757539e-04	2.639766e-06	-0.2626151	0.0559109
cg02448802	Six3	17	185393753	3.921853e-04	2.787929e-06	0.2262492	0.0482834
cg27646139	Satb1	17	151739337	4.062222e-04	2.904902e-06	0.2368988	0.0506472
cg13662954	Bmper	9	22954674	4.307110e-04	3.104773e-06	0.2015879	0.0432243
cg03617050	Cacna1d	14	130089325	4.307110e-04	3.116472e-06	0.1638029	0.0351283
cg17406224	Cdk5rap2	4	69618413	4.555972e-04	3.315818e-06	0.1817324	0.0390804
cg01311296	Dyrk1a	16	194694783	4.643028e-04	3.418470e-06	0.2448126	0.0527167
cg12566943	Vwc2l	1	70750958	4.643028e-04	3.403320e-06	0.1703192	0.0366684
cg08304325	Gm28036	2	156098355	4.726279e-04	3.499762e-06	0.2988614	0.0644227
cg20630917	Tanc1	2	59799651	4.955506e-04	3.690471e-06	0.3487187	0.0753482
cg21160194	Vrk2	11	126815350	4.982973e-04	3.742833e-06	0.3020646	0.0653088
cg26741512	Mbnl1	3	60614538	4.982973e-04	3.774181e-06	0.1489497	0.0322162
cg12366733	Hoxb6	11	196299102	4.982973e-04	3.771484e-06	-0.1902757	0.0411532
cg27224831	Mamld1	20	71054025	5.219465e-04	3.975389e-06	0.1691671	0.0366745
cg21226777	Gm20172	1	25504481	5.332155e-04	4.083781e-06	-0.2091648	0.0454008
cg01823948	Nrxn3	12	189112244	5.442240e-04	4.191121e-06	0.2454939	0.0533488
cg08823201	Otx2	14	148750623	5.561269e-04	4.306319e-06	0.1683356	0.0366264
cg11454083	Slc25a5	20	36798422	5.937236e-04	4.622568e-06	0.1747651	0.0381481
cg27046391	Pebp4	14	169885697	5.940453e-04	4.675345e-06	0.2707155	0.0591230
cg18170214	Cacna2d2	9	107459085	5.940453e-04	4.658276e-06	-0.3546924	0.0774502
cg17762161	Zfp507	7	35980788	6.008190e-04	4.754079e-06	0.2780121	0.0607629
cg11232667	Cemip	7	84110734	6.064847e-04	4.824572e-06	0.1865095	0.0407914
cg06643163	Tnr	1	159816317	6.103148e-04	4.880866e-06	0.1934990	0.0423426
cg18185838	Tenm3	8	48434449	6.329967e-04	5.089044e-06	0.2906196	0.0637172
cg14194584	Rassf10	7	112906565	6.375545e-04	5.178231e-06	0.2545069	0.0558443
cg21193679	Satb1	17	151828363	6.375545e-04	5.179641e-06	0.2071164	0.0454464
cg26376143	Epc1	18	16436069	6.421820e-04	5.244409e-06	0.2368408	0.0519985
cg11929511	Kdm7a	6	39205484	6.478591e-04	5.318185e-06	-0.1406428	0.0308981
cg10277318	Pbx3	2	34275832	6.495529e-04	5.359574e-06	0.2649771	0.0582342
cg25382102	Dmbx1	4	115944224	6.675431e-04	5.536261e-06	-0.2011877	0.0442816
cg03471163	4922502N22Rik	6	139293940	6.764490e-04	5.638744e-06	0.2013998	0.0443661
cg11724972	Zfp507	7	36075168	6.821117e-04	5.714811e-06	0.2280815	0.0502750
cg20494382	Ankrd28	14	131711989	6.996539e-04	5.950596e-06	0.2965308	0.0654863
cg22533833	Foxp2	6	15396674	6.996539e-04	5.945908e-06	0.2333916	0.0515406
cg11545945	Poll	19	145541583	6.996539e-04	5.931938e-06	-0.0695990	0.0153681
cg23043982	4930441H08Rik	7	71349212	7.003841e-04	5.986442e-06	0.2346633	0.0518379
cg24243964	Ofcc1	13	140504405	7.230927e-04	6.211138e-06	0.2564557	0.0567497
cg01580681	Hand2os1	8	57322330	7.246708e-04	6.255357e-06	0.1895409	0.0419564
cg26621766	Bbx	16	150197628	7.343132e-04	6.369661e-06	0.2943258	0.0652067
cg23484089	Cntln	4	84987365	7.506591e-04	6.548719e-06	0.1177418	0.0261193
cg27609789	Acaca	11	184349543	7.506591e-04	6.584695e-06	-0.2415046	0.0535880
cg17593187	Rps6kc1	1	190807769	7.506591e-04	6.606740e-06	0.2344153	0.0520232
cg12134769	Syn2	6	115274241	7.579693e-04	6.703152e-06	0.2021623	0.0448960
cg00217702	Trpm7	2	126822534	7.676894e-04	6.821596e-06	0.2397525	0.0532880
cg18828923	Mir6417	5	51931612	7.695733e-04	6.870900e-06	0.2892714	0.0643161
cg02148584	Ppargc1a	5	51587374	7.755573e-04	6.957142e-06	0.2082512	0.0463296
cg09079792	Sox12	2	152396787	7.947167e-04	7.162639e-06	-0.0985552	0.0219558
cg11534391	Pdzrn4	15	192597108	8.125177e-04	7.391838e-06	-0.3134468	0.0699333
cg21118939	Hnrnpa3	2	75314992	8.125177e-04	7.367841e-06	0.1438316	0.0320854
cg10128645	Tbc1d8b	20	139732363	8.149337e-04	7.448300e-06	0.2625093	0.0585898
cg05642781	Armh1	4	117240036	8.197149e-04	7.526684e-06	-0.1218604	0.0272118
cg27447131	Megf11	9	64700117	8.240250e-04	7.601127e-06	0.1663820	0.0371710
cg20586522	A830082K12Rik	13	178602077	8.350546e-04	7.738203e-06	-0.2045171	0.0457297
cg27078219	4933406G16Rik	11	119174759	8.589959e-04	7.996408e-06	0.2472379	0.0553689
cg12906630	Taok1	11	177553737	8.914665e-04	8.336398e-06	0.2785179	0.0624990
cg25046890	4933406K04Rik	12	1107105036	8.961274e-04	8.417902e-06	0.2325839	0.0522159
cg10405348	Gm12128	11	137679586	8.965864e-04	8.460152e-06	0.3284802	0.0737628
cg23593195	Csde1	3	103040589	9.106251e-04	8.631153e-06	0.2045444	0.0459764
cg27528346	Faf1	4	109763279	9.221012e-04	8.778943e-06	0.3730922	0.0839305
cg05475402	Pbx3	2	34229562	9.473014e-04	9.058948e-06	0.2337063	0.0526544
cg17806656	D030025E07Rik	3	128674698	9.617074e-04	9.237405e-06	0.2224224	0.0501596
cg05812699	Tenm2	11	136636152	9.831126e-04	9.484605e-06	0.1546591	0.0349228
cg09537487	Fign	2	63752740	1.014614e-03	9.831445e-06	0.3501856	0.0792123
cg08351436	Uncx	5	139550131	1.018436e-03	9.911577e-06	-0.2105715	0.0476504
cg27192328	Sat1	20	155215212	1.030396e-03	1.007158e-05	0.1567144	0.0354908
cg11924467	Idh2	7	80086014	1.042337e-03	1.023239e-05	0.1219856	0.0276473
cg14215583	Lbx1	19	145244415	1.108370e-03	1.092752e-05	-0.2165739	0.0492442
cg20614809	2810405F15Rik	2	116201460	1.113016e-03	1.102043e-05	0.3347728	0.0761519
cg04197976	1700008P02Rik	3	6104803	1.116960e-03	1.110674e-05	0.2498904	0.0568654
cg24282768	Itgb7	15	1102215554	1.120851e-03	1.129420e-05	0.2705908	0.0616270
cg19298067	Mir6378	3	35262810	1.120851e-03	1.121552e-05	0.1925585	0.0438400
cg02958663	Rragc	4	124087234	1.120851e-03	1.133120e-05	0.1279082	0.0291358
cg14812516	Abcd4	12	184590133	1.120851e-03	1.133515e-05	-0.0871185	0.0198448
cg27175110	Mbd5	2	49258247	1.121474e-03	1.146263e-05	0.2188190	0.0498725
cg14530830	Nog	11	189301114	1.121474e-03	1.148380e-05	-0.2466125	0.0562123
cg14592546	Zfp521	18	113589851	1.121474e-03	1.147917e-05	0.2099557	0.0478558
cg25200003	Atxn2	5	121781111	1.131223e-03	1.167299e-05	0.0949923	0.0216699
cg14070544	Uri1	7	37887160	1.131223e-03	1.167937e-05	0.1629578	0.0371754
cg11473209	Dlx1	2	71530661	1.136056e-03	1.177734e-05	-0.3593310	0.0820078
cg16299574	Rragc	4	124087355	1.137706e-03	1.184258e-05	0.0992362	0.0226543
cg23188031	Cuedc2	19	146330747	1.141134e-03	1.192655e-05	0.1730897	0.0395279
cg03443886	Arx	20	93377747	1.142963e-03	1.199403e-05	0.1874530	0.0428200
cg03345607	Foxp2	6	15123751	1.153020e-03	1.217901e-05	0.1671222	0.0382050
cg18539981	Cacna1e	1	154561732	1.153020e-03	1.219714e-05	0.1478820	0.0338091
cg06658605	Sox6	7	115747711	1.168071e-03	1.240578e-05	-0.0605285	0.0138499
cg20092403	Tmem260	14	148393336	1.169771e-03	1.247334e-05	0.2897882	0.0663260
cg22103694	Rbfox1	16	17555264	1.184709e-03	1.280841e-05	0.1844174	0.0422651
cg26603143	Sox4	13	128949874	1.184709e-03	1.283313e-05	-0.0992672	0.0227524
cg14247424	Epha3	16	163958324	1.184709e-03	1.276344e-05	-0.3002004	0.0687883
cg18058532	Pax6	2	105675601	1.184709e-03	1.277033e-05	-0.2253022	0.0516274
cg13142119	Prrx1	1	163248395	1.190630e-03	1.294766e-05	0.3067564	0.0703410
cg10972783	Mllt10	2	18048432	1.194763e-03	1.304315e-05	-0.2114147	0.0484965
cg26851215	Npas3	12	153647596	1.195753e-03	1.314887e-05	0.1852173	0.0425043
cg07367585	Ola1	2	73128115	1.195753e-03	1.315516e-05	0.1999130	0.0458778
cg18506907	Msr1	8	39746398	1.216427e-03	1.343408e-05	0.1737723	0.0399209
cg25430192	Dlx6os1	6	6871767	1.217867e-03	1.350151e-05	-0.2862769	0.0657833
cg24901288	Msantd4	9	4427125	1.246054e-03	1.386672e-05	0.0812673	0.0186995
cg23503238	Zbtb7c	18	175835728	1.262303e-03	1.415060e-05	0.1480253	0.0340953
cg17199893	Hoxb5os	11	196310702	1.262303e-03	1.415437e-05	-0.2589021	0.0596349
cg22618711	A930004D18Rik	2	18035793	1.286851e-03	1.453854e-05	0.3001709	0.0692345
cg07467137	Dynll2	11	187981285	1.286851e-03	1.452276e-05	0.2217331	0.0511400
cg16673182	Lcorl	5	45732367	1.362285e-03	1.544841e-05	-0.3493055	0.0808167
cg10586028	Cdk8	5	146283668	1.374838e-03	1.566230e-05	0.2481824	0.0574608
cg24268851	Atp9b	18	180812934	1.374838e-03	1.570711e-05	0.2689437	0.0622767
cg11846721	Sdk1	5	141245156	1.386393e-03	1.589779e-05	0.2101188	0.0486852
cg18033417	Ptma	1	86545796	1.419084e-03	1.633271e-05	0.2116096	0.0490985
cg13615735	Fign	2	64366825	1.424696e-03	1.645758e-05	0.2683627	0.0622909
cg22773167	Rhob	12	18499563	1.425153e-03	1.652317e-05	-0.0530141	0.0123079
cg00423854	Sall1	8	89560560	1.455771e-03	1.693975e-05	0.1835163	0.0426601
cg02132378	Satb1	17	151702531	1.457935e-03	1.707554e-05	0.1391392	0.0323575
cg25362942	Rac2	15	178564932	1.457935e-03	1.708831e-05	-0.1306724	0.0303897
cg23805666	1700123L14Rik	6	96180617	1.463076e-03	1.721047e-05	0.3021725	0.0703003
cg16278300	Reln	5	22080769	1.475076e-03	1.741405e-05	0.1421629	0.0330942
cg12830810	Psme4	11	130807816	1.493242e-03	1.769169e-05	0.2598219	0.0605336
cg02321338	Gm10248	14	122930623	1.503205e-03	1.787334e-05	0.1800246	0.0419645
cg11099953	Tshz3	7	36873887	1.523994e-03	1.839670e-05	-0.0961924	0.0224564
cg17260978	Zbtb20	16	143371444	1.523994e-03	1.829679e-05	0.2684641	0.0626561
cg13634725	Ndufb9	15	158941539	1.523994e-03	1.831221e-05	0.2280349	0.0532228
cg17777454	Kalrn	16	134175763	1.523994e-03	1.844295e-05	0.2005224	0.0468187
cg00013247	Cdh5	8	103896817	1.523994e-03	1.837896e-05	0.2726008	0.0636364
cg08629862	Phf12	11	178030104	1.530976e-03	1.865701e-05	0.2356602	0.0550558
cg16007321	Nr5a2	1	136854380	1.530976e-03	1.860599e-05	0.1818532	0.0424792
cg15243041	Cacng4	11	1107735172	1.532085e-03	1.873535e-05	0.1709688	0.0399511
cg02429111	Stx17	4	48092407	1.545290e-03	1.896222e-05	0.2377898	0.0556003
cg14877474	Itpr1	6	108391888	1.550381e-03	1.909029e-05	0.1625608	0.0380235
cg26547442	I730028E13Rik	9	61145110	1.565976e-03	1.934858e-05	0.3549150	0.0830739
cg17011396	Hmx3	7	131497027	1.573707e-03	1.951069e-05	-0.1505081	0.0352443
cg25149527	Cacna2d3	14	128827255	1.584483e-03	1.971133e-05	0.2809625	0.0658279
cg04281230	Mir195b	2	56336072	1.604849e-03	2.003260e-05	0.2257936	0.0529469
cg10316830	Zbtb44	9	31066713	1.654419e-03	2.072136e-05	-0.2160615	0.0507547
cg10471264	Bcl11a	11	124078433	1.661592e-03	2.095182e-05	-0.2899815	0.0681588
cg12324159	Slc14a2	18	178753832	1.661592e-03	2.088518e-05	0.2884126	0.0677787
cg19489133	Gm19466	18	153693469	1.690095e-03	2.138274e-05	0.1244755	0.0292888
cg24676367	Tnik	3	28668013	1.700278e-03	2.158353e-05	0.2931967	0.0690224
cg03990624	Irx3	8	91827376	1.717432e-03	2.194663e-05	0.0954674	0.0224941
cg25133549	Tnrc6a	7	123170393	1.717432e-03	2.191470e-05	0.2407627	0.0567244
cg01168718	Gabrg2	11	141389625	1.717769e-03	2.202361e-05	0.1336173	0.0314889
cg04787747	Donson	16	191678171	1.719481e-03	2.223251e-05	0.1339533	0.0315838
cg13505793	Otp	13	194880332	1.719481e-03	2.226383e-05	-0.3657658	0.0862475
cg24743148	Esrrb	12	186580800	1.719481e-03	2.216894e-05	-0.1585646	0.0373810
cg03450698	Zic4	9	91399020	1.741695e-03	2.262515e-05	0.2047908	0.0483308
cg00194417	Tshz3	7	36458294	1.771159e-03	2.308285e-05	0.3028978	0.0715601
cg07023974	Rbfox2	15	177095035	1.794370e-03	2.346128e-05	0.3216605	0.0760586
cg20200185	Satb1	17	151803730	1.815670e-03	2.381659e-05	0.1836604	0.0434624
cg19000923	Il1rap	16	126662986	1.822984e-03	2.398968e-05	0.2139166	0.0506419
cg04290072	Prkd1	12	150295408	1.834543e-03	2.421941e-05	0.3567635	0.0845020
cg19381434	Lrmda	14	122363208	1.849376e-03	2.465000e-05	0.2721084	0.0645115
cg20194570	Kcnn2	18	145685661	1.849376e-03	2.455100e-05	0.2673507	0.0633699
cg21119395	Rps6ka3	20	159363542	1.849376e-03	2.458373e-05	0.2445062	0.0579592
cg26178630	Gm6249	7	136738628	1.904847e-03	2.555056e-05	0.1276718	0.0303267
cg10070910	4930405A10Rik	14	122534894	1.904847e-03	2.552643e-05	0.3180250	0.0755387
cg06333512	Bend4	5	67434890	1.909462e-03	2.587351e-05	0.1990507	0.0473137
cg13094532	Lrmda	14	122192352	1.909462e-03	2.593565e-05	0.2296320	0.0545898
cg04900296	Ppp2r1b	9	50913478	1.909462e-03	2.591128e-05	0.1303768	0.0309926
cg00718342	Fmn1	2	113619072	1.909462e-03	2.576411e-05	0.1514966	0.0360020
cg02762813	Cnot6	11	149683231	1.958811e-03	2.668884e-05	0.3067778	0.0730420
cg20468818	Xylt1	7	117579259	1.962123e-03	2.681698e-05	0.1988816	0.0473647
cg08982699	Celf6	9	59589242	1.969652e-03	2.724363e-05	0.2051619	0.0489021
cg22070870	Foxp1	6	98945391	1.969652e-03	2.725326e-05	0.2366584	0.0564106
cg08150966	AU016765	17	164547121	1.969652e-03	2.719005e-05	0.1802259	0.0429538
cg13844820	Elavl4	4	110287961	1.969652e-03	2.712380e-05	0.1651384	0.0393528
cg10040836	Nr2f2	7	70359974	1.977049e-03	2.743927e-05	-0.1001196	0.0238736
cg27484500	A330048O09Rik	13	148284927	1.995427e-03	2.784991e-05	0.1076701	0.0256946
cg17475635	Rbfox1	16	17520747	1.995427e-03	2.786319e-05	0.1749473	0.0417509
cg06750335	Mir195b	2	56119710	2.005193e-03	2.833895e-05	0.0619607	0.0148004
cg06674865	Wnt2	6	18024340	2.005193e-03	2.811562e-05	0.2529083	0.0603857
cg07479793	1700109G15Rik	11	184766109	2.005193e-03	2.831861e-05	0.2765542	0.0660573
cg08005019	C130071C03Rik	13	183729752	2.005193e-03	2.822703e-05	-0.1482860	0.0354131
cg14576454	Irx3	8	91990999	2.038306e-03	2.889318e-05	0.2966645	0.0709381
cg24414269	Cdk12	11	198224594	2.040783e-03	2.901464e-05	0.3339927	0.0798822
cg19753302	Atad2b	12	15119192	2.057053e-03	2.933301e-05	0.1076853	0.0257708
cg09117361	Fap	2	62503122	2.058087e-03	2.943483e-05	0.1586078	0.0379645
cg23053149	Ric8b	10	185004830	2.080442e-03	2.984258e-05	0.1673805	0.0400944
cg02522446	Mir196a-2	15	1102970938	2.085935e-03	3.000964e-05	-0.0475370	0.0113905
cg15060270	Spred2	11	119924391	2.114803e-03	3.051445e-05	-0.1225231	0.0293849
cg15035143	Mir142	11	187756842	2.122365e-03	3.071336e-05	0.0692433	0.0166126
cg17663591	Csmd1	8	15892880	2.122627e-03	3.086859e-05	0.2347536	0.0563369
cg11567215	4930524B15Rik	11	131931452	2.122627e-03	3.089679e-05	0.2432975	0.0583902
cg06562958	Ola1	2	73143899	2.125166e-03	3.106837e-05	0.1741530	0.0418085
cg15439774	Gm38409	14	167555169	2.125166e-03	3.111360e-05	-0.0626607	0.0150440
cg15677669	Fgf13	20	59125894	2.185863e-03	3.209472e-05	0.2909908	0.0699822
cg10378662	Sox5os3	6	144503671	2.196149e-03	3.251955e-05	0.2314982	0.0557147
cg13263798	Strbp	2	37580741	2.196149e-03	3.246763e-05	0.2087136	0.0502267
cg21191048	Celf4	18	126197240	2.196149e-03	3.252453e-05	0.3182001	0.0765819
cg14172937	Slc12a5	2	164968267	2.201301e-03	3.269398e-05	-0.0856883	0.0206287
cg23179251	Foxp2	6	15416584	2.204407e-03	3.292666e-05	0.2321290	0.0559048
cg03451546	Hoxb7	11	196285274	2.204407e-03	3.284368e-05	-0.3347077	0.0805982
cg02508227	Ascc3	10	150763653	2.221881e-03	3.328168e-05	0.2706899	0.0652302
cg10932472	Pbx3	2	34254181	2.270944e-03	3.411268e-05	0.2434754	0.0587521
cg14415460	Slc6a6	6	91748402	2.275921e-03	3.428374e-05	0.3883723	0.0937425
cg20426917	Tas1r2	4	139737094	2.333414e-03	3.524855e-05	0.3829075	0.0925657
cg20733736	Gm10578	7	137248673	2.363306e-03	3.600009e-05	0.1244203	0.0301132
cg02253804	4933427E13Rik	11	125287618	2.363306e-03	3.591199e-05	-0.2025494	0.0490159
cg26135564	Gzf1	2	148707212	2.363306e-03	3.589647e-05	-0.1034284	0.0250285
cg27531402	Paupar	2	105660539	2.405418e-03	3.683121e-05	-0.1934066	0.0468693
cg06798772	Lrmda	14	122037387	2.405418e-03	3.684515e-05	0.2034333	0.0493002
cg12813238	Cacna2d4	6	119359495	2.407099e-03	3.697275e-05	0.1363899	0.0330592
cg15428926	Bnc2	4	84307165	2.420718e-03	3.728437e-05	0.2480226	0.0601457
cg10353262	Zfp148	16	133434686	2.435657e-03	3.761752e-05	-0.1301191	0.0315697
cg04297588	A730082K24Rik	7	115089065	2.454953e-03	3.801942e-05	-0.2628076	0.0638007
cg16666801	NA	19	155931560	2.491097e-03	3.868457e-05	0.1650557	0.0401088
cg25993405	Tcf4	18	169529964	2.561058e-03	3.998775e-05	0.2467848	0.0600808
cg13602621	Sp5	2	70425883	2.561058e-03	3.991770e-05	0.1816421	0.0442172
cg20888789	Hat1	2	71421302	2.563506e-03	4.029918e-05	0.1982649	0.0482895
cg01579422	Atg4c	4	99266846	2.563506e-03	4.035139e-05	0.2647110	0.0644778
cg20187980	Celf2	2	8029261	2.563506e-03	4.034417e-05	0.0833327	0.0202978
cg15772697	Gm12128	11	137650267	2.570110e-03	4.056409e-05	0.2322405	0.0565855
cg05371975	Srek1	13	1103764400	2.570885e-03	4.068511e-05	0.1086714	0.0264823
cg04246600	4930433B08Rik	3	18714425	2.574773e-03	4.085559e-05	0.2675026	0.0652034
cg08152313	Foxp2	6	15407361	2.579125e-03	4.114290e-05	0.2835148	0.0691337
cg26299486	4930555K19Rik	15	140961245	2.579125e-03	4.112141e-05	0.2001349	0.0488005
cg08772487	Nedd4	9	72619984	2.589577e-03	4.141921e-05	0.3098546	0.0755850
cg09141136	Usp34	11	123414775	2.606139e-03	4.179439e-05	0.2082193	0.0508183
cg24654889	Gm32123	14	124837753	2.618504e-03	4.210348e-05	0.1434721	0.0350306
cg12015981	Cyld	8	88758504	2.630354e-03	4.240532e-05	0.2228548	0.0544349
cg19261448	Rora	9	69210492	2.645510e-03	4.276160e-05	0.1126722	0.0275346
cg21176649	1700057H15Rik	4	124219373	2.649867e-03	4.294416e-05	0.1626176	0.0397497
cg00719335	Gpat3	5	101033928	2.684734e-03	4.362281e-05	0.2239388	0.0547875
cg19044429	Diaph3	14	186772639	2.708792e-03	4.435757e-05	0.2368759	0.0580077
cg19642684	Baz2b	2	59983809	2.708792e-03	4.432617e-05	0.1202818	0.0294542
cg23254416	Pcsk1	13	175099328	2.708792e-03	4.427244e-05	0.2520337	0.0617129
cg22758731	Adk	14	121369281	2.777236e-03	4.559589e-05	-0.2553109	0.0626203
cg20420324	Slc12a8	16	133466940	2.857240e-03	4.703027e-05	0.2788986	0.0685269
cg10784922	Hdac8	20	102402632	2.963421e-03	4.890340e-05	0.1689060	0.0415942
cg17971729	Cdc42bpa	1	180093965	2.966881e-03	4.911890e-05	0.1812680	0.0446497
cg02259423	Gm6639	3	35464455	2.966881e-03	4.921159e-05	0.2796705	0.0688956
cg19336073	Pigv	4	133679041	3.062220e-03	5.104175e-05	0.2023500	0.0499530
cg15383869	Skor1	9	63217522	3.062220e-03	5.105212e-05	0.2784830	0.0687484
cg06413694	Rps6kc1	1	190713945	3.075729e-03	5.140747e-05	0.1555413	0.0384135
cg01548368	Aatf	11	184376647	3.161833e-03	5.298040e-05	0.1759561	0.0435311
cg03574837	Rassf10	7	112876092	3.291131e-03	5.528621e-05	0.2028146	0.0503003
cg25802459	Zdhhc1	8	105476640	3.336099e-03	5.618277e-05	0.1239778	0.0307767
cg14023941	Lncbate1	8	108281792	3.338548e-03	5.636529e-05	0.1383862	0.0343601
cg12441103	A730082K24Rik	7	115223729	3.356875e-03	5.681674e-05	0.2494755	0.0619714
cg10234511	Casz1	4	148867362	3.417902e-03	5.828352e-05	-0.1383812	0.0344261
cg07848252	Ago1	4	126443081	3.417902e-03	5.803573e-05	0.2021158	0.0502693
cg16698248	Tcf4	18	169593590	3.417902e-03	5.825273e-05	-0.2823008	0.0702279
cg13273888	Rbm15	3	107326119	3.439431e-03	5.893501e-05	0.1703263	0.0424010
cg09529245	Gm33948	18	127629535	3.439431e-03	5.894171e-05	0.2523279	0.0628149
cg25069660	Qk	17	110209154	3.441946e-03	5.913045e-05	0.1261244	0.0314035
cg19090034	5730522E02Rik	11	125536284	3.445659e-03	5.934005e-05	0.1307972	0.0325737
cg09286791	Bahcc1	11	1120232977	3.451055e-03	5.957899e-05	-0.1525192	0.0379923
cg23711940	Fancb	20	165129188	3.494063e-03	6.046934e-05	0.2771118	0.0690884
cg27313161	Med13	11	186270438	3.525259e-03	6.115839e-05	0.0580567	0.0144841
cg11531782	Etv1	12	138773113	3.599363e-03	6.259630e-05	0.2146873	0.0536342
cg06492659	Mtrex	13	1112901501	3.623299e-03	6.316587e-05	0.2712879	0.0678108
cg18496572	E330013P04Rik	19	160148961	3.674361e-03	6.421153e-05	0.1765154	0.0441645
cg19605887	Gm33301	15	140314514	3.743646e-03	6.558073e-05	0.3189755	0.0799082
cg23885267	Nnt	13	1119151081	3.802615e-03	6.677465e-05	-0.0612261	0.0153545
cg24727294	Dach1	14	198536637	3.816046e-03	6.777420e-05	0.2496775	0.0626706
cg12249796	Gm13205	4	148984460	3.816046e-03	6.734344e-05	0.1457693	0.0365751
cg26430247	Gsk3b	16	138243494	3.816046e-03	6.781786e-05	0.1510710	0.0379212
cg09751476	Pax6	2	105720279	3.816046e-03	6.752744e-05	0.1778809	0.0446395
cg24395509	Pax2	19	144724276	3.816046e-03	6.773393e-05	-0.0996529	0.0250126
cg06931862	Hoxa9	6	52226298	3.847702e-03	6.854324e-05	-0.1574632	0.0395508
cg24995571	Zfp507	7	35892595	3.919572e-03	6.998940e-05	0.3133223	0.0787970
cg09513654	Tcf7l2	19	155888060	3.942725e-03	7.056965e-05	-0.1999342	0.0503061
cg15802836	Unc79	12	1102949676	3.982604e-03	7.145195e-05	-0.1613791	0.0406353
cg18980984	A830082K12Rik	13	179346083	4.008428e-03	7.219673e-05	0.2796960	0.0704714
cg20125647	Sost	11	1101963996	4.008428e-03	7.225449e-05	0.0665384	0.0167656
cg23505379	Gm4791	9	47055111	4.013629e-03	7.251808e-05	0.3457404	0.0871350
cg07922932	Gpcpd1	2	132530686	4.080502e-03	7.389899e-05	0.2204036	0.0556101
cg16774573	Cables1	18	111905983	4.083094e-03	7.429148e-05	0.2162475	0.0545789
cg03619501	Lrmda	14	122046656	4.083094e-03	7.417969e-05	0.1928801	0.0486768
cg26472407	Scyl3	1	163934647	4.118483e-03	7.510964e-05	0.1158012	0.0292465
cg24823249	Car11	7	45700451	4.123409e-03	7.537395e-05	-0.2590200	0.0654314
cg05513775	Cacybp	1	160219348	4.135860e-03	7.595156e-05	0.2444498	0.0617792
cg25180674	Cnot2	10	1116507099	4.135860e-03	7.585841e-05	0.2726348	0.0688973
cg00687049	Camsap1	2	25952744	4.138040e-03	7.616670e-05	-0.2241159	0.0566500
cg19298746	Ipo5	14	1120911270	4.163070e-03	7.697972e-05	0.1149576	0.0290766
cg24079029	5730522E02Rik	11	126043567	4.163070e-03	7.689504e-05	0.2200273	0.0556485
cg11022831	Pbx3	2	34288925	4.167827e-03	7.741968e-05	-0.3152107	0.0797547
cg06794599	Fbxo33	12	159202482	4.167827e-03	7.742039e-05	-0.1605198	0.0406148
cg03165986	Bcl11a	11	124168136	4.199926e-03	7.819436e-05	0.2373516	0.0600910
cg13044883	Calcoco1	15	1102694513	4.236496e-03	7.905449e-05	-0.2456492	0.0622330
cg23237751	Atp11c	20	60236388	4.295246e-03	8.033254e-05	0.2471525	0.0626749
cg15693636	Celf2	2	6553935	4.296860e-03	8.054454e-05	0.1785174	0.0452771
cg27569107	Smarce1	11	199225045	4.306947e-03	8.128034e-05	0.1765520	0.0448034
cg15812839	Mef2c	13	183491076	4.306947e-03	8.120995e-05	0.2746759	0.0697005
cg12499300	Vps41	13	118613622	4.306947e-03	8.107148e-05	0.2996949	0.0760413
cg15659936	Celf4	18	125753508	4.367124e-03	8.260079e-05	0.1265304	0.0321410
cg10986437	Zfhx4	3	5222996	4.384169e-03	8.310870e-05	0.2444478	0.0621174
cg06860536	4930402F11Rik	7	69226496	4.402084e-03	8.389540e-05	0.1871181	0.0475765
cg11895464	4933406G16Rik	11	119265492	4.402084e-03	8.400710e-05	0.1716598	0.0436497
cg23170538	4933427E13Rik	11	125287626	4.402084e-03	8.367800e-05	-0.2333922	0.0593328
cg18014986	Gm20696	6	99467586	4.451093e-03	8.513070e-05	0.2713896	0.0690651
cg14699463	Chrd	16	120736085	4.469535e-03	8.567256e-05	-0.2064734	0.0525652
cg16820308	A830082K12Rik	13	178678608	4.473638e-03	8.594049e-05	-0.2214296	0.0563836
cg20546446	Slitrk1	14	1108913232	4.484631e-03	8.634144e-05	-0.2769437	0.0705395
cg20405104	Wwc1	11	136152724	4.548751e-03	8.800026e-05	-0.1435112	0.0365960
cg21007937	Tra2a	6	49252508	4.548751e-03	8.812608e-05	0.2612980	0.0666380
cg18059870	Slitrk1	14	1108913223	4.548751e-03	8.815334e-05	-0.1623146	0.0413954
cg26278617	Mir205	1	193610520	4.589667e-03	8.914049e-05	0.2398747	0.0612176
cg25326950	Ptch1	13	163554990	4.621606e-03	9.034749e-05	-0.1784293	0.0455741
cg21870895	Fto	8	91622456	4.621606e-03	9.029688e-05	0.1431266	0.0365559
cg25019647	Cdca2	14	167633016	4.621606e-03	9.029543e-05	-0.1083423	0.0276716
cg22454306	Skap2	6	51847017	4.689223e-03	9.226688e-05	0.1377189	0.0352215
cg00859590	B230323A14Rik	9	69670263	4.689223e-03	9.246300e-05	-0.1971957	0.0504393
cg14155184	Tmem63b	17	145662872	4.689223e-03	9.188092e-05	-0.2289085	0.0585281
cg23977950	Uncx	5	139549064	4.689223e-03	9.230996e-05	-0.2010928	0.0514309
cg14219120	Rragc	4	124087353	4.704533e-03	9.296395e-05	-0.0450695	0.0115319
cg13385016	Pitx2	3	129219349	4.730925e-03	9.368565e-05	-0.2440330	0.0624702
cg11873500	Ppfia2	10	1106835255	4.818733e-03	9.562838e-05	0.2172277	0.0556791
cg07847256	3100003L05Rik	7	124502578	4.845940e-03	9.637338e-05	0.2380797	0.0610532
cg20246785	Tnrc6b	15	180929729	4.892231e-03	9.750099e-05	0.2801050	0.0718821
cg11079986	Dlx1	2	71530104	4.919617e-03	9.825495e-05	-0.1010330	0.0259401
cg08307607	2900052N01Rik	9	46899689	5.062415e-03	1.016480e-04	0.2267430	0.0583393
cg11718387	Mir466f-4	13	171301635	5.062415e-03	1.015339e-04	0.2405001	0.0618746
cg02925560	Mab21l2	3	86560624	5.062415e-03	1.017496e-04	0.3404405	0.0875983
cg02973003	Gdf11	10	1128889342	5.097851e-03	1.026775e-04	0.2036192	0.0524228
cg18026227	Zfhx4	3	5218543	5.098004e-03	1.028963e-04	-0.2646488	0.0681442
cg00923443	Ccn3	15	154768444	5.105273e-03	1.032590e-04	-0.2082434	0.0536322
cg02594577	Stag1	9	100643642	5.172556e-03	1.048642e-04	0.1356426	0.0349680
cg03296938	Srbd1	17	185889818	5.172556e-03	1.050576e-04	0.1234671	0.0318329
cg02536733	Slc5a8	10	188902482	5.218887e-03	1.062195e-04	0.2236925	0.0577133
cg06998890	Ralgapb	2	158443304	5.229373e-03	1.068249e-04	0.1615901	0.0417056
cg25231515	Npas3	12	153647611	5.229373e-03	1.068754e-04	0.1793534	0.0462916
cg19695329	Fignl1	11	111758242	5.238103e-03	1.075274e-04	0.1627169	0.0420137
cg23733711	Tenm2	11	136714644	5.238103e-03	1.077188e-04	0.3075047	0.0794070
cg02146878	Wapl	14	134692111	5.238103e-03	1.072913e-04	0.2318345	0.0598517
cg02864518	Luc7l2	6	38568909	5.248798e-03	1.086050e-04	0.2186465	0.0564903
cg15663090	Agap1	1	89798683	5.248798e-03	1.083915e-04	0.1800862	0.0465219
cg11230269	Trrap	5	144816379	5.248798e-03	1.085827e-04	0.1651584	0.0426703
cg01491819	Nova1	12	147400865	5.298291e-03	1.098533e-04	0.0869439	0.0224793
cg22719807	Kif2a	13	1106993939	5.332912e-03	1.108863e-04	0.1842976	0.0476782
cg14700070	Mbnl1	3	60614690	5.332912e-03	1.110224e-04	-0.1498090	0.0387590
cg05575546	Nxph1	6	8956282	5.423333e-03	1.131343e-04	-0.1894829	0.0490819
cg22671032	Smad2	18	176286898	5.522746e-03	1.154418e-04	0.1722848	0.0446842
cg10436985	Pou3f4	20	110817802	5.538355e-03	1.162368e-04	0.1703508	0.0442018
cg18261844	Pou2f1	1	166002575	5.538355e-03	1.160300e-04	-0.1533949	0.0397977
cg14141896	Stra6	9	58061322	5.622555e-03	1.182419e-04	0.2170975	0.0563927
cg15736995	Gm10440	5	54279237	5.697468e-03	1.200583e-04	0.2612687	0.0679325
cg11777734	Ankfn1	11	189718503	5.705795e-03	1.204752e-04	0.1980544	0.0515075
cg26182201	2310008N11Rik	8	26530005	5.707345e-03	1.207495e-04	0.0626360	0.0162920
cg18640545	Mtx2	2	75073959	5.709961e-03	1.210464e-04	0.1078010	0.0280440
cg19715364	Nfib	4	82292742	5.815391e-03	1.240197e-04	0.1854289	0.0483134
cg17864122	1700061F12Rik	2	9388546	5.815391e-03	1.235573e-04	0.1813719	0.0472451
cg14388852	Ndufb2	6	39615743	5.815391e-03	1.238775e-04	-0.1780621	0.0463906
cg06647284	Calu	6	29361379	5.835140e-03	1.246878e-04	0.1466730	0.0382287
cg03957964	4930519K11Rik	14	124003796	5.925207e-03	1.268631e-04	-0.1335964	0.0348591
cg11985489	Gm14664	20	61026826	5.951016e-03	1.276675e-04	-0.3324798	0.0867886
cg20281703	Zbtb20	16	143221998	6.016626e-03	1.293296e-04	0.2043192	0.0533787
cg22956901	Gm36669	6	16769056	6.034555e-03	1.299703e-04	0.1746550	0.0456434
cg27505352	Prpf38b	3	108910375	6.051777e-03	1.305973e-04	-0.1464237	0.0382774
cg14587979	Gpd2	2	57567463	6.065451e-03	1.311491e-04	0.2668861	0.0697871
cg03626038	1810013L24Rik	16	18855906	6.075567e-03	1.316248e-04	0.1016877	0.0265962
cg13785336	Chmp4b	2	154694714	6.162659e-03	1.337724e-04	-0.2543298	0.0665888
cg18998268	Cntfr	4	41686224	6.184911e-03	1.345172e-04	0.0502547	0.0131624
cg08733030	Ptprm	17	166842810	6.220591e-03	1.355564e-04	0.1663040	0.0435791
cg21170489	Ahcyl2	6	29906720	6.234814e-03	1.361301e-04	0.2977082	0.0780343
cg22068328	Mbd5	2	49258068	6.254200e-03	1.368181e-04	0.2947007	0.0772712
cg09299803	Gm10578	7	137238669	6.315062e-03	1.384167e-04	0.1368567	0.0359111
cg06151126	Bnc2	4	84367260	6.342691e-03	1.392907e-04	0.2552900	0.0670154
cg07434650	B230303A05Rik	13	116745834	6.426105e-03	1.413944e-04	-0.2595000	0.0681869
cg25050264	Arhgef6	20	57243436	6.477335e-03	1.429669e-04	0.2346665	0.0617060
cg09715291	1700017J07Rik	2	169078340	6.477335e-03	1.430698e-04	0.2071978	0.0544856
cg00847015	Skap2	6	51863306	6.692799e-03	1.481121e-04	0.1094308	0.0288415
cg10605443	Mef2c	13	183461653	7.113564e-03	1.580257e-04	0.2240341	0.0592980
cg24868356	Lhx1os	11	184564293	7.113564e-03	1.580023e-04	0.1487024	0.0393586
cg27381861	Zfp536	7	37450470	7.167513e-03	1.595524e-04	0.2228674	0.0590266
cg05308779	Fignl1	11	111761323	7.167513e-03	1.598307e-04	0.1303547	0.0345285
cg00452125	1700109G15Rik	11	184726113	7.172333e-03	1.603113e-04	0.1545624	0.0409488
cg01301067	Appl1	14	126949582	7.172333e-03	1.608487e-04	0.2656056	0.0703835
cg05399218	Pax6	2	105684792	7.172333e-03	1.606098e-04	0.1185401	0.0314091
cg19945696	Dnajc24	2	106074573	7.204078e-03	1.618654e-04	0.1941596	0.0514723
cg20129790	Celf4	18	125486897	7.216442e-03	1.624486e-04	-0.0645182	0.0171080
cg20051624	Gapvd1	2	34717294	7.227614e-03	1.630059e-04	0.2664262	0.0706632
cg06059859	Arntl	7	113207518	7.227668e-03	1.634470e-04	-0.0671711	0.0178187
cg07408640	Sfta3-ps	12	156473156	7.227668e-03	1.636188e-04	0.1997952	0.0530040
cg09228164	Pcdhgc4	18	137815784	7.284901e-03	1.652227e-04	-0.1589995	0.0422086
cg07150211	H2al1j	20	11672294	7.291253e-03	1.656752e-04	0.1916844	0.0508944
cg15048337	B230323A14Rik	9	69735124	7.296258e-03	1.664064e-04	0.1541132	0.0409308
cg07951445	Dpyd	3	118756377	7.296258e-03	1.662825e-04	0.2324927	0.0617445
cg08845156	Tmem218	9	37197254	7.324548e-03	1.673616e-04	0.2089323	0.0555112
cg25403836	Ola1	2	73157339	7.350405e-03	1.682634e-04	0.0936246	0.0248840
cg25828009	Zbtb10	3	9280356	7.403426e-03	1.697904e-04	0.2174662	0.0578340
cg24882108	Vrk2	11	126815320	7.471710e-03	1.716726e-04	0.1507677	0.0401253
cg09911517	Acaca	11	184362082	7.493050e-03	1.724800e-04	0.1879101	0.0500260
cg04501234	Nhsl2	20	102076198	7.508655e-03	1.731569e-04	0.1097369	0.0292221
cg16663507	Nova1	12	146696409	7.575027e-03	1.750080e-04	0.2494024	0.0664612
cg16713026	Pex14	4	149061890	7.590678e-03	1.756908e-04	0.2441724	0.0650844
cg05714931	Hgf	5	16778822	7.599436e-03	1.765366e-04	-0.2140147	0.0570642
cg01998099	Ccnt1	15	198546772	7.599436e-03	1.763850e-04	0.1674154	0.0446365
cg26530885	Ptprg	14	112156087	7.614422e-03	1.772070e-04	0.1773694	0.0473052
cg14419060	Cd101	3	101007499	7.670302e-03	1.788320e-04	-0.2185272	0.0583177
cg00469450	Ctcf	8	105671326	7.670569e-03	1.794874e-04	0.2794480	0.0745938
cg01451179	Pex14	4	149061892	7.670569e-03	1.793799e-04	0.1831041	0.0488745
cg04404249	C030029H02Rik	7	136196703	7.832525e-03	1.836085e-04	0.2071585	0.0553816
cg03215611	Slc25a36	9	97089531	7.843086e-03	1.841879e-04	0.1014787	0.0271350
cg14539976	Otx1	11	122017592	7.998405e-03	1.881739e-04	0.2477481	0.0663424
cg05457273	Kcnn2	18	145559339	8.016335e-03	1.892741e-04	-0.0669142	0.0179254
cg25429952	9230020A06Rik	11	171409556	8.016335e-03	1.890131e-04	0.2819244	0.0755168
cg10033233	Psmd7	8	107603547	8.018117e-03	1.896555e-04	-0.2167819	0.0580809
cg17860780	Mir3064	11	1106782730	8.028845e-03	1.902489e-04	0.2125717	0.0569649
cg01784456	A930004D18Rik	2	18030916	8.056306e-03	1.913475e-04	0.1975800	0.0529680
cg06530207	1700121N20Rik	12	1106479602	8.056306e-03	1.915814e-04	-0.2159093	0.0578866
cg05773824	Mllt3	4	88030453	8.065546e-03	1.921424e-04	0.2259084	0.0605794
cg03565531	Gm21054	6	103966835	8.183756e-03	1.953048e-04	0.1407697	0.0377904
cg26476875	Rnf11	4	109454311	8.278277e-03	1.979108e-04	0.1400204	0.0376230
cg07241696	Sdc3	4	130780937	8.311574e-03	1.990586e-04	-0.2179262	0.0585790
cg02409454	Vrk1	12	1106143168	8.320547e-03	1.996255e-04	-0.2601964	0.0699549
cg01434924	1700057H15Rik	4	124465387	8.368336e-03	2.011262e-04	0.1565978	0.0421234
cg25430306	Ush2a	1	188199813	8.416040e-03	2.026288e-04	0.2405263	0.0647322
cg17416197	Mir148a	6	51088987	8.520845e-03	2.055127e-04	-0.1928817	0.0519597
cg21410921	Tsx	20	103389499	8.530259e-03	2.061007e-04	0.1976226	0.0532472
cg03847760	Wdr7	18	163852649	8.596798e-03	2.080721e-04	-0.2178567	0.0587372
cg16089221	Msantd2	9	37513620	8.616406e-03	2.089113e-04	-0.1616487	0.0435947
cg00857016	Gm13205	4	148988880	8.617383e-03	2.092996e-04	0.1014449	0.0273619
cg20638433	5730522E02Rik	11	125601998	8.617823e-03	2.096750e-04	0.1331542	0.0359190
cg25848520	Eif3m	2	105003814	8.771017e-03	2.137734e-04	0.2652736	0.0716538
cg13517739	Gm30731	4	23173922	8.796519e-03	2.155115e-04	0.1739476	0.0470116
cg03649609	Pou5f2	13	177890165	8.796519e-03	2.153392e-04	-0.2217857	0.0599371
cg03160987	Mir3108	8	108942881	8.796519e-03	2.154105e-04	0.3262141	0.0881607
cg16299341	Osbpl9	4	109202173	8.826965e-03	2.166310e-04	-0.1909002	0.0516115
cg14090030	Tenm4	7	95639922	8.871873e-03	2.181085e-04	0.2021692	0.0546837
cg11921792	Trps1	15	150776685	8.907462e-03	2.194130e-04	0.2693366	0.0728814
cg19384540	Zfp536	7	37569908	8.907462e-03	2.197373e-04	-0.1569830	0.0424832
cg10283598	Csnk1g3	18	154058160	8.909564e-03	2.201661e-04	0.0993276	0.0268840
cg18663956	Casz1	4	148748300	9.001467e-03	2.228180e-04	-0.1997270	0.0541026
cg14471976	5730522E02Rik	11	125693548	9.011128e-03	2.234384e-04	0.1710558	0.0463449
cg02347319	Stag2	20	42151270	9.018805e-03	2.240104e-04	0.3171504	0.0859422
cg24517026	C430042M11Rik	17	183861967	9.047933e-03	2.251168e-04	0.1363440	0.0369594
cg24839708	Brpf1	6	113319793	9.075607e-03	2.261893e-04	0.2854755	0.0774105
cg21097107	Wdr72	9	74148365	9.193226e-03	2.295097e-04	0.2494622	0.0677131
cg18366518	1700061F12Rik	2	9435461	9.240166e-03	2.312279e-04	0.1658370	0.0450375
cg04415268	Ptprg	14	112220661	9.240166e-03	2.314636e-04	-0.1475957	0.0400864
cg03346667	Npm1	11	133155218	9.258334e-03	2.323104e-04	0.1491532	0.0405196
cg06455702	Hoxd9	2	74699205	9.276272e-03	2.331530e-04	-0.1280056	0.0347833
cg21801898	Mosmo	7	120730535	9.276460e-03	2.335503e-04	0.1552084	0.0421802
cg18491911	Celf2	2	6607954	9.344806e-03	2.356664e-04	-0.2093411	0.0569271
cg14290519	Ranbp17	11	133300099	9.480972e-03	2.395016e-04	0.2483180	0.0676020
cg16573177	Sfta3-ps	12	156459074	9.486647e-03	2.400463e-04	-0.0666471	0.0181469
cg21584134	Grb14	2	64863657	9.583814e-03	2.429105e-04	0.2067926	0.0563526
cg23137310	Mir6343	1	76513744	9.810847e-03	2.490800e-04	0.1501082	0.0409773
cg24032550	Ofcc1	13	140067939	9.837444e-03	2.505878e-04	0.1840849	0.0502737
cg27414251	Csde1	3	103040490	9.837444e-03	2.505162e-04	-0.1719869	0.0469687
cg11465136	4930578E11Rik	18	129835531	9.860101e-03	2.515822e-04	-0.2559972	0.0699323
cg15664051	Zeb2	2	44983856	9.869937e-03	2.522508e-04	0.1879271	0.0513467
cg07237739	Doc2g	19	14004640	1.000257e-02	2.560639e-04	0.2752917	0.0752962
cg05174060	Kmt2b	7	30583455	1.010062e-02	2.593158e-04	0.1843596	0.0504697
cg02136371	Bach2	4	32585770	1.010062e-02	2.594286e-04	0.0955879	0.0261686
cg06702418	Ahdc1	4	133077132	1.010683e-02	2.600157e-04	0.1385107	0.0379254
cg21461169	Hebp2	10	118516061	1.012099e-02	2.608083e-04	0.0539650	0.0147792
cg18149408	Mef2c	13	183663715	1.013293e-02	2.615448e-04	0.2237898	0.0613008
cg16283106	Farp1	14	1121253989	1.013735e-02	2.622575e-04	0.2126013	0.0582472
cg02699578	A530013C23Rik	2	167765295	1.013735e-02	2.625167e-04	-0.1477217	0.0404747
cg19850445	Bcl9l	9	44500948	1.014756e-02	2.636399e-04	0.1753120	0.0480487
cg25408888	Tra2a	6	49252585	1.014756e-02	2.634244e-04	0.1278711	0.0350443
cg14182504	Lrmda	14	122385758	1.018804e-02	2.651228e-04	0.2631365	0.0721477
cg08318939	Taok2	7	126867387	1.028169e-02	2.679949e-04	0.1597698	0.0438396
cg24830181	Ttc29	8	78271982	1.031607e-02	2.693275e-04	0.1493935	0.0410067
cg16159306	Zdhhc17	10	1110962351	1.040436e-02	2.728348e-04	0.0663523	0.0182296
cg00332561	Zeb2	2	45170634	1.040436e-02	2.726321e-04	0.1570111	0.0431349
cg15377754	Btaf1	19	137021930	1.040436e-02	2.731944e-04	0.1365689	0.0375243
cg18655951	Cadm3	1	173390339	1.040436e-02	2.733934e-04	-0.2758488	0.0757975
cg25938965	Sin3a	9	57113593	1.040647e-02	2.738892e-04	0.1836638	0.0504734
cg21171640	Gria2	3	80690679	1.041520e-02	2.750005e-04	0.1551367	0.0426460
cg25922445	Nsd3	8	25675094	1.041520e-02	2.748025e-04	0.2073985	0.0570095
cg25332315	Zbtb20	16	143540421	1.041552e-02	2.754497e-04	-0.1138616	0.0313034
cg03371633	Got2	8	96780622	1.057127e-02	2.800158e-04	0.1169089	0.0321787
cg13885848	Asf1a	10	153606187	1.057422e-02	2.809889e-04	0.2749001	0.0756837
cg17489004	Wdr20	12	1110738272	1.057422e-02	2.805607e-04	0.0977633	0.0269126
cg07874737	Zfhx3	8	107827674	1.060186e-02	2.821719e-04	0.1080049	0.0297441
cg01136078	Foxo6	4	120267142	1.061911e-02	2.830918e-04	0.1957774	0.0539287
cg11211699	B130024G19Rik	7	70424012	1.061911e-02	2.835297e-04	0.1626111	0.0447977
cg01841970	1700019E08Rik	2	46327097	1.062083e-02	2.844745e-04	0.2325176	0.0640713
cg08013737	Aatf	11	184370503	1.062083e-02	2.844372e-04	0.2714123	0.0747883
cg12035531	Ebf1	11	144745891	1.062510e-02	2.851283e-04	0.1219184	0.0336007
cg10732227	Brd1	15	188712775	1.062510e-02	2.858406e-04	0.2414950	0.0665678
cg01021339	Npm2	14	170664563	1.062510e-02	2.859377e-04	0.2189709	0.0603605
cg05690537	Rbm15b	9	106863136	1.067271e-02	2.876706e-04	0.0901458	0.0248599
cg23386094	Mitf	6	98080434	1.067429e-02	2.886163e-04	-0.2055952	0.0567111
cg01342157	Osr1	12	19368850	1.067429e-02	2.885810e-04	0.1820075	0.0502042
cg02930311	Piezo2	18	163010496	1.076889e-02	2.916299e-04	0.1670966	0.0461258
cg06793460	Psat1	19	115791793	1.082777e-02	2.936827e-04	0.1595548	0.0440661
cg21694863	Fbxw2	2	34822985	1.085313e-02	2.952889e-04	0.1186461	0.0327806
cg01184817	H2al1j	20	11631343	1.085313e-02	2.949948e-04	0.2082844	0.0575426
cg18710779	D930020B18Rik	10	1121685895	1.085495e-02	2.976349e-04	0.2485325	0.0687057
cg27135856	Prox1	1	190118668	1.085495e-02	2.972599e-04	0.1877584	0.0519003
cg07863286	4930426D05Rik	18	121575816	1.085495e-02	2.969975e-04	0.2203370	0.0609018
cg02237133	Egln3	12	154072131	1.085495e-02	2.961210e-04	0.1724388	0.0476525
cg07039010	Irx3	8	91665636	1.085495e-02	2.968094e-04	0.1642819	0.0454060
cg23807698	Gpd2	2	57378532	1.087661e-02	2.986891e-04	0.1655767	0.0457845
cg10581670	Faxc	4	22134234	1.095266e-02	3.012411e-04	-0.1933546	0.0534981
cg16537155	Eri3	4	117648549	1.096828e-02	3.021347e-04	0.1278755	0.0353886
cg07960607	Mir5120	4	44561054	1.098462e-02	3.030497e-04	-0.2543057	0.0703925
cg23531839	Rasa1	13	185227004	1.099422e-02	3.040476e-04	0.2152389	0.0595928
cg01819137	Pou4f3	18	142395941	1.099422e-02	3.042450e-04	0.0684754	0.0189596
cg25112368	Ebf1	11	144904134	1.100743e-02	3.050763e-04	0.1994370	0.0552312
cg03957712	Atf7ip	6	136603295	1.105335e-02	3.068167e-04	0.1249920	0.0346289
cg18440438	Nfib	4	82295056	1.112240e-02	3.092038e-04	0.2666720	0.0739223
cg12149303	Sp3	2	72936705	1.117448e-02	3.111245e-04	0.1698619	0.0471072
cg23712344	Rarb	14	116575148	1.117859e-02	3.117120e-04	-0.1047586	0.0290563
cg13155053	Arrdc3	13	180515064	1.118190e-02	3.122776e-04	0.1883247	0.0522414
cg13160087	Gm30731	4	23050906	1.119019e-02	3.129824e-04	0.1839661	0.0510406
cg03415532	B3galt2	1	143640696	1.120809e-02	3.139575e-04	-0.0885959	0.0245860
cg16846234	4930448I06Rik	1	41121063	1.129384e-02	3.168374e-04	0.1450921	0.0402907
cg02576158	Mink1	11	170607772	1.130500e-02	3.176287e-04	0.0950058	0.0263870
cg20668249	Wdr1	5	38526859	1.131878e-02	3.189738e-04	0.1771684	0.0492219
cg24667552	1700109G15Rik	11	184723068	1.131878e-02	3.189539e-04	0.1028063	0.0285621
cg26709901	Nrxn1	17	190704070	1.133444e-02	3.198946e-04	0.1881529	0.0522845
cg13089275	Lmo1	7	109170441	1.133844e-02	3.204874e-04	-0.0764050	0.0212345
cg16477041	Foxd3	4	99444890	1.135869e-02	3.215404e-04	0.1590894	0.0442247
cg21461483	Dnm2	9	21478929	1.146596e-02	3.260325e-04	0.1834451	0.0510465
cg16920926	Otx1	11	122078917	1.146596e-02	3.252945e-04	0.1728462	0.0480893
cg02001174	Igbp1b	6	138709002	1.146596e-02	3.260166e-04	-0.2519682	0.0701139
cg23147149	Mnt	11	174831009	1.146829e-02	3.265841e-04	0.0714369	0.0198809
cg11577476	Galnt3	2	66093670	1.146870e-02	3.270809e-04	0.2499099	0.0695576
cg23864825	Pbx3	2	34245162	1.148707e-02	3.280910e-04	-0.1063023	0.0295938
cg12311671	Pou6f2	13	118336540	1.151844e-02	3.294741e-04	0.1347886	0.0375356
cg14155777	Chd9	8	91008744	1.157552e-02	3.315969e-04	-0.1497550	0.0417229
cg06186797	Arx	20	93253878	1.162394e-02	3.334758e-04	0.0893116	0.0248931
cg23938194	Kpnb1	11	197171664	1.163285e-02	3.345736e-04	0.1247117	0.0347682
cg19449076	Efna5	17	162810756	1.163285e-02	3.347157e-04	0.1989170	0.0554575
cg02384111	Pld2	11	170551229	1.164872e-02	3.361638e-04	0.2153779	0.0600657
cg00847238	Sec63	10	142783450	1.164872e-02	3.358039e-04	0.1212035	0.0337992
cg02877097	Ythdf2	4	132204574	1.164872e-02	3.366510e-04	0.1279446	0.0356856
cg23179691	Pax1	2	147340143	1.170999e-02	3.390440e-04	0.1606750	0.0448377
cg12435096	Mosmo	7	120731161	1.170999e-02	3.404038e-04	0.2854921	0.0796922
cg04091966	Evx2	2	74659894	1.170999e-02	3.402251e-04	-0.1182456	0.0330058
cg08034440	Evx2	2	74651128	1.170999e-02	3.398784e-04	0.2511562	0.0700997
cg07239853	Gm6260	3	143790463	1.189241e-02	3.472163e-04	0.2376769	0.0664411
cg12847291	Nfia	4	98116888	1.189241e-02	3.466063e-04	0.1686472	0.0471382
cg18535797	A730082K24Rik	7	115092883	1.189241e-02	3.467792e-04	0.2352361	0.0657527
cg23469509	Atp1a2	1	172280627	1.189484e-02	3.477905e-04	0.1617764	0.0452290
cg04345269	Zfp521	18	114091264	1.192351e-02	3.491333e-04	0.1678941	0.0469526
cg24700341	Exoc2	13	130877357	1.199345e-02	3.516886e-04	0.1481527	0.0414539
cg19526275	Stard10	7	101343963	1.200049e-02	3.524031e-04	0.0972544	0.0272164
cg08882563	Bcl9	3	97265823	1.200770e-02	3.531229e-04	0.2196249	0.0614706
cg23589509	Egfl6	20	166576332	1.205426e-02	3.550021e-04	0.1863996	0.0521915
cg10032440	Dscaml1	9	45753597	1.205519e-02	3.555395e-04	0.1998210	0.0559556
cg23698708	Ebf1	11	144753656	1.212663e-02	3.592824e-04	0.1214311	0.0340304
cg21328218	Fignl1	11	111761313	1.212663e-02	3.602123e-04	-0.1258538	0.0352765
cg01855583	Camta1	4	151835859	1.212663e-02	3.590297e-04	0.1095442	0.0306975
cg05655186	Cryba1	11	177712091	1.212663e-02	3.590486e-04	0.3100936	0.0868978
cg24056059	Rragc	4	124087199	1.212663e-02	3.601812e-04	0.0991459	0.0277902
cg07445298	Lhx9	1	138831029	1.214185e-02	3.619598e-04	0.1408369	0.0394903
cg10428279	Gabpb1	2	126675368	1.214185e-02	3.622026e-04	-0.1513647	0.0424443
cg01487930	Sap130	18	131648226	1.214185e-02	3.622057e-04	-0.0760410	0.0213228
cg04222851	Dennd1a	2	38126568	1.216543e-02	3.634237e-04	0.1311370	0.0367813
cg09079366	Habp2	19	156234679	1.220148e-02	3.650169e-04	0.1084458	0.0304267
cg25343690	Gm7134	20	110076539	1.221836e-02	3.660391e-04	0.1571413	0.0440983
cg19002093	Fign	2	63980880	1.238096e-02	3.714339e-04	0.2382095	0.0669205
cg22025436	Crem	18	13268118	1.242414e-02	3.739314e-04	0.0908500	0.0255352
cg13843674	Gm12353	4	19611805	1.242414e-02	3.738277e-04	0.1707094	0.0479803
cg27245728	Prickle2	6	92545149	1.242414e-02	3.743065e-04	0.1563469	0.0439477
cg15946322	Ythdc1	5	86829448	1.247829e-02	3.764661e-04	0.2240086	0.0629936
cg08560335	Lmo4	3	144327472	1.249764e-02	3.775787e-04	0.1723543	0.0484784
cg05079374	Sox6	7	115406148	1.262979e-02	3.821057e-04	0.2453045	0.0690582
cg02551260	Psmd7	8	107603376	1.271796e-02	3.853111e-04	-0.2243734	0.0632048
cg20911152	Gm29443	7	16564897	1.275593e-02	3.870012e-04	0.2113981	0.0595690
cg23798080	Vti1a	19	155384487	1.277191e-02	3.880265e-04	0.2055583	0.0579348
cg25639785	Slc25a21	12	157076737	1.277509e-02	3.886636e-04	0.1415510	0.0398998
cg21677205	Dazap2	15	1100620645	1.277741e-02	3.897446e-04	0.0709924	0.0200151
cg16889221	Pepd	7	34908796	1.277741e-02	3.898157e-04	0.1728818	0.0487419
cg17527816	Pea15a	1	172199224	1.289769e-02	3.957689e-04	0.1018072	0.0287356
cg20273694	Mir6994	19	111920859	1.289769e-02	3.956184e-04	0.1491090	0.0420856
cg27435315	Spred2	11	119763506	1.289769e-02	3.957366e-04	-0.2493509	0.0703802
cg01962309	Hps1	19	142931604	1.289769e-02	3.962139e-04	0.1923929	0.0543085
cg24125696	Etnk1	6	143192891	1.289769e-02	3.956007e-04	0.1792778	0.0506005
cg12616024	Epha4	1	77310546	1.291694e-02	3.973517e-04	0.1951722	0.0551048
cg12583849	Ccdc171	4	83865659	1.295760e-02	3.995762e-04	0.2250766	0.0635744
cg00712594	Zfp423	8	87749998	1.295760e-02	3.996992e-04	0.1662462	0.0469584
cg14464354	Btrc	19	145446927	1.302768e-02	4.024121e-04	-0.1238888	0.0350117
cg07211246	Lmo4	3	143972273	1.305974e-02	4.039552e-04	0.2510986	0.0709822
cg06109074	Mir721	5	136434679	1.316558e-02	4.077861e-04	-0.0875727	0.0247731
cg04121186	Gm16551	9	74855098	1.317330e-02	4.088680e-04	-0.2174697	0.0615313
cg21221291	Zfhx3	8	108790378	1.317330e-02	4.096973e-04	0.1029245	0.0291261
cg26538921	Cadm1	9	47386643	1.317330e-02	4.094529e-04	0.2094424	0.0592664
cg23738105	Ascl1	10	187389201	1.319408e-02	4.114600e-04	0.2085982	0.0590491
cg13235828	Fgfr2	7	130198471	1.319408e-02	4.109610e-04	0.0825858	0.0233759
cg18315873	Mir1951	2	115658903	1.320293e-02	4.134121e-04	0.1834931	0.0519609
cg07473509	Nrxn3	12	188900430	1.320293e-02	4.131286e-04	0.1666960	0.0472019
cg24824483	1700095J12Rik	4	138103318	1.320293e-02	4.130297e-04	0.1598387	0.0452594
cg06611078	1700019E08Rik	2	45605993	1.321210e-02	4.142582e-04	-0.2677816	0.0758410
cg19024429	Npvf	6	50667827	1.322587e-02	4.152498e-04	-0.2404545	0.0681136
cg27251994	Asxl1	2	153397902	1.325366e-02	4.166831e-04	0.1222865	0.0346491
cg00557468	Mir6944	13	155473000	1.362695e-02	4.289954e-04	0.1909718	0.0542291
cg20350922	Foxp1	6	98945174	1.365873e-02	4.311519e-04	0.2422378	0.0688128
cg04814124	Zfhx2	14	155072830	1.365873e-02	4.306031e-04	0.2162817	0.0614335
cg02260294	Zadh2	18	184232712	1.378774e-02	4.358076e-04	0.2576108	0.0732391
cg17398634	Spag9	11	194044414	1.385279e-02	4.384500e-04	-0.2515516	0.0715491
cg19192708	Cadps2	6	23464398	1.387537e-02	4.409260e-04	0.2181816	0.0620841
cg05297127	Ing4	6	125047229	1.387537e-02	4.405924e-04	0.2082887	0.0592656
cg21203153	Msx2	13	153463666	1.387537e-02	4.406742e-04	-0.1926405	0.0548139
cg27124812	Rsbn1	3	103928455	1.391686e-02	4.434221e-04	0.1967153	0.0559997
cg07693105	Nbea	3	55750828	1.391686e-02	4.429988e-04	-0.2347147	0.0668123
cg02960107	Zeb2	2	45113126	1.394121e-02	4.467655e-04	-0.0764823	0.0217849
cg02523045	Phip	9	82916003	1.394121e-02	4.452987e-04	0.1662651	0.0473464
cg03915996	Tshz3	7	36731998	1.394121e-02	4.454031e-04	0.1768442	0.0503599
cg02227217	1700034P13Rik	1	9724383	1.394121e-02	4.471474e-04	0.1491901	0.0424974
cg03833577	Zfpm2	15	140825525	1.394121e-02	4.468654e-04	-0.2084714	0.0593811
cg14620112	Mllt10	2	18050739	1.399714e-02	4.495336e-04	-0.2628966	0.0749174
cg15715091	Hectd1	12	151754997	1.413643e-02	4.546053e-04	0.1222511	0.0348674
cg19962725	Skor1	9	63136182	1.418734e-02	4.568430e-04	-0.2486924	0.0709564
cg12296383	Map3k7	4	31328928	1.429041e-02	4.607664e-04	0.1590173	0.0454000
cg17633606	Lef1	3	131137275	1.435085e-02	4.647993e-04	0.1528526	0.0436689
cg00038376	Tbca	13	194685382	1.435085e-02	4.651441e-04	0.2030564	0.0580150
cg00312241	Camp	9	109842511	1.435085e-02	4.643116e-04	0.2470783	0.0705829
cg01943432	Cacna1c	6	118741872	1.435085e-02	4.640007e-04	0.1133263	0.0323723
cg19834279	Jag1	2	137090872	1.437540e-02	4.665481e-04	0.1279230	0.0365571
cg09922578	Ppp3cb	14	120523702	1.447250e-02	4.703119e-04	0.2650688	0.0757963
cg11547453	Zdhhc16	19	141939710	1.447385e-02	4.709681e-04	0.1032819	0.0295366
cg18828625	Fign	2	64097221	1.449644e-02	4.723165e-04	-0.1971958	0.0564064
cg12543498	C230079O03Rik	7	136360574	1.450903e-02	4.734738e-04	0.1388605	0.0397274
cg07173733	Smc5	19	123257597	1.450903e-02	4.739547e-04	-0.1419349	0.0406101
cg24176069	Hoxc4	15	1103032736	1.451083e-02	4.746276e-04	-0.1760521	0.0503772
cg21757210	Gm13205	4	148988739	1.451314e-02	4.753170e-04	0.1403836	0.0401751
cg00599230	Phf12	11	178024926	1.452049e-02	4.761722e-04	-0.0786384	0.0225079
cg11741181	Rbm39	2	156178850	1.452757e-02	4.770192e-04	-0.2480278	0.0710002
cg04724018	Stag2	20	42276562	1.457869e-02	4.793147e-04	0.1840801	0.0527139
cg23552337	Bcl11a	11	124087341	1.458239e-02	4.800532e-04	-0.2037183	0.0583445
cg17764331	4930441J16Rik	2	74151997	1.468151e-02	4.839376e-04	0.1861652	0.0533502
cg07502526	4933427E13Rik	11	125311276	1.475609e-02	4.875100e-04	0.1064786	0.0305313
cg05376468	Jakmip2	18	143562614	1.475609e-02	4.876448e-04	0.1138168	0.0326361
cg11232780	Gm30731	4	22987129	1.488816e-02	4.926393e-04	0.2000238	0.0574001
cg00658751	Srrm4	5	116516215	1.494844e-02	4.952663e-04	0.2101961	0.0603439
cg06678289	Mir760	3	122293026	1.499564e-02	4.974648e-04	0.0882426	0.0253417
cg01369969	Cyp7b1	3	18206157	1.504655e-02	4.997900e-04	-0.2138920	0.0614479
cg01088086	Slit2	5	48249843	1.505031e-02	5.005519e-04	0.1946635	0.0559304
cg03779905	Tmem28	20	99821662	1.507222e-02	5.019185e-04	0.0623170	0.0179086
cg26456205	Hoxb5	11	196303344	1.526948e-02	5.091336e-04	-0.2160413	0.0621540
cg12237348	Kcnma1	14	123363933	1.535867e-02	5.127573e-04	0.1091907	0.0314308
cg27633182	Prdm16	4	154456684	1.538714e-02	5.144132e-04	0.1616168	0.0465334
cg24364591	Zfp507	7	36208018	1.538714e-02	5.150097e-04	-0.2529509	0.0728372
cg19910880	Gm16294	15	140517435	1.539012e-02	5.164122e-04	0.1485139	0.0427736
cg09401976	Pcf11	7	92669488	1.539012e-02	5.157629e-04	0.1470613	0.0423511
cg04733387	Ptprd	4	75942064	1.542189e-02	5.181305e-04	0.2141627	0.0616970
cg23087335	Hmx3	7	131497689	1.544921e-02	5.203559e-04	0.1339154	0.0385918
cg09494436	Zfp608	18	154889026	1.544921e-02	5.197943e-04	0.1624638	0.0468149
cg18117590	1700108J01Rik	14	1122233303	1.546010e-02	5.213770e-04	-0.2349075	0.0677059
cg25581768	Egln3	12	153837501	1.547147e-02	5.224150e-04	0.1404929	0.0404996
cg10180387	Bnc2	4	84285345	1.547663e-02	5.232442e-04	-0.1330857	0.0383691
cg17853439	Acvr2a	2	48250479	1.562136e-02	5.287981e-04	0.1210414	0.0349252
cg10876456	1700025G04Rik	1	151893318	1.562527e-02	5.302530e-04	0.0960926	0.0277324
cg26867175	Hif1an	19	144632858	1.562527e-02	5.297373e-04	0.0997265	0.0287790
cg12958309	Prcp	7	93023579	1.573813e-02	5.356541e-04	-0.1624233	0.0469125
cg14522338	Prkd1	12	150260879	1.573813e-02	5.360806e-04	0.1857635	0.0536571
cg25204951	Prkd1	12	150158033	1.573813e-02	5.359527e-04	0.2577185	0.0744397
cg14491323	1700057H15Rik	4	124375676	1.574509e-02	5.371806e-04	-0.1484620	0.0428895
cg18047414	Mir568	16	143642548	1.574509e-02	5.376502e-04	-0.0847440	0.0244835
cg04842881	Gm17066	14	1105031885	1.578548e-02	5.397107e-04	0.2147805	0.0620711
cg08008510	Zfr	15	112170846	1.578548e-02	5.403653e-04	0.0932482	0.0269511
cg22381406	5730522E02Rik	11	125857697	1.584066e-02	5.429244e-04	0.1548709	0.0447781
cg21408215	Mrps6	16	192078113	1.584789e-02	5.451840e-04	0.0783936	0.0226734
cg09973787	Lmo1	7	109261846	1.584789e-02	5.446673e-04	0.1431797	0.0414081
cg05762667	Mir195b	2	56519661	1.584789e-02	5.444856e-04	0.1547751	0.0447604
cg24082322	Nxpe4	9	48140862	1.598026e-02	5.504140e-04	-0.1223144	0.0354027
cg27432588	Ccdc92b	11	174630024	1.614155e-02	5.577562e-04	0.1946102	0.0563864
cg03422384	Clk3	9	57758277	1.614155e-02	5.578527e-04	0.0943204	0.0273288
cg09349516	Zbtb20	16	143371482	1.614155e-02	5.580184e-04	0.1295720	0.0375436
cg16456408	Map2k5	9	63230565	1.625563e-02	5.626498e-04	0.1156803	0.0335402
cg06267904	Meis1	11	118747886	1.627110e-02	5.638737e-04	0.1932626	0.0560438
cg07000689	Csnk1a1	18	161571809	1.630682e-02	5.658018e-04	0.1121124	0.0325199
cg24844787	Enox1	14	177611347	1.636670e-02	5.685720e-04	0.1096104	0.0318063
cg08868548	Pex14	4	149056511	1.638963e-02	5.700622e-04	-0.2391310	0.0694044
cg01595678	Dscam	16	196772412	1.639995e-02	5.725028e-04	-0.0873729	0.0253673
cg02453401	Cplane1	15	18182292	1.639995e-02	5.719853e-04	0.2363539	0.0686165
cg16617027	Slit2	5	48220023	1.639995e-02	5.720690e-04	0.0772836	0.0224367
cg02020196	Hnrnpl	7	28817396	1.642810e-02	5.750428e-04	0.2092306	0.0607677
cg23229181	Slc4a10	2	61983010	1.642810e-02	5.755708e-04	-0.2663026	0.0773490
cg01034352	Bnc2	4	84634770	1.642810e-02	5.751976e-04	0.1758643	0.0510781
cg03421587	Ebf3	7	137320038	1.648606e-02	5.782990e-04	-0.2319381	0.0673927
cg05008190	Mnt	11	174830320	1.648833e-02	5.790763e-04	0.0621500	0.0180604
cg10583293	Gm29683	7	70123058	1.654506e-02	5.817688e-04	0.1212500	0.0352474
cg03023666	Mir195b	2	56519648	1.659029e-02	5.840612e-04	0.1719308	0.0499957
cg17542851	Hivep2	10	114017939	1.665879e-02	5.871778e-04	-0.2712159	0.0788999
cg16789680	Ebf3	7	137316766	1.680239e-02	5.929503e-04	-0.1771849	0.0515849
cg23959331	4930565N06Rik	16	136893340	1.683433e-02	5.947897e-04	0.1491698	0.0434393
cg18255911	Prrc2c	1	162675728	1.685185e-02	5.964017e-04	0.0583350	0.0169912
cg22400231	Evx2	2	74651273	1.685185e-02	5.968348e-04	0.3290347	0.0958433
cg07988062	Zfp507	7	36134272	1.686169e-02	5.983726e-04	0.0721968	0.0210342
cg11778327	A730082K24Rik	7	115132023	1.686169e-02	5.986105e-04	-0.2598980	0.0757225
cg12228274	Dlx6os1	6	6869137	1.686707e-02	5.997544e-04	-0.2063204	0.0601215
cg15325057	Adk	14	121369214	1.686707e-02	6.002288e-04	-0.1401388	0.0408388
cg21072342	Hoxc4	15	1103034895	1.688351e-02	6.022427e-04	-0.0822165	0.0239656
cg21149585	Vrk1	12	1106055878	1.688351e-02	6.017204e-04	0.1916087	0.0558489
cg06131655	Thoc2	20	41814369	1.695417e-02	6.054805e-04	0.1242084	0.0362214
cg07283072	Gmpr	13	145549955	1.708096e-02	6.121766e-04	0.1032223	0.0301277
cg22075177	Srsf4	4	131873821	1.708096e-02	6.120593e-04	-0.0747884	0.0218283
cg14894237	Sp3	2	72970669	1.708096e-02	6.118160e-04	0.1589076	0.0463785
cg12042753	Nr6a1	2	38925403	1.708415e-02	6.136814e-04	0.0729556	0.0212978
cg22806872	Med12	20	101281768	1.708415e-02	6.137370e-04	0.1551111	0.0452817
cg16433982	Spred2	11	119529462	1.722277e-02	6.194454e-04	0.1967309	0.0574740
cg04920811	Rabl3	16	137567550	1.723565e-02	6.206381e-04	0.1386735	0.0405190
cg11137360	Gm32921	5	106385441	1.753490e-02	6.321556e-04	0.2039428	0.0596773
cg22253511	Cenpv	11	162536327	1.764823e-02	6.377350e-04	0.1839499	0.0538647
cg03665107	Ppp1r1b	11	198339214	1.764823e-02	6.376201e-04	-0.1656499	0.0485053
cg04181061	Vrk1	12	1106129501	1.771964e-02	6.410651e-04	0.1856216	0.0543768
cg26803233	Foxp2	6	15201707	1.795324e-02	6.502761e-04	0.1528186	0.0448184
cg06897917	Xpo7	14	170687628	1.796029e-02	6.527021e-04	0.1733871	0.0508659
cg00179574	Rock1	18	110065834	1.796029e-02	6.526451e-04	0.1278057	0.0374936
cg13299559	Gm12159	11	145154477	1.796029e-02	6.528113e-04	-0.1467048	0.0430387
cg25392099	Mzt1	14	198708229	1.804149e-02	6.572822e-04	0.2289209	0.0671952
cg13026235	Ptk2b	14	166177717	1.804149e-02	6.572894e-04	0.1386404	0.0406952
cg18279167	Mms22l	4	24213531	1.804914e-02	6.583320e-04	0.1974109	0.0579535
cg13349882	Mir196a-2	15	1102970929	1.810876e-02	6.637380e-04	-0.1747141	0.0513241
cg24236358	Kcnn2	18	145592411	1.810876e-02	6.643379e-04	0.1665868	0.0489401
cg19101454	Dmbx1	4	115963189	1.810876e-02	6.616257e-04	0.0416981	0.0122461
cg19434731	Srbd1	17	186036195	1.810876e-02	6.630191e-04	0.2502615	0.0735105
cg23017421	Aftph	11	120698300	1.810876e-02	6.636135e-04	0.0910234	0.0267387
cg05275734	Kmt2e	5	23435938	1.815936e-02	6.680024e-04	-0.1683301	0.0494741
cg12675684	BC005537	13	124809943	1.815936e-02	6.682541e-04	0.1932723	0.0568066
cg05553771	Vldlr	19	127241345	1.815936e-02	6.684992e-04	0.1342831	0.0394697
cg18271715	A830082K12Rik	13	178451535	1.816642e-02	6.695279e-04	0.1043145	0.0306648
cg00553886	Tead1	7	112680122	1.816684e-02	6.705874e-04	-0.1046953	0.0307807
cg19325516	Kcnc1	7	46438448	1.816684e-02	6.710807e-04	-0.1447216	0.0425510
cg11566569	Meis2	2	115905141	1.818160e-02	6.723955e-04	0.2464831	0.0724824
cg25399166	Mir1966	8	105616952	1.825985e-02	6.760619e-04	-0.2009492	0.0591182
cg04309649	Camta1	4	151830466	1.839880e-02	6.827634e-04	0.1896749	0.0558457
cg05484346	Egr3	14	170001899	1.839880e-02	6.821101e-04	-0.2051541	0.0603986
cg15225054	Nova1	12	146697952	1.841456e-02	6.841276e-04	0.2225174	0.0655260
cg01026068	Neb	2	52201454	1.841689e-02	6.849933e-04	0.0909967	0.0267991
cg11061300	Mir3963	3	150752049	1.843282e-02	6.863656e-04	0.1462084	0.0430662
cg06910030	Fam204a	19	160308721	1.847049e-02	6.885501e-04	0.2268882	0.0668479
cg01301023	4930441H08Rik	7	71324738	1.848817e-02	6.916767e-04	0.1910219	0.0563012
cg20655780	Chst12	5	140524172	1.848817e-02	6.923384e-04	0.1595624	0.0470325
cg09572367	Memo1	17	174225478	1.848817e-02	6.902423e-04	-0.0944962	0.0278468
cg07001258	Wnt5a	14	128505775	1.848817e-02	6.913595e-04	-0.0667965	0.0196867
cg05250259	Tbc1d14	5	36507602	1.849820e-02	6.942794e-04	0.0829618	0.0244593
cg06954407	Trp53bp1	2	121228135	1.849820e-02	6.936774e-04	0.2194162	0.0646851
cg15482199	Hoxc4	15	1103032739	1.853369e-02	6.963958e-04	-0.2571365	0.0758292
cg21015914	Ikzf1	11	111676047	1.869009e-02	7.030631e-04	0.2548549	0.0752144
cg25474998	Psat1	19	115340637	1.869139e-02	7.046937e-04	0.1911309	0.0564183
cg19195912	Fign	2	64326769	1.869139e-02	7.041392e-04	0.1674996	0.0494396
cg15892348	Gm10578	7	137207065	1.883091e-02	7.107507e-04	0.1572476	0.0464488
cg16176526	Galnt5	2	57907078	1.909845e-02	7.216568e-04	-0.2655981	0.0785511
cg23362864	Dph6	2	114438524	1.912951e-02	7.236486e-04	0.0811722	0.0240122
cg20376754	Atoh1	6	64754755	1.912951e-02	7.252589e-04	0.1218926	0.0360645
cg06077233	Tenm2	11	136420330	1.912951e-02	7.251650e-04	0.1828792	0.0541081
cg21785710	Wdpcp	11	121694156	1.923506e-02	7.306615e-04	0.2125042	0.0629119
cg23585860	Ier5l	2	30472832	1.923506e-02	7.308883e-04	0.0630670	0.0186715
cg07237683	Arf6	12	169373008	1.952487e-02	7.439624e-04	0.1170897	0.0347154
cg10340837	Ptprd	4	75957188	1.952487e-02	7.443788e-04	0.2250690	0.0667328
cg15549480	Zfp423	8	87707907	1.952487e-02	7.439750e-04	0.1599952	0.0474364
cg03866292	Mtch2	2	90847307	1.976806e-02	7.550464e-04	0.0854924	0.0253779
cg22798915	Mir3108	8	108908770	1.976806e-02	7.553235e-04	-0.2016228	0.0598524
cg26363439	Klhl29	12	15239963	1.982429e-02	7.583109e-04	-0.1718868	0.0510416
cg04915010	Mir32	4	56895210	1.984403e-02	7.599057e-04	0.2441557	0.0725143
cg10319365	4930519F24Rik	9	100203419	1.988321e-02	7.639297e-04	0.2188869	0.0650376
cg11474776	Arhgap15os	2	44313678	1.988321e-02	7.627183e-04	0.2359598	0.0701013
cg12902457	Dnah11	12	1117943846	1.988321e-02	7.635280e-04	0.1707526	0.0507333
cg05081037	Zeb2	2	44987143	1.991564e-02	7.660185e-04	0.2212545	0.0657558
cg13260139	Kat6b	14	121625158	1.999679e-02	7.699861e-04	0.1963304	0.0583732
cg23629468	Dcun1d1	3	35895657	2.000189e-02	7.710287e-04	0.1396259	0.0415184
cg02779952	6530403H02Rik	3	120429535	2.003287e-02	7.730705e-04	0.2197269	0.0653509
cg11470772	Lrmda	14	122037262	2.008551e-02	7.759517e-04	0.2535558	0.0754353
cg15569409	Csnk1d	11	1120963860	2.015760e-02	7.795897e-04	-0.2617458	0.0779019
cg17677607	Pou2f1	1	166002449	2.019183e-02	7.817679e-04	-0.2474420	0.0736616
cg15969104	Ppm1l	3	69317615	2.022105e-02	7.840637e-04	0.1327228	0.0395201
cg01702540	1700101O22Rik	12	17412197	2.022105e-02	7.846105e-04	0.2002726	0.0596375
cg15161323	Slc15a5	6	138002386	2.032897e-02	7.896584e-04	0.1324225	0.0394538
cg02190583	1500015L24Rik	19	120035441	2.053352e-02	7.993415e-04	-0.2683906	0.0800444
cg22418060	Bcl11a	11	124016396	2.053352e-02	7.988368e-04	0.1628332	0.0485606
cg18735834	B230110G15Rik	6	138560870	2.056301e-02	8.016664e-04	0.1553645	0.0463468
cg22556822	4930474H20Rik	14	191776341	2.056301e-02	8.022296e-04	0.2364252	0.0705321
cg23396613	Vti1a	19	155455759	2.064847e-02	8.064375e-04	0.1735006	0.0517823
cg23593328	Gm12130	11	138193931	2.068276e-02	8.086518e-04	0.1816798	0.0542357
cg14212735	Cadm1	9	47529191	2.069619e-02	8.100527e-04	-0.2772262	0.0827705
cg14769305	Gtf3c4	2	28835031	2.072797e-02	8.121735e-04	-0.1475073	0.0440503
cg00038872	Itga1	13	1115379932	2.072810e-02	8.130560e-04	-0.2562431	0.0765291
cg07607664	Etaa1	11	117812131	2.074372e-02	8.145465e-04	0.2327225	0.0695150
cg17706566	4930486I03Rik	1	20106670	2.086842e-02	8.203258e-04	0.2303791	0.0688553
cg14569995	Nrxn1	17	190704057	2.089108e-02	8.221007e-04	0.1664224	0.0497490
cg02632028	R3hcc1l	19	142539770	2.098260e-02	8.265901e-04	0.2274689	0.0680284
cg22625901	Mir721	5	136462848	2.104080e-02	8.297731e-04	-0.1225079	0.0366497
cg10317946	Ahcyl2	6	29896377	2.117299e-02	8.359190e-04	0.2110844	0.0631872
cg03927039	Pbx3	2	34247166	2.117299e-02	8.367777e-04	0.1658979	0.0496651
cg22015587	Npr3	15	111699815	2.120623e-02	8.397211e-04	0.2295591	0.0687435
cg16646236	Meis1	11	118882633	2.120623e-02	8.398863e-04	0.1696516	0.0508045
cg10190963	Sfta3-ps	12	156482863	2.122282e-02	8.414413e-04	-0.1582189	0.0473881
cg07700991	Bmp8a	4	123350584	2.124220e-02	8.445134e-04	-0.2544694	0.0762392
cg06179749	A3galt2	4	128743543	2.124220e-02	8.449063e-04	0.1812387	0.0543013
cg20409532	Smg1	7	118135509	2.124220e-02	8.434322e-04	0.1208211	0.0361942
cg21538469	Rims2	15	139275453	2.124593e-02	8.460036e-04	0.1994023	0.0597498
cg22022094	Ythdf3	3	16938850	2.124593e-02	8.468527e-04	0.1038699	0.0311267
cg12597701	Foxp1	6	99099980	2.141951e-02	8.546779e-04	0.2291035	0.0687080
cg26978528	Ddx42	11	1106238586	2.144143e-02	8.572186e-04	0.1492712	0.0447774
cg06044403	Ptch1	13	163554810	2.144143e-02	8.573669e-04	0.1726051	0.0517777
cg25734186	Tcf7l2	19	155627269	2.156635e-02	8.632747e-04	0.0941139	0.0282483
cg03554099	Foxp1	6	99321496	2.158737e-02	8.686336e-04	0.2785501	0.0836501
cg25111516	Rbms2	10	1128116065	2.158737e-02	8.671142e-04	0.1951317	0.0585905
cg19442410	Nol7	13	143402810	2.158737e-02	8.686816e-04	0.1833924	0.0550740
cg19158243	Ebf3	7	137308339	2.158737e-02	8.660575e-04	0.1413473	0.0424368
cg23981308	Slc7a11	3	50381897	2.158737e-02	8.686831e-04	-0.2012435	0.0604348
cg08973498	Cab39	1	85837297	2.170345e-02	8.742727e-04	0.1714501	0.0515153
cg22926123	4930448F12Rik	13	118085585	2.179781e-02	8.793292e-04	0.1010766	0.0303850
cg23545926	A830019L24Rik	3	143434408	2.179781e-02	8.799185e-04	0.2142828	0.0644198
cg00616272	4930428E07Rik	12	138436031	2.180621e-02	8.811801e-04	0.2424004	0.0728816
cg03220494	Sp9	2	73287626	2.186816e-02	8.846636e-04	0.0625583	0.0188154
cg03989701	Smim4	14	131110489	2.186816e-02	8.855343e-04	0.2263227	0.0680757
cg19529611	Isl2	9	55546788	2.188157e-02	8.879289e-04	0.1357399	0.0408385
cg12689672	1700109G15Rik	11	184729068	2.188157e-02	8.876429e-04	0.1463931	0.0440424
cg25370017	Mnd1-ps	14	19861909	2.188626e-02	8.890453e-04	0.1178735	0.0354670
cg12197907	Ppargc1a	5	50916223	2.197611e-02	8.936252e-04	0.1801560	0.0542306
cg07107696	4933430M04Rik	11	124330531	2.199297e-02	8.955486e-04	-0.1665892	0.0501557
cg20913086	Txndc11	16	111116865	2.199297e-02	8.989635e-04	0.2144401	0.0645831
cg22588215	Mllt10	2	18122326	2.199297e-02	8.978912e-04	0.2286217	0.0688473
cg18250414	Mecom	3	30286614	2.199297e-02	8.987348e-04	0.1310095	0.0394554
cg23560020	Gm12353	4	19621971	2.199297e-02	8.967409e-04	-0.3034676	0.0913765
cg03279079	Foxp2	6	15435479	2.220304e-02	9.084900e-04	0.1206880	0.0363800
cg11629501	Pinx1	14	163883865	2.223008e-02	9.105369e-04	0.0989955	0.0298466
cg23328459	Ranbp17	11	133430482	2.223284e-02	9.115908e-04	0.2190848	0.0660594
cg02190444	Ube2k	5	65581427	2.226326e-02	9.143591e-04	0.2466802	0.0743991
cg06369774	Gpatch2	1	187287141	2.226326e-02	9.147218e-04	0.2152359	0.0649176
cg20650220	Pknox2	9	37058308	2.233854e-02	9.187603e-04	0.1842377	0.0555889
cg03962027	Zfpm2	15	140658283	2.243434e-02	9.245990e-04	0.1978905	0.0597402
cg02001939	Pard3	8	127359742	2.243434e-02	9.239014e-04	0.0907502	0.0273944
cg05827187	Rnf220	4	117302433	2.245330e-02	9.263305e-04	0.1482095	0.0447493
cg18357091	Ttc21b	2	66201237	2.254110e-02	9.309066e-04	0.2359033	0.0712566
cg09136462	Brpf1	6	113309897	2.268239e-02	9.377011e-04	0.2297044	0.0694269
cg23223379	Mir6387	12	115791738	2.270402e-02	9.405170e-04	0.1843466	0.0557319
cg05162670	Etv5	16	122438665	2.270402e-02	9.403584e-04	-0.1690629	0.0511106
cg09525637	Fto	8	91631725	2.274426e-02	9.431461e-04	0.0998856	0.0302047
cg02248486	Hoxa5	6	52204320	2.277695e-02	9.454654e-04	-0.1807013	0.0546541
cg09371761	Melk	4	44319647	2.279064e-02	9.477982e-04	0.2639259	0.0798425
cg19792425	Arx	20	93367360	2.279064e-02	9.479624e-04	0.0598652	0.0181106
cg16293579	Mtr	13	112195291	2.279192e-02	9.489801e-04	0.2279001	0.0689513
cg11694987	Micall2	5	139682213	2.286063e-02	9.528083e-04	-0.2536945	0.0767817
cg19296935	Spata48	11	111528304	2.288568e-02	9.557894e-04	0.1525974	0.0461965
cg21352559	Nova1	12	146020901	2.288568e-02	9.556593e-04	0.2217766	0.0671386
cg02740381	Lin52	12	184483220	2.290542e-02	9.575828e-04	0.1594720	0.0482853
cg19891121	Zfp407	18	184556584	2.290975e-02	9.587334e-04	0.1212287	0.0367097
cg24913251	Ddx20	3	105667001	2.301809e-02	9.642412e-04	0.2235682	0.0677324
cg06182411	Rnf220	4	117492727	2.316310e-02	9.712956e-04	0.1117936	0.0338901
cg17803853	Tshz2	2	169832358	2.321282e-02	9.785354e-04	0.0969736	0.0294160
cg07144534	Birc6	17	174686176	2.321282e-02	9.818860e-04	0.1188593	0.0360653
cg11975481	2310008N11Rik	8	26562864	2.321282e-02	9.760411e-04	0.1322216	0.0400994
cg06360539	Phc3	3	30914473	2.321282e-02	9.822207e-04	0.1880296	0.0570553
cg22245041	Ss18	18	114637456	2.321282e-02	9.768685e-04	0.1920516	0.0582486
cg02058618	Csnk1a1	18	161569548	2.321282e-02	9.821309e-04	0.2340798	0.0710280
cg05192044	Pex2	3	6009730	2.321282e-02	9.754279e-04	0.1967695	0.0596720
cg00072466	Ythdc1	5	86828207	2.321282e-02	9.773486e-04	0.0922494	0.0279801
cg09531545	Atg4c	4	99375004	2.321282e-02	9.817081e-04	0.1109509	0.0336652
cg12395671	Cpeb2	5	43289357	2.342681e-02	9.972228e-04	0.1526695	0.0463857
cg03265769	Egln3	12	153926698	2.342681e-02	9.948608e-04	0.1032302	0.0313581
cg05839622	Kmt2a	9	44846885	2.342681e-02	9.956360e-04	0.1573364	0.0477971
cg13530363	Vps11	9	44356271	2.342681e-02	9.926873e-04	0.0749191	0.0227538
cg04901692	5730522E02Rik	11	125732749	2.342681e-02	9.933962e-04	0.1293458	0.0392863
cg01967702	Lrmda	14	122152590	2.342681e-02	9.963592e-04	0.2467321	0.0749592
cg19977128	Ptch1	13	163554974	2.348904e-02	1.001083e-03	-0.1731525	0.0526264
cg10446885	Tfap2b	1	19700110	2.348904e-02	1.001860e-03	-0.1552334	0.0471833
cg12315723	Fubp1	3	152232778	2.350250e-02	1.003428e-03	0.2211255	0.0672203
cg13690286	Stard10	7	101321745	2.350927e-02	1.004712e-03	0.1151066	0.0349953
cg16825463	Luc7l3	11	194292456	2.361482e-02	1.010222e-03	0.0968236	0.0294506
cg07597118	Nrxn3	12	189191170	2.379806e-02	1.019068e-03	0.1088876	0.0331448
cg03603703	Mpped2	2	106699448	2.387488e-02	1.024378e-03	0.1586687	0.0483195
cg02334175	Gm7977	3	48408625	2.387488e-02	1.023752e-03	0.1623721	0.0494447
cg10870239	Abraxas2	7	132859278	2.392794e-02	1.027667e-03	0.1603533	0.0488459
cg09374907	Map4k4	1	40011704	2.394484e-02	1.029406e-03	-0.1404444	0.0427876
cg04949439	Kirrel3	9	34540639	2.402220e-02	1.033748e-03	0.1124375	0.0342674
cg14455689	Ptprg	14	112102727	2.444657e-02	1.053045e-03	0.1628443	0.0497089
cg12358638	D130009I18Rik	14	1104567917	2.446421e-02	1.054840e-03	0.1995080	0.0609096
cg09816614	4930405A10Rik	14	122505740	2.449056e-02	1.057012e-03	0.2174292	0.0663927
cg22713419	Pptc7	5	122323483	2.455720e-02	1.060928e-03	0.1177913	0.0359794
cg20224547	Psmb7	2	38602739	2.459086e-02	1.064107e-03	0.1615809	0.0493678
cg10790706	Immp1l	2	105913713	2.459086e-02	1.064463e-03	0.1981171	0.0605324
cg27272373	Wdr26	1	181177698	2.461920e-02	1.066731e-03	0.1564421	0.0478079
cg23728998	Tenm3	8	48311607	2.466550e-02	1.069781e-03	0.1530751	0.0467905
cg07087497	Ctdspl2	2	121988813	2.486038e-02	1.079928e-03	0.2270081	0.0694463
cg09487905	Scn1a	2	66289062	2.486038e-02	1.081389e-03	0.1763065	0.0539419
cg15357236	Zfhx3	8	107940370	2.486038e-02	1.080450e-03	0.1087443	0.0332684
cg08167680	Sgip1	4	102933612	2.488954e-02	1.083711e-03	0.2283635	0.0698821
cg07869104	Pcdh9	14	193013748	2.493352e-02	1.086681e-03	0.2436374	0.0745738
cg04397347	Riok3	18	112148951	2.509891e-02	1.096924e-03	0.1042934	0.0319486
cg03491724	Nme2	11	193945469	2.509891e-02	1.097075e-03	-0.1824647	0.0558958
cg25843357	Ttll11	2	36011563	2.509891e-02	1.096704e-03	-0.0572366	0.0175332
cg25997426	Hsf5	11	187616232	2.512184e-02	1.099694e-03	0.1639057	0.0502209
cg11979881	Ivns1abp	1	151354712	2.512184e-02	1.100203e-03	0.1482408	0.0454230
cg24551749	Atp5g2	15	1102672488	2.528207e-02	1.108290e-03	0.0951161	0.0291634
cg07658653	Otx1	11	122078880	2.547469e-02	1.117812e-03	0.1986190	0.0609436
cg07719417	4933406G16Rik	11	119265522	2.547864e-02	1.119614e-03	-0.0962306	0.0295312
cg22244593	Nrip1	16	176358445	2.547864e-02	1.122298e-03	0.1257666	0.0386033
cg08942224	9330117O12Rik	18	154580906	2.547864e-02	1.122120e-03	0.1446532	0.0443998
cg15661483	Mir26a-1	9	119026968	2.547864e-02	1.120357e-03	0.1331332	0.0408582
cg21398335	Mir7669	3	90009203	2.548861e-02	1.124819e-03	0.1325155	0.0406827
cg05215308	Skap2	6	51993405	2.548861e-02	1.124894e-03	0.1146816	0.0352079
cg01743293	Lmo1	7	109161740	2.550771e-02	1.127578e-03	0.2312594	0.0710127
cg19390002	Sox6	7	115476530	2.550771e-02	1.127896e-03	0.1844699	0.0566465
cg00419202	6530403H02Rik	3	120429522	2.551389e-02	1.129249e-03	0.1880937	0.0577653
cg14589467	Ccar2	14	170131344	2.556215e-02	1.133548e-03	0.1140144	0.0350264
cg18276556	Lama2	10	127146028	2.556215e-02	1.133299e-03	0.1997662	0.0613692
cg19065912	Zfp503	14	121994537	2.572956e-02	1.142060e-03	-0.2623076	0.0806364
cg03516596	5730522E02Rik	11	125855571	2.576639e-02	1.144785e-03	-0.2428897	0.0746826
cg15763339	Pik3c2a	7	116356348	2.579703e-02	1.147238e-03	0.1321031	0.0406261
cg09984378	Son	16	191665726	2.590421e-02	1.154064e-03	0.2218962	0.0682758
cg25973323	Kat6b	14	121622056	2.590421e-02	1.154197e-03	0.1611269	0.0495780
cg09170211	Casz1	4	148908991	2.601857e-02	1.161494e-03	0.2113997	0.0650827
cg12966966	Gm10578	7	137172887	2.601857e-02	1.160911e-03	0.1090134	0.0335600
cg07000752	Tbc1d8b	20	139732366	2.608536e-02	1.165580e-03	0.2342145	0.0721288
cg24156613	Bcor	20	12073854	2.609511e-02	1.167119e-03	0.1350060	0.0415813
cg22557786	A330032B11Rik	19	137105799	2.610413e-02	1.168838e-03	0.1532569	0.0472086
cg13103551	Mrps9	1	42873506	2.610413e-02	1.169732e-03	0.1159097	0.0357067
cg17525319	Ebf3	7	137269475	2.611857e-02	1.171484e-03	0.1004045	0.0309343
cg18822954	Otx1	11	122079002	2.613028e-02	1.173115e-03	-0.0663967	0.0204591
cg05871467	Cul3	1	80322986	2.617089e-02	1.176046e-03	0.1534391	0.0472902
cg18384829	Mef2a	7	67268326	2.618342e-02	1.178825e-03	0.0847658	0.0261304
cg24480649	Tox3	8	90349787	2.618342e-02	1.178039e-03	-0.0482565	0.0148749
cg03722442	Gm12830	4	114821978	2.633509e-02	1.186767e-03	-0.0448074	0.0138207
cg06113157	Pou3f2	4	22487053	2.641208e-02	1.191355e-03	-0.2501988	0.0771994
cg01988652	Huwe1	20	151934846	2.664572e-02	1.204033e-03	-0.1735428	0.0535970
cg20481374	Mir107	19	134840942	2.664572e-02	1.204148e-03	0.2206335	0.0681410
cg23439597	Mir5127	18	181897999	2.665431e-02	1.205664e-03	0.0753114	0.0232619
cg07630183	Adgrl3	5	81787520	2.669110e-02	1.208457e-03	0.0891771	0.0275503
cg02349847	Btbd10	7	113325939	2.670053e-02	1.211144e-03	0.2716752	0.0839477
cg13627994	Ankrd28	14	131706789	2.670053e-02	1.210930e-03	0.2056300	0.0635388
cg18683425	Rnf165	18	177458560	2.675352e-02	1.215812e-03	0.2344997	0.0724851
cg15711932	Cdca7l	12	1117806197	2.675352e-02	1.215067e-03	-0.1498202	0.0463077
cg00317287	Grb14	2	64653430	2.677217e-02	1.217792e-03	0.2002884	0.0619191
cg04102296	Gm11149	9	49507625	2.683137e-02	1.221620e-03	0.2543019	0.0786391
cg13742657	Ncoa1	12	14297555	2.686598e-02	1.224333e-03	0.1614200	0.0499266
cg24151104	Sp5	2	70444422	2.692919e-02	1.228353e-03	-0.2071515	0.0640897
cg27501557	Nktr	9	121728640	2.699955e-02	1.234079e-03	0.1684016	0.0521224
cg23352003	Kctd1	18	115151237	2.699955e-02	1.234990e-03	-0.1847898	0.0571985
cg26375896	Maf	8	115703346	2.699955e-02	1.234110e-03	0.2498994	0.0773472
cg20464004	1700019E08Rik	2	45998159	2.704101e-02	1.238031e-03	0.1792954	0.0555099
cg12639822	Memo1	17	174217091	2.706184e-02	1.240129e-03	0.1066719	0.0330306
cg22537620	Calcoco1	15	1102777386	2.708465e-02	1.242596e-03	-0.1494585	0.0462875
cg24657928	Galntl6	8	57958356	2.708465e-02	1.243467e-03	0.1257622	0.0389511
cg03909395	Cadps2	6	23328921	2.712614e-02	1.246519e-03	-0.1906011	0.0590459
cg27527751	Efna5	17	162568906	2.722009e-02	1.251988e-03	0.1125852	0.0348910
cg15762979	Nckap1l	15	1103472825	2.731331e-02	1.257432e-03	0.1508637	0.0467719
cg23346326	Megf9	4	70811057	2.740987e-02	1.263037e-03	-0.1104905	0.0342686
cg12790916	Ythdf3	3	16189491	2.753508e-02	1.269972e-03	-0.2647178	0.0821421
cg02394031	Mecom	3	30349545	2.770420e-02	1.279655e-03	-0.1689514	0.0524612
cg18824846	Hspa2	12	176405157	2.770420e-02	1.280116e-03	0.1247608	0.0387408
cg11164166	Bcor	20	12058729	2.773381e-02	1.287932e-03	0.1354769	0.0420911
cg10815883	Map2k5	9	63230130	2.773381e-02	1.286158e-03	0.2146723	0.0666881
cg23623785	Zmym2	14	156959842	2.773381e-02	1.282847e-03	0.1505895	0.0467700
cg08640766	Gm28036	2	156098175	2.773381e-02	1.289699e-03	0.1367978	0.0425067
cg21739934	4931429L15Rik	9	46510498	2.773381e-02	1.289363e-03	-0.0934824	0.0290468
cg22376496	Fgf18	11	133117167	2.773381e-02	1.287375e-03	0.1610721	0.0500414
cg10152878	Mtx2	2	74884757	2.773381e-02	1.287312e-03	0.2337538	0.0726215
cg22656609	Kdm7a	6	39149334	2.773444e-02	1.290902e-03	0.1481577	0.0460404
cg08752411	Zfp521	18	113739154	2.775033e-02	1.292816e-03	0.1646654	0.0511769
cg18775232	Cul3	1	80267265	2.775160e-02	1.296947e-03	0.2335891	0.0726186
cg12938952	Sall3	18	180984755	2.775160e-02	1.297445e-03	-0.2449645	0.0761577
cg00738572	Hmx3	7	131497749	2.775160e-02	1.294530e-03	0.1152771	0.0358316
cg15885769	Skap1	11	196582700	2.775160e-02	1.297572e-03	0.1245193	0.0387125
cg01408643	Kcnj2	11	1111215267	2.777291e-02	1.300919e-03	-0.1437821	0.0447115
cg14428370	Pou4f1	14	1104280663	2.777291e-02	1.300435e-03	0.2126074	0.0661117
cg15116103	Pola1	20	93442543	2.782955e-02	1.308999e-03	0.1570999	0.0488799
cg03897040	Mir6356	18	168737474	2.782955e-02	1.309380e-03	0.2558877	0.0796187
cg08018810	Klhl13	20	23284637	2.782955e-02	1.306457e-03	0.1204165	0.0374597
cg05013596	Col4a3	1	82716095	2.782955e-02	1.309460e-03	0.1508955	0.0469509
cg09276076	Ropn1l	15	131458854	2.782955e-02	1.306654e-03	0.1187665	0.0369469
cg19888236	NA	19	155999537	2.807077e-02	1.321997e-03	0.2718001	0.0846423
cg15454070	Shoc2	19	153988209	2.812738e-02	1.325854e-03	0.0981566	0.0305753
cg08715757	Arhgap15	2	43781405	2.814520e-02	1.329076e-03	0.1812436	0.0564687
cg18932952	Irf5	6	29531247	2.814520e-02	1.328896e-03	0.1273375	0.0396731
cg11730804	Tenm2	11	136476047	2.843800e-02	1.344105e-03	0.1965505	0.0612996
cg14811158	Fign	2	63670294	2.848097e-02	1.347342e-03	0.1692028	0.0527818
cg08594840	Phtf1	3	104046855	2.850361e-02	1.349619e-03	0.0920132	0.0287073
cg07784624	Msantd4	9	4427068	2.876508e-02	1.363216e-03	0.1007093	0.0314488
cg07992909	Zswim8	14	120723211	2.877910e-02	1.365098e-03	0.1670280	0.0521648
cg15061730	Mex3c	18	173590634	2.883112e-02	1.370844e-03	0.0917577	0.0286678
cg08945781	Lcor	19	141552465	2.883112e-02	1.369848e-03	0.1534199	0.0479298
cg03237342	Tcf12	9	71976205	2.883112e-02	1.371226e-03	-0.2003403	0.0625938
cg16273547	Gtdc1	2	44465677	2.884088e-02	1.373667e-03	0.2005863	0.0626807
cg08912313	Cntln	4	85130193	2.884088e-02	1.374131e-03	0.1671461	0.0522327
cg02076583	Wwox	8	114597725	2.895316e-02	1.380705e-03	0.2202801	0.0688665
cg02361987	Srsf7	17	180204686	2.905650e-02	1.386863e-03	-0.1403343	0.0438905
cg00843792	Lrrc41	4	116075485	2.910920e-02	1.390610e-03	-0.0790424	0.0247271
cg24613973	Kctd1	18	115063559	2.922898e-02	1.397569e-03	0.0442984	0.0138643
cg22036685	Il20rb	9	100252389	2.927287e-02	1.400906e-03	0.1133736	0.0354906
cg16800482	Ezh2	6	47544597	2.933523e-02	1.405132e-03	0.0984889	0.0308395
cg15708887	Gm36669	6	16548312	2.959479e-02	1.418817e-03	0.1081474	0.0338935
cg08729928	Zfhx3	8	108086809	2.971450e-02	1.427071e-03	-0.2432763	0.0762832
cg25565513	Hoxd13	2	74670026	2.971450e-02	1.427018e-03	-0.0750183	0.0235231
cg01118512	Mdfic	6	15806147	2.980084e-02	1.432478e-03	0.1622595	0.0508966
cg14702549	Nt5e	9	88073699	2.994548e-02	1.440698e-03	0.1592696	0.0499846
cg14302062	Tmem33	5	67231771	2.996802e-02	1.443050e-03	-0.1095928	0.0343993
cg05176833	Dock3	9	106908482	2.998430e-02	1.445283e-03	-0.1292674	0.0405806
cg14233818	Sox14	9	99869140	2.998430e-02	1.446372e-03	-0.1137358	0.0357072
cg00634704	Osr2	15	135302847	3.002360e-02	1.449538e-03	0.1947341	0.0611487
cg10974737	Rbm39	2	156178858	3.016670e-02	1.458999e-03	-0.2141657	0.0672902
cg03956142	Mlf1	3	67340821	3.016670e-02	1.457790e-03	0.2086239	0.0655440
cg07394963	Cbll1	12	131494695	3.029769e-02	1.466617e-03	0.1749032	0.0549801
cg14182445	Foxp2	6	15123062	3.032314e-02	1.469776e-03	0.1492117	0.0469133
cg12780461	Gm33948	18	127411031	3.032314e-02	1.471871e-03	0.2049646	0.0644508
cg07600198	Mir6340	2	173688226	3.032314e-02	1.472659e-03	0.0959801	0.0301822
cg18536396	Zfp36l1	12	180109166	3.032314e-02	1.472981e-03	0.0744887	0.0234244
cg19329327	Gm6260	3	143822617	3.049825e-02	1.482778e-03	0.1505784	0.0473810
cg16102730	Mapkap1	2	34455816	3.055244e-02	1.486705e-03	0.1618228	0.0509314
cg17977572	Eri3	4	117640819	3.056711e-02	1.488713e-03	0.2184261	0.0687550
cg21129179	5730522E02Rik	11	125659855	3.063289e-02	1.494294e-03	0.1047095	0.0329712
cg11417765	B230323A14Rik	9	69769881	3.063289e-02	1.494509e-03	-0.1856669	0.0584640
cg03586368	4922502N22Rik	6	139278907	3.065818e-02	1.497040e-03	0.1614061	0.0508325
cg12016197	Smad2	18	176423687	3.067554e-02	1.499185e-03	-0.1467783	0.0462317
cg07777480	Ddx10	9	53233936	3.069084e-02	1.501232e-03	0.2302769	0.0725408
cg21611883	Myo1d	11	180779074	3.082363e-02	1.509326e-03	-0.1503514	0.0473864
cg08999225	Ikzf2	1	69745593	3.082363e-02	1.510336e-03	0.1613109	0.0508436
cg16004878	C1d	11	117370785	3.082380e-02	1.511648e-03	0.0911477	0.0287311
cg22390917	Son	16	191657370	3.086513e-02	1.514981e-03	0.0807324	0.0254532
cg11479269	Pcdh10	3	45385298	3.088970e-02	1.518801e-03	0.1747353	0.0551030
cg20138719	1700039M10Rik	14	157602629	3.088970e-02	1.518149e-03	0.1755722	0.0553647
cg21429502	Hoxc8	15	1102994015	3.097603e-02	1.524356e-03	-0.0843487	0.0266084
cg09496347	Bcor	20	12137509	3.100008e-02	1.526852e-03	0.0902999	0.0284900
cg25269791	Dnm1l	16	116314006	3.105314e-02	1.530779e-03	0.2223069	0.0701553
cg14915305	Mir3961	13	182297283	3.134011e-02	1.550288e-03	0.1577959	0.0498549
cg10880576	1700113H08Rik	10	187154172	3.134011e-02	1.548073e-03	0.1350027	0.0426479
cg16388915	Chchd3	6	32853555	3.134011e-02	1.546872e-03	0.1730294	0.0546568
cg09715604	Plxna4os1	6	32505020	3.134011e-02	1.551556e-03	0.1513011	0.0478065
cg08007141	Tmem33	5	67205742	3.134011e-02	1.549905e-03	0.0883545	0.0279146
cg11419859	Grin1os	2	25292431	3.150640e-02	1.561122e-03	0.1768475	0.0559100
cg23254987	4930441H08Rik	7	71353777	3.151562e-02	1.562912e-03	0.1608947	0.0508719
cg24604865	Isl2	9	55582032	3.171713e-02	1.574248e-03	0.1957087	0.0619207
cg16733575	Barhl2	5	106463695	3.182174e-02	1.580786e-03	-0.1058092	0.0334900
cg00110825	Khdrbs1	4	129714003	3.183137e-02	1.583959e-03	0.1964630	0.0621946
cg10986567	Hnrnpa0	13	158127177	3.183137e-02	1.583356e-03	-0.1317883	0.0417189
cg02810085	Fubp3	2	31547821	3.203300e-02	1.595347e-03	0.1903360	0.0602948
cg06285055	Kdm5c	20	152248797	3.209971e-02	1.600028e-03	0.1636761	0.0518635
cg22498951	Bclaf1	10	120327474	3.219257e-02	1.606018e-03	0.2443984	0.0774685
cg15139258	Mir32	4	56895262	3.219615e-02	1.607560e-03	0.1621703	0.0514087
cg20650821	Hmx3	7	131497414	3.222716e-02	1.610472e-03	0.0926768	0.0293838
cg00095474	4930432J09Rik	14	1104208467	3.229053e-02	1.617386e-03	0.1642458	0.0520960
cg12712534	Cdh18	15	123460471	3.229053e-02	1.617737e-03	0.1281301	0.0406415
cg17073188	Rnf165	18	177462340	3.229053e-02	1.616551e-03	0.1528362	0.0484747
cg11406035	Mir568	16	143610525	3.233759e-02	1.621463e-03	0.0896447	0.0284404
cg08690021	Pou5f2	13	177894038	3.236871e-02	1.625672e-03	0.2070227	0.0656952
cg15673180	Nxpe4	9	48140964	3.236871e-02	1.625763e-03	-0.1463195	0.0464323
cg19732321	Tnik	3	28666123	3.275391e-02	1.646496e-03	0.1525227	0.0484577
cg15180682	Zfhx4	3	5243807	3.279200e-02	1.651164e-03	0.1066791	0.0339017
cg14991111	Slc23a4	6	35051175	3.279200e-02	1.651186e-03	0.1080769	0.0343460
cg26828604	Ppp4r3b	11	129211174	3.297059e-02	1.662969e-03	0.1717392	0.0546135
cg25172570	Nup98	7	102180437	3.297059e-02	1.661879e-03	0.1778280	0.0565463
cg25709820	1700019E08Rik	2	45922451	3.305636e-02	1.668694e-03	0.1457448	0.0463620
cg27559875	Slc25a37	14	169247600	3.310036e-02	1.672315e-03	-0.1709379	0.0543870
cg00211423	Map2k5	9	63230124	3.310915e-02	1.674161e-03	0.2429492	0.0773067
cg08359777	Mettl21a	1	64597484	3.312653e-02	1.676441e-03	0.2484740	0.0790747
cg25658543	Eif4g2	7	111077241	3.314395e-02	1.678725e-03	0.1417123	0.0451044
cg11355954	Sp3os	2	73100005	3.315634e-02	1.680755e-03	0.1044932	0.0332620
cg04546455	Sdccag8	1	176994933	3.319822e-02	1.684283e-03	0.1029786	0.0327863
cg02230564	Bub3	7	131585765	3.335843e-02	1.693823e-03	0.1856665	0.0591436
cg27207181	Cldn18	9	99744719	3.338680e-02	1.703025e-03	0.1939794	0.0618230
cg06989803	Psmd6	14	114116174	3.338680e-02	1.700907e-03	0.1236411	0.0394009
cg02480322	Ranbp17	11	133300082	3.338680e-02	1.703740e-03	0.2004131	0.0638759
cg24163300	Actrt1	20	47061038	3.338680e-02	1.697408e-03	0.1803966	0.0574763
cg06784608	Vwc2l	1	70726076	3.338680e-02	1.700221e-03	0.0562682	0.0179304
cg10287351	Gm33301	15	140314643	3.338680e-02	1.703505e-03	0.1556369	0.0496042
cg19992880	Bnip3l	14	167016510	3.343907e-02	1.707822e-03	-0.1913385	0.0609973
cg14778330	Sox12	2	152396680	3.369745e-02	1.722444e-03	-0.1037899	0.0331138
cg14156441	Trib1	15	159653092	3.380146e-02	1.730621e-03	-0.0834943	0.0266504
cg04094567	Adgrl3	5	81787557	3.380146e-02	1.730350e-03	-0.1347195	0.0430003
cg27650171	Vars2	17	135668010	3.381369e-02	1.732678e-03	0.1557557	0.0497210
cg09420504	Mzt1	14	198708241	3.392366e-02	1.742619e-03	0.1575556	0.0503225
cg24665462	Arx	20	93377896	3.392366e-02	1.740333e-03	0.1216456	0.0388483
cg13027777	Hivep2	10	113967546	3.392366e-02	1.741773e-03	-0.1241229	0.0396425
cg22827537	Tnrc6a	7	123187460	3.403553e-02	1.749806e-03	0.1205255	0.0385102
cg04354551	Myo9a	9	59907416	3.407459e-02	1.753256e-03	0.1917550	0.0612806
cg11236345	Elavl4	4	110205350	3.409755e-02	1.755880e-03	0.1983765	0.0634056
cg02047891	Gm765	6	98510788	3.411192e-02	1.758064e-03	0.1196791	0.0382566
cg15362498	Egln3	12	153872523	3.421313e-02	1.764728e-03	0.1075846	0.0344027
cg19561086	Vrk2	11	126802756	3.425339e-02	1.768254e-03	0.1536551	0.0491441
cg05313144	Asxl1	2	153397926	3.445875e-02	1.780313e-03	0.1217655	0.0389696
cg04941359	Elavl2	4	91252641	3.452745e-02	1.785323e-03	0.2479971	0.0793896
cg03597059	Prkd1	12	150295286	3.464797e-02	1.794487e-03	0.1257377	0.0402710
cg07158988	Bcl9l	9	44499562	3.464797e-02	1.794256e-03	-0.0896277	0.0287054
cg06994774	Lamc1	1	153220108	3.469821e-02	1.798557e-03	0.0968738	0.0310331
cg12131127	Bzw2	12	136124023	3.472142e-02	1.801230e-03	0.0850141	0.0272377
cg26000775	Satb2	1	56845683	3.475988e-02	1.804695e-03	0.1313200	0.0420814
cg03768031	Zfp507	7	36134486	3.496448e-02	1.822341e-03	0.1282802	0.0411450
cg15476781	Esrrg	1	188000524	3.496448e-02	1.825089e-03	0.1320704	0.0423668
cg07257404	Gm38100	1	175994037	3.496448e-02	1.817638e-03	0.1467276	0.0470505
cg21706719	Mettl15	2	108649465	3.496448e-02	1.822872e-03	0.0776183	0.0248963
cg22860697	Otx1	11	122081234	3.496448e-02	1.825675e-03	-0.1387556	0.0445127
cg24975558	Prune2	19	117039707	3.496448e-02	1.822605e-03	0.0668718	0.0214490
cg16256434	Egln3	12	153926651	3.496448e-02	1.821466e-03	0.1325168	0.0425020
cg17064345	A3galt2	4	128743400	3.509703e-02	1.834081e-03	0.1170249	0.0375578
cg11614260	Serbp1	6	67272179	3.510196e-02	1.840280e-03	0.1499820	0.0481504
cg14572170	Alcam	16	152268799	3.510196e-02	1.840154e-03	0.2221765	0.0713273
cg09260635	Maf	8	115303446	3.510196e-02	1.836152e-03	-0.1610069	0.0516788
cg05664157	Prpf38b	3	108910475	3.510196e-02	1.839463e-03	-0.1366741	0.0438762
cg19872161	Rsbn1	3	103928487	3.513120e-02	1.843299e-03	0.1710565	0.0549247
cg15482183	Arhgap15os	2	44208107	3.521753e-02	1.849319e-03	0.2205057	0.0708242
cg12814030	Zfp219	14	152008734	3.530128e-02	1.855211e-03	0.1575921	0.0506323
cg24470121	Mfsd4a	1	132067688	3.533297e-02	1.858371e-03	-0.1441150	0.0463097
cg00741609	Tlx1	19	145153509	3.533786e-02	1.860123e-03	0.1949444	0.0626488
cg05350610	Ofcc1	13	140067890	3.541911e-02	1.865899e-03	0.1320003	0.0424331
cg14107769	Med1	11	198158408	3.543900e-02	1.869946e-03	-0.1518169	0.0488134
cg22075146	Cacna2d2	9	107521814	3.543900e-02	1.868579e-03	-0.0903003	0.0290321
cg10436531	Klf7	1	64156601	3.550661e-02	1.875016e-03	0.0904268	0.0290823
cg13922970	Tlk1	2	70825269	3.558399e-02	1.880608e-03	-0.0900054	0.0289549
cg03219288	Otx1	11	122034351	3.582743e-02	1.894990e-03	0.0873986	0.0281367
cg23292290	Skor1	9	63217746	3.590539e-02	1.900632e-03	0.1457130	0.0469234
cg07639660	Hottip	6	52270993	3.590791e-02	1.902285e-03	-0.1562512	0.0503212
cg05272031	Tspan2	3	102748870	3.610245e-02	1.914864e-03	0.2911557	0.0938265
cg27473842	Dnajc24	2	106040743	3.610245e-02	1.915646e-03	0.1131648	0.0364694
cg24411365	Hif1an	19	144641627	3.621687e-02	1.923250e-03	0.2252297	0.0726117
cg08827873	Lsamp	16	141923938	3.624405e-02	1.926227e-03	0.1934498	0.0623755
cg25762464	Pola1	20	93429282	3.627582e-02	1.929450e-03	0.1763582	0.0568736
cg11832449	Npas3	12	153566876	3.636491e-02	1.937195e-03	0.1320829	0.0426116
cg06933499	En1	1	120600428	3.636491e-02	1.937267e-03	-0.1712231	0.0552389
cg15033935	4930405A10Rik	14	122442862	3.640764e-02	1.941084e-03	0.1498552	0.0483544
cg02106733	Dlg1	16	131847647	3.654430e-02	1.949916e-03	0.1530825	0.0494172
cg07011087	Nkain2	10	132402289	3.656239e-02	1.953976e-03	0.1899268	0.0613233
cg10221825	Gbx2	1	89941764	3.656239e-02	1.953941e-03	-0.1862622	0.0601400
cg02422559	Wsb1	11	179243528	3.656528e-02	1.955677e-03	0.2176579	0.0702829
cg13086047	Pax2	19	144783640	3.658693e-02	1.958494e-03	0.1571512	0.0507520
cg17872415	St8sia5	18	177145050	3.658693e-02	1.959931e-03	-0.1964891	0.0634606
cg04339551	Dyrk1a	16	194663790	3.659241e-02	1.966066e-03	0.2404257	0.0776742
cg18649537	Gm33948	18	127497681	3.659241e-02	1.965980e-03	0.0859710	0.0277745
cg00222071	Evx2	2	74659901	3.659241e-02	1.962584e-03	-0.0812785	0.0262541
cg00128439	Dhx40	11	186773846	3.659241e-02	1.967966e-03	0.2109168	0.0681470
cg03434240	Prdm11	2	92973815	3.659241e-02	1.966780e-03	0.1889920	0.0610596
cg26984621	Tnks	8	34889680	3.662929e-02	1.974600e-03	0.1637921	0.0529382
cg00191058	Zbtb20	16	143537693	3.662929e-02	1.973282e-03	0.1998110	0.0645755
cg16452780	Bcor	20	11800828	3.662929e-02	1.973661e-03	0.0892050	0.0288300
cg16328301	Tmem183a	1	134355555	3.673125e-02	1.981650e-03	0.1530086	0.0494698
cg27603363	Tab3	20	85502422	3.674328e-02	1.985441e-03	0.1780754	0.0575848
cg04080945	Dach1	14	198536605	3.674328e-02	1.990073e-03	0.1905206	0.0616231
cg13406103	Zcchc3	2	152413751	3.674328e-02	1.987535e-03	0.0782168	0.0252958
cg20217707	Gtdc1	2	44575843	3.674328e-02	1.986308e-03	0.1565142	0.0506146
cg06684308	Lmo4	3	144227877	3.674328e-02	1.988886e-03	0.1187643	0.0384116
cg12734405	Mbnl2	14	1120404663	3.676733e-02	2.002266e-03	0.2018420	0.0653232
cg26891414	Rrp15	1	186782828	3.676733e-02	2.002040e-03	0.1649489	0.0533827
cg18138089	Abi1	2	22971228	3.676733e-02	1.993117e-03	0.0994724	0.0321786
cg08708887	Zc3h3	15	175834947	3.676733e-02	2.000121e-03	0.0997659	0.0322845
cg25567445	Mecom	3	30349622	3.676733e-02	1.997254e-03	0.1653192	0.0534903
cg08441764	Cux2	5	121895458	3.676733e-02	1.994660e-03	-0.1207805	0.0390745
cg16018243	Tbr1	2	61804111	3.676733e-02	1.999404e-03	-0.1177917	0.0381163
cg09451873	1700019E08Rik	2	45837015	3.704313e-02	2.018853e-03	0.2088403	0.0676418
cg14785049	Otx1	11	122045641	3.709523e-02	2.023262e-03	-0.0854304	0.0276761
cg01977579	Pabpc1	15	136608780	3.712114e-02	2.026246e-03	0.0844229	0.0273536
cg04861468	Prpf3	3	95849776	3.715308e-02	2.029858e-03	0.1563125	0.0506550
cg26256970	Ophn1	20	98891023	3.715308e-02	2.031134e-03	0.2397256	0.0776907
cg22142552	Foxp1	6	98944641	3.722640e-02	2.036717e-03	0.1165160	0.0377707
cg07724254	Otx1	11	122079063	3.732162e-02	2.043506e-03	0.1394618	0.0452235
cg04182655	Relt	7	100835411	3.759507e-02	2.060069e-03	0.0877501	0.0284771
cg12961607	Srsf7	17	180204844	3.760545e-02	2.062229e-03	0.1130415	0.0366884
cg26934556	Fnbp1l	3	122552145	3.766434e-02	2.069488e-03	0.2312320	0.0750735
cg09394345	B130024G19Rik	7	71145669	3.766434e-02	2.071070e-03	0.1809903	0.0587660
cg13832595	Ythdc1	5	86830558	3.766434e-02	2.071833e-03	0.2339901	0.0759773
cg07598624	Mab21l2	3	86600486	3.766434e-02	2.070458e-03	0.1617321	0.0525115
cg24557648	Zfp407	18	184415164	3.767770e-02	2.074163e-03	0.1982073	0.0643655
cg08568054	Celf4	18	125810565	3.774938e-02	2.079706e-03	0.1974444	0.0641343
cg16751878	Cdk17	10	193239073	3.783287e-02	2.086390e-03	0.1737205	0.0564458
cg25658983	Siah3	14	175455793	3.783287e-02	2.087507e-03	-0.1368200	0.0444583
cg05039938	Sspn	6	146001860	3.791436e-02	2.095213e-03	0.0833939	0.0271077
cg06659440	Bcl11a	11	124061974	3.791436e-02	2.095175e-03	-0.1026952	0.0333816
cg03561281	Nsd2	5	33882862	3.792923e-02	2.097639e-03	0.1262678	0.0410487
cg14896592	Gm32123	14	125039202	3.813525e-02	2.112260e-03	0.1479144	0.0481183
cg23043074	Ebf1	11	144963757	3.813525e-02	2.111748e-03	0.1452557	0.0472522
cg26425349	Usp14	18	110016574	3.816729e-02	2.115650e-03	0.2267689	0.0737820
cg17126395	Mtdh	15	134123727	3.822048e-02	2.121597e-03	0.2349330	0.0764591
cg01872427	Map3k20	2	72378730	3.822048e-02	2.121832e-03	0.1896446	0.0617207
cg12131548	Mindy2	9	70616830	3.823789e-02	2.124417e-03	0.1604515	0.0522258
cg14826942	Macroh2a1	13	156088286	3.831680e-02	2.130423e-03	-0.4449525	0.1448686
cg20156837	Cyhr1	15	176649121	3.840312e-02	2.136847e-03	0.1165697	0.0379641
cg21513836	Fgf14	14	1124677591	3.841514e-02	2.139141e-03	-0.1395653	0.0454580
cg08206382	Dock11	20	36052505	3.861649e-02	2.152543e-03	0.0952263	0.0310352
cg20515845	Rhpn1	15	175726102	3.861649e-02	2.154915e-03	0.1744386	0.0568573
cg07895812	Epb41l4b	4	57077026	3.861649e-02	2.156889e-03	-0.1045422	0.0340780
cg04275146	Ccdc73	2	104894033	3.861649e-02	2.155509e-03	0.1192926	0.0388838
cg13455298	Tbc1d2b	9	90420292	3.861979e-02	2.158708e-03	-0.2399858	0.0782354
cg25558559	Kcnma1	14	123373797	3.870828e-02	2.171843e-03	0.2085109	0.0680148
cg14547563	Nf1	11	179565959	3.870828e-02	2.169787e-03	0.2217916	0.0723402
cg15720698	Zeb2	2	45021122	3.870828e-02	2.166584e-03	0.1805486	0.0588798
cg10998986	Pbx1	1	168183013	3.870828e-02	2.171331e-03	-0.2005330	0.0654110
cg18174545	Dcun1d4	5	73560623	3.870828e-02	2.169172e-03	0.1099058	0.0358462
cg24455002	Nova1	12	146698919	3.882422e-02	2.179992e-03	0.1470960	0.0479993
cg08220031	Zc3h15	2	83658119	3.921592e-02	2.203645e-03	0.1387565	0.0453257
cg24325388	Cct2	10	1117081035	3.927908e-02	2.208856e-03	0.1308791	0.0427624
cg02883001	Prpf38b	3	108905875	3.931755e-02	2.212683e-03	0.0854030	0.0279086
cg22512644	Usp34	11	123454666	3.937007e-02	2.219568e-03	0.1594646	0.0521269
cg06685968	Gm28308	6	52213380	3.937007e-02	2.220010e-03	-0.0744286	0.0243302
cg17630503	Trip12	1	84763867	3.937007e-02	2.220636e-03	0.2559061	0.0836563
cg03137308	Zfhx4	3	5330211	3.950662e-02	2.230010e-03	0.1737366	0.0568183
cg11766397	1700109G15Rik	11	184641449	3.950904e-02	2.233477e-03	0.2282541	0.0746590
cg27359471	Mir6348	1	168479781	3.950904e-02	2.233491e-03	-0.1084169	0.0354618
cg22183370	NA	19	155931449	3.954707e-02	2.237314e-03	0.1474590	0.0482400
cg05316560	Uri1	7	37896740	3.972859e-02	2.249264e-03	0.1511595	0.0494765
cg25092086	1700066C05Rik	16	180507696	3.972916e-02	2.250977e-03	0.2128506	0.0696740
cg04590080	Tent4b	8	88199980	3.974858e-02	2.254779e-03	-0.0671791	0.0219939
cg21104978	Slc12a2	18	157900084	3.974858e-02	2.262169e-03	0.2014767	0.0659830
cg07720842	Dock3	9	106952382	3.974858e-02	2.257668e-03	0.1676120	0.0548817
cg17711602	Gata3	2	9892450	3.974858e-02	2.259569e-03	-0.1959150	0.0641543
cg24370741	4933430M04Rik	11	124371323	3.974858e-02	2.258728e-03	0.1990567	0.0651807
cg02211939	Bnc2	4	84536772	3.974858e-02	2.261429e-03	0.1156628	0.0378780
cg05942016	Snord90	2	37398289	3.983789e-02	2.271199e-03	0.0904028	0.0296182
cg10380094	Rasal2	1	157299192	3.983789e-02	2.272309e-03	-0.1499054	0.0491152
cg22346366	Ntrk3	7	78698952	3.983789e-02	2.269150e-03	0.1950678	0.0639035
cg17144424	Rrp15	1	186850638	3.985578e-02	2.275016e-03	0.1934115	0.0633770
cg11195606	Nr4a3	4	48084740	3.988005e-02	2.279776e-03	0.1467284	0.0480898
cg27273275	Rnf165	18	177461822	3.988005e-02	2.278937e-03	0.0978668	0.0320744
cg05223397	Ush2a	1	188199902	3.988162e-02	2.286423e-03	0.1657687	0.0543457
cg12843514	Pola1	20	93409227	3.988162e-02	2.286392e-03	0.1829630	0.0599826
cg27029166	Prpf3	3	95849739	3.988162e-02	2.286616e-03	-0.2123275	0.0696102
cg26016635	Grid2	6	64665919	3.988162e-02	2.282572e-03	0.0684864	0.0224489
cg02675830	Chic2	5	75006723	3.989604e-02	2.290200e-03	0.1834750	0.0601604
cg06721025	Arhgap15os	2	44081178	3.989604e-02	2.290819e-03	0.1346812	0.0441624
cg12942440	Tmem218	9	37197230	3.996132e-02	2.296849e-03	0.1477133	0.0484481
cg10397346	Dyrk1a	16	194692018	3.996132e-02	2.297949e-03	0.0975563	0.0319988
cg01925203	Arhgap15os	2	44241449	4.009142e-02	2.308823e-03	0.1499657	0.0492121
cg20433492	Glra2	20	165289411	4.009142e-02	2.307480e-03	0.1261562	0.0413965
cg13186343	Eri3	4	117651865	4.014618e-02	2.316266e-03	0.0883092	0.0289884
cg18433069	U2surp	9	95488000	4.014618e-02	2.317073e-03	0.1509444	0.0495507
cg16972264	Ubp1	9	113959475	4.014618e-02	2.315982e-03	0.0942143	0.0309264
cg09901424	Bcor	20	12073910	4.039266e-02	2.333008e-03	0.1583999	0.0520334
cg23247277	Mtfr2	10	120399661	4.039967e-02	2.336455e-03	0.1772561	0.0582360
cg06380810	Tac4	11	195210847	4.039967e-02	2.336832e-03	-0.1182293	0.0388439
cg15667815	Mir3961	13	183055290	4.042339e-02	2.339914e-03	-0.1579234	0.0518920
cg02156108	9130227L01Rik	1	55937082	4.045800e-02	2.343630e-03	0.1822559	0.0598968
cg27144659	Hmgxb4	8	75000023	4.056409e-02	2.351492e-03	0.1564358	0.0514283
cg15845854	Mir378d	10	1126615911	4.063455e-02	2.359015e-03	0.1779943	0.0585341
cg05749574	Birc6	17	174702420	4.063455e-02	2.358416e-03	0.1015071	0.0333802
cg04191285	Tox	4	6795755	4.065268e-02	2.363508e-03	-0.1128208	0.0371086
cg14142471	Gm19585	17	152330431	4.065268e-02	2.361868e-03	0.1297353	0.0426691
cg05850866	Sorl1	9	41940096	4.071529e-02	2.368871e-03	0.1684104	0.0554053
cg09844922	Lmo1	7	109208266	4.075586e-02	2.372956e-03	0.2060702	0.0678066
cg10688581	Meis2	2	115905164	4.080732e-02	2.383474e-03	0.2151011	0.0708092
cg16275162	Lmo3	6	138380280	4.080732e-02	2.386766e-03	0.1696340	0.0558496
cg08491617	Foxp2	6	15282431	4.080732e-02	2.385625e-03	0.0640173	0.0210758
cg19789891	Zfp536	7	37640105	4.080732e-02	2.381251e-03	0.1662903	0.0547361
cg03559209	Lhx2	2	38369048	4.080732e-02	2.388039e-03	-0.1049515	0.0345556
cg09099665	Klhl29	12	15239931	4.080732e-02	2.386118e-03	-0.1335509	0.0439685
cg21695479	Gpat3	5	101090620	4.080732e-02	2.383682e-03	0.1694516	0.0557823
cg27052685	Pantr1	1	41919060	4.087952e-02	2.393994e-03	0.1316370	0.0433526
cg14058051	BC006965	11	1112542761	4.097838e-02	2.403251e-03	0.1377582	0.0453859
cg21536160	Wwox	8	114604747	4.097838e-02	2.402925e-03	0.2485806	0.0818964
cg09674317	Cadps2	6	23451541	4.123940e-02	2.420304e-03	0.1264306	0.0416832
cg27311928	Vsx2	12	184520904	4.134081e-02	2.437107e-03	0.1594775	0.0526147
cg01313856	Btrc	19	145312174	4.134081e-02	2.435423e-03	0.1731398	0.0571183
cg00257950	Rere	4	150526330	4.134081e-02	2.430886e-03	-0.1075817	0.0354843
cg25810458	Zfp407	18	184353434	4.134081e-02	2.429653e-03	0.1548215	0.0510630
cg03463065	Fam172a	13	177470318	4.134081e-02	2.443749e-03	-0.2634122	0.0869284
cg27113320	Btrc	19	145324768	4.134081e-02	2.435548e-03	0.1919255	0.0633159
cg09521804	Cnbp	6	87844086	4.134081e-02	2.438253e-03	0.2001973	0.0660521
cg27603860	Evx2	2	74651651	4.134081e-02	2.442741e-03	-0.2074923	0.0684715
cg11861802	Sall1	8	89675078	4.134081e-02	2.441583e-03	0.1693841	0.0558933
cg03214411	Gria2	3	80689229	4.134081e-02	2.439987e-03	0.0508578	0.0167810
cg09189709	Rc3h2	2	37374406	4.136603e-02	2.446990e-03	0.1711527	0.0564894
cg02839202	Relt	7	100836113	4.143929e-02	2.453077e-03	-0.1183889	0.0390842
cg25587386	Elavl2	4	91311575	4.149436e-02	2.458092e-03	0.1601845	0.0528932
cg23283355	Luc7l2	6	38554998	4.155334e-02	2.463345e-03	0.1912228	0.0631555
cg15318407	Zfhx4	3	5242669	4.156394e-02	2.466650e-03	0.2376986	0.0785157
cg12366082	Dach1	14	197786926	4.156394e-02	2.467491e-03	0.2324872	0.0767969
cg15430884	Bnc2	4	84406340	4.157369e-02	2.469828e-03	0.1847965	0.0610491
cg16915042	Kctd16	18	140260993	4.164722e-02	2.475959e-03	0.1634085	0.0539968
cg23234941	Dach1	14	198019552	4.171475e-02	2.481739e-03	0.1924542	0.0636095
cg11956374	Gm6260	3	143914577	4.172996e-02	2.484410e-03	-0.1567586	0.0518170
cg14411125	Cadm1	9	47829386	4.173971e-02	2.487470e-03	-0.1711074	0.0565670
cg20913926	Dennd1a	2	38159825	4.173971e-02	2.488523e-03	-0.2342771	0.0774538
cg20916701	Pex14	4	149044311	4.182291e-02	2.495253e-03	0.2476550	0.0818988
cg05182469	R3hcc1l	19	142539790	4.189732e-02	2.501465e-03	0.1928515	0.0637913
cg19014505	Elavl4	4	110205455	4.193433e-02	2.505449e-03	0.1520600	0.0503063
cg17416451	Kctd15	7	34650549	4.201431e-02	2.512005e-03	0.1100096	0.0364042
cg16747818	Tex13a	20	138220467	4.201485e-02	2.513815e-03	0.1996146	0.0660609
cg05951790	Oga	19	145761597	4.207975e-02	2.523929e-03	0.1317373	0.0436150
cg15024159	Cadm1	9	47275051	4.207975e-02	2.524820e-03	0.0951739	0.0315109
cg17840695	Pcgf1	6	83078431	4.207975e-02	2.524547e-03	0.0347868	0.0115173
cg22870684	Shank2	7	144285038	4.207975e-02	2.520270e-03	-0.1987750	0.0658000
cg21947443	Llph	10	1120245913	4.208080e-02	2.528445e-03	0.1516253	0.0502084
cg17577212	Gpr26	7	131778664	4.208080e-02	2.527773e-03	0.0879147	0.0291109
cg23141081	Rps13	7	116350858	4.217641e-02	2.535974e-03	0.1446170	0.0479020
cg03134455	Prdm16	4	154456678	4.225700e-02	2.542608e-03	0.1165979	0.0386313
cg20971724	4930513N10Rik	8	95788655	4.260901e-02	2.567394e-03	0.0925691	0.0307000
cg12896068	Skor1	9	63217539	4.260901e-02	2.566209e-03	0.1647870	0.0546481
cg23839018	Dhx35	2	158882721	4.272360e-02	2.576107e-03	-0.1089306	0.0361385
cg24217623	Pbx3	2	34359904	4.281644e-02	2.583517e-03	0.1889813	0.0627140
cg02273345	Csmd3	15	147755439	4.284801e-02	2.587235e-03	0.1815058	0.0602419
cg24296072	Cntnap2	6	47107964	4.290840e-02	2.592697e-03	-0.1040484	0.0345411
cg13613983	Pura	18	136286952	4.299125e-02	2.599522e-03	-0.0583412	0.0193727
cg15115387	Klhl28	12	164957641	4.299126e-02	2.601341e-03	0.1459190	0.0484572
cg19537999	Prune2	19	117060278	4.304966e-02	2.606697e-03	0.1158676	0.0384856
cg21005654	Ptf1aos	2	19455293	4.306226e-02	2.610069e-03	-0.1913822	0.0635762
cg14678442	Nog	11	189301072	4.306226e-02	2.612926e-03	-0.1258943	0.0418261
cg13484249	Agap1	1	89824306	4.306226e-02	2.611202e-03	0.2598132	0.0863124
cg03775588	Pax6	2	105682292	4.314319e-02	2.619662e-03	-0.3605501	0.1198173
cg26939636	Lmo1	7	109261998	4.333558e-02	2.633178e-03	0.1308647	0.0435113
cg26809863	Ift20	11	178541365	4.338899e-02	2.638667e-03	0.1536096	0.0510845
cg25664402	Akt3	1	177258708	4.338899e-02	2.640095e-03	0.1069828	0.0355802
cg07520422	Pou4f3	18	142421771	4.347607e-02	2.648961e-03	0.1002074	0.0333382
cg02523575	Pparg	6	115463248	4.347607e-02	2.649073e-03	0.1482884	0.0493345
cg20274287	Riok3	18	112148939	4.379349e-02	2.670272e-03	0.1468383	0.0488915
cg16769396	Fmr1	20	68710760	4.379349e-02	2.672120e-03	0.1567254	0.0521872
cg11570499	Celf2	2	6606834	4.392422e-02	2.684836e-03	0.1696247	0.0565097
cg14792778	Cdh18	15	123460342	4.392422e-02	2.682906e-03	0.1333962	0.0444371
cg14363797	Kif5a	10	1127262785	4.392422e-02	2.687531e-03	-0.1535929	0.0511740
cg23075119	Ltbp3	19	15741195	4.392422e-02	2.686498e-03	0.1311293	0.0436879
cg27325093	St18	1	6757890	4.394732e-02	2.692664e-03	-0.1490713	0.0496771
cg19235908	Arhgap15os	2	44303060	4.394732e-02	2.691438e-03	-0.2487534	0.0828917
cg16149925	Mipol1	12	157331895	4.399178e-02	2.697249e-03	0.0812840	0.0270921
cg26905937	Arx	20	93368053	4.402738e-02	2.701295e-03	0.1877414	0.0625840
cg23476265	Pnisr	4	21874644	4.402992e-02	2.705177e-03	0.1606578	0.0535634
cg03756336	Sox2ot	3	34443842	4.402992e-02	2.703747e-03	0.1101116	0.0367093
cg19821567	Camta1	4	151549205	4.412937e-02	2.713154e-03	0.1365293	0.0455326
cg04296683	Lrch2	20	147480505	4.415281e-02	2.716464e-03	0.1478765	0.0493230
cg24033437	Sox6	7	115919833	4.419158e-02	2.721283e-03	0.1926000	0.0642517
cg10583229	D030024E09Rik	15	161692982	4.419158e-02	2.722589e-03	0.1886522	0.0629378
cg22776920	Eya4	10	123109996	4.424961e-02	2.728036e-03	0.2396856	0.0799797
cg02230860	Fam193b	13	155569789	4.429182e-02	2.733031e-03	-0.1183100	0.0394857
cg14318001	Srsf5	12	180948286	4.429182e-02	2.734387e-03	0.0859919	0.0287011
cg13276805	Fam118b	9	35227390	4.434879e-02	2.740953e-03	0.1707679	0.0570103
cg02736176	Otx1	11	122045575	4.434879e-02	2.741657e-03	0.0897242	0.0299549
cg07584109	Srek1	13	1103764328	4.448227e-02	2.751791e-03	0.1548395	0.0517134
cg01444413	Pogz	3	94862487	4.452884e-02	2.756626e-03	0.1149800	0.0384080
cg13634781	Adgrb3	1	25228464	4.452884e-02	2.758440e-03	-0.1519946	0.0507757
cg05633263	Srcin1	11	197558366	4.456092e-02	2.762313e-03	-0.1301745	0.0434927
cg05638983	I730028E13Rik	9	61145113	4.465336e-02	2.769933e-03	0.2170327	0.0725333
cg09133264	A830082K12Rik	13	179141544	4.477624e-02	2.781344e-03	0.1269617	0.0424490
cg09200783	Tmem260	14	148456488	4.477624e-02	2.780405e-03	0.1103639	0.0368983
cg04336027	4930519F24Rik	9	100210798	4.479074e-02	2.784141e-03	0.2163945	0.0723578
cg09235324	Ltbp1	17	175276435	4.484347e-02	2.789316e-03	0.2052911	0.0686581
cg17619764	Slc35b3	13	138814686	4.488694e-02	2.793919e-03	0.1612848	0.0539496
cg09391013	Meis1	11	118882620	4.488701e-02	2.795823e-03	0.1737709	0.0581302
cg14536337	Hoxa13	6	52257206	4.504705e-02	2.807697e-03	-0.1330770	0.0445365
cg15982050	Skap1	11	196644683	4.510135e-02	2.816807e-03	0.1302065	0.0435903
cg00264131	Cadm1	9	47529152	4.510135e-02	2.813478e-03	0.1617437	0.0541417
cg15813117	Otx1	11	122053455	4.510135e-02	2.816367e-03	0.0926461	0.0310154
cg26089982	Esx1	20	137162685	4.513898e-02	2.821067e-03	0.1109128	0.0371369
cg14748407	Lcor	19	141552490	4.521076e-02	2.827466e-03	0.2130779	0.0713614
cg09481972	Hoxc6	15	1102998229	4.530297e-02	2.835149e-03	0.1808733	0.0605927
cg23413592	Mapkap1	2	34455835	4.532616e-02	2.838519e-03	0.2228497	0.0746639
cg06750881	Gtdc1	2	44633244	4.534629e-02	2.841699e-03	-0.1558985	0.0522384
cg18409580	Ccar1	10	162764505	4.539695e-02	2.846794e-03	0.0819498	0.0274648
cg22036407	Ppp6r3	19	13478308	4.544681e-02	2.854308e-03	0.1456987	0.0488429
cg05513929	Nrxn1	17	190162430	4.544681e-02	2.855689e-03	0.1153487	0.0386705
cg12799227	Scn9a	2	66563587	4.544681e-02	2.852626e-03	0.0866778	0.0290554
cg11407867	Nlk	11	178572376	4.546199e-02	2.872376e-03	0.1884383	0.0632115
cg25323435	Mef2c	13	183524300	4.546199e-02	2.858738e-03	-0.1722198	0.0577428
cg04550865	Lrmda	14	122075063	4.546199e-02	2.875880e-03	0.2155522	0.0723159
cg19471843	Ccdc171	4	83865444	4.546199e-02	2.862730e-03	0.1391722	0.0466691
cg15146514	Ogt	20	101642982	4.546199e-02	2.873725e-03	-0.1072041	0.0359633
cg23390662	Hoxb5	11	196303511	4.546199e-02	2.866410e-03	-0.0465405	0.0156087
cg04976865	Dedd	1	171341015	4.546199e-02	2.874006e-03	0.1050267	0.0352332
cg21283418	Castor2	5	133663018	4.546199e-02	2.864503e-03	0.1222871	0.0410096
cg17563080	Pola1	20	93561931	4.546199e-02	2.871129e-03	0.1453989	0.0487718
cg07982366	Sertad4	1	192898853	4.546199e-02	2.870714e-03	0.0933666	0.0313179
cg09570546	Zfp507	7	35866145	4.554712e-02	2.887047e-03	0.0969923	0.0325531
cg01960173	Usf2	7	30956011	4.554712e-02	2.885523e-03	-0.1000359	0.0335727
cg07256954	Diaph3	14	186866446	4.554712e-02	2.886975e-03	0.2029872	0.0681274
cg09982766	Tra2a	6	49252486	4.555196e-02	2.897097e-03	0.1607856	0.0539830
cg26081366	Hnrnph1	11	150381469	4.555196e-02	2.898270e-03	-0.2496427	0.0838198
cg10146038	Zfhx3	8	108731923	4.555196e-02	2.894600e-03	-0.0488300	0.0163930
cg10606240	Dnajc24	2	106149981	4.555196e-02	2.898919e-03	-0.1465719	0.0492140
cg05950040	Ccdc66	14	127480699	4.555196e-02	2.891972e-03	0.1619581	0.0543667
cg12396418	Eif5a	11	169921304	4.555196e-02	2.892835e-03	-0.0852952	0.0286331
cg11559504	Tm4sf19	16	132381789	4.555604e-02	2.903354e-03	0.1253970	0.0421108
cg16208774	Cadps	14	112507197	4.555604e-02	2.902398e-03	-0.0688168	0.0231093
cg20406520	Zfp740	15	1102208834	4.555604e-02	2.904962e-03	0.1247714	0.0419031
cg27340951	Zcchc7	4	44799925	4.558526e-02	2.908754e-03	0.2210864	0.0742593
cg16909474	Ankrd17	5	90228955	4.560937e-02	2.912222e-03	0.1629129	0.0547265
cg21793027	Tusc3	8	39096970	4.567829e-02	2.920469e-03	0.1404213	0.0471848
cg07442023	Triqk	4	13248594	4.567829e-02	2.920488e-03	-0.1954504	0.0656759
cg17630580	Tle4	19	115058022	4.578437e-02	2.931145e-03	0.1635718	0.0549846
cg23647082	Zc3h3	15	175835247	4.578437e-02	2.929490e-03	0.1010286	0.0339587
cg17362055	2900052N01Rik	9	46660555	4.578618e-02	2.935136e-03	0.2154131	0.0724211
cg17092321	Gm29443	7	16564516	4.578618e-02	2.933967e-03	0.1292583	0.0434544
cg25821931	Pard3b	1	61782823	4.578822e-02	2.937204e-03	0.0815888	0.0274319
cg24677779	Nckap1	2	80545047	4.586050e-02	2.943781e-03	0.1507305	0.0506904
cg02369056	Zc3h3	15	175808394	4.590532e-02	2.949567e-03	0.1088010	0.0365970
cg03952681	Eif3j1	2	122011852	4.590532e-02	2.950543e-03	0.1850858	0.0622588
cg21942865	Calm2	17	187532300	4.591555e-02	2.953143e-03	-0.2213770	0.0744732
cg23012887	Scaf8	17	13159304	4.598452e-02	2.959525e-03	0.1172934	0.0394673
cg24918496	Lta4h	10	193482277	4.610228e-02	2.972956e-03	0.0878906	0.0295876
cg00611309	Dach1	14	197588276	4.610228e-02	2.969769e-03	-0.2532888	0.0852580
cg10712152	Zfhx3	8	108675009	4.610228e-02	2.972542e-03	-0.1175715	0.0395788
cg11551674	Slc35b3	13	138976848	4.611037e-02	2.975429e-03	0.2121858	0.0714366
cg19494369	5730522E02Rik	11	125531214	4.615979e-02	2.980571e-03	0.1204723	0.0405667
cg25713925	Tnpo3	6	29571035	4.616966e-02	2.983162e-03	0.2305824	0.0776511
cg06501452	AW554918	18	125241225	4.632023e-02	2.994851e-03	0.2171693	0.0731637
cg02021058	Kdm6a	20	18279682	4.646961e-02	3.007168e-03	-0.2104230	0.0709210
cg26872866	Slc35b3	13	139047589	4.646961e-02	3.010408e-03	0.1661752	0.0560140
cg08375848	Enox2	20	49038892	4.646961e-02	3.009394e-03	0.1097274	0.0369854
cg24472499	Mir691	16	174295737	4.667489e-02	3.027656e-03	0.0745970	0.0251599
cg26150823	Dph6	2	114460272	4.667489e-02	3.026929e-03	0.1620818	0.0546652
cg20211977	Mapkap1	2	34557013	4.678633e-02	3.038845e-03	0.1637019	0.0552341
cg25278451	Gm33948	18	127629619	4.678633e-02	3.038167e-03	0.1153868	0.0389314
cg04769815	Ndufa4	6	11535060	4.683042e-02	3.043690e-03	-0.1683263	0.0568038
cg09955719	Insm1	2	146223670	4.686627e-02	3.048003e-03	0.1054249	0.0355822
cg01240843	Mipol1	12	157317198	4.687917e-02	3.050825e-03	0.2038502	0.0688086
cg21540320	Zeb2	2	45058392	4.697018e-02	3.058736e-03	0.1288609	0.0435080
cg27640306	Bzw2	12	136134899	4.712628e-02	3.070896e-03	0.1632449	0.0551400
cg10359643	Foxp2	6	15286296	4.722819e-02	3.079535e-03	0.1068655	0.0361070
cg04759478	Tlx3	11	133192777	4.728140e-02	3.086414e-03	0.2422603	0.0818724
cg18674676	Filip1	9	79815872	4.728140e-02	3.087006e-03	0.2235290	0.0755436
cg16937191	Ebf1	11	144904213	4.742942e-02	3.098677e-03	0.1687282	0.0570456
cg12321772	Cnot2	10	1116498239	4.747335e-02	3.105564e-03	0.1104328	0.0373451
cg12378720	2810403D21Rik	20	108832856	4.747335e-02	3.104016e-03	0.1618158	0.0547184
cg11515877	Rwdd3	3	121059818	4.758218e-02	3.121685e-03	0.0966568	0.0327041
cg08600163	Arid5b	10	168279760	4.758218e-02	3.118903e-03	-0.1028832	0.0348076
cg06225551	Son	16	191664950	4.758218e-02	3.118851e-03	0.0988779	0.0334524
cg01194026	Sema3d	5	12585096	4.758218e-02	3.122751e-03	0.1620766	0.0548410
cg19179483	Opcml	9	28687441	4.758218e-02	3.120435e-03	-0.2037395	0.0689330
cg18261337	Dennd4a	9	64873065	4.770479e-02	3.132816e-03	0.1810468	0.0612805
cg04267424	Pbx1	1	168431932	4.773292e-02	3.136683e-03	-0.0668234	0.0226212
cg12143541	Vapa	17	165594964	4.773765e-02	3.139014e-03	0.1190539	0.0403055
cg15814754	Tpm1	9	67032452	4.782606e-02	3.146851e-03	-0.0633875	0.0214653
cg03617806	Zbtb7a	10	181144164	4.783286e-02	3.149322e-03	-0.1512422	0.0512204
cg01526265	4930555B11Rik	2	57182126	4.805792e-02	3.166174e-03	-0.1154671	0.0391264
cg00906973	Tfap2a	13	140738322	4.815024e-02	3.174293e-03	-0.1133632	0.0384239
cg20211859	Uchl3	14	1101667659	4.817143e-02	3.177729e-03	0.1787682	0.0605994
cg12221457	Snx10	6	51657154	4.817694e-02	3.180131e-03	-0.0800110	0.0271245
cg26879535	Gm12130	11	139042068	4.830063e-02	3.194426e-03	0.1280357	0.0434258
cg23145858	Nova1	12	146697884	4.830063e-02	3.191719e-03	0.1074004	0.0364237
cg21364331	Poll	19	145540169	4.830063e-02	3.192429e-03	0.2104013	0.0713569
cg04647787	Arx	20	93377867	4.832626e-02	3.200060e-03	0.1192567	0.0404557
cg13489443	Nkx6-1	5	101658915	4.832626e-02	3.200212e-03	-0.0898102	0.0304666
cg12001273	Tox	4	6687495	4.844176e-02	3.213360e-03	0.1514116	0.0513860
cg22978368	Gm13205	4	148973075	4.844176e-02	3.214009e-03	0.1043697	0.0354217
cg06029967	Smad7	18	175370701	4.844176e-02	3.211046e-03	-0.1456408	0.0494238
cg00678568	Srek1	13	1103764404	4.849050e-02	3.219295e-03	0.0665338	0.0225846
cg09474736	Celf4	18	126146657	4.849764e-02	3.221821e-03	0.0897475	0.0304669
cg05671448	Cpeb1	7	81355885	4.867185e-02	3.235454e-03	0.0912637	0.0309953
cg11781618	Nrxn1	17	190702065	4.871592e-02	3.240444e-03	0.1437706	0.0488358
cg27151981	Zfc3h1	10	1115431709	4.878122e-02	3.246852e-03	0.1329252	0.0451613
cg21846387	Rab3ip	10	1116910140	4.894142e-02	3.259586e-03	0.1051930	0.0357540
cg16197517	Pdha1	20	160086396	4.921529e-02	3.279909e-03	0.1032302	0.0351098
cg11212378	Mms22l	4	23732743	4.925398e-02	3.284571e-03	0.1553861	0.0528566
cg17470118	Ebf1	11	144657355	4.934124e-02	3.292478e-03	0.2130281	0.0724826
cg02294284	Slitrk1	14	1108913248	4.955144e-02	3.309337e-03	-0.1984918	0.0675731
cg00252404	Foxp1	6	99505418	4.955144e-02	3.319079e-03	0.0974455	0.0331839
cg25572043	Ankrd28	14	131781852	4.955144e-02	3.311737e-03	-0.2106741	0.0717258
cg01445252	Myof	19	137881931	4.955144e-02	3.319085e-03	0.1028529	0.0350254
cg26137465	Mknk1	4	115864274	4.955144e-02	3.315999e-03	-0.0830952	0.0282943
cg14030728	Npr2	4	43632736	4.955144e-02	3.316003e-03	-0.1137424	0.0387298
cg25611243	Sox5	6	144871553	4.956722e-02	3.323269e-03	0.2627006	0.0894715
cg11389621	Rnf165	18	177461770	4.956722e-02	3.325587e-03	0.1241812	0.0422972
cg18758604	Dbpht2	12	174295362	4.956722e-02	3.326434e-03	0.1233062	0.0420003
cg13916266	Chd3	11	169369837	4.967046e-02	3.338650e-03	-0.2009155	0.0684619
cg05598763	Strbp	2	37580758	4.967046e-02	3.341769e-03	0.1749277	0.0596125
cg18753452	Pcbp2	15	1102486092	4.967046e-02	3.341238e-03	0.0968893	0.0330177
cg25691921	Bcor	20	11821997	4.967046e-02	3.340307e-03	0.0898977	0.0306342
cg19575317	Cdkl5	20	160807536	4.967054e-02	3.343877e-03	0.1146202	0.0390633
cg11902343	Gtdc1	2	44394747	4.971629e-02	3.349060e-03	0.1924801	0.0656092
cg02494169	Lrmda	14	122075044	4.978865e-02	3.356041e-03	0.1610164	0.0548965
cg02785457	Tank	2	61656497	4.981575e-02	3.362083e-03	0.1620543	0.0552609
cg15863913	Mms22l	4	23628807	4.981575e-02	3.360956e-03	0.1979782	0.0675086
cg07210941	Zfpm2	15	140662229	4.998167e-02	3.375396e-03	0.2246353	0.0766332

# Save to outputs

write.csv(betaResults, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_stats_table_FullJ20.csv")


sig_genotype <- betaResults[which(betaResults[,"FDR_adj_genotype"] < 0.05),]
write.csv(sig_genotype, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_FullJ20_sig_genotype.csv")

sig_age <- betaResults[which(betaResults[,"FDR_adj_age"] < 0.05),]
write.csv(sig_age, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_FullJ20_sig_age.csv")

sig_pathology <- betaResults[which(betaResults[,"FDR_adj_pathology"] < 0.05),]
write.csv(sig_pathology, file = "/gpfs/ts0/projects/Research_Project-191406/Aisha/data/Array/DMPs_FullJ20_sig_interaction.csv")